LOCUS       NP_536718               1248 aa            linear   ROD 25-FEB-2025
DEFINITION  structural maintenance of chromosomes protein 1B [Mus musculus].
ACCESSION   NP_536718
VERSION     NP_536718.1
DBSOURCE    REFSEQ: accession NM_080470.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1248)
  AUTHORS   Cincotta,S.A., Richardson,N., Foecke,M.H. and Laird,D.J.
  TITLE     Differential susceptibility of male and female germ cells to
            glucocorticoid-mediated signaling
  JOURNAL   Elife 12, 90164 (2024)
   PUBMED   38226689
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1248)
  AUTHORS   Biswas,U., Deb Mallik,T., Pschirer,J., Lesche,M., Sameith,K. and
            Jessberger,R.
  TITLE     Cohesin SMC1beta promotes closed chromatin and controls TERRA
            expression at spermatocyte telomeres
  JOURNAL   Life Sci Alliance 6 (7), e202201798 (2023)
   PUBMED   37160312
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1248)
  AUTHORS   Dahlet,T., Truss,M., Frede,U., Al Adhami,H., Bardet,A.F., Dumas,M.,
            Vallet,J., Chicher,J., Hammann,P., Kottnik,S., Hansen,P., Luz,U.,
            Alvarez,G., Auclair,G., Hecht,J., Robinson,P.N., Hagemeier,C. and
            Weber,M.
  TITLE     E2F6 initiates stable epigenetic silencing of germline genes during
            embryonic development
  JOURNAL   Nat Commun 12 (1), 3582 (2021)
   PUBMED   34117224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1248)
  AUTHORS   Viera,A., Berenguer,I., Ruiz-Torres,M., Gomez,R., Guajardo,A.,
            Barbero,J.L., Losada,A. and Suja,J.A.
  TITLE     PDS5 proteins regulate the length of axial elements and telomere
            integrity during male mouse meiosis
  JOURNAL   EMBO Rep 21 (6), e49273 (2020)
   PUBMED   32285610
REFERENCE   5  (residues 1 to 1248)
  AUTHORS   Schimenti,J.C. and Handel,M.A.
  TITLE     Unpackaging the genetics of mammalian fertility: strategies to
            identify the 'reproductive genome'
  JOURNAL   Biol Reprod 99 (6), 1119-1128 (2018)
   PUBMED   29878059
  REMARK    Review article
REFERENCE   6  (residues 1 to 1248)
  AUTHORS   Storre,J., Schafer,A., Reichert,N., Barbero,J.L., Hauser,S.,
            Eilers,M. and Gaubatz,S.
  TITLE     Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells
            by E2F6
  JOURNAL   J Biol Chem 280 (50), 41380-41386 (2005)
   PUBMED   16236716
  REMARK    GeneRIF: E2F6 silences SMC1beta and STAG3 in somatic cells
REFERENCE   7  (residues 1 to 1248)
  AUTHORS   Kouznetsova,A., Novak,I., Jessberger,R. and Hoog,C.
  TITLE     SYCP2 and SYCP3 are required for cohesin core integrity at
            diplotene but not for centromere cohesion at the first meiotic
            division
  JOURNAL   J Cell Sci 118 (Pt 10), 2271-2278 (2005)
   PUBMED   15870106
REFERENCE   8  (residues 1 to 1248)
  AUTHORS   Revenkova,E., Eijpe,M., Heyting,C., Hodges,C.A., Hunt,P.A.,
            Liebe,B., Scherthan,H. and Jessberger,R.
  TITLE     Cohesin SMC1 beta is required for meiotic chromosome dynamics,
            sister chromatid cohesion and DNA recombination
  JOURNAL   Nat Cell Biol 6 (6), 555-562 (2004)
   PUBMED   15146193
  REMARK    GeneRIF: SMC1 beta-deficient mice of both sexes are sterile. Male
            meiosis is blocked in pachytene; female meiosis is highly
            error-prone but continues until metaphase II.
REFERENCE   9  (residues 1 to 1248)
  AUTHORS   Lee,J., Iwai,T., Yokota,T. and Yamashita,M.
