LOCUS       NM_053124               4658 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus SNF2 related chromatin remodeling ATPase 5 (Smarca5),
            mRNA.
ACCESSION   NM_053124 XM_906785 XM_920073
VERSION     NM_053124.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4658)
  AUTHORS   Yu,P.C., Hou,D., Chang,B., Liu,N., Xu,C.H., Chen,X., Hu,C.L.,
            Liu,T., Wang,X., Zhang,Q., Liu,P., Jiang,Y., Fei,M.Y., Zong,L.J.,
            Zhang,J.Y., Liu,H., Chen,B.Y., Chen,S.B., Wang,Y., Li,Z.J., Li,X.,
            Deng,C.H., Ren,Y.Y., Zhao,M., Jiang,S., Wang,R., Jin,J., Yang,S.,
            Xue,K., Shi,J., Chang,C.K., Shen,S., Wang,Z., He,P.C., Chen,Z.,
            Chen,S.J., Sun,X.J. and Wang,L.
  TITLE     SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control
            leukemogenesis
  JOURNAL   Dev Cell 59 (15), 1954-1971 (2024)
   PUBMED   38776924
  REMARK    GeneRIF: SMARCA5 reprograms AKR1B1-mediated fructose metabolism to
            control leukemogenesis.
REFERENCE   2  (bases 1 to 4658)
  AUTHORS   Wang,K., Liu,F., Muchu,B., Deng,J., Peng,J., Xu,Y., Li,F. and
            Ouyang,M.
  TITLE     E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to
            promote colon inflammation and Th17/Treg imbalance in ulcerative
            colitis mice
  JOURNAL   Arch Pharm Res 47 (7), 645-658 (2024)
   PUBMED   39060657
  REMARK    GeneRIF: E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5
            axis to promote colon inflammation and Th17/Treg imbalance in
            ulcerative colitis mice.
REFERENCE   3  (bases 1 to 4658)
  AUTHORS   Turkova,T., Kokavec,J., Zikmund,T., Dibus,N., Pimkova,K., Nemec,D.,
            Holeckova,M., Ruskova,L., Sedlacek,R., Cermak,L. and Stopka,T.
  TITLE     Differential requirements for Smarca5 expression during
            hematopoietic stem cell commitment
  JOURNAL   Commun Biol 7 (1), 244 (2024)
   PUBMED   38424235
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4658)
  AUTHORS   Wang,J., Zhou,H., Shao,J., Zhang,S. and Jin,J.
  TITLE     Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional
            Homeostasis to Facilitate Endothelial Dysfunction in Diabetes
  JOURNAL   Diabetes Metab J 47 (3), 366-381 (2023)
   PUBMED   36872061
  REMARK    GeneRIF: Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional
            Homeostasis to Facilitate Endothelial Dysfunction in Diabetes.
REFERENCE   5  (bases 1 to 4658)
  AUTHORS   Kuzelova,A., Dupacova,N., Antosova,B., Sunny,S.S., Kozmik,Z. Jr.,
            Paces,J., Skoultchi,A.I., Stopka,T. and Kozmik,Z.
  TITLE     Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell
            Proliferation and Photoreceptor Maintenance
  JOURNAL   Cells 12 (7), 1035 (2023)
   PUBMED   37048108
  REMARK    GeneRIF: Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal
            Cell Proliferation and Photoreceptor Maintenance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4658)
  AUTHORS   Bozhenok,L., Wade,P.A. and Varga-Weisz,P.
  TITLE     WSTF-ISWI chromatin remodeling complex targets heterochromatic
            replication foci
  JOURNAL   EMBO J 21 (9), 2231-2241 (2002)
   PUBMED   11980720
  REMARK    Erratum:[EMBO J 2002 Jun 17;21(12):3212]
REFERENCE   7  (bases 1 to 4658)
  AUTHORS   Strohner,R., Nemeth,A., Jansa,P., Hofmann-Rohrer,U., Santoro,R.,
            Langst,G. and Grummt,I.
  TITLE     NoRC--a novel member of mammalian ISWI-containing chromatin
            remodeling machines
  JOURNAL   EMBO J 20 (17), 4892-4900 (2001)
   PUBMED   11532953
REFERENCE   8  (bases 1 to 4658)
  AUTHORS   Lazzaro,M.A. and Picketts,D.J.
