LOCUS       NM_001252684            5772 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus structural maintenance of chromosomes 5 (Smc5),
            transcript variant 1, mRNA.
ACCESSION   NM_001252684
VERSION     NM_001252684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5772)
  AUTHORS   Atkins A, Xu MJ, Li M, Rogers NP, Pryzhkova MV and Jordan PW.
  TITLE     SMC5/6 is required for replication fork stability and faithful
            chromosome segregation during neurogenesis
  JOURNAL   Elife 9, e61171 (2020)
   PUBMED   33200984
  REMARK    GeneRIF: SMC5/6 is required for replication fork stability and
            faithful chromosome segregation during neurogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5772)
  AUTHORS   Gaddipati H, Pryzhkova MV and Jordan PW.
  TITLE     Conditional Mutation of SMC5 in Mouse Embryonic Fibroblasts
  JOURNAL   Methods Mol Biol 2004, 35-46 (2019)
   PUBMED   31147908
  REMARK    GeneRIF: Study the function and properties of the SMC5/6 complex in
            mammals.
REFERENCE   3  (bases 1 to 5772)
  AUTHORS   Hwang G, Verver DE, Handel MA, Hamer G and Jordan PW.
  TITLE     Depletion of SMC5/6 sensitizes male germ cells to DNA damage
  JOURNAL   Mol Biol Cell 29 (25), 3003-3016 (2018)
   PUBMED   30281394
  REMARK    GeneRIF: SMC5/6 complex is essential only when meiotic DNA
            processing events are perturbed during mouse spermatogenesis
REFERENCE   4  (bases 1 to 5772)
  AUTHORS   Hwang G, Sun F, O'Brien M, Eppig JJ, Handel MA and Jordan PW.
  TITLE     SMC5/6 is required for the formation of segregation-competent
            bivalent chromosomes during meiosis I in mouse oocytes
  JOURNAL   Development 144 (9), 1648-1660 (2017)
   PUBMED   28302748
  REMARK    GeneRIF: age-dependent depletion of the SMC5/6 complex in oocytes
            could contribute to increased incidence of oocyte aneuploidy and
            spontaneous abortion in aging females.
REFERENCE   5  (bases 1 to 5772)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (bases 1 to 5772)
  AUTHORS   Kogo H, Kowa-Sugiyama H, Yamada K, Bolor H, Tsutsumi M, Ohye T,
            Inagaki H, Taniguchi M, Toda T and Kurahashi H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   7  (bases 1 to 5772)
  AUTHORS   Brouwer AK, Schimmel J, Wiegant JC, Vertegaal AC, Tanke HJ and
            Dirks RW.
  TITLE     Telomeric DNA mediates de novo PML body formation
  JOURNAL   Mol Biol Cell 20 (22), 4804-4815 (2009)
   PUBMED   19793919
REFERENCE   8  (bases 1 to 5772)
  AUTHORS   Cobbe N and Heck MM.
  TITLE     The evolution of SMC proteins: phylogenetic analysis and structural
            implications
  JOURNAL   Mol Biol Evol 21 (2), 332-347 (2004)
   PUBMED   14660695
REFERENCE   9  (bases 1 to 5772)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 5772)
  AUTHORS   Taylor EM, Moghraby JS, Lees JH, Smit B, Moens PB and Lehmann AR.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144941.7 and AJ534941.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by
            NM_001252684.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ534941.1, SRR10223969.19058.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC144941.7         54164-54242
            80-3385             AJ534941.1         1-3306
            3386-5772           AC144941.7         119234-121620
FEATURES             Location/Qualifiers
     source          1..5772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 18.04 cM"
     gene            1..5772
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /note="structural maintenance of chromosomes 5"
                     /db_xref="GeneID:226026"
                     /db_xref="MGI:MGI:2385088"
