LOCUS       NM_025695               5603 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus structural maintenance of chromosomes 6 (Smc6),
            transcript variant 1, mRNA.
ACCESSION   NM_025695 NM_026052
VERSION     NM_025695.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5603)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5603)
  AUTHORS   Atkins,A., Xu,M.J., Li,M., Rogers,N.P., Pryzhkova,M.V. and
            Jordan,P.W.
  TITLE     SMC5/6 is required for replication fork stability and faithful
            chromosome segregation during neurogenesis
  JOURNAL   Elife 9, e61171 (2020)
   PUBMED   33200984
  REMARK    GeneRIF: SMC5/6 is required for replication fork stability and
            faithful chromosome segregation during neurogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5603)
  AUTHORS   Hwang,G., Verver,D.E., Handel,M.A., Hamer,G. and Jordan,P.W.
  TITLE     Depletion of SMC5/6 sensitizes male germ cells to DNA damage
  JOURNAL   Mol Biol Cell 29 (25), 3003-3016 (2018)
   PUBMED   30281394
  REMARK    GeneRIF: SMC5/6 complex is essential only when meiotic DNA
            processing events are perturbed during mouse spermatogenesis
REFERENCE   4  (bases 1 to 5603)
  AUTHORS   Hwang,G., Sun,F., O'Brien,M., Eppig,J.J., Handel,M.A. and
            Jordan,P.W.
  TITLE     SMC5/6 is required for the formation of segregation-competent
            bivalent chromosomes during meiosis I in mouse oocytes
  JOURNAL   Development 144 (9), 1648-1660 (2017)
   PUBMED   28302748
  REMARK    GeneRIF: age-dependent depletion of the SMC5/6 complex in oocytes
            could contribute to increased incidence of oocyte aneuploidy and
            spontaneous abortion in aging females.
REFERENCE   5  (bases 1 to 5603)
  AUTHORS   Pryzhkova,M.V. and Jordan,P.W.
  TITLE     Conditional mutation of Smc5 in mouse embryonic stem cells perturbs
            condensin localization and mitotic progression
  JOURNAL   J Cell Sci 129 (8), 1619-1634 (2016)
   PUBMED   26919979
REFERENCE   6  (bases 1 to 5603)
  AUTHORS   Verver,D.E., van Pelt,A.M., Repping,S. and Hamer,G.
  TITLE     Role for rodent Smc6 in pericentromeric heterochromatin domains
            during spermatogonial differentiation and meiosis
  JOURNAL   Cell Death Dis 4 (8), e749 (2013)
   PUBMED   23907463
  REMARK    GeneRIF: Smc6 has a role in the prevention of aberrant
            recombination events between pericentromeric regions during the
            first meiotic prophase.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5603)
  AUTHORS   Ju,L., Wing,J., Taylor,E., Brandt,R., Slijepcevic,P., Horsch,M.,
            Rathkolb,B., Racz,I., Becker,L., Hans,W., Adler,T., Beckers,J.,
            Rozman,J., Klingenspor,M., Wolf,E., Zimmer,A., Klopstock,T.,
            Busch,D.H., Gailus-Durner,V., Fuchs,H., de Angelis,M.H., van der
            Horst,G. and Lehmann,A.R.
  TITLE     SMC6 is an essential gene in mice, but a hypomorphic mutant in the
            ATPase domain has a mild phenotype with a range of subtle
            abnormalities
  JOURNAL   DNA Repair (Amst) 12 (5), 356-366 (2013)
   PUBMED   23518413
  REMARK    GeneRIF: Mice deleted for the SMC6 gene are inviable, and mice
            mutated at Ser-994 in the SMC6 ATPase domain have a mild phenotype.
REFERENCE   8  (bases 1 to 5603)
  AUTHORS   Brouwer,A.K., Schimmel,J., Wiegant,J.C., Vertegaal,A.C., Tanke,H.J.
            and Dirks,R.W.
