LOCUS       NM_018817               6715 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus SNF2 related chromatin remodeling ATPase like 1
            (Smarcal1), mRNA.
ACCESSION   NM_018817
VERSION     NM_018817.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6715)
  AUTHORS   Georgieva,D., Wang,N., Taglialatela,A., Jerabek,S., Reczek,C.R.,
            Lim,P.X., Sung,J., Du,Q., Horiguchi,M., Jasin,M., Ciccia,A.,
            Baer,R. and Egli,D.
  TITLE     BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA
            repair pathway choice at replication-associated double-strand
            breaks
  JOURNAL   Cell Rep 43 (4), 114006 (2024)
   PUBMED   38554279
REFERENCE   2  (bases 1 to 6715)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6715)
  AUTHORS   Leuzzi,G., Vasciaveo,A., Taglialatela,A., Chen,X., Firestone,T.M.,
            Hickman,A.R., Mao,W., Thakar,T., Vaitsiankova,A., Huang,J.W.,
            Cuella-Martin,R., Hayward,S.B., Kesner,J.S., Ghasemzadeh,A.,
            Nambiar,T.S., Ho,P., Rialdi,A., Hebrard,M., Li,Y., Gao,J.,
            Gopinath,S., Adeleke,O.A., Venters,B.J., Drake,C.G., Baer,R.,
            Izar,B., Guccione,E., Keogh,M.C., Guerois,R., Sun,L., Lu,C.,
            Califano,A. and Ciccia,A.
  TITLE     SMARCAL1 is a dual regulator of innate immune signaling and PD-L1
            expression that promotes tumor immune evasion
  JOURNAL   Cell 187 (4), 861-881 (2024)
   PUBMED   38301646
  REMARK    GeneRIF: SMARCAL1 is a dual regulator of innate immune signaling
            and PD-L1 expression that promotes tumor immune evasion.
REFERENCE   4  (bases 1 to 6715)
  AUTHORS   Nagai,T.H., Hartigan,C., Mizoguchi,T., Yu,H., Deik,A., Bullock,K.,
            Wang,Y., Cromley,D., Schenone,M., Cowan,C.A., Rader,D.J.,
            Clish,C.B., Carr,S.A. and Xu,Y.X.
  TITLE     Chromatin regulator SMARCAL1 modulates cellular lipid metabolism
  JOURNAL   Commun Biol 6 (1), 1298 (2023)
   PUBMED   38129665
  REMARK    GeneRIF: Chromatin regulator SMARCAL1 modulates cellular lipid
            metabolism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6715)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6715)
  AUTHORS   Baradaran-Heravi,A., Raams,A., Lubieniecka,J., Cho,K.S.,
            DeHaai,K.A., Basiratnia,M., Mari,P.O., Xue,Y., Rauth,M.,
            Olney,A.H., Shago,M., Choi,K., Weksberg,R.A., Nowaczyk,M.J.,
            Wang,W., Jaspers,N.G. and Boerkoel,C.F.
  TITLE     SMARCAL1 deficiency predisposes to non-Hodgkin lymphoma and
            hypersensitivity to genotoxic agents in vivo
  JOURNAL   Am J Med Genet A 158A (9), 2204-2213 (2012)
   PUBMED   22888040
  REMARK    GeneRIF: did not find evidence of defective NER or NHEJ; however,
            Smarcal1-deficient mice were hypersensitive to several genotoxic
            agents
REFERENCE   7  (bases 1 to 6715)
  AUTHORS   Baradaran-Heravi,A., Cho,K.S., Tolhuis,B., Sanyal,M., Morozova,O.,
            Morimoto,M., Elizondo,L.I., Bridgewater,D., Lubieniecka,J.,
            Beirnes,K., Myung,C., Leung,D., Fam,H.K., Choi,K., Huang,Y.,
            Dionis,K.Y., Zonana,J., Keller,K., Stenzel,P., Mayfield,C.,
            Lucke,T., Bokenkamp,A., Marra,M.A., van Lohuizen,M., Lewis,D.B.,
            Shaw,C. and Boerkoel,C.F.
