LOCUS       NM_001301412            5531 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus structural maintenance of chromosomes 2 (Smc2),
            transcript variant 1, mRNA.
ACCESSION   NM_001301412 XM_006537610
VERSION     NM_001301412.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5531)
  AUTHORS   Xu,K., Qiao,J.Y., Zhao,B.W., Dong,M.Z., Lei,W.L., Li,Y.Y., Ju,Z.,
            Schatten,H., Wang,Z.B., Liu,K. and Sun,Q.Y.
  TITLE     Maternal SMC2 is essential for embryonic development via
            participating chromosome condensation in mice
  JOURNAL   J Cell Physiol 238 (11), 2535-2545 (2023)
   PUBMED   37642322
  REMARK    GeneRIF: Maternal SMC2 is essential for embryonic development via
            participating chromosome condensation in mice.
REFERENCE   2  (bases 1 to 5531)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5531)
  AUTHORS   Naiman,N., Fujioka,K., Fujino,M., Valerius,M.T., Potter,S.S.,
            McMahon,A.P. and Kobayashi,A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   4  (bases 1 to 5531)
  AUTHORS   Armfield,B.A., Seifert,A.W., Zheng,Z., Merton,E.M., Rock,J.R.,
            Lopez,M.C., Baker,H.V. and Cohn,M.J.
  TITLE     Molecular Characterization of the Genital Organizer: Gene
            Expression Profile of the Mouse Urethral Plate Epithelium
  JOURNAL   J Urol 196 (4), 1295-1302 (2016)
   PUBMED   27173853
REFERENCE   5  (bases 1 to 5531)
  AUTHORS   Lee,J., Ogushi,S., Saitou,M. and Hirano,T.
  TITLE     Condensins I and II are essential for construction of bivalent
            chromosomes in mouse oocytes
  JOURNAL   Mol Biol Cell 22 (18), 3465-3477 (2011)
   PUBMED   21795393
REFERENCE   6  (bases 1 to 5531)
  AUTHORS   Fazzio,T.G. and Panning,B.
  TITLE     Condensin complexes regulate mitotic progression and interphase
            chromatin structure in embryonic stem cells
  JOURNAL   J Cell Biol 188 (4), 491-503 (2010)
   PUBMED   20176923
REFERENCE   7  (bases 1 to 5531)
  AUTHORS   Onn,I., Aono,N., Hirano,M. and Hirano,T.
  TITLE     Reconstitution and subunit geometry of human condensin complexes
  JOURNAL   EMBO J 26 (4), 1024-1034 (2007)
   PUBMED   17268547
REFERENCE   8  (bases 1 to 5531)
  AUTHORS   Nagamori,I., Yomogida,K., Adams,P.D., Sassone-Corsi,P. and
            Nojima,H.
  TITLE     Transcription factors, cAMP-responsive element modulator (CREM) and
            Tisp40, act in concert in postmeiotic transcriptional regulation
  JOURNAL   J Biol Chem 281 (22), 15073-15081 (2006)
   PUBMED   16595651
REFERENCE   9  (bases 1 to 5531)
  AUTHORS   Cobbe,N. and Heck,M.M.
  TITLE     The evolution of SMC proteins: phylogenetic analysis and structural
            implications
  JOURNAL   Mol Biol Evol 21 (2), 332-347 (2004)
   PUBMED   14660695
REFERENCE   10 (bases 1 to 5531)
  AUTHORS   Guthridge,M.A., Seldin,M. and Basilico,C.
  TITLE     Induction of expression of growth-related genes by FGF-4 in mouse
            fibroblasts
  JOURNAL   Oncogene 12 (6), 1267-1278 (1996)
   PUBMED   8649829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ049961.1, AK145341.1 and
            BC094380.1.
            
            On Aug 19, 2014 this sequence version replaced XM_006537610.1.