  TITLE     Cloning and characterization of the murine Imitation Switch (ISWI)
            genes: differential expression patterns suggest distinct
            developmental roles for Snf2h and Snf2l
  JOURNAL   J Neurochem 77 (4), 1145-1156 (2001)
   PUBMED   11359880
REFERENCE   9  (bases 1 to 4658)
  AUTHORS   Poot,R.A., Dellaire,G., Hulsmann,B.B., Grimaldi,M.A., Corona,D.F.,
            Becker,P.B., Bickmore,W.A. and Varga-Weisz,P.D.
  TITLE     HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1
            and two novel histone-fold proteins
  JOURNAL   EMBO J 19 (13), 3377-3387 (2000)
   PUBMED   10880450
REFERENCE   10 (bases 1 to 4658)
  AUTHORS   Stopka,T., Zakova,D., Fuchs,O., Kubrova,O., Blafkova,J.,
            Jelinek,J., Necas,E. and Zivny,J.
  TITLE     Chromatin remodeling gene SMARCA5 is dysregulated in primitive
            hematopoietic cells of acute leukemia
  JOURNAL   Leukemia 14 (7), 1247-1252 (2000)
   PUBMED   10914549
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC053069.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_920073.1, XM_906785.1, NM_053124.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053069.1, AF375046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4658
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 38.41 cM"
     gene            1..4658
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /note="SNF2 related chromatin remodeling ATPase 5"
                     /db_xref="GeneID:93762"
                     /db_xref="MGI:MGI:1935129"
     exon            1..537
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..3519
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /note="sucrose nonfermenting protein 2 homolog; mSnf2h;
                     SWI/SNF related, matrix associated, actin dependent
                     regulator of chromatin, subfamily a, member 5"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A member
                     5"
                     /protein_id="NP_444354.2"
                     /db_xref="CCDS:CCDS22442.1"
                     /db_xref="GeneID:93762"
                     /db_xref="MGI:MGI:1935129"
                     /translation="MSSAVEPPPPPPPESAPSKPSAAGAGGSSSGNKGGPEGGAAPAA
                     PCAAGSGPADTEMEEVFDHGSPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFA
                     HFIQPAAQKTPTSPLKMKPGRPRVKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKA
                     TNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLL
                     GYMKHYRNIPGPHMVLVPKSTLHNWMSEFKKWVPTLRSVCLIGDKEQRAAFVRDVLLP
                     GEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLL
                     TGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLL
                     RRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNILM
                     QLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMT
                     RVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGIN
                     LATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKL
                     RLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAK
                     KTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKAN
                     YAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYK
                     VPRSPDLPNAAQAQKEEQLKIDEAEPLNDEELEEKEKLLTQGFTNWNKRDFNQFIKAN
                     EKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRI
                     SIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYDEL
                     RQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGPKPS
                     TQKRKMDGAPDGRGRKKKLKL"
     exon            538..612
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            613..779