  TITLE     Telomeric DNA mediates de novo PML body formation
  JOURNAL   Mol Biol Cell 20 (22), 4804-4815 (2009)
   PUBMED   19793919
REFERENCE   9  (bases 1 to 5603)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104880.13 and AC139207.10.
            
            On Nov 17, 2006 this sequence version replaced NM_025695.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090630.1, SRR7652917.820755.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AC104880.13        191005-191407
            404-546             AC104880.13        196848-196990
            547-664             AC104880.13        199113-199230
            665-770             AC104880.13        201379-201484
            771-907             AC104880.13        204724-204860
            908-969             AC104880.13        205460-205521
            970-1050            AC139207.10        69379-69459
            1051-1152           AC139207.10        70090-70191
            1153-1272           AC139207.10        72117-72236
            1273-1371           AC139207.10        72330-72428
            1372-1518           AC139207.10        76147-76293
            1519-1607           AC139207.10        76656-76744
            1608-1772           AC139207.10        76911-77075
            1773-1951           AC139207.10        77732-77910
            1952-2156           AC139207.10        78545-78749
            2157-2271           AC139207.10        81504-81618
            2272-2432           AC139207.10        81942-82102
            2433-2568           AC139207.10        84169-84304
            2569-2649           AC139207.10        85281-85361
            2650-2820           AC139207.10        86278-86448
            2821-2958           AC139207.10        87590-87727
            2959-3104           AC139207.10        88541-88686
            3105-3230           AC139207.10        93097-93222
            3231-3336           AC139207.10        96218-96323
            3337-3489           AC139207.10        101626-101778
            3490-3587           AC139207.10        103638-103735
            3588-5603           AC139207.10        104789-106804
FEATURES             Location/Qualifiers
     source          1..5603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 5.58 cM"
     gene            1..5603
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /note="structural maintenance of chromosomes 6"
                     /db_xref="GeneID:67241"
                     /db_xref="MGI:MGI:1914491"
     exon            1..403
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..546
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..3702
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     structural maintenance of chromosomes protein 6; SMC
                     protein 6; SMC6 structural maintenance of chromosomes
                     6-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 6
                     isoform 1"
                     /protein_id="NP_079971.2"
                     /db_xref="CCDS:CCDS25815.1"
                     /db_xref="GeneID:67241"
                     /db_xref="MGI:MGI:1914491"
                     /translation="MAKRKEENFCSPENAKRPRQEELEDFDKDGDEDECTISFTNGTS
                     TLTAAEVGIIESIQLRNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGK
                     AVATNRGSSLKGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGSRSY
                     KLKSEKGTVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMK
                     ATQLEQMKEDYSYIMETKERTKEQINQGEERLTELKRQCLEKEERFQNIAGLSTMKTN
                     LEYLKHEMAWAVVNEIEKQLNAIRDNIKIGEERAAKLDRKMEEQQVRLNDAEKKYKDI
                     QDKLEKISEETNARAPECMALKTDVIARTRAFNDAEVLYNRSLNEYKALKKDGEQLCK
                     RIEELKKSTDQSLEPERLERQKRICWLKEKVKALQDQEHTVNQEAEQFEQAIEKDKQE
                     HGRVRKEDIEVRHALNYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTH
                     KPIGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQSLMKKFYPPGTSRP
                     QIIVSEFRDEVYDVRLRAAYHPEFPTVLTALEIDNAVVANSLIDMRSIETVLLIKNNS
                     VARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLETEIE
                     NKKGHIITLQQRLSALEKDIKRNEELLKRCQLHYKEIKMKIRKNISEIRELENIEEHQ
                     SVDIATLEDEAEENKIKMQMVEKNMEQQKENMENLKSLKIEAENKYDTIKLKINQLSE
                     LADPLKDELNLADSEVDSQKRGKQHYEDKQKEHLDTLNKKRRELDMKEKELQEKMSQA
                     RQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREEIMKQYQEARETYLDLDNK
                     VRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNET
                     LSITVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMV
                     NRRIAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPV
                     TQEEDDSAS"
     exon            547..664
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..770
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..907
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..969
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1050
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1152
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1272
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1371
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1518
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1607
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1772
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1951
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2156
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2271
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2432
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2568
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2649
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2820
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2958
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3104
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3230
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3336
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3489
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3587
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..5603
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4045..4050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /note="hexamer: AATAAA"
     polyA_site      4065
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /note="major polyA site"
     regulatory      5576..5581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
                     /note="hexamer: AATAAA"
     polyA_site      5603
                     /gene="Smc6"
                     /gene_synonym="2810489L22Rik; 3830418C19Rik; mKIAA4103;
                     SMC-6; Smc6l1"
ORIGIN      
        1 gtcggccggg cagacgcatg cgtagacctg ttgccaaggc gccgggagat cttcccaccc
       61 acctcccccg ctgtctagat ccgccgcagc ggggcgcgtg cctccgcgct ttccccacgc