  TITLE     Penetrance of biallelic SMARCAL1 mutations is associated with
            environmental and genetic disturbances of gene expression
  JOURNAL   Hum Mol Genet 21 (11), 2572-2587 (2012)
   PUBMED   22378147
  REMARK    GeneRIF: SMARCAL1 annealing helicase buffers fluctuations in gene
            expression and that alterations in gene expression contribute to
            the penetrance of SIOD.
REFERENCE   8  (bases 1 to 6715)
  AUTHORS   Yusufzai,T., Kong,X., Yokomori,K. and Kadonaga,J.T.
  TITLE     The annealing helicase HARP is recruited to DNA repair sites via an
            interaction with RPA
  JOURNAL   Genes Dev 23 (20), 2400-2404 (2009)
   PUBMED   19793863
REFERENCE   9  (bases 1 to 6715)
  AUTHORS   Bansbach,C.E., Betous,R., Lovejoy,C.A., Glick,G.G. and Cortez,D.
  TITLE     The annealing helicase SMARCAL1 maintains genome integrity at
            stalled replication forks
  JOURNAL   Genes Dev 23 (20), 2405-2414 (2009)
   PUBMED   19793861
REFERENCE   10 (bases 1 to 6715)
  AUTHORS   Coleman,M.A., Eisen,J.A. and Mohrenweiser,H.W.
  TITLE     Cloning and characterization of HARP/SMARCAL1: a prokaryotic
            HepA-related SNF2 helicase protein from human and mouse
  JOURNAL   Genomics 65 (3), 274-282 (2000)
   PUBMED   10857751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY739344.1, AK146767.1, AK083488.1 and AC163484.4.
            
            On May 7, 2009 this sequence version replaced NM_018817.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.428.1, AK154020.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY739344.1         2-10
            10-1614             AK146767.1         4-1608
            1615-1944           AK146767.1         1610-1939
            1945-2725           AK146767.1         1941-2721
            2726-2994           AK083488.1         2704-2972
            2995-6715           AC163484.4         54237-57957         c
FEATURES             Location/Qualifiers
     source          1..6715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.72 cM"
     gene            1..6715
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /note="SNF2 related chromatin remodeling ATPase like 1"
                     /db_xref="GeneID:54380"
                     /db_xref="MGI:MGI:1859183"
     exon            1..188
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            189..955
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1006
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1219
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1270
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1457
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1608
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1767
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1833
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1974
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2190
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2261
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2364
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2547