  TITLE     Temporally and spatially selective loss of Rec8 protein from
            meiotic chromosomes during mammalian meiosis
  JOURNAL   J Cell Sci 116 (Pt 13), 2781-2790 (2003)
   PUBMED   12759374
REFERENCE   10 (residues 1 to 1248)
  AUTHORS   Revenkova,E., Eijpe,M., Heyting,C., Gross,B. and Jessberger,R.
  TITLE     Novel meiosis-specific isoform of mammalian SMC1
  JOURNAL   Mol Cell Biol 21 (20), 6984-6998 (2001)
   PUBMED   11564881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF303827.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF303827.1, BC129800.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1248
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.25 cM"
     Protein         1..1248
                     /product="structural maintenance of chromosomes protein
                     1B"
                     /note="SMC-1-beta; SMC protein 1B; structural maintenace
                     of chromosomes 1B"
                     /calculated_mol_wt=144383
     Region          3..1203
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Site            648
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q14683; propagated from
                     UniProtKB/Swiss-Prot (Q920F6.1)"
     Site            713
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q14683; propagated from
                     UniProtKB/Swiss-Prot (Q920F6.1)"
     Site            1032
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9CU62; propagated from
                     UniProtKB/Swiss-Prot (Q920F6.1)"
     Region          1219..1248
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920F6.1)"
     CDS             1..1248
                     /gene="Smc1b"
                     /gene_synonym="SMC-1B; SMC1beta; Smc1l2"
                     /coded_by="NM_080470.1:21..3767"
                     /db_xref="CCDS:CCDS27718.1"
                     /db_xref="GeneID:140557"
                     /db_xref="MGI:MGI:2154049"
ORIGIN      
        1 mghlelllve nfkswrgrqv igpfkrftci igpngsgksn vmdalsfvmg ekttnlrvkn
       61 iqelihgaht gkpvsssasv tiiyiedsge ektftriirg gcseyhfgdk pvsrsvyvaq
      121 lenigiivka qnclvfqgtv esismkkpke rtqffeeist sgefigeyea kkkklqkaee
      181 daqfhfnvkk nvaaerkhak iekeeaehyq nlleelkink iqlmlfqlyy neekinvlnt
      241 eleqmdgnls vvkdtlshhe nifkakkkdy gmltrqlqqt akelksveai lnqkrpqyik
      301 akentshhlk kldlskklit dnekqcskqe dgiralvael adldrawksf ekqmeekilq
      361 kgrdielens qldrykllke qvrrkvgimt qqleklqweq kaekerlafe krrhgdtqgn
      421 lkqikeqiee hkkrieklee ytktcmdcle dkkqqeealk keientksrm sevneelsli
      481 rnelqnagid nhegkrqqkr aevlehlkrl ypdsvfgrll dlchpihkky qlavtklfgr
      541 ymvaivvase kiakdcirfl kaeraepetf laldyldikp inerlreikg ckmmidvikt
      601 qfpqlkkviq fvcgnglvce tveearhiaf ggperrkava ldgtlflksg visggssdlk
      661 hkalcwdeke lhnlrdkrsq lvqelkelmk tlrketdlkq iqtlvqgtnt rlkysqnele
      721 mikkkhlatf yreqsqlqse llnidsqctm lseginkqqq kieefqdkid eveddifqdf
      781 ceeigvenir efenkhvkqq qendqkrlef ekqktrlniq leysrnqlkk klnnidtlkt
      841 tiqkgkedid nlkkteeecl kiveelmvkq eqikevlatq ssniekihiq ieeerkkvla
      901 vdrevgklqk evviiqgsle qkllekhnll ldckvqdidi slvlgsledi iemeltetes
      961 tqatadiyek easiqidysp lredlkalqs dkeveahltl llqqvasqen tllkttapnl
     1021 raqenlktvr dkfqesadvf easrkearic rqefeqvkrr rydafsqcfe hisvsidqiy
     1081 kklcrnnsaq aflspenpee pyldgisync vapgkrfmpm dnlsggekcv aalallfavh
     1141 sfrpapffvl devdaaldnt nigkvssyik eqsqeqfqmi iislkeefys kadaligvyp
     1201 ehnecmfshv ltldlskypd tedqegsrsh rkprvprvsm spkspqsr
//
