LOCUS       NM_133786               4335 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus structural maintenance of chromosomes 4 (Smc4),
            transcript variant 1, mRNA.
ACCESSION   NM_133786 XM_905196 XM_919177 XM_919187 XM_919197 XM_919205
            XM_919209
VERSION     NM_133786.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4335)
  AUTHORS   Zhu,M., Zhang,X., Gao,K., Zhang,L., Feng,X., Wang,H., Li,J. and
            Jia,J.
  TITLE     Structural Maintenance of Chromosome Protein 4 Promotes the
            Progression of Cardia Adenocarcinoma via Regulation of the
            Wnt/beta-catenin Signaling Pathway
  JOURNAL   Comb Chem High Throughput Screen 27 (4), 611-620 (2024)
   PUBMED   37170988
  REMARK    GeneRIF: Structural Maintenance of Chromosome Protein 4 Promotes
            the Progression of Cardia Adenocarcinoma via Regulation of the
            Wnt/beta-catenin Signaling Pathway.
REFERENCE   2  (bases 1 to 4335)
  AUTHORS   Sun,X., He,L., Liu,H., Thorne,R.F., Zeng,T., Liu,L., Zhang,B.,
            He,M., Huang,Y., Li,M., Gao,E., Ma,M., Cheng,C., Meng,F., Lang,C.,
            Li,H., Xiong,W., Pan,S., Ren,D., Dang,B., Yang,Y., Wu,M. and Liu,L.
  TITLE     The diapause-like colorectal cancer cells induced by SMC4
            attenuation are characterized by low proliferation and chemotherapy
            insensitivity
  JOURNAL   Cell Metab 35 (9), 1563-1579 (2023)
   PUBMED   37543034
REFERENCE   3  (bases 1 to 4335)
  AUTHORS   Yang,Z., Pan,X., Wu,X., Lin,Q., Chen,Y., Cai,S., Zhang,Y., Mai,Z.,
            Ahmad,N., Ma,D. and Deng,L.
  TITLE     TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3
            inflammasome through the SMC4/NEMO pathway
  JOURNAL   FEBS J 290 (6), 1549-1562 (2023)
   PUBMED   36181338
  REMARK    GeneRIF: TREM-1 induces pyroptosis in cardiomyocytes by activating
            NLRP3 inflammasome through the SMC4/NEMO pathway.
REFERENCE   4  (bases 1 to 4335)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4335)
  AUTHORS   Peng,L., Tang,Y., Zhang,Y., Guo,S., Peng,L., Ye,L., Wang,Y. and
            Jiang,Y.
  TITLE     Structural maintenance of chromosomes 4 is required for leukemia
            stem cell maintenance in MLL-AF9 induced acute myeloid leukemia
  JOURNAL   Leuk Lymphoma 59 (10), 2423-2430 (2018)
   PUBMED   29043883
  REMARK    GeneRIF: Study examined the expression of SMC4 in acute myeloid
            leukemia (AML) pediatric patients cells and normal cells and
            revealed that SMC4 was significantly higher than control. Utilizing
            SMC4 gene knockdown in the established MLL-AF9 AML mouse model
            study found that SMC4 knockdown inhibited AML progression by
            maintaining leukemia stem cells.
REFERENCE   6  (bases 1 to 4335)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   7  (bases 1 to 4335)
  AUTHORS   Cobbe,N. and Heck,M.M.
  TITLE     The evolution of SMC proteins: phylogenetic analysis and structural
            implications
  JOURNAL   Mol Biol Evol 21 (2), 332-347 (2004)
   PUBMED   14660695
REFERENCE   8  (bases 1 to 4335)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 4335)
  AUTHORS   Losada,A. and Hirano,T.
  TITLE     Shaping the metaphase chromosome: coordination of cohesion and
            condensation
  JOURNAL   Bioessays 23 (10), 924-935 (2001)
   PUBMED   11598959
  REMARK    Review article
REFERENCE   10 (bases 1 to 4335)
  AUTHORS   Strunnikov,A.V. and Jessberger,R.