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2648
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2745
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..6715
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /note="hexamer: AATAAA"
     polyA_site      3059
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /note="major polyA site"
     regulatory      5557..5562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /note="hexamer: AATAAA"
     polyA_site      5580
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
     regulatory      6693..6698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
                     /note="hexamer: AATAAA"
     polyA_site      6715
                     /gene="Smarcal1"
                     /gene_synonym="6030401P21Rik; Mharp"
ORIGIN      
        1 gtagttcgac ggtggccgag ccattcaaat gccaatggcc cgctccaaga tgggtgaaat
       61 tgtagcgctt gaattctagt tcctctaaca gtccaaccag aagcgaaaac tgcctaggca
      121 aggctctgaa agacgctcct ggtctagggc tgttctgcta aggtgcctca ccttactggc
      181 ctcgctagct tttaccaact tcccaactaa agggtgacat ccctgcatga gcctatcctg
      241 ttaaaaatgt ccttgccact tacagaggag cagaggaaaa agattgaaga gaatcggcaa
      301 aaagctttgg cccgtcgagc tgagaagttg tcagaacagc cacagagcgc agcttcaggc
      361 tcctctgctg ccggcccgtc ccagtccaag cagggctctc tcctgaatct cctagcggag
      421 ccttcaaagc cagtgggcca tgcctccatt ttcaagcaac agaatctcag taattcattt
      481 cctactgatc agagacctca cagctcccgc tgttctcagc ccagcccagc agaggaaacg
      541 acggggctat ggaagaccca aggagagatg tccacagcct gcccaaagcc taacccaagt
      601 cctccaggag cctctaacca accacttttg ggttataaat ccagcgaggg tcaaccccag
      661 gcaacctggg acacaggagc ttcctcttct ggaccattcc ccagggaccc cgagttagag
      721 gccaaggcag caaggccttc cacctctagg cagagcattt cggacagctt ttatgtgtta
      781 gggggaaaaa cacctaggac agaagggaga cccccaaaca tactgcaaac cacaccccaa
      841 aacacaggct ttctacgggg agcgtgcata aagactgggg atcgcttccg ggtaaagatc
      901 ggctacaacc aagagctcat tgccgtgttt aagtctctgc ccagcagaca ctatgattct
      961 tttacaaaga cctgggactt cagcatgagc gactacagag ccttgatgaa ggcagtcgag
     1021 cgactctcca cggtctccct gaagccactg gacgaggctg gtggcagtgt tggaggacag
     1081 accagccttc cctcagctcc atccctgacc tttgtgacag ggaagtgcat gctcatctct
     1141 cgagtccgct tcgaggttga catcggctat tcggaggcgg tgattggcct gtttaaacag
     1201 atggagtcca ggagttacga tatcaagacc aggaagtgga gttttctctt ggaagagcac
     1261 aataaactaa ttgcaaggtc acgtgaactg aagcaagttc agctggaccc actgcccaag
     1321 acagtgaccc tggcatttgc atctcagctg gagaaaacgt ctcccaaact gaaagcagac
     1381 gtgccagaag cggacctttc cggagtggat gccaagcttg tgtctagcct catgcccttt
     1441 cagagggagg gagttagctt tgccatatca aaaagaggcc gcctgctact tgccgatgac
     1501 atgggcctag ggaagaccgt ccaagccatc tgcatagcag ctttttaccg aaaggaatgg
     1561 ccactgctgg tggtcgtgcc ttcctctgtg cgcttcacct gggagcaggc ctttcttcgg
     1621 tggcttccat ctcttagccc agagaacatc aacgtggtgg tgaccgggaa gggccgccta
     1681 acagctggct tggtcaatat tgtcagcttt gacctccttt gcaagttgga gaggcagcta
     1741 aaaacccctt tcaaagtcgt cattattgat gaatcacact tcctcaagaa cataaagact