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            780..880
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            881..981
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1161
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1317
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1449
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1518
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1628
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1855
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1977
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2130
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2263
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2412
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2532
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2643
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2757
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2880
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3013
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3132
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3345
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3453
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..4639
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4616..4621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /note="hexamer: AATATA"
     polyA_site      4639
                     /gene="Smarca5"
                     /gene_synonym="4933427E24Rik; D030040M08Rik;
                     D330027N15Rik; MommeD4; Snf2h"
                     /note="major polyA site"
ORIGIN      
        1 gaggagaagg cgccgggagg cctctgagaa ccttccgttt tcctttccct ttccctcggc
       61 cctccgcctc ctcagagtca gcccgccttc cctgacctcc gtgaccccgc tggccccgcc
      121 cactcccgtc gacgtgattc ccgccgtgag gtaaacgcct gtggagcaga gtcccgcgga
      181 agaggacggc gaggcgagcg gcgcggctgg gccggctcgg gtcggtggcg gagccctcgc
      241 gcgtgagagc ttccgggcag gtctcactcc tccggcggcc cggacgcccg tgtcgcgcag
      301 gcccaagccg cttccctcgg cgccgcgcct gcccgtggcc gcggcgggtg acgcagccgg
      361 aacatgtcgt ccgcggtgga gcctccgccg cccccgcctc ccgagagcgc gccttccaag
      421 ccctcggcgg cgggcgccgg cgggagcagc agcggcaaca aaggcggccc cgagggcggc
      481 gcggcgcccg cggctccgtg tgctgcgggc tcgggccccg cggacaccga gatggaggaa
      541 gtatttgatc atggatcacc tggaaagcaa aaagaaatcc aagaaccaga tcctacatat
      601 gaagaaaaaa tgcaaactga ccgagcaaat agatttgagt atttattaaa gcagacagag
      661 ctgttcgcac atttcattca gcctgctgct cagaagactc caacctcacc cttgaagatg
      721 aaaccagggc gcccacgggt aaaaaaggat gaaaaacaga atttgctttc agttggagat
      781 taccgacacc gtagaacgga gcaagaggag gatgaagagc tattaacaga aagttccaaa
      841 gcaactaatg tttgtactcg atttgaagat tctccatcat atgtaaaatg gggtaaactg
      901 agagattatc aggtgcgagg attgaattgg ctcatctctc tgtatgagaa tggcatcaat
      961 gggatccttg cagatgaaat gggtttggga aagacacttc aaacaatttc tcttcttgga
     1021 tacatgaaac actatagaaa tattcctggt cctcatatgg ttttggttcc caagtctaca
     1081 ttgcacaact ggatgagtga attcaagaaa tgggtaccaa cacttaggtc tgtttgcttg
     1141 ataggagata aagagcaaag agctgcattt gtcagggatg ttttattacc aggagagtgg
     1201 gatgtgtgtg tcacatctta tgaaatgctt attaaagaga agtctgtgtt caaaaaattc
     1261 aactggagat acttagttat agatgaagct cacaggataa aaaatgaaaa atctaagttg
     1321 tcagaaatag tgagagaatt caagactaca aatcggctgt tgctaacagg gacgcctctt
     1381 cagaacaacc tgcatgagct ctggtcactt ctaaactttt tgttaccaga tgtgtttaat
     1441 tcagctgatg actttgattc ctggtttgat acaaataatt gccttgggga tcaaaagcta
     1501 gttgagaggc ttcatatggt tttgcgtcca ttcctccttc gtcgaattaa agctgatgtt
     1561 gaaaagagtt tgcctccaaa aaaagaagta aaaatctatg tgggtcttag caaaatgcaa
     1621 agagaatggt atactcggat attaatgaaa gatatagaca tattaaactc agcagggaag
