LOCUS       NM_001174078            6376 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus SWI/SNF related, matrix associated, actin dependent
            regulator of chromatin, subfamily a, member 4 (Smarca4), transcript
            variant 1, mRNA.
ACCESSION   NM_001174078
VERSION     NM_001174078.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6376)
  AUTHORS   Swer,P.B., Kharbuli,B., Syiem,D. and Sharma,R.
  TITLE     Age-related decline in the expression of BRG1, ATM and ATR are
            partially reversed by dietary restriction in the livers of female
            mice
  JOURNAL   Biogerontology 25 (6), 1025-1037 (2024)
   PUBMED   38970714
  REMARK    GeneRIF: Age-related decline in the expression of BRG1, ATM and ATR
            are partially reversed by dietary restriction in the livers of
            female mice.
REFERENCE   2  (bases 1 to 6376)
  AUTHORS   Wang,J., Yang,L., Du,Y., Wang,J., Weng,Q., Liu,X., Nicholson,E.,
            Xin,M. and Lu,Q.R.
  TITLE     BRG1 programs PRC2-complex repression and controls oligodendrocyte
            differentiation and remyelination
  JOURNAL   J Cell Biol 223 (7) (2024)
   PUBMED   38652118
  REMARK    GeneRIF: BRG1 programs PRC2-complex repression and controls
            oligodendrocyte differentiation and remyelination.
REFERENCE   3  (bases 1 to 6376)
  AUTHORS   Ma,X., Zhao,J. and Feng,Y.
  TITLE     Epicardial SMARCA4 deletion exacerbates cardiac injury in
            myocardial infarction and is related to the inhibition of
            epicardial epithelial-mesenchymal transition
  JOURNAL   J Mol Cell Cardiol 191, 76-87 (2024)
   PUBMED   38718920
  REMARK    GeneRIF: Epicardial SMARCA4 deletion exacerbates cardiac injury in
            myocardial infarction and is related to the inhibition of
            epicardial epithelial-mesenchymal transition.
REFERENCE   4  (bases 1 to 6376)
  AUTHORS   Ren,G., Ku,W.L., Ge,G., Hoffman,J.A., Kang,J.Y., Tang,Q., Cui,K.,
            He,Y., Guan,Y., Gao,B., Liu,C., Archer,T.K. and Zhao,K.
  TITLE     Acute depletion of BRG1 reveals its primary function as an
            activator of transcription
  JOURNAL   Nat Commun 15 (1), 4561 (2024)
   PUBMED   38811575
  REMARK    GeneRIF: Acute depletion of BRG1 reveals its primary function as an
            activator of transcription.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6376)
  AUTHORS   Saha,D., Animireddy,S., Lee,J., Thommen,A., Murvin,M.M., Lu,Y.,
            Calabrese,J.M. and Bartholomew,B.
  TITLE     Enhancer switching in cell lineage priming is linked to eRNA,
            Brg1's AT-hook, and SWI/SNF recruitment
  JOURNAL   Mol Cell 84 (10), 1855-1869 (2024)
   PUBMED   38593804
  REMARK    GeneRIF: Enhancer switching in cell lineage priming is linked to
            eRNA, Brg1's AT-hook, and SWI/SNF recruitment.
REFERENCE   6  (bases 1 to 6376)
  AUTHORS   Jarvis,C.D., Geiman,T., Vila-Storm,M.P., Osipovich,O., Akella,U.,
            Candeias,S., Nathan,I., Durum,S.K. and Muegge,K.
  TITLE     A novel putative helicase produced in early murine lymphocytes
  JOURNAL   Gene 169 (2), 203-207 (1996)
   PUBMED   8647447
REFERENCE   7  (bases 1 to 6376)
  AUTHORS   Dunaief,J.L., Strober,B.E., Guha,S., Khavari,P.A., Alin,K.,
            Luban,J., Begemann,M., Crabtree,G.R. and Goff,S.P.
  TITLE     The retinoblastoma protein and BRG1 form a complex and cooperate to
            induce cell cycle arrest
  JOURNAL   Cell 79 (1), 119-130 (1994)
   PUBMED   7923370
REFERENCE   8  (bases 1 to 6376)
  AUTHORS   Randazzo,F.M., Khavari,P., Crabtree,G., Tamkun,J. and Rossant,J.
  TITLE     brg1: a putative murine homologue of the Drosophila brahma gene, a
            homeotic gene regulator
  JOURNAL   Dev Biol 161 (1), 229-242 (1994)
   PUBMED   7904967
REFERENCE   9  (bases 1 to 6376)
  AUTHORS   Tamkun,J.W., Deuring,R., Scott,M.P., Kissinger,M., Pattatucci,A.M.,
            Kaufman,T.C. and Kennison,J.A.
  TITLE     brahma: a regulator of Drosophila homeotic genes structurally
            related to the yeast transcriptional activator SNF2/SWI2
  JOURNAL   Cell 68 (3), 561-572 (1992)
   PUBMED   1346755
REFERENCE   10 (bases 1 to 6376)
  AUTHORS   Wassarman,D.A. and Steitz,J.A.