            
            Summary: The protein encoded by this gene is a component of both
            condensin I and condensin II complexes, and forms a heterodimer
            with structural maintenance of chromosome 4 (Smc4). This
            heterodimer is the catalytic subunit for both condensin complexes,
            and is involved in several processes, including chromosome
            condensation during mitosis and meiosis, cohesin removal during
            mitosis and meiosis, and single-strand break (SSB) repair. Reduced
            expression of this gene results in chromosome segregation defects
            during mitosis and meiosis, with a more severe defect observed in
            embryonic stem cells. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145341.1, SRR9219381.205854.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                CJ049961.1         2-49
            49-531              AK145341.1         3-485
            532-5426            BC094380.1         428-5322
            5427-5531           AK145341.1         5382-5486
FEATURES             Location/Qualifiers
     source          1..5531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 28.31 cM"
     gene            1..5531
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /note="structural maintenance of chromosomes 2"
                     /db_xref="GeneID:14211"
                     /db_xref="MGI:MGI:106067"
     exon            1..190
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..413
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..3821
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /note="XCAP-E homolog; FGF-inducible protein 16;
                     chromosome-associated protein E; SMC protein 2; fibroblast
                     growth factor inducible 16; SMC2 structural maintenance of
                     chromosomes 2-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 2"
                     /protein_id="NP_001288341.1"
                     /db_xref="CCDS:CCDS18180.1"
                     /db_xref="GeneID:14211"
                     /db_xref="MGI:MGI:106067"
                     /translation="MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDS
                     ICFLLGISNLSQVRASNLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEIT
                     VTRQVVIGGRNKYLINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE
                     ILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL
                     EYQKVMREIEHLSRLYIAYQFLRAEDTKERSAGELKEMQDKIVNLQEVLSENEKKIKA
                     LNCEIEELERRKDKETGGKLKSLEDACAEAQRVNTKSQSAFDLKKKNLASEETKRKEL
                     QNSMAEDSKALAAKEKEVKKITDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSSNED
                     GAEATLAGQMIACKNDISKAQTEAKQAQMKLKHAQQELKSKQAEVKKMDSGYKKDQDA
                     FEAVKKAKEKLETEMKKLNYEENKEEKLLEKHRQLSRDINNLKGKHEALLAKFPNLQF
                     AYKDPEKNWNRNSVKGLVASLINVKDNSTATALEVVAGERLYNVVVDTEVTAKKLLEK
                     GELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVDYKPELQKGMEFVF
                     GTTFVCNNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQEVK
                     DVQDELRTKENELRALEEELAGLKNVAEKYRQLKQQWEMKTEEGDLLQTKLQQSSYHK
                     QQEELDALKKTIEESEETLKSTKEIQKKAEEKYEALENKMKNAEAEREKELKDAQKKL
                     DCAKTKADASSKKMKEKQQEVEAITLELEELKREHASNEQQLDAVNEAIKAYEGQIEK
                     MAAEVAKNKESVNKAQDELMKQKQIITAQDNIIKDKCAEVAKHNLQNNESQLKIKELD
                     HSISKHKREADDAAAKVSKMLSDYDWINAEKHLFGQPNSAYDFKTNNPKEAGQRLQKL
                     QEVKEKLGRNVNLRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQAL
                     NIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGG
                     QRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLK
                     EGMFNNANVLFKTKFVDGVSTVARFTQSQAGKIPKEAKSRGKEPN"
     exon            414..563
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..686
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..725
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..836
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..881
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1115
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1265