     1801 gcccgctgcc gagcagctgt gcctatccta aaggttgcca agagggtgat cctactgtca
     1861 ggcacacccg ccatgtctcg gcccgcagag ctctacacgc agatcattgc tgtcaagcca
     1921 accttcttcc ctcagtttca tgcctttgga ctccgctact gtgacgccaa acggctccct
     1981 tggggctggg actactcagg ctcctccaac ctgggcgagc tgaagctgct gctagaggaa
     2041 gcaatcatgc tgcggcgcct caaatccgac gtgctctccc agcttccggc caagcagcgc
     2101 aagatggtgg tggtcaaccc tggtcggatc agctccaggg ctaaggcagc cctggatgca
     2161 gcagccaaag aaatgaccaa ggacaaaact aaacagcaac agaaagaagc tctccttgtc
     2221 ttcttcaaca gaacagcaga agctaaaatc ccatgtgtcg tcgagtatat cctggacctt
     2281 ctggacagcg gacgagagaa gtttctagtg tttgcacacc ataaggtgat tctggatgca
     2341 gttgccaagg agctcgagag gaagaacgtt caacacatcc ggatcgatgg ctccactccc
     2401 tcagcagacc gggaggctca gtgccagcgg ttccagctgt ccaaagggca cacagtggca
     2461 ctgttgtcca tcacagccgc caacatgggc ctcaccttct ccacagctga tctggtcgtg
     2521 tttgctgagc tcttctggaa cccaggggtg ctgatccagg ccgaggaccg tgtgcaccgc
     2581 attggacaga caaactctgt gagcatccac tacctggtgg caaaaggcac agcagatgac
     2641 tacctttggc ctctgattca agagaagatt aaagttctgg gggaagctgg gctttctgag
     2701 accaatttct cggaaatgac ggaagctaca gactacgtgc acaaggaccc aaagcagaag
     2761 acgatctatg acctgttcca gcagtccttt gaagacgatg gaaatgacat ggaattcctg
     2821 gaagcagcag agtcctttga gctaggaagt acttcaggaa cctctggaaa catttcccag
     2881 gatctgggag atctcttaga tgaagacgaa ggcagtccgc caaagaaaag cagatttgaa
     2941 ttctttgata attgggacag cttttcctct cccttttgac agggtcagaa aaggaaagaa
     3001 acgaaagaaa gcagtcacaa aatcatgggg ctcattgaaa taaagtattt tctttaaaag
     3061 cctgtattcc gtttgtcacg cagaagagtc caaggccagt aggtaccatc atctcctttc
     3121 tgtgttccta gacaaggcct gcttggaggc ttaattactt ttttagcttt tctggattaa
     3181 aagatacagt ggcttagagt agtcatagtt tacattctta agtagtgagg acttcctata
     3241 cacctccaat atctagttaa aaacttcaac tagtacagtt attaagcacc tcatagtaca
     3301 ggcactgtcc aacgtcgtaa ccttctaaac taaaggcaaa gtctctgtgg ggtttatcca
     3361 gcaggaaaag cggcagtgat ggcaagtcct ctttcctagt acaggaaagt tctgcttatg
     3421 gacatgaaat gtaaaatgtg attttctcat catgaatttt attttgattt tgtaaaccat
     3481 cacaagtgtg agaaaacatt ctgaggtcac agacttgggt gcaggcagtg ggcagacagt
     3541 gcgcagcatg gttcttagct ttccagcctc tgactgaagc agcatcgtcc aatagtgata
     3601 taatgtgaac cacagggtgt gatttcactt tcctaacatt taaatttaca agcaaaagca
     3661 atgtattcct cctgctagag tcaacagact agcatacgaa cttgaggttt ttgagacagg
     3721 cttcctttca tatatccaag ttagtctccc acctgctcat atatcagagg agaaccctga
     3781 actgctcatc ttcctggccc cacctcctgg tgttggaggt gtgcaccccc ttccctaccc
     3841 acctcgctca ttaagggaga cagcaatcac accattagag aaaaaattct ttgggataag
     3901 ttaaggacca gaaaatgaag ggggttttgt ctgttttgag aaaatcggaa agggacattt
     3961 gacactcact tctacaccca tctgcagtgt gctgtgtgtt tgatgtcaca gctttcagaa
     4021 acatccggaa gcgctccccc catgaccgca ggctgttttc agggacatga gacgccatag
     4081 gaaaacagag aacactgtaa aaatcggtct ttttcctcct ggtcccaggc tcccagaata
     4141 atgcctgtga gactcaacta tatttacaaa tacctaggcc agtaagcttt ggctgtctcc
     4201 tgattagatc ataacttaat atcccattta ttctaagttc tgccgcatgg ctggtcacct