     exon            1..264
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..3385
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     structural maintenance of chromosomes protein 5; SMC
                     protein 5; protein expressed in male leptotene and
                     zygotene spermatocytes 453; SMC5 structural maintenance of
                     chromosomes 5-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 5
                     isoform 1"
                     /protein_id="NP_001239613.1"
                     /db_xref="CCDS:CCDS89364.1"
                     /db_xref="GeneID:226026"
                     /db_xref="MGI:MGI:2385088"
                     /translation="MATPSGKAAPPNPQVSKRSLPRDASSEVPSKRKNSNPLPTLPRP
                     SGTFVEGSIVRIAMENFLTYDICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPA
                     FMGRADKVGFFVKRGCSKGLVEIELFRTSGNLIITREIDVIKNQSFWFINKKPVTQKI
                     VEEQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSVGPPEMHRYHCELKNF
                     REKEKQLETSCKEKTEYLEKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYE
                     NVRQEYEGVKLIRDRVKEEVRKLKEGQIPMTRRIEEIDRQRHTLEVRIKEKSTDIKEA
                     SQKCKQRQDLIERKDRQIKELQQALTVKQNEELDRQKRISNTRKMIEDLQSELKTAEN
                     CENLQPQIDTVTNDLRRVQEEKALCEGEIIDKQREKEMLEKQRRSVSDHITRFDNLMN
                     QKEDKLRQRYRDTYDAVLWLRNNRDRFKQRVCEPIMLTINMKDNKNAKYVENHISSND
                     LRAFVFESQEDMEIFLREVRDNKKLRVNAVIAPKISYADKAPSRSLNDLKQYGFFSYL
                     RELFDAPDPVMSYLCCQYHIHEVPVGTERTRERIERVIQETRLKQIYTAEEKYVLKTS
                     VYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEMNRQLEAVDSGLAALRDTNRH
                     LELKDNELRLKKKELLERKTRKRQLEQKISSKLASIRLMEQDTCNLEEEERKASTKIK
                     EINVQKAKLVTELTGLVKICTSFQIQKVDLILQNTTVISEKNKLEADYMASSSQLRVT
                     EQQFIELDDNRQRLLQKCKELMKKARQVCNLSADQAVPQEFQTQVPTIPNGHSSSPPM
                     AFQDLPNTLDEIDALLTEERSRASCFTGLNPSVVEEYSKREVEIQQLTEELQGKKVEL
                     DEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIR
                     IRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINE
                     RRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEPNRWNLKAF
                     QRRRRRITFTQPQ"
     exon            265..406
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..459
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..622
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..757
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..898
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1060
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1132
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1388
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1543
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1657
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1752
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1885
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2059
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2229
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2353
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2476
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2602
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2647
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2743
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2848
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2968
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3148
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3244
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..5772
                     /gene="Smc5"