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1499
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1659
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1777
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1916
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2036
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2241
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2377
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2502
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2696
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2840
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3035
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3236
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3353
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3514
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3662
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3663..5531
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5401..5406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /note="hexamer: ATTAAA"
     polyA_site      5426
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /note="major polyA site"
     regulatory      5454..5459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
                     /note="hexamer: AATATA"
     polyA_site      5473
                     /gene="Smc2"
                     /gene_synonym="5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2;
                     Smc2l1"
ORIGIN      
        1 gttggggtcc tttgctcgcg ccgaaattca aaggaacagt tccggcacgg ttgttggctg
       61 cagcggatgc ggtgcccggg atggtggcgt tcgcccggta gcgcctgagt acaggtcggg
      121 tggcctcact gtccactttc gcgtcgggtt ggaactttgc tggttcccct ggccagccgc
      181 tttgtggcgg acgtgacttg tagcttgttg cctaacaggc ttactaaccc aagacagttt
      241 agaaaatgta tgttaaatca atcattctcg aaggattcaa gtcctatgca cagaggactg
      301 aagtcaatgg ttttgacccc ctcttcaatg cgatcactgg tttaaatggt agtggaaaat
      361 ccaacatatt ggactccata tgctttctcc taggcatctc caacctgtcc caggtgcggg
      421 cttcaaattt acaagatctc gtttataaaa atggacaggc tgggattacc aaagcctctg
      481 tttcaatcac ttttgataat tctgacaaaa agcagagtcc gttgggattt gaagctcatg
      541 atgaaatcac agtaacaaga caggtggtta ttggtggcag aaataaatac ttaatcaatg
      601 gagtgaatgc caacaacacc agagtccaag atctcttttg ttctgtgggc ctgaatgtta
      661 acaaccctca ctttctcatc atgcagggca gaattacgaa agtattaaat atgaaaccac
      721 cagagatatt atccatgatt gaagaagctg ctggaaccag gatgtatgag tacaaaaaaa
      781 tagccgccca gaaaactata gaaaaaaagg aggctaagct gaaagaaata aaaacgatac
      841 tggaagaaga gattactcca acgattcaaa aattaaaaga ggaaagatct tcttacttgg
      901 agtaccagaa agtaatgcgg gagatagagc atctgagtcg tttatacatt gcctatcagt
      961 ttttgcgggc tgaagacacc aaggaacgct cagctgggga gctaaaggaa atgcaggata
     1021 aaatagtaaa tcttcaagaa gtactgtcag agaatgaaaa aaaaataaag gctctcaatt
     1081 gtgaaatcga agaattggag agaagaaaag ataaggaaac tggaggcaaa ctcaagtctc
     1141 tagaggatgc ttgtgcagaa gcccagcgag ttaatactaa gtctcaaagt gcatttgacc
     1201 tcaagaagaa aaacctagct agtgaagaaa ccaagcgcaa agagctacaa aacagtatgg
     1261 ctgaggattc taaagcatta gcagcaaagg aaaaagaagt taagaagata acagatggac
     1321 tgcatggcct tcaagaagca agcaataaag atgctgaagc tttggctgct gcacagcagc
     1381 acttcaatgc tgtttctgct ggcttgtcca gtaacgaaga tggagcagaa gcaactctgg
     1441 ctgggcagat gatagcctgt aaaaacgata tcagcaaagc tcagactgag gccaagcagg
     1501 ctcagatgaa gctgaaacat gcccaacaag aactaaagag taagcaagca gaggttaaga
     1561 agatggacag tggctacaag aaggatcaag acgcttttga agctgtgaaa aaagctaaag
     1621 aaaaacttga aactgaaatg aagaagctaa attacgaaga aaacaaagag gaaaagcttt
     1681 tggaaaagca caggcagctg tcccgtgaca tcaacaacct aaaaggaaaa catgaagctc
     1741 tcttggccaa gtttcccaat cttcaatttg catacaagga cccagagaag aactggaatc
     1801 gaaattctgt gaaaggactt gtagcttctc tgataaatgt gaaagataat tctacagcca
     1861 cagctctgga agtggtggct ggggaacgac tctacaatgt tgtagtagac acagaggtaa
     1921 ctgctaagaa gctactagaa aagggggagt tgaagcgtcg atacacaata attcctctca
     1981 ataagatttc agccagatgt attgctcctg aaactctgag ggtcgctcag aatcttgttg
     2041 gtcctgacaa tgttcatgta gctctttcct tggttgacta taaaccagaa cttcagaaag
     2101 gaatggaatt tgtctttgga acaacatttg tttgtaacaa tatggataat gccaaaaaag
