LOCUS       NM_080470               4056 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus structural maintenance of chromosomes 1B (Smc1b),
            mRNA.
ACCESSION   NM_080470
VERSION     NM_080470.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4056)
  AUTHORS   Cincotta,S.A., Richardson,N., Foecke,M.H. and Laird,D.J.
  TITLE     Differential susceptibility of male and female germ cells to
            glucocorticoid-mediated signaling
  JOURNAL   Elife 12, 90164 (2024)
   PUBMED   38226689
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4056)
  AUTHORS   Biswas,U., Deb Mallik,T., Pschirer,J., Lesche,M., Sameith,K. and
            Jessberger,R.
  TITLE     Cohesin SMC1beta promotes closed chromatin and controls TERRA
            expression at spermatocyte telomeres
  JOURNAL   Life Sci Alliance 6 (7), e202201798 (2023)
   PUBMED   37160312
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4056)
  AUTHORS   Dahlet,T., Truss,M., Frede,U., Al Adhami,H., Bardet,A.F., Dumas,M.,
            Vallet,J., Chicher,J., Hammann,P., Kottnik,S., Hansen,P., Luz,U.,
            Alvarez,G., Auclair,G., Hecht,J., Robinson,P.N., Hagemeier,C. and
            Weber,M.
  TITLE     E2F6 initiates stable epigenetic silencing of germline genes during
            embryonic development
  JOURNAL   Nat Commun 12 (1), 3582 (2021)
   PUBMED   34117224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4056)
  AUTHORS   Viera,A., Berenguer,I., Ruiz-Torres,M., Gomez,R., Guajardo,A.,
            Barbero,J.L., Losada,A. and Suja,J.A.
  TITLE     PDS5 proteins regulate the length of axial elements and telomere
            integrity during male mouse meiosis
  JOURNAL   EMBO Rep 21 (6), e49273 (2020)
   PUBMED   32285610
REFERENCE   5  (bases 1 to 4056)
  AUTHORS   Schimenti,J.C. and Handel,M.A.
  TITLE     Unpackaging the genetics of mammalian fertility: strategies to
            identify the 'reproductive genome'
  JOURNAL   Biol Reprod 99 (6), 1119-1128 (2018)
   PUBMED   29878059
  REMARK    Review article
REFERENCE   6  (bases 1 to 4056)
  AUTHORS   Storre,J., Schafer,A., Reichert,N., Barbero,J.L., Hauser,S.,
            Eilers,M. and Gaubatz,S.
  TITLE     Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells
            by E2F6
  JOURNAL   J Biol Chem 280 (50), 41380-41386 (2005)
   PUBMED   16236716
  REMARK    GeneRIF: E2F6 silences SMC1beta and STAG3 in somatic cells
REFERENCE   7  (bases 1 to 4056)
  AUTHORS   Kouznetsova,A., Novak,I., Jessberger,R. and Hoog,C.
  TITLE     SYCP2 and SYCP3 are required for cohesin core integrity at
            diplotene but not for centromere cohesion at the first meiotic
            division
  JOURNAL   J Cell Sci 118 (Pt 10), 2271-2278 (2005)
   PUBMED   15870106
REFERENCE   8  (bases 1 to 4056)
  AUTHORS   Revenkova,E., Eijpe,M., Heyting,C., Hodges,C.A., Hunt,P.A.,
            Liebe,B., Scherthan,H. and Jessberger,R.
  TITLE     Cohesin SMC1 beta is required for meiotic chromosome dynamics,
            sister chromatid cohesion and DNA recombination
  JOURNAL   Nat Cell Biol 6 (6), 555-562 (2004)
   PUBMED   15146193
  REMARK    GeneRIF: SMC1 beta-deficient mice of both sexes are sterile. Male
            meiosis is blocked in pachytene; female meiosis is highly
            error-prone but continues until metaphase II.
REFERENCE   9  (bases 1 to 4056)
  AUTHORS   Lee,J., Iwai,T., Yokota,T. and Yamashita,M.