                     /gene_synonym="mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgggagcc gggcgcggag gctcctgggc tgcggctcgc cgggaacgga agccgctgcg
       61 ggacgcggag gaagccagga tggcgactcc gagcgggaag gctgctcccc ccaaccccca
      121 ggtttccaag cggtctctcc cgagagatgc ttcctccgag gtcccgagca agagaaagaa
      181 ctcgaacccg ttgccgacgc tgccgcggcc gtccgggacc ttcgtcgagg gctcaatcgt
      241 ccgcatcgcc atggagaact tcttaacata tgacatctgt gaagtgtctc ctgggcccca
      301 tctgaacatg atcattggag ccaatggaac agggaagtca agcatcgtgt gtgccatttg
      361 cctcggactc gcaggcaaac ctgctttcat gggacgtgca gataaggttg ggtttttcgt
      421 gaagagagga tgttccaaag gtttggttga aattgaactg ttcaggactt ctggaaatct
      481 tataatcacc cgcgagattg atgtgataaa aaatcagtcc ttttggttca tcaacaaaaa
      541 gcctgtaacc cagaagatag tggaagaaca ggttgcagcc ttaaacatcc aagtgggcaa
      601 tctgtgccag ttcttgcctc aggacaaagt tggggaattt gctaaactca gcaaaattga
      661 actccttgaa gctactgaga agtcagttgg tcctccagag atgcacagat accactgtga
      721 actcaaaaac ttcagggaga aggagaagca gctagagacc tcttgcaaag agaaaactga
      781 atacctagag aaaatggttc agagaaatga aaggtacaaa caagatgtgg aaagattcta
      841 tgaacgaaaa cgacatttag atttaattga gatgcttgag gccaaaagac catgggtgga
      901 atatgagaat gtacgtcagg aatatgaagg tgtgaaacta attcgtgacc gagtgaagga
      961 agaggtcagg aaacttaaag aagggcagat tcctatgaca cggcggattg aggagattga
     1021 ccggcagcgt cacactttgg aagttcgaat caaagaaaag tcaaccgata ttaaggaagc
     1081 atctcagaaa tgcaagcaaa ggcaagactt gattgaacgg aaggacagac agattaagga
     1141 acttcagcag gcattaacag tcaagcagaa tgaagagctg gaccggcaga agagaataag
     1201 taacacccgc aagatgatag aggatctgca gagtgagctc aagactgcgg aaaactgcga
     1261 gaaccttcag cctcagatcg acaccgtcac aaatgatctg aggcgtgtgc aggaggagaa
     1321 agccttatgt gaaggcgaga tcattgataa acagcgagaa aaggaaatgc tggagaagca
     1381 gagacggagt gtgagtgatc atattacacg gtttgacaat cttatgaatc agaaggaaga
     1441 taagctgaga cagcggtacc gggatacgta tgatgcagtc ttgtggctga gaaataacag
     1501 agacaggttt aaacaaagag tctgtgaacc cataatgctc acgattaata tgaaagataa
     1561 taaaaatgca aaatatgttg aaaatcatat ttcatcaaat gacttaagag cctttgtgtt
     1621 tgaaagtcaa gaagatatgg agattttcct cagagaggtt cgtgacaaca agaagttaag
     1681 agtaaatgct gttattgccc ccaagatctc atatgcagac aaagcccctt caagatctct
     1741 gaatgactta aaacaatatg gatttttttc atatcttcgg gagttatttg atgcacctga
     1801 tcctgtgatg agttaccttt gctgccagta tcatattcat gaggttcctg tgggaactga
     1861 aaggacccga gaaagaattg aacgggtaat acaagaaact cgattaaaac aaatttatac
     1921 agcagaagaa aagtatgtgt taaaaacttc tgtgtattca aataaagtta tttctagtaa
     1981 tacatccctg aaagtagccc agttcctcac tgttactgtg gatctagagc aaagaagaca
     2041 cttggaagag cagctaaagg aaatgaatag acaactggaa gcagtggact cagggttggc
     2101 tgccttgcgt gatacgaaca ggcaccttga gctcaaagac aacgagctaa ggctgaagaa
     2161 gaaggagctt cttgaaagaa aaaccaggaa aaggcagctg gagcagaaaa tcagctccaa
     2221 gctggcaagt ataaggctga tggaacagga tacttgcaat ctggaagagg aagaacgaaa
     2281 agcaagtacc aaaataaaag aaataaatgt tcagaaagca aaacttgtta ctgaattaac
     2341 aggccttgta aagatatgca cttcttttca aattcaaaaa gttgatttga ttcttcaaaa
     2401 tactacagtg atctctgaga agaacaagtt agaagcagat tacatggcgt catcttccca
     2461 gctgcgcgtc acagaacaac aattcattga attggatgac aacagacaga gattgttaca
     2521 gaagtgcaag gaacttatga agaaagctag gcaagtatgc aacctgagtg ctgaccaagc
     2581 tgttccacaa gaattccaga cacaagtacc caccattcca aatggacaca gctcctcacc
     2641 ccccatggct tttcaagatc tcccaaacac attggatgaa atcgatgcat tattaactga
     2701 agaaaggtca agagcttcgt gcttcacagg actgaatcct tcggtggttg aggagtactc
     2761 aaaaagagaa gtagaaatac agcagttgac cgaagaactg caggggaaga aagttgaact
     2821 agatgaatac agggaaaaca tttcgcaggt gaaagaaagg tggctgaacc ccttaaagga