     2161 tggcctttga taaaaggata atgaccagaa ctgtaaccct tgggggtgat gtatttgatc
     2221 ctcatggaac attgagtgga ggtgctaggt cccaggcagc ttcgatttta accaagtttc
     2281 aagaagtcaa agatgttcaa gatgagctga ggaccaagga gaatgaactg cgcgctctag
     2341 aagaggagtt agcaggtctt aaaaatgttg ctgaaaagta tcgccaactg aaacagcagt
     2401 gggagatgaa gacagaggag ggagacttat tgcaaactaa acttcagcaa agctcttatc
     2461 ataagcaaca agaagaatta gatgccctta aaaaaaccat tgaggaaagt gaggagacat
     2521 taaaaagcac aaaagaaatc caaaagaaag ctgaagaaaa gtatgaagca ttggagaata
     2581 aaatgaaaaa tgcggaagct gaaagagaga aagaactgaa ggatgctcag aaaaaactag
     2641 attgtgccaa aacaaaggca gatgcatcta gcaagaaaat gaaagaaaaa caacaggagg
     2701 ttgaagctat tactctagag ctggaggagc tcaaaagaga gcatgcttct aatgagcagc
     2761 agcttgatgc cgtgaatgaa gccatcaaag cctatgaagg tcagattgaa aaaatggcag
     2821 ctgaggtcgc taaaaataag gaatcagtaa ataaagctca agacgagctg atgaagcaaa
     2881 agcaaataat aacagcccag gacaacataa ttaaagataa atgtgcagaa gtggcgaaac
     2941 acaatttgca aaacaatgag tctcaactta aaattaagga gttggaccac agcataagca
     3001 aacataagcg ggaagcggat gatgctgctg caaaggtatc caaaatgtta agtgattatg
     3061 attggattaa tgctgagaaa cacctatttg gccaacctaa tagtgcctat gatttcaaaa
     3121 caaacaaccc caaagaagct ggccagagac ttcagaagtt acaggaagta aaagagaaac
     3181 tagggagaaa tgtcaacctg agagctatga acgtgctgac agaagctgaa gagcggtata
     3241 atgatttgat gaagaagaaa agaattgtag aaaatgacaa atccaaaatc cttgcaacta
     3301 tagaagatct tgaccagaag aaaaaccagg ccctaaatat tgcttggcaa aaggtgaaca
     3361 aagactttgg ctctattttt tctacccttt tgcctggtgc caatgctatg cttgcaccac
     3421 cagaagggca gacagtttta gatggtctgg agttcaaggt tgccttagga aatacgtgga
     3481 aagaaaacct aactgagctt agtggtggtc agaggtctct agtggctctc tcactaatat
     3541 tgtccatgct cctcttcaaa cctgctccaa tttatatctt ggatgaggtg gatgcggcct
     3601 tggatctttc tcatacccag aatattgggc agatgctgcg gactcacttc acacattctc
     3661 aattcattgt ggtatccctc aaagaaggta tgttcaacaa tgcaaacgtt ctcttcaaaa
     3721 ccaagtttgt ggatggtgtt tctacagtag ccagatttac gcagagtcaa gctgggaaga
     3781 ttccgaagga agcaaagtcc agaggaaaag aacccaactg agtgcatgcc agttcagagt
     3841 acagacttct caccttgacg tttttacaca tgaacttcca agaatttggg atccaagttg
     3901 tttatataat aatgttaaca ttattttcat atgtaattct ttttagcact tttaaaattg
     3961 cagattcctc ttttcttacc tagtgtgatt atggtccaat tattgtagtt gtgattgcat
     4021 gtatatcatc aatttttttc ttacaaaaat cttttgtatg tattaaagaa cctgaggtac
     4081 atatagttgg taaattgtgt atgcaaatgc ccaaaataca aagaaacaga tgaagttata
     4141 ggataaatat agctgacagt cagcttttaa ctagtttaat ttctaagtac agtattaatg
     4201 acttttcttt tgcttataaa atcattcaga tacagaatag ttgtaaagaa agtcactgga
     4261 ccattaaagg gaacacatag caattatgca tacaccgagc tacttgaggt cagtcctgtg
     4321 gagacagcat gccagatcct tggctgggaa atggatctgg agagactttc acgttagtga
     4381 ggttggacta tcatgtttat gtatgtttaa taattgatct ccacaagctt gaaatttgag
     4441 tgttttttag ctttgagtat tttagtagga gcttgggaag aaatgtgtta ttacacagta
     4501 ttacacttgg attattctat ctacagtcct gtaatatttt gtaagatttc tatcagactt
     4561 ctcataatct aatcaataat tttttggtga atgtaggacc tagcagatta aatgaaaagt
     4621 atattttata agagtctggt aaaggtaact aagtctgtct tctctaccaa aaaaacctcc
     4681 aaagcttcat gattgatgaa attcttggtg ccttctgctt gtctgggtca aaggtaaaac
     4741 tcctttagaa agcaggaggg gcccagtaca caccctgaga tcctgcagct cttactgtct
     4801 ctacgtacat ttccacatca gcacctcatg cccgtaatcc tcagagcgct aatgtgatct
     4861 gattggattg gacagatggg gcccatgttt cgtcctgata cttaaccctt agttccttga
     4921 tgttctactt tctttgttgt gtcatacagg ccctgagttg gacatttctc aaacttatat
     4981 atgtggtgtt atatagacct taagtcattt gtaccctgga acattttgga aattatttca
     5041 tctggaggga agtggcagta ggctgaaaat actgactgat gcatagtaga aatctcagat
     5101 aatggaccta cacaatgttt tgttttccaa ggggttataa actattggtc aaaatagttg
     5161 tgtttattta ccctgtctct aatagtggta ttctaatttg atcacaatct agtcaatgcc
     5221 agctgttaat attttgtatt aggcaattat aaaatagcgt tgaattgctg tcttaagctt
     5281 ataagtgact attttgtgtg atttcctttg tctataaatt atttccttgt atgcctttct
     5341 gttttgtttt cttttgtttt tgtattttat atatagtttc actcatattt ttgtgcatat
     5401 attaaatttc tgtgagacat gctaaatttt tgtagtacta cagtttttat ttcaatatag
     5461 aaaagttgtt aaatagtgac ttttcatata ttcataagaa ggtgggttaa ctaacattaa
     5521 taacttaagc c
//
