LOCUS       NM_001130187            2767 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SWI/SNF related BAF chromatin remodeling complex
            subunit D2 (Smarcd2), transcript variant 1, mRNA.
ACCESSION   NM_001130187
VERSION     NM_001130187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2767)
  AUTHORS   Zhong,J., Ji,X., Zhao,Y., Jia,Y., Song,C., Lv,J., Chen,Y., Zhou,Y.,
            Lv,X., Yang,Z., Zhang,Z., Xu,Q., Wang,W., Chen,H., Cui,A., Li,Y.
            and Meng,Z.X.
  TITLE     Identification of BAF60b as a Chromatin-Remodeling Checkpoint of
            Diet-Induced Fatty Liver Disease
  JOURNAL   Diabetes 73 (10), 1615-1630 (2024)
   PUBMED   39046829
REFERENCE   2  (bases 1 to 2767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2767)
  AUTHORS   Bohuslavova,R., Fabriciova,V., Smolik,O., Lebron-Mora,L.,
            Abaffy,P., Benesova,S., Zucha,D., Valihrach,L., Berkova,Z.,
            Saudek,F. and Pavlinkova,G.
  TITLE     NEUROD1 reinforces endocrine cell fate acquisition in pancreatic
            development
  JOURNAL   Nat Commun 14 (1), 5554 (2023)
   PUBMED   37689751
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2767)
  AUTHORS   Li,J., Xu,J., Jiang,H., Zhang,T., Ramakrishnan,A., Shen,L. and
            Xu,P.X.
  TITLE     Chromatin Remodelers Interact with Eya1 and Six2 to Target
            Enhancers to Control Nephron Progenitor Cell Maintenance
  JOURNAL   J Am Soc Nephrol 32 (11), 2815-2833 (2021)
   PUBMED   34716243
REFERENCE   5  (bases 1 to 2767)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2767)
  AUTHORS   Zhang,H.S., Gavin,M., Dahiya,A., Postigo,A.A., Ma,D., Luo,R.X.,
            Harbour,J.W. and Dean,D.C.
  TITLE     Exit from G1 and S phase of the cell cycle is regulated by
            repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
  JOURNAL   Cell 101 (1), 79-89 (2000)
   PUBMED   10778858
REFERENCE   7  (bases 1 to 2767)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   8  (bases 1 to 2767)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   9  (bases 1 to 2767)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   10 (bases 1 to 2767)
  AUTHORS   Calvert,I., Peng,Z.Q., Kung,H.F. and Raziuddin.
  TITLE     Cloning and characterization of a novel sequence-specific
            DNA-binding protein recognizing the negative regulatory element
            (NRE) region of the HIV-1 long terminal repeat
  JOURNAL   Gene 101 (2), 171-176 (1991)
   PUBMED   2055486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB642181.1, AK159259.1, DV648475.1 and BE853586.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159259.1, AK166123.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               BB642181.1         30-197
            169-1399            AK159259.1         6-1236
            1400-2172           DV648475.1         46-818
            2173-2745           AK159259.1         2010-2582
            2746-2767           BE853586.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.89 cM"
     gene            1..2767
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit D2"
                     /db_xref="GeneID:83796"
                     /db_xref="MGI:MGI:1933621"
     exon            1..480
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1860
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily D member 2;
                     BRG1-associated factor 60B; 60 kDa BRG-1/Brm-associated
                     factor subunit B; SWI/SNF related, matrix associated,
                     actin dependent regulator of chromatin, subfamily d,
                     member 2"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily D member
                     2 isoform 1"
                     /protein_id="NP_001123659.1"
                     /db_xref="CCDS:CCDS48958.1"
                     /db_xref="GeneID:83796"
                     /db_xref="MGI:MGI:1933621"
                     /translation="MSGRGAGGFPLPPLSPGGGAVAAALGAPPPPAGPGMLPSPALRG
                     PGPSGGMGVPGAAAFRPMGPAGPAAQYQRPGMSPGSRMPMAGLQVGPPAGSPFGTAAP
                     LRPGMPPTMMDPFRKRLLVPQAQPPMPAQRRGLKRRKMADKVLPQRIRELVPESQAYM
                     DLLAFERKLDQTIARKRMEIQEAIKKPLTQKRKLRIYISNTFSPSKADGDNAGTAGTP
                     GGTPAADKVASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHR
                     MPTTQETDGFQVKRPGDLNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRAAIMQA
                     LWLYIKHNQLQDGHEREYINCNRYFRQIFSCGRLRFSEIPMKLAGLLQHPDPIVINHV
                     ISVDPNDQKKTACYDIDVEVDDPLKAQMSNFLASTTNQQEIASLDVKIHETIESINQL
                     KTQRDFMLSFSTEPQDFIQEWLRSQRRDLKIITDVIGNPEEERRAAFYHQPWAQEAVG