     4261 ctgctcagct ccggtgcttc taacctccat gttcccaggc gaatgctctc aagcttggct
     4321 aaatcccaga attcaatctc ccaactgatg tcctactttc tatttgctgc ctaaacttat
     4381 aggctaatca gcattttatt gacaggtgtt gaatccaaga ctgctccttt tttttaatta
     4441 ttattttttc aaaatagata catcaagtct gatcgtctat ttacccgttc cttccactta
     4501 cccaccaagt cagttcagga gtatcaccat aaggggcttg gaaagggtta attagagcag
     4561 tctcaaatct ctgcctttga tttggttttc ctgtagggtt tcagtgaggg aaacaacctc
     4621 aggagatggc actaagccct tagtcttggg tactgtgagt cagtctctgg gctacaacgg
     4681 cagcagtcag acactcagtt ctgtggctct ctctgcccat gtttcccttc tattcgatgc
     4741 attgtactat cagctactct tccaactctt tcgttctgag ggtgaaatat gcaaaaagtt
     4801 cataaaacag tttgcagctt aactgaaaca agcgcttggg taggcacagc ccagtcttat
     4861 caagatgcta tctagaacca ctgctccttt gccttatgct tagctttatt tgtctggaat
     4921 gagataggtc taggttcact tttccccaat gaagatgcag ttattctcag caccacatat
     4981 taaaagactg tcctttcagc tgtcagtctg tggggacatt tactcactgc gatatctttg
     5041 atgtaaaact attctagaaa tgtatattat aagtgagaaa tgaaggtcct acactctccc
     5101 tctcacccct agcctactat ttcttaaagg tgataactaa tataatttga gatggggcca
     5161 tttgtaattt attctgtata tacctgaaag ttgttttaca aaaattgtac tgaattgatt
     5221 gaactgctgt ggtccgtgtt tcctatgact gtctcagatt acacttgccc attgtttcag
     5281 atcgttctac tctgtctccc tttaagtgac ctgtgaccct cccagatgcc ttcttggtat
     5341 tggcccttta acaaagcctg ggtgattttc ttaagtgaat gcgaggagct acagaagaca
     5401 aggatatctg tgtgtgaatc cattttggac ataatgatct ctttgtccag aactagctac
     5461 ggaggcatca acagaacgct ggacattcct gtgactctgg gataaacctt tatgtctgtg
     5521 tcatgagatg aacctgtgcc ccagatggct tttaagaata aagtgttgca tatgccctaa
     5581 gagaactggt tgcctcagcg gctaaaaggg tctctctctg gaagtgactt tggttaatga
     5641 ctttagagat ggaaggtgaa ttctgagtgc ttccgaagag cgaggcgatt gattcagaca
     5701 aggtttttac tgagactcgc attggagcat gctgtggtga acatctataa ctcagggtcc
     5761 tctaatggca tggaaatttg cccataaatc agacgaattg agaatttatg agaggcacaa
     5821 ttttctgcag tcacttagag ctgatttcat gagagctatt tgtatctccc tgagcttact
     5881 atttagagag aattgctggg tttgatgaaa ttgctgtgag catgaaggat ttcctcctat
     5941 cataaagtgt ctcattttca catctcgctc atgcacggtc tcttctcatc cctgtcgcag
     6001 caggccagaa gccatgccag gggacatagt tcatttgctg agtggtgatc catattagac
     6061 tatagaacca aggtagagtt cactctgcat ggcctagtct gccttaacac aaacccagtg
     6121 ttggaggatg tttctgtgca catgtattca actgtgattg gagtaaggcc attaatgtat
     6181 cttgcttcta tctggcctac tcaagaatat ctggtataga aaacagaaaa accagggggt
     6241 gaggggtgaa aggtgggagt ggcctgagag gggtgctgga gagttaccca tctggacata
     6301 aaggatatgc caagctgaga ttaagatggc aggtgacagg ccacatggca ggatgtaggc
     6361 caggtcagta tggtcagctt agaatagcca gagtctgccc agctatagcg cctaacgctt
     6421 ataataaata aatataataa gtctccatgt tattactcag agcaagggca ggcacagaaa
     6481 gtcaaacttc tataccgaag tacctaccca cacagccact gctaggggcc cagactgaca
     6541 ggaaggccat gaaaaatagt ttgtccacac agcagccaca aacatcaatc tcatttgttt
     6601 gaacacatat gggtttttgc tgtgcagttt ctgtaagcag gcacagtcta catggtgagt
     6661 tttccattgt taccctggtt cccttctgga aaaataaaaa atatggctgc tccca
//