  TITLE     Structural maintenance of chromosomes (SMC) proteins: conserved
            molecular properties for multiple biological functions
  JOURNAL   Eur J Biochem 263 (1), 6-13 (1999)
   PUBMED   10429180
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122876.4, CN722683.1 and BC062939.1.
            
            On Oct 13, 2017 this sequence version replaced NM_133786.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062939.1, SRR9219381.243732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC122876.4         139374-139381
            9-234               CN722683.1         1-226
            235-4335            BC062939.1         1-4101
FEATURES             Location/Qualifiers
     source          1..4335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 32.14 cM"
     gene            1..4335
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /note="structural maintenance of chromosomes 4"
                     /db_xref="GeneID:70099"
                     /db_xref="MGI:MGI:1917349"
     exon            1..353
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..491
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..4219
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     XCAP-C homolog; chromosome-associated polypeptide C; SMC
                     protein 4; SMC4 structural maintenance of chromosomes
                     4-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 4
                     isoform 1"
                     /protein_id="NP_598547.1"
                     /db_xref="CCDS:CCDS17401.1"
                     /db_xref="GeneID:70099"
                     /db_xref="MGI:MGI:1917349"
                     /translation="MRRKGTKPSTACHQEEGPPPSQDGAHSDEEMEQPAGEAESAAPA
                     KPPGEELDNRSLEEILNSIPPPPPPAMASEAGAPRLMITHIVNQNFKSYAGEKVLGPF
                     HKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEV
                     HFQKIIDKEGDDYEVLPNSNFYVSRTAYRDSTSVYHISGKKKTFKDVGNLLRSHGIDL
                     DHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILN
                     EHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEMFKKKNHICQYYIYDLQNRIAE
                     ITTQKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDVEKKLNKVTKFIEQNKEKFTQLD
                     LEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSVPAKSKTVINETTTRNNSLEKE
                     REKEEKKLKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYL
                     SRHNTAVSQLSKAKEALITASETLKERKAAIKDINTKLPQTQQELKEKEKELQKLTQE
                     EINLKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAID
                     EKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHNIGIATFIGLDKMTVWAKKMSKI
                     QTPENTPRLFDLVKVKNEEIRQAFYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQG
                     QIIEQSGTMSGGGSKVMRGRMGSSVIDEISVEEVNKMESQLERHSKQAMQIQEQKVQH
                     EEAVVKLRHSERDMRNTLEKFAASIQGLSEQEEYLCVQIKELEANVLTTAPDRKQQKL
                     LEENVSVFKKEYDAVAEKAGKVEAEIKRLHNTIIDINNRKLKAQQNKLDTINKQLDEC
                     ASAITKAQVAIKTADRNLKKAQDSVCRTEKEIKDTEKEINDLKTELKNIEDKAEEVIN
                     NTKTAETSLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHISEHNSKI
                     KYWQKEISKIKLHPVEDNPVETVAVLSQEELEAIKNPESITNEIALLEAQCREMKPNL
                     GAIAEYKKKEDLYLQRVAELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKLKE
                     NYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFA
                     LHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIG
                     IYKTYNSTKSVAVNPKQIASKGLC"
     exon            492..670
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..862
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1039
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1204
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1332
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1473
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1624
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1789
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2023
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2209
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2371
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2597
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2677
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2830
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2957
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3147
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3292
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3466
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3649
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3882
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4066
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4316
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4296..4301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /note="hexamer: AATACA"
     polyA_site      4316
                     /gene="Smc4"
                     /gene_synonym="2500002A22Rik; SMC-4; Smc4l1"
                     /note="major polyA site"
ORIGIN      
        1 gctgtcgttc tagaagtgcg aaactctcat ttctgttaaa gtccacagaa aggacgtagc
       61 cctgcttgct ctcccttccc agtcgtaact tggccctcgg cgccacggtc cctggggtag
      121 agcccgcgca tgcgcccgaa cggcccgaag atggcggtgg gactcgccgc actttttttc
      181 aaattcgcgg gtcccagaaa cccttgcgcg cgtttgtaac gaatttccgt tcgagtttgg
      241 attttaggcg ccattttcga gtgaaggacc cggagccgag acaccgggag gagcgaggcg
      301 gggggtcggc cgtgccacca tttcagcccg gctcggagtg gacccgccga cagccaccat
      361 gcggcgtaag ggcaccaagc cctccactgc ctgccaccag gaggaagggc cgccgccctc
      421 ccaggacggt gcccacagcg acgaagagat ggagcaaccg gccggcgaag cggagagcgc
      481 tgcacccgca aagcctccag gtgaggagct ggataacaga agtttagagg agattttgaa
      541 tagtatccct ccacccccac ctccagccat ggccagtgaa gctggagctc ctcgtctcat
      601 gataactcat attgtaaacc aaaacttcaa gtcctatgct ggagagaaag ttctgggacc
      661 tttccataag cgcttttcct gtattattgg accaaatggc agtggaaaat ccaatgttat
      721 tgattccatg ctttttgtgt ttggctatcg agcacaaaaa ataaggtcta aaaagctatc
      781 ggtactgata cataattctg atgaacacaa ggatattcag agttgtactg tagaagttca
      841 ttttcaaaag ataattgata aggaaggaga tgattacgaa gtccttccta acagcaactt
      901 ctatgtatcc agaaccgcct acagagatag cacttctgtc taccacataa gtgggaagaa
      961 gaagacgttt aaagatgttg gaaatctcct tagaagccat ggcattgact tagaccataa
     1021 tcgattttta atcttgcagg gtgaagttga acagattgct atgatgaaac ccaaaggcca
     1081 gactgaacat gatgaaggta tgcttgagta tttagaagat ataattggct gtggacggct
     1141 aaatgaacct attaaagtct tgtgtcggag agttgaaata ttaaatgaac acagaggaga
     1201 aaagttaaat agagtgaaaa tggtagaaaa ggagaaggat gcactagagg gagagaaaaa
     1261 catagccatt gagttcctta ccctggaaaa tgaaatgttt aagaaaaaga atcacatctg
     1321 tcaatactac atttatgatc tgcagaatag aattgctgaa ataacgactc aaaaggaaaa
     1381 aattcatgaa gatactaaag aaattactga gaagagcaat gtgctttcca atgaaatgaa
     1441 agcgaagaat tcagctgtaa aggatgtaga aaagaagctc aataaagtta caaaatttat
     1501 cgaacagaat aaagaaaaat ttacacaact agatttggaa gatgttcaag ttagggaaaa