      121 tcccgcccgc tgagcgcact tccggttctc tctggctgac cagagcggcg cgaaagcccg
      181 ggagcgcgca ggcgcgggcg gagtccgggg gcggggaggg gcggggcgca ggcgcggact
      241 gtcctgcggc gggcgcctgt ctgcagggct cccgcctgca tttgggcggg tgtgccctgc
      301 ttggcgggcg agcggtggcc gaggtccgac gccctcaggg tggccttcgt gtcgtgacag
      361 ccgcggcgtg tagcttcccc ggggtgaccg cgacttgttg gagatctgat ggccaaaaga
      421 aaggaagaaa atttctgctc tcctgaaaat gctaaaagac caagacaaga agaactggaa
      481 gattttgata aagatggaga tgaagatgaa tgtacaattt ctttcacgaa tggaacatct
      541 actttgactg cagcagaagt tggaataatt gagagtattc agctaagaaa tttcatgtgt
      601 cattcaatgc ttggaccttt taagtttggt tctaacgtca actttgttgt tggcaataat
      661 ggaagtggga agagtgctgt gctcaccgca ctcatagttg gtcttggtgg aaaagcagtt
      721 gctactaaca gagggtcctc tttaaaaggc tttgtgaaag ctggacagaa ctcagcagat
      781 atctcaataa cattaaggaa cagaggagat gatgccttca gagcaaatgt gtatggtgac
      841 tctatagttg tgcagcaaca cattagcgtg gatggaagtc gatcttacaa actaaaaagt
      901 gaaaaaggca ccgtggtttc tactaggaaa gaagagctga ttgcaattct tgaccatttt
      961 aacatccagg tggataatcc ggtttctgtt ttaacacaag agatgagcaa gcagttctta
     1021 cagtccaaaa atgagggaga caaatacaaa ttcttcatga aagcaaccca gctcgaacag
     1081 atgaaggaag attattcata tattatggaa acaaaagaaa gaacaaagga acaaataaat
     1141 cagggagaag agcgacttac tgaactaaaa cgccagtgtt tggagaaaga ggaacgtttt
     1201 caaaatattg ctggtttaag tacaatgaag actaatttag agtacttgaa acatgaaatg
     1261 gcttgggcag tggtcaatga aattgaaaaa caattgaatg ctattcgaga caatatcaaa
     1321 attggagaag aacgtgctgc aaaacttgac aggaaaatgg aagagcagca ggtcagactt
     1381 aatgatgcag aaaaaaagta caaagatata caagataaac tagaaaaaat tagtgaagag
     1441 acaaatgcac gagcaccaga atgtatggca ttgaaaacag atgtcattgc aaggacaaga
     1501 gcctttaatg acgctgaggt tttatataac cgttccctaa atgaatataa agcattaaaa
     1561 aaagatggtg aacagctttg taaaagaatt gaagaactga agaaaagtac tgatcagtca
     1621 ttagaaccag agcgattgga aaggcaaaaa aggatctgct ggttaaaaga gaaagtcaag
     1681 gccttacagg atcaggaaca tacagtcaat caggaggctg agcagtttga gcaagccata
     1741 gaaaaggaca agcaagagca tggccgagtt aggaaagaag atatagaagt gagacatgca
     1801 ctcaactata atcagagaca attgaaagaa ctgaaagata gtaaaactga tcgactaaaa
     1861 agatttggtc ctcatgttcc agctcttctg gaagcaatag atgatgctta cagacggaga
     1921 caatttaccc ataaacctat cggcccttta ggtgcttgca ttcatctacg ggaccctgaa
     1981 cttgctttgg ccattgaatc ttgcttaaaa ggacttctgc aagcctattg ttgccataat
     2041 catgctgatg agagagtact tcagtctttg atgaaaaaat tttatccacc agggacctct
     2101 cggccacaga taattgtgtc tgagtttcgg gatgaggtat atgatgtgag actcagagct
     2161 gcttaccatc cagagtttcc aactgttctg acagctttag aaatagacaa tgctgttgtg
     2221 gcaaacagcc tgattgacat gcggagcata gagacagtgc tgctgatcaa aaataattct
     2281 gtggctcgtg cagtcatgca atcccaaaag ccacccaaaa attgtagaga agcttttact
     2341 gctgatggtg atcaagtgtt tgcaggacgt tattattcat ctgaaagtac aagacccaag
     2401 tttctaagca gagatgtgga ttctgaaata agtgacttgg agactgagat tgaaaataaa
     2461 aagggccaca taataaccct tcagcagcgt ctgtctgcgc ttgagaagga tatcaaacgc
     2521 aatgaagaac ttcttaaaag gtgccaacta cattataaag aaataaagat gaaaataaga
     2581 aaaaatattt ctgaaattcg ggaacttgag aatatagaag aacaccaatc tgtagatatt
     2641 gcaaccttgg aagatgaagc tgaagaaaat aaaataaaaa tgcaaatggt ggagaaaaat
     2701 atggaacaac aaaaagaaaa catggagaat cttaaaagtc taaaaattga agcagaaaat
     2761 aagtatgata caattaaatt gaagattaat cagctatcag agctagcgga tccacttaag
     2821 gatgagttaa atcttgctga ctctgaagtg gatagccaga aacgaggaaa gcagcactat