     1681 atggacaaaa tgaggctatt gaacattttg atgcagttga ggaaatgctg caatcatcct
     1741 tatctcttcg atggagctga acctggtcca ccgtacacaa cagatatgca tctagttacc
     1801 aacagtggca agatggtggt gttagacaag ctactcccta aactgaaaga acaaggttca
     1861 agagtactaa tctttagtca gatgacaaga gtattagaca ttttggaaga ttattgcatg
     1921 tggagaaatt atgagtactg caggttggat ggacagacac cccatgatga gagacaagac
     1981 tccatcaatg catacaatga accaaatagc acaaagtttg tatttatgct aagcacacgt
     2041 gctggtggtc tgggcatcaa tcttgcaact gctgatgtag tcattttata tgactcagat
     2101 tggaatccgc aagttgatct tcaggctatg gaccgtgccc atagaattgg acaaacgaag
     2161 actgtccgag tgtttcgctt tataactgat aacactgtgg aagaaagaat agtggaacgt
     2221 gctgagatga aacttagact ggattcgata gtaattcaac aagggaggct tgtagatcag
     2281 aacctgaaca aaattgggaa agatgaaatg cttcaaatga ttcgacatgg tgctacacat
     2341 gtgtttgctt caaaagaaag tgaaatcact gatgaggata ttgatggtat tttagaaaga
     2401 ggtgcaaaga agactgcaga aatgaacgaa aagctctcca agatgggtga aagttcactt
     2461 agaaacttta cgatggacac agagtccagt gtttataact ttgaaggaga agactataga
     2521 gaaaaacaaa agattgcatt cacagagtgg attgaaccac caaaaagaga aagaaaagcc
     2581 aactatgctg ttgatgcata tttcagggaa gctctccgtg ttagtgagcc taaagcaccc
     2641 aaggcacctc gacctccaaa acaaccaaat gttcaggatt tccagttctt tcctccgcgt
     2701 ttatttgaat tactggaaaa agaaattctg tattacagga aaactattgg gtataaggta
     2761 cctcggagtc ctgatctacc taatgcagca caggcacaga aagaggaaca gctaaaaatt
     2821 gatgaagcag agcccctcaa tgacgaggag ttagaggaaa aagagaagct tctgacacag
     2881 gggtttacaa attggaataa gagagatttt aaccagttta tcaaggctaa tgagaagtgg
     2941 ggtcgtgatg atattgaaaa tatagccaga gaagtagaag gaaaaactcc agaagaagtc
     3001 attgaatact cagctgtgtt ctgggaaaga tgcaatgagc ttcaggacat agagaagatt
     3061 atggctcaga ttgaaagggg agaggcaaga attcaaagaa gaataagtat caagaaagca
     3121 ctagatacaa agattggacg gtacaaagca ccctttcatc agctaagaat atcatatggt
     3181 actaacaaag gaaaaaacta tactgaagaa gaggatcgtt ttctcatttg tatgctgcac
     3241 aagcttggct tcgacaagga aaatgtgtat gatgaattac gacaatgcat ccgaaactcc
     3301 cctcagttta gatttgattg gtttctcaag tccagaactg cgatggagct ccagaggagg
     3361 tgtaatacct taattacttt gattgaaaga gaaaatatgg aactagaaga aaaggagaag
     3421 gcagagaaaa agaaaagagg accaaaacct tccacacaga aacgtaagat ggacggtgcc
     3481 cctgatggcc gtggaagaaa aaagaagctg aaactatgaa tgcatttttg tcttataatc
     3541 actaactggt agttctttaa tttacgggtc ttcataagat gtgctgtaca gtgctcaact
     3601 gttatgtcat tcagacatca ggtccatctg cttactgagc tagaaacata gtatgtagtt
     3661 tcactttttt taaatgcaac agctgtgctg aaattttttt tatcattaac aattgaagta
     3721 ataaaacagg cttcatttat taataaatgt ttcatttgat ttatttttct aatagtttca
     3781 tttgtgagga ttgtggcttt ttatcagcta ctttaacact tgtatggctt aaaaacaagc
     3841 aaacaagtaa aaaaatactg cagataacat ttgattggtc ccttcagctt ggttgtgtaa
     3901 ttaattactt cacattcttt gcctttgctg attttttttt ttttttgtgg tactattgag
     3961 tctcatctgg aaagattgta aattgcattc ttgcttatta tagaatgggg aagacaagta
     4021 ttaataattt tctatgcata tttctgttat actttctgtt cctatggttc tgatgtgaat
     4081 gtgtcctatt ttgttggatg aatggccttt tttagttgta tagccaaaga catttagtat
     4141 tttctggttc tttaaggtga tgtattattt tgtaaaagga atttttttaa gtatttggaa
     4201 aatattttga caaatggcct tgcagcagcc acaagataat gtcagaagta aggtgatttt
     4261 ttttttttta aatttgaatg acccagccaa aatgaggttt gaatttgtca tactgttata
     4321 atactaatag aatgtaccct ctcagtttat agtatttttg agtttttaga gtaaatgaaa
     4381 attttatttt attatatttt aaaaataact tctaagtctt agtagcaaga tggagtataa
     4441 ttccagtttt tattttctat ggaatagact ggtaaactgg agaccctgaa gcaggaatac
     4501 ccagaggcct ttatgtgcta cacatcattt gtataaagtt ttatatgtgc aaattgggta
     4561 cataagcagt tctccatttt tctaagggaa tgcaataaat gtagcatcgt gaataaatat
     4621 aacttttata atccttaaaa aaaaaaaaaa aaaaaaaa
//