     1561 attaaaacat gctacaagta aagccaagaa actggagaaa caacttcaaa aagataaaga
     1621 aaaggttgaa gagctgaaaa gtgtacctgc caagagtaag actgtcataa atgagacaac
     1681 aactagaaac aattcgcttg agaaagaaag agagaaagaa gaaaaaaaat taaaagaggt
     1741 catggacagc cttaagcagg aaacacaggg gcttcagaaa gaaaaggaga ttcaagaaaa
     1801 ggaacttatg ggttttaaca aatcagtaaa tgaagcacgt tcaaagatgg aagttgctca
     1861 gtcagaactt gatatctatc tcagtcgaca taatacagca gtgtctcaat taagtaaggc
     1921 gaaggaagcc ttaattacag cttctgagac tctcaaggag aggaaagctg caatcaagga
     1981 tataaacaca aagctccctc agacgcaaca ggaactaaag gagaaagaaa aagaacttca
     2041 gaaactgaca caagaagaaa taaacttaaa aagtttggtt catgatcttt tccaaaaagt
     2101 tgaagaagca aagagttcct tagcaatgaa tcgaagtagg gggaaagtac ttgatgcaat
     2161 aattcaagaa aaaaaatcag gcaggatccc aggaatatat ggaagattgg gagacttagg
     2221 agctattgat gaaaaatatg acattgctat ttcatcctgt tgccatgcat tggactacat
     2281 tgttgttgat tctattgata cagcccaaga atgtgtaaac ttccttaaaa agcataatat
     2341 tgggattgca actttcatag gtttggataa gatgacagtg tgggccaaaa aaatgagcaa
     2401 aattcaaact cctgaaaata ctcctcggtt atttgatcta gttaaagtga aaaatgagga
     2461 aatccgccaa gccttttact ttgctttacg agataccttg gtggctaaca atttggatca
     2521 agctacaaga gtagcgtacc aaagagacag acgctggaga gtagtgactc tgcagggaca
     2581 gatcatagaa cagtcaggta caatgagtgg cggtggaagc aaggtgatga gaggaaggat
     2641 gggctcttcg gttatcgatg aaatctctgt agaagaggta aataagatgg aatcccagtt
     2701 ggaaaggcat tctaaacaag caatgcaaat ccaagaacag aaagtacaac atgaagaagc
     2761 agtagttaag ttacggcaca gtgaacgaga catgagaaat acactggaaa agttcgctgc
     2821 aagcatccag ggcttatcag agcaagaaga gtatctgtgt gtacaaatta aagaactgga
     2881 agctaacgtt cttactacgg cccctgacag aaaacaacag aaactgctgg aagaaaatgt
     2941 cagtgttttc aaaaaagaat atgatgctgt ggctgagaaa gctggtaaag ttgaagctga
     3001 gattaaacgg ctacacaata ccatcataga tatcaacaac cgaaaactca aggcccagca
     3061 aaacaaactt gacacgataa ataagcagct tgatgaatgt gcttctgcta ttactaaggc
     3121 ccaagtagca atcaagactg ctgacagaaa tcttaaaaag gcacaggatt ctgtttgccg
     3181 cacagagaaa gaaataaaag acactgaaaa agaaataaat gacttaaaga cagagctaaa
     3241 aaatattgaa gacaaggcag aagaggtcat aaacaataca aaaactgcag agacatcctt
     3301 accagaaatc cagaaagaac atcgtaatct acttcaggaa ctaaaagtta ttcaagaaaa
     3361 tgaacatgct cttcagaaag atgcacttag tattaagttg aaacttgaac agatagatgg
     3421 ccacatttct gaacataact caaaaataaa atactggcaa aaagagattt caaaaataaa
     3481 attgcatcct gttgaagata atcctgttga gacagtagca gttctaagcc aggaggagct
     3541 tgaggcaatc aagaatccag agtctataac aaatgaaatt gcacttttgg aagctcagtg
     3601 tcgtgaaatg aaaccaaacc ttggagccat cgctgagtat aaaaaaaagg aagatttata
     3661 tttgcaaaga gtagccgaac tggacaaaat tacttctgaa agagataatt ttagacaagc
     3721 atatgaagat cttcgaaaac aaaggctgaa tgaatttatg gctggttttt acgtaataac
     3781 aaataaacta aaagaaaact accagatgct cacattggga ggagatgctg aactggagct
     3841 tgtggacagt ttagatcctt tttctgaagg aatcatgttc agtgttcggc cacctaagaa
     3901 aagttggaag aagatcttta acctctcagg aggcgagaaa acccttagtt ccttggcctt
     3961 agtgtttgct cttcatcact acaagcccac tcccctctac ttcatggatg agattgatgc
     4021 agctctggat tttaaaaatg tgtctattgt tgcattttat atatatgagc aaacaaaaaa
     4081 tgcccagttc ataataatct ctcttcgaaa taatatgttt gagatttcag acagacttat
     4141 tggcatctat aaaacatata atagtacaaa aagtgttgca gtgaacccaa aacaaattgc
     4201 gtctaaagga ctctgttgaa gttgttcaca ctgaaaattt tcaaatctag attgggtgtt
     4261 ctagttttgt ctgtaaaaga ctgtaagttg tataaaatac atttttctaa attgaaaaaa
     4321 aaaaaaaaaa aaaaa
//
