LOCUS       NM_011418               1674 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus SWI/SNF related BAF chromatin remodeling complex
            subunit B1 (Smarcb1), transcript variant 1, mRNA.
ACCESSION   NM_011418
VERSION     NM_011418.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1674)
  AUTHORS   Fischer,A., Albert,T.K., Moreno,N., Interlandi,M., Mormann,J.,
            Glaser,S., Patil,P., de Faria,F.W., Richter,M., Verma,A.,
            Balbach,S.T., Wagener,R., Bens,S., Dahlum,S., Gobel,C., Munter,D.,
            Inserte,C., Graf,M., Kremer,E., Melcher,V., Di Stefano,G.,
            Santi,R., Chan,A., Dogan,A., Bush,J., Hasselblatt,M., Cheng,S.,
            Spetalen,S., Fossa,A., Hartmann,W., Herbruggen,H., Robert,S.,
            Oyen,F., Dugas,M., Walter,C., Sandmann,S., Varghese,J., Rossig,C.,
            Schuller,U., Tzankov,A., Pedersen,M.B., d'Amore,F.A., Mellgren,K.,
            Kontny,U., Kancherla,V., Veloza,L., Missiaglia,E., Fataccioli,V.,
            Gaulard,P., Burkhardt,B., Soehnlein,O., Klapper,W., de Leval,L.,
            Siebert,R. and Kerl,K.
  TITLE     Lack of SMARCB1 expression characterizes a subset of human and
            murine peripheral T-cell lymphomas
  JOURNAL   Nat Commun 15 (1), 8571 (2024)
   PUBMED   39362842
  REMARK    GeneRIF: Lack of SMARCB1 expression characterizes a subset of human
            and murine peripheral T-cell lymphomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1674)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1674)
  AUTHORS   Lobon-Iglesias,M.J., Andrianteranagna,M., Han,Z.Y., Chauvin,C.,
            Masliah-Planchon,J., Manriquez,V., Tauziede-Espariat,A.,
            Turczynski,S., Bouarich-Bourimi,R., Frah,M., Dufour,C.,
            Blauwblomme,T., Cardoen,L., Pierron,G., Maillot,L., Guillemot,D.,
            Reynaud,S., Bourneix,C., Pouponnot,C., Surdez,D., Bohec,M.,
            Baulande,S., Delattre,O., Piaggio,E., Ayrault,O., Waterfall,J.J.,
            Servant,N., Beccaria,K., Dangouloff-Ros,V. and Bourdeaut,F.
  TITLE     Imaging and multi-omics datasets converge to define different
            neural progenitor origins for ATRT-SHH subgroups
  JOURNAL   Nat Commun 14 (1), 6669 (2023)
   PUBMED   37863903
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1674)
  AUTHORS   Brugmans,A.K., Walter,C., Moreno,N., Gobel,C., Holdhof,D., de
            Faria,F.W., Hotfilder,M., Jeising,D., Fruhwald,M.C., Skryabin,B.V.,
            Rozhdestvensky,T.S., Wachsmuth,L., Faber,C., Dugas,M., Varghese,J.,
            Schuller,U., Albert,T.K. and Kerl,K.
  TITLE     A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus
            Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice
  JOURNAL   Cell Mol Neurobiol 43 (7), 3511-3526 (2023)
   PUBMED   37219662
  REMARK    GeneRIF: A Carboxy-terminal Smarcb1 Point Mutation Induces
            Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling
            Pathways in Mice.
REFERENCE   5  (bases 1 to 1674)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1674)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   7  (bases 1 to 1674)
  AUTHORS   Reyes,J.C., Barra,J., Muchardt,C., Camus,A., Babinet,C. and
            Yaniv,M.
  TITLE     Altered control of cellular proliferation in the absence of
            mammalian brahma (SNF2alpha)
  JOURNAL   EMBO J 17 (23), 6979-6991 (1998)
   PUBMED   9843504
REFERENCE   8  (bases 1 to 1674)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   9  (bases 1 to 1674)
  AUTHORS   Wang,W., Cote,J., Xue,Y., Zhou,S., Khavari,P.A., Biggar,S.R.,
            Muchardt,C., Kalpana,G.V., Goff,S.P., Yaniv,M., Workman,J.L. and
            Crabtree,G.R.
  TITLE     Purification and biochemical heterogeneity of the mammalian SWI-SNF
            complex
  JOURNAL   EMBO J 15 (19), 5370-5382 (1996)
   PUBMED   8895581
REFERENCE   10 (bases 1 to 1674)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150169.1, AK075906.1 and AI840539.1.