  TITLE     Temporally and spatially selective loss of Rec8 protein from
            meiotic chromosomes during mammalian meiosis
  JOURNAL   J Cell Sci 116 (Pt 13), 2781-2790 (2003)
   PUBMED   12759374
REFERENCE   10 (bases 1 to 4056)
  AUTHORS   Revenkova,E., Eijpe,M., Heyting,C., Gross,B. and Jessberger,R.
  TITLE     Novel meiosis-specific isoform of mammalian SMC1
  JOURNAL   Mol Cell Biol 21 (20), 6984-6998 (2001)
   PUBMED   11564881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF303827.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF303827.1, BC129800.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.25 cM"
     gene            1..4056
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /note="structural maintenance of chromosomes 1B"
                     /db_xref="GeneID:140557"
                     /db_xref="MGI:MGI:2154049"
     exon            1..129
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..3767
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /note="SMC-1-beta; SMC protein 1B; structural maintenace
                     of chromosomes 1B"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein
                     1B"
                     /protein_id="NP_536718.1"
                     /db_xref="CCDS:CCDS27718.1"
                     /db_xref="GeneID:140557"
                     /db_xref="MGI:MGI:2154049"
                     /translation="MGHLELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDA
                     LSFVMGEKTTNLRVKNIQELIHGAHTGKPVSSSASVTIIYIEDSGEEKTFTRIIRGGC
                     SEYHFGDKPVSRSVYVAQLENIGIIVKAQNCLVFQGTVESISMKKPKERTQFFEEIST
                     SGEFIGEYEAKKKKLQKAEEDAQFHFNVKKNVAAERKHAKIEKEEAEHYQNLLEELKI
                     NKIQLMLFQLYYNEEKINVLNTELEQMDGNLSVVKDTLSHHENIFKAKKKDYGMLTRQ
                     LQQTAKELKSVEAILNQKRPQYIKAKENTSHHLKKLDLSKKLITDNEKQCSKQEDGIR
                     ALVAELADLDRAWKSFEKQMEEKILQKGRDIELENSQLDRYKLLKEQVRRKVGIMTQQ
                     LEKLQWEQKAEKERLAFEKRRHGDTQGNLKQIKEQIEEHKKRIEKLEEYTKTCMDCLE
                     DKKQQEEALKKEIENTKSRMSEVNEELSLIRNELQNAGIDNHEGKRQQKRAEVLEHLK
                     RLYPDSVFGRLLDLCHPIHKKYQLAVTKLFGRYMVAIVVASEKIAKDCIRFLKAERAE
                     PETFLALDYLDIKPINERLREIKGCKMMIDVIKTQFPQLKKVIQFVCGNGLVCETVEE
                     ARHIAFGGPERRKAVALDGTLFLKSGVISGGSSDLKHKALCWDEKELHNLRDKRSQLV
                     QELKELMKTLRKETDLKQIQTLVQGTNTRLKYSQNELEMIKKKHLATFYREQSQLQSE
                     LLNIDSQCTMLSEGINKQQQKIEEFQDKIDEVEDDIFQDFCEEIGVENIREFENKHVK
                     QQQENDQKRLEFEKQKTRLNIQLEYSRNQLKKKLNNIDTLKTTIQKGKEDIDNLKKTE
                     EECLKIVEELMVKQEQIKEVLATQSSNIEKIHIQIEEERKKVLAVDREVGKLQKEVVI
                     IQGSLEQKLLEKHNLLLDCKVQDIDISLVLGSLEDIIEMELTETESTQATADIYEKEA
                     SIQIDYSPLREDLKALQSDKEVEAHLTLLLQQVASQENTLLKTTAPNLRAQENLKTVR
                     DKFQESADVFEASRKEARICRQEFEQVKRRRYDAFSQCFEHISVSIDQIYKKLCRNNS
                     AQAFLSPENPEEPYLDGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAP
                     FFVLDEVDAALDNTNIGKVSSYIKEQSQEQFQMIIISLKEEFYSKADALIGVYPEHNE
                     CMFSHVLTLDLSKYPDTEDQEGSRSHRKPRVPRVSMSPKSPQSR"
     exon            130..318
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..431