     2881 gaggataaac agaaagagca tttggatacc ttaaataaaa agagacgaga gcttgacatg
     2941 aaggaaaagg agttacagga gaaaatgtca caggcaagac agatctgccc agaacggata
     3001 gaagtaaaaa aatctgcatc aattctagac aaagaaataa atcgattaag acaaaaaatt
     3061 caggcagaac atgccagtca tggagatcgg gaggaaataa tgaagcagta tcaagaagca
     3121 agagaaacct accttgatct ggataataaa gtaaggactt taagaaggtt cattaaattg
     3181 ctagaagaaa taatgaccca taggtacaaa acataccaac aatttagaag gtgtttgaca
     3241 ttacgatgca aattatactt tgacaactta ttatctcagc gtgcttattg tggaaaaatg
     3301 aattttgatc acaagaatga aactcttagt ataacagttc agcccggaga ggggaacaaa
     3361 gcctccttca atgacatgcg tgctttgtcc ggcggtgagc gctctttctc caccgtgtgc
     3421 ttcatccttt ccctgtggtc cattgctgaa tcacctttca gatgcctgga tgagtttgat
     3481 gtctacatgg atatggttaa taggagaatt gcgatggaca tgatccttaa gatggcagat
     3541 tcccaacgtt ttagacaatt tatcttgctt acccctcaaa gcatgagctc ccttccctca
     3601 agtaaactga ttagaattct tcgaatgtct gaccctgaaa gagggcaaac cacactgccc
     3661 ttccgacctg tgactcaaga ggaagatgac agtgcaagtt gacagcttag tgccttgcct
     3721 cgtactgaag gggaattgtg aggggataac tggactggtg gatgaaatgg cgtgagacag
     3781 aggcactctg aaataaagga gctcctttaa catcactcat cgcttgtgta aataagccta
     3841 gaaagccagc tgttccttgt gaaaaccaat ttcataatac tggttttaaa tctttttatg
     3901 tttgtttgct ttggagtttc tgtgttttat ttgtttttac catctacttt tataaatttt
     3961 ttcaggagta aaattttgta cataatgcac atgtacatat ctgttcagtt tgggtttgtt
     4021 tctatagtat tttgtaagaa ttaaaataaa agtttgagca cctgatgttt tgtgtttcca
     4081 ggttgttaca gtctactttt aaaaagtgtc tgtggcaaaa aaacaaaaaa caaacaaaca
     4141 aacaaaaaac caacaaaagt tgcatatgtc tgtggaaaga gcagtttctc agcatgggat
     4201 ggggggatgc agtgagcgag aacattaggc cgacatactg atgtttacgt attagagatc
     4261 tgctaagatt ggtgatactg gcaagatctc tgcttgccat tgttttttaa ccctgtggta
     4321 caactgtaga tttggataca gtttctaatc actacacttc atcagttata agatcttctc
     4381 cactagacac ttttatgcag ccttgaagca ctgccaactg tgacaagtgc tttctccttt
     4441 gtcctttaac tatcctcctt caagaaggag cttagcatgg ctgtgacagt ttccactttg
     4501 gcctgtggca tggtggccaa attgtaaaag ccctcagctt ttggtgggtg caaccactgg
     4561 ggtggcagat gcaagaagat cacaagttca aggccagcct ggatagcttg gcctccggct
     4621 taaaatgaaa gtgaaattga ggcctgaaaa tacagcttag ttgtcgagca gggctggaga
     4681 aagcgggaag gcgagtgcct gtggtcaggt agaggagcta gtggctattg agtcaaaata
     4741 tacatctcat gtgagatgat ataagctaca ccctgaactt agagacatta aaatgtccac
     4801 aatgatcagt ttcctgtaaa aaaaaaaaat ggtatttgtg aatttaattt tttttttaaa
     4861 agaaaacagt gtatttgtgc ctatgttctg tttcatacta gggttaggac tagcctttaa
     4921 actttgaata gcctcaagaa gcattccttt tattaccagc aataaattag aatacatatt
     4981 tatgaactta aaaaggaagt attttaagaa aagtactatt tttaaaagct agtataattc
     5041 tatagttatt gatgaaaact gagttttgtt ttggtgggga agagaatgta ttcttagaat
     5101 acaatagttg ccaaaaatcc aaaagcattt ctactctaag aatatagaag gagaaaactg
     5161 ttgttttaaa ctttcctcac caaccataag cagtataact cctttgtatc agaactattt
     5221 taacataaca tacatttttt caaataaata aaaatgaagt gagaccagtg cattaatttt
     5281 aattagtgaa gaagtttgag tattttgagt ttttgtggta gttttaaatg tgcttctaca
     5341 gaatgagaaa tgcagccctc agatcctgag catctcctgc cgaagacaat gcattatggg
     5401 aaatgaaacc ctcagatccg agcatctcct gctgaagaca gtattattgc tttggcctca
     5461 gaaagctttg gtttcaatca taagtgaagc cttcatctaa tgttctaagg agtaataaca
     5521 tccattggaa aacaaaaaaa gctattgttc ttttaaacta tgtgtaactt ccaaaaataa
     5581 aacttaaaat ttatatgaat taa
//