            
            On Jun 19, 2009 this sequence version replaced NM_011418.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075906.1, AB041578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AK150169.1         2-19
            19-1649             AK075906.1         2-1632
            1650-1674           AI840539.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.61 cM"
     gene            1..1674
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit B1"
                     /db_xref="GeneID:20587"
                     /db_xref="MGI:MGI:1328366"
     exon            1..312
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1377
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily B member 1; SWI/SNF
                     related, matrix associated, actin dependent regulator of
                     chromatin, subfamily b, member 1; BRG1-associated factor
                     47; integrase interactor 1 protein; mSNF5; SNF5 homolog"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily B member
                     1 isoform 1"
                     /protein_id="NP_035548.1"
                     /db_xref="CCDS:CCDS23936.1"
                     /db_xref="GeneID:20587"
                     /db_xref="MGI:MGI:1328366"
                     /translation="MMMMALSKTFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLY
                     KRYPSLWRRLATVEERKKIVASSHGKKTKPNTKDHGYTTLATSVTLLKASEVEEILDG
                     NDEKYKAVSISTEPPTYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDK
                     KRTFPLCFDDHDPAVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMF
                     SEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLV
                     DQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLP
                     TVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRRMRRLANTAPAW"
     exon            313..451
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..581
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..719
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..847
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1014
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1205
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1337
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1657
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /note="hexamer: AATAAA"
     polyA_site      1653
                     /gene="Smarcb1"
                     /gene_synonym="Baf47; Ini1; Snf5; SNF5/INI1"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcttct ccacgcatgc gcaccgaggg cggcctgctc gttgcagaga cggccaagga
       61 gcccagtagt gacacgagcg ctcgcccggt tcgcccggct tgccctgccc gaccttcacc
      121 tccaggcctc cgttcctttc ggtccgacgc gcctcggccc cgccctagcc caccggattc
      181 tttccagctc gaccccggct gccggtttcc cccgccgcca tgatgatgat ggcgttgagc
      241 aagaccttcg ggcagaagcc cgtcaagttt cagctggagg acgacgggga gttctacatg
      301 atcggctccg aggtgggaaa ctacctgcgt atgttccgag gttctctgta caagagatac
      361 ccctcactct ggcggcgact agccactgtg gaagaaagga agaaaatagt ggcatcgtca
      421 catggtaaaa aaacaaaacc taacactaag gatcatggat ataccaccct ggccaccagc
      481 gtgacactcc tgaaagcctc agaggtagaa gagatcctgg atggcaatga cgagaagtac
      541 aaggctgtgt ccatcagcac agagcccccg acctacctca gggagcagaa ggccaagagg
      601 aacagccagt gggtccccac cctgcccaac agctcccacc acctggatgc tgtgccctgt
      661 tccaccacca tcaacaggaa ccgcatgggt cgggacaaga agagaacctt ccccttgtgc
      721 tttgatgacc acgacccagc tgtgatccat gagaatgcgt cacagcctga ggtgctggtg
      781 cccatccggc tcgacatgga gatcgacggg cagaagctgc gagacgcttt tacctggaac
      841 atgaatgaga agctaatgac tcctgagatg ttttcagaaa tactttgtga tgacctggat
      901 ttgaatccac tgacttttgt gccagctatt gcctctgcca ttcgacagca gattgagtcc
      961 taccccacag acagcatcct agaggatcaa tccgaccagc gtgtcatcat caagctgaac
     1021 atccacgtgg ggaacatctc cctggtggac cagtttgagt gggacatgtc agagaaagag
     1081 aactccccag agaagtttgc cctgaagctg tgctcagagc tgggcttggg cggggagttt
     1141 gtcaccacca ttgcatacag catccgagga cagctgagct ggcaccagaa gacctatgcc
     1201 ttcagtgaga acccacttcc cacagtggag attgccatcc gaaataccgg agatgctgac
     1261 cagtggtgcc ccctgctgga gacactgact gatgccgaga tggagaaaaa gatccgggat
     1321 caagatagga acacaaggcg aatgaggcgt cttgccaaca ctgccccagc ctggtgatga
     1381 agacatccat gctcgacctc tacggagcat ctcagactgc ctttccttcc tctgtggaaa
     1441 gagaaaggca aagggacagc tggtgccatc ctgaggactg gggtaggagc ctcctaggtg
     1501 cctcccttca gcacacattc catttgctaa accccaacac tgtcccccag agtctagagt
     1561 cggaagcagc ctcattttgg gttgtgtttt gtttttgtat aggagcccag gcagggctgg
     1621 taacactttt taaataaaaa gtaccatgtt caatttcaaa aaaaaaaaaa aaaa
//