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..635
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..874
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1133
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1274
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1357
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1565
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1751
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1931
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2078
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2216
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2333
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2440
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2582
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2728
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2882
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2978
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3135
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3290
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3442
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3512
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3623
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..4040
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaggcacg gcgcgcagcc atggggcacc ttgagctgct gctcgtggag aatttcaagt
       61 cgtggcgagg ccgccaggtc atcggccctt tcaagaggtt cacctgcatc attggcccca
      121 acggctccgg aaaatctaat gtaatggatg cacttagttt tgtaatggga gaaaagacaa
      181 ctaatttaag agtaaaaaac attcaagaac ttattcatgg agcacatact ggaaaacctg
      241 tttcttcttc tgcaagtgtg acaattatat acatagagga cagtggagaa gagaaaacat
      301 tcacaaggat tatccgaggg gggtgctcag aatatcattt tggggataaa cccgtgagtc
      361 gttctgtgta tgtagcccag ttggaaaaca taggcataat agtcaaagca cagaactgtc
      421 tagtttttca gggaactgta gagtcaatat ccatgaaaaa gcccaaagag agaacccagt
      481 tttttgaaga aatcagtact tcaggagaat ttataggaga atatgaggca aagaaaaaga
      541 aattacaaaa agctgaagaa gatgcacaat ttcattttaa tgtgaaaaaa aatgtagctg
      601 cagaacggaa gcatgcaaaa atagagaaag aagaggcaga acattaccaa aatctccttg
      661 aagaattgaa aataaacaag atacaactga tgcttttcca actatattat aatgaggaaa
      721 aaatcaatgt tttaaacact gaattagagc aaatggacgg gaatttaagt gttgtaaaag
      781 acactctttc tcaccatgaa aacatattta aagctaagaa aaaggattat ggaatgttaa
      841 ctagacaact acagcaaaca gcaaaagaac tgaaatctgt tgaagcaatt ttaaatcaga
      901 agaggcctca gtacattaag gctaaagaaa acacttctca tcatctaaaa aaattagatt
      961 tgtctaagaa attgataaca gacaatgaaa aacaatgttc taagcaggaa gatggcatac
     1021 gagccttagt ggcagaactg gctgatttgg atagagcatg gaaaagtttt gaaaagcaga
     1081 tggaagagaa aatcttacaa aaagggcgag atattgaatt ggaaaatagc cagctggatc
     1141 gttacaaact gcttaaggag caagtcagac ggaaggttgg tataatgaca caacaactgg
     1201 aaaaactgca gtgggaacag aaggcagaaa aagaaagact tgcatttgaa aagaggaggc
     1261 atggagacac tcagggaaat ctaaaacaga taaaagaaca aatagaagag cataaaaaac
     1321 gaatagagaa gttggaggaa tatacaaaga cgtgcatgga ttgcttggaa gataaaaaac
     1381 agcaagaaga ggccctgaaa aaagaaattg aaaatacgaa atcaagaatg tctgaagtta
     1441 atgaagaatt gagtcttatt agaaatgaat tgcagaatgc tggaattgat aaccatgagg