                     RHIFAKVQQRRQELEQVLGIRLT"
     exon            481..665
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            666..708
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            709..831
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            832..987
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1083
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1185
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1347
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1445
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1581
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1704
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1806
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2755
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2723..2728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /note="hexamer: AATAAA"
     polyA_site      2745
                     /gene="Smarcd2"
                     /gene_synonym="Baf60b"
                     /note="major polyA site"
ORIGIN      
        1 ctccggcgat caaacctccg gaggccggga gaggcctgcg ggctcgcggc acatcccgga
       61 tctggagtat ccctggcagg agcggagtca gaggggccgc gggatcctaa agccgggctg
      121 caaagaactt gcgaacttgg agtagaagat cccggaaccc ggtagtaaaa tcgggaagtc
      181 ccggatcgcg gaacgtagct cgcggagcgg actcaacacg gagaccggag gccggatcgc
      241 tgcaccgcgg gacgggacag agtgatgtcc ggccgtggcg cgggcgggtt cccgctgcct
      301 ccgctgagcc ccggcggcgg cgccgttgcc gcggcccttg gtgcgccgcc tccgcctgcg
      361 ggacccggaa tgctgcccag cccggcgctc aggggcccgg ggccttctgg aggcatgggg
      421 gtaccggggg ccgccgcctt ccgccccatg ggccccgctg gccccgcggc gcagtaccag
      481 cgtcctggca tgtcaccagg aagcaggatg cccatggctg gcttgcaggt gggacctcct
      541 gccggttccc catttggcac agctgctccg ctccgacctg gcatgccacc taccatgatg
      601 gatccattcc gaaaacgcct gcttgtgcct caggcccagc ccccgatgcc tgcccagcgc
      661 cgagggttaa agaggaggaa gatggcagat aaggttctac ctcagcgaat ccgggagctt
      721 gtcccagagt ctcaggcata catggatctt ttagctttcg agaggaagct ggaccagacc
      781 atcgctcgca agcggatgga gattcaagag gccatcaaga agcctctgac gcaaaagcga
      841 aaacttcgga tctatatttc caatacattc agccccagca aggcggatgg agataatgcg
      901 ggaactgcgg ggacccctgg gggaaccccg gcagcagaca aggtggcctc ctgggagctt
      961 cgagtagagg ggaaactgct ggatgatcct agcaaacaga agaggaagtt ctcatcattc
     1021 tttaagagcc ttgtgattga gttggacaag gaactctatg ggccggacaa ccatctggtg
     1081 gagtggcatc ggatgcccac cacacaggaa acagatggct ttcaggtgaa acggccagga
     1141 gatctcaatg tcaagtgcac ccttctgctc atgctggatc atcagcctcc tcagtataaa
     1201 ctggaccccc gcctggcgag gttgctggga gtgcacacac agaccagggc ggcaatcatg
     1261 caggcactgt ggctttacat caaacacaac cagctgcagg acggccatga gcgcgagtac
     1321 atcaactgca atcgttactt ccgccagatc ttcagttgtg gccgactccg tttctccgag
     1381 attcccatga agctggctgg attgctgcag catccagacc ccattgttat taatcatgtc
     1441 attagtgtgg atcctaatga ccaaaagaag acagcctgct atgacattga tgtagaggtt
     1501 gatgacccac tgaaggccca gatgagcaac ttcctggcct ctaccaccaa ccagcaggag
     1561 attgcttctc ttgacgtcaa gatccatgag accattgagt ccatcaacca gctaaagacc
     1621 cagagggatt tcatgctcag ctttagcacc gagccccagg acttcatcca ggagtggctc
     1681 cgttcccaac gccgagacct caagatcatc acagatgtga ttggaaaccc tgaggaggag
     1741 agacgagctg ctttctacca ccagccctgg gctcaggaag cagtggggag gcacatcttt
     1801 gccaaggtgc agcagcgaag gcaggaactg gaacaggtgc tgggaattcg cctgacctaa
     1861 ctgctcaggg attgcctcct tccttcctcc cctgccctgg atggaacctg gcaagagccc
     1921 gtcctctggg ttctggcttg ggctgcagac atgtaggatg gagtgaggtg tgtttcctgt
     1981 caccctccac tccccagctt tagtttcata aatgtagttt tagatccctc actgcttggt
     2041 tcccaaagcc ttattactga ccttttagcg ctggctttaa ttgggtttgc aatgagcggc
     2101 ctcagccccc tgcaggcagg caggcctgag taggaggctg gaggctgtgc tttaactttg
     2161 taccagacat ttccaaacca aaggctgctg ggtttgcatg tttacaggct ccaccctagg
     2221 gccagtgcca gagctggctt tggggagctg ggcaaggaag agaaggccct agactcttcc
     2281 tggcctttct aaccaaagtt ttttgccatt cctacaagcc cagtcttgct gctggtttgt
     2341 ccttcttttt gggtatttgc actatttggg gagcaggttt ttctatgtgg gagccacttt
     2401 tttgtacaga ggtaatgggg tttttcaggg agcccacttg gtgcctcctt cttcctttct
     2461 tttcttaatc tatgcaagcg gctgcagccg ccatcatctc ctggtatgcc acaaggctgc
     2521 ccacccatag ctgcttgggc agggggaggt ggaatctcct gagagtggca atgccagttc
     2581 tctaacccag ttacagcagg ggtgtgtgtg cgtgcgtgcg tgcgtgctgc aggggaaggg
     2641 gaaagctgga ggactgctgt taccttttgc agtcggtctt aaagaggatg ggcctaaggc
     2701 ttggcaaact tggaaaattc caaataaatc tttttgttta ttggtggtgc ccagaaaaaa
     2761 aaaaaaa
//