     2881 gctagtagaa aaaattaatg agaaattcag caactttttt agttccatgc agtgtgctgg
     2941 tgaagttgat cttcatacag aaaatgagga agattatgat aaatatggaa tccggattag
     3001 agtaaaattt cgcagtagta ctcagctgca tgaattaact cctcatcatc aaagtggagg
     3061 tgaaagaagt gtttctacta tgctatactt gatggcactt caggagctta acagatgtcc
     3121 gttcagagta gtcgatgaaa ttaatcaggg tatggaccca attaatgaac ggagagtatt
     3181 tgaaatggtt gtgaacactg cctgtaaaga gaacacatcc cagtatttct tcatcacacc
     3241 gaagcttcta cagaatcttc cttattctga aaagatgaca gtgttgtttg tctacaatgg
     3301 tcctcatatg ctggagccaa accgatggaa tttaaaggct tttcaaaggc gtcggcgaag
     3361 gataaccttt actcaacctc agtgaaagga aagaacagga ggggcctttg gaggtttttt
     3421 tcctttaact gtttatatgt gtcgctcgct caagtgaata aaagttagca gatttattga
     3481 aagagaaaga ttggttattt ttggaaacct gcttttaaaa acaaataggt tgatgaagta
     3541 gagaccacag tgactctggg acattttcta gtgaaaactg agtcttcact tttggtggac
     3601 attgcctcgt tagttctctg tgagcacggg attgttgtgt gcagctttgt gctgcccctc
     3661 aggtgtggtg gcccacatct agcccagcgt ttaggagtag gaggcaggaa ggttatcagt
     3721 ttttgagtgg tttcatgtgt cataacagaa aaggctattt cctgttgcaa atcgaaggta
     3781 tggcagcgtg ggatttcagt cagagtgttt actaactaca acagtgctga gtgcagaaca
     3841 ttgactgaga gaataaaggc aacccaggat tagaaatccc acttttcttc cagtattata
     3901 tctagttctt acaaactagt atgggaatgg ctgcttaata gatagtgatt gacagcagat
     3961 ctgttcattt ctttgtttaa aaaaaataaa ggttccctta ttttcataga aaatatgtta
     4021 taggtaacat gttataggtt acttcaaaga attgggaaaa catatgcatg aggcttcaaa
     4081 atgacaggag gactttgaga ggtcacaagg taaagatgat acagaatgtg gctcagacac
     4141 tggcagggtg agatcaggtg acaggagtta gcgtataagt gttgtcgtag ggctttgtgt
     4201 gtgtttgttt gtttgtttgt ttgtttgttt aatttaaagt tgaatgtatt ttacatctta
     4261 catttctaga aagcattttt ataattactt ttagtaaaat ttttcttaaa atttcatatg
     4321 cgagttttta caatttgtat ttgaaatttc tcagtgctat ataaagagcg aaggcaaaga
     4381 attgattgaa aaaagaatca aatcatgttt ttagaatttg taggtccttc cttataccca
     4441 gtattttaga aaaatctcat atgaattgtt ttcttccacc ttgaaaatat taattgaaaa
     4501 ccatttttct ctgagaatgc taattaacaa tgccaaacaa attctgttct ttgaaaaaac
     4561 taaatcttga aagaaaatag aaatgtcatt gaatagtgga atgaaccata tctttgatga
     4621 tactgacaaa attatttttt tgctagcctg aacaaagttt gggctttgtc tattatcgta
     4681 atagccaatg aaatttacat tcttatttgg ttaaaaaata atggaacatg agtttatgtc
     4741 ctctcactta gacattttct cttttagaag ttgtatttct ttttaaaact tgtaaaagaa
     4801 ccctcccctc ttagactaag tatcatacag gtagtataaa gatattttaa taacattttt
     4861 atcaacatga acaagtcaaa aaattaaaaa cttggtagca tattagtgaa ggctattact
     4921 aaacatttgt gttgttgctt gggtttctga tataatatct tcactgatat gtgtttgatg
     4981 tagtttggtt ttatatgaaa gaaagacata cttaaaactc acatcatcag caattccatt
     5041 tccgtttaca tataccaaaa ataattacat atcatgctaa caagctttca gagagcaaaa
     5101 ttaatgttct gttttatatt gaactttggg ctgggaagga taaattatgt atcattcatc
     5161 atattaaaaa tagtcaaaca taatataatg tcattttctg caactgttga ttttttaaat
     5221 tacattcaaa ttgtaaaaat tccaggtaaa agcctgatgt gataaataaa atatttaaaa
     5281 cctgacggtt aaaaatattt ttaataacta aatttttaca ttgatttgcc taaggtcagt
     5341 ctctgttagg aagtttttca tgttcaaaaa aagaaaaaaa agggggggtt gttttggttt
     5401 ttttgtaaga tttatttatt ttatgtgaat aattgttttg cctatatgta tgtctgtata
     5461 cctggtactt gctaaggctg gaagagagca tcagatctcc taggagtgga gttaaaggta
     5521 gtttgaactg gtatatgggt gctgggtata gaaattgggt cctgtggaag agcatccagt
     5581 agacttaacc actgagccat ctctccagtt ccaaacagag atttcttgct gctttccaat
     5641 agccttggac ataagcacgt caggggcatc acttcattct ggtttgtgta aatgtaattg
     5701 actaaaacta tgttgtaaat gctactttgt tggtaataaa tacgtatttt tccattggta
     5761 taggttattt aa
//