     1501 gaaaacgtca gcagaaaaga gcagaagttc tggaacacct taaaagactt tacccagatt
     1561 ctgtgtttgg aagactgctt gatctgtgtc atcctattca taagaagtac cagctggctg
     1621 tgactaagct ttttggccgg tacatggttg ccattgttgt agcctcagaa aagatagcga
     1681 aagattgtat tcgatttctg aaggcagaaa gagctgaacc tgagacattc cttgctctag
     1741 attaccttga tatcaagcca atcaatgaac gactaaggga aattaaaggc tgtaagatga
     1801 tgatcgatgt tataaagacc cagtttcctc agctgaagaa agtgattcag tttgtttgtg
     1861 gaaatggcct tgtctgtgag actgtggaag aagcaagaca tattgcattc ggtggacctg
     1921 aaagacggaa ggcagtagca cttgatggaa cactgttttt gaaatctgga gtgatttctg
     1981 gagggtcaag tgacttaaag cacaaagctc tgtgctggga tgagaaagag ttacacaatc
     2041 taagagacaa aagaagccaa ctagtccaag agctaaagga gttaatgaag acactccgca
     2101 aggaaacaga tctgaagcaa atacagactt tagtacaagg aaccaataca cgactcaaat
     2161 attcacaaaa tgaactagag atgattaaaa agaagcacct tgctacattt taccgggaac
     2221 aatctcagct acaaagtgaa ttactgaata ttgattctca atgtactatg ttgagtgaag
     2281 gaatcaacaa acagcaacaa aaaattgaag aatttcaaga taagatagat gaggtagaag
     2341 atgacatatt ccaagacttc tgtgaagaaa ttggtgtgga aaatatccgt gaatttgaga
     2401 ataaacatgt taaacagcag caagaaaatg atcaaaaaag attagagttt gaaaaacaaa
     2461 aaactcggct taatattcag ctcgaatata gtcgaaatca gcttaagaag aaactgaata
     2521 atatcgacac attaaaaacc acaatccaga agggcaaaga agatattgat aacctaaaaa
     2581 agaccgaaga agaatgtctg aaaattgttg aggaactcat ggtgaagcaa gagcaaatta
     2641 aggaagtgct tgccacacag agttccaaca ttgaaaaaat tcacatacaa attgaagagg
     2701 aacgcaagaa ggttttggct gttgataggg aagttggaaa attacagaag gaagttgtaa
     2761 tcattcaggg ttctttggaa cagaaactgc tagagaaaca taacttgctg ctagattgca
     2821 aagttcaaga cattgacata agtcttgtgc tggggtcatt ggaggacatc attgaaatgg
     2881 agctaactga aacagaaagc acccaggcaa cagctgatat ctatgagaaa gaagcatcca
     2941 tccaaataga ctacagccct ctaagggagg atttaaaggc tctacaatca gataaggagg
     3001 tggaggccca ccttacactc cttctacagc aagtagcatc ccaagaaaac actctactga
     3061 agactacagc tccaaacttg cgagcacagg agaacttaaa gactgtcaga gacaagtttc
     3121 aagaatctgc agatgttttt gaggccagca gaaaggaagc cagaatatgt aggcaagagt
     3181 ttgaacaggt gaaaagacgg aggtacgatg ctttcagtca atgttttgaa cacatctcag
     3241 tctcaattga tcaaatctac aagaagctct gcaggaacaa cagtgcccag gcatttctta
     3301 gcccagagaa ccctgaagaa ccttacttag atggaattag ctacaactgt gtggctccag
     3361 gcaaacggtt catgcccatg gacaacctgt cagggggaga aaagtgtgtg gctgctctgg
     3421 ctcttctgtt tgctgtacac agttttcggc ctgctccatt ctttgtatta gatgaagtag
     3481 atgcagccct ggacaatact aacattggca aagtctcaag ttacatcaaa gagcagagtc
     3541 aggaacagtt tcagatgata atcatttccc tgaaagagga gttctactcc aaagctgatg
     3601 cactgatagg cgtctaccca gagcacaatg agtgcatgtt cagccatgtg ttgactctgg
     3661 acctttccaa gtatccagac accgaagacc aagaaggcag caggagccac cggaagccca
     3721 gagtaccacg agtatcaatg tctccaaagt ctccccagtc tcgttagaaa tgagtatact
     3781 cttgaacagc caccagctat agaagcttta ccctgaccct gtggaggtca ggccagtctc
     3841 tgtttagacc catgtgtcat agaagaaaaa tctcttacca ttttagtaga aaaaaaacta
     3901 tagcccactc agctaaggag tgctcagtgt cattccaatg gaggttccta tggcatcaat
     3961 gaatgaggta tatggttttc ttttgctttt aagggctttt gttttgaaac aaattggtta
     4021 taaaattttg aattctgcaa aaaaaaaaaa aaaaaa
//