  TITLE     RNA splicing. Alive with DEAD proteins
  JOURNAL   Nature 349 (6309), 463-464 (1991)
   PUBMED   1825133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079560.1 and AK160825.1.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon and uses an alternate in-frame splice junction compared to
            variant 4. The resulting isoform (1) has the same N- and C-termini
            but is shorter compared to isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                BC079560.1         1-96
            97-6376             AK160825.1         1-6280
FEATURES             Location/Qualifiers
     source          1..6376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.84 cM"
     gene            1..6376
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /note="SWI/SNF related, matrix associated, actin dependent
                     regulator of chromatin, subfamily a, member 4"
                     /db_xref="GeneID:20586"
                     /db_xref="MGI:MGI:88192"
     exon            1..232
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            233..482
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..5114
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription activator BRG1; SWI/SNF-related
                     matrix-associated actin-dependent regulator of chromatin
                     subfamily A member 4; protein brahma homolog 1;
                     BRG1-associated factor 190A; ATP-dependent helicase
                     SMARCA4; SNF2-beta"
                     /codon_start=1
                     /product="transcription activator BRG1 isoform 1"
                     /protein_id="NP_001167549.1"
                     /db_xref="CCDS:CCDS52737.1"
                     /db_xref="GeneID:20586"
                     /db_xref="MGI:MGI:88192"
                     /translation="MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMG
                     PSPGPPSAGHPMPTQGPGGYPQDNMHQMHKPMESMHEKGMPDDPRYNQMKGMGMRSGA
                     HTGMAPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGSDPQ
                     ALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMP
                     TLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP
                     PGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPG
                     QPAQPAPLVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSL
                     AGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA
                     RITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFREYHRSVTGKLQKLTKAVATYH
                     ANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTE
                     LVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVES
                     GKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQPAQPPTL
                     PVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTE
                     RVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLME
                     HKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVL
                     LTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPL
                     QNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVL
                     RPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKG
                     GTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRI
                     LPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPG
                     SEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRL
                     CTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDE
                     VPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAE
                     VERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKK
                     SSRKRKRDSEAGSSTPTTSTRSRDKDEESKKQKKRGRPPAEKLSPNPPNLTKKMKKIV
                     DAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLND
                     LEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGE
                     EEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRS
                     GSGSEED"
     exon            483..615
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            616..1020
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1119
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1378
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1505
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1679
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1853
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2021
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2072
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2203
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2261
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2383
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2534
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2698
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2765
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2876
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3119
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3233
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3341
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3428
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3475
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3642
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3806
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..4034
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4112
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            4113..4331
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..4594
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4703
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4805
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            4806..4938
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            4939..5081
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..6376
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5489..5494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /note="hexamer: AATAAA"
     polyA_site      5513
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /note="major polyA site"
     regulatory      6076..6081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /note="hexamer: AATAAT"
     polyA_site      6080
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
     polyA_site      6097
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
     regulatory      6352..6357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
                     /note="hexamer: AATAAA"
     polyA_site      6371
                     /gene="Smarca4"
                     /gene_synonym="b2b508.1Clo; b2b692Clo; BAF190A; Brg1;
                     HP1-BP72; SNF2beta; SW1/SNF"
ORIGIN      
        1 ggcaagtgga gcgggtagac agggaggcgg gggcgcgcgg cgggcgcgtg cggtgggggg
       61 gggtggcctg gcgaagccca gcgggcgcgc gcgcgaggct ttcccactcg cttggcagcg
      121 gcggagacgg cttctttgtt tcctgaggag aagcgagacg cccactctgt ccccgacccc
      181 tcgtggaggg ttgggggcgg cgccaggaag gttacggcgc cgttacctcc aggagaccag
      241 tgcctgtagc tccagtaaag atgtctactc cagacccacc cttgggtggg actcctcggc
      301 ctggtccttc cccaggccct ggtccttcac ctggtgcaat gctgggtcct agccctggcc
      361 cctcaccagg ttctgcccac agcatgatgg ggccaagccc aggacctcct tcagcaggac
      421 atcccatgcc cacccagggg cctggagggt acccccagga caacatgcat cagatgcaca
      481 agcctatgga gtccatgcac gagaagggca tgcctgatga cccacgatac aaccagatga
      541 aagggatggg catgcggtca ggggcccaca caggcatggc acctccacct agtcccatgg
      601 accagcattc tcaaggttac ccctcacccc tcggcggctc tgaacatgcc tccagtcctg
      661 tcccagccag tggcccatct tcaggccccc agatgtcctc tgggccagga ggggccccac
      721 tagatggttc tgatccccag gccttgggac agcaaaacag aggcccaacc ccatttaacc
      781 agaaccagct gcatcaactc agagctcaga taatggccta caagatgttg gccaggggcc
      841 agccattgcc cgaccacctg cagatggccg tgcaaggcaa gcggccgatg cctggaatgc
      901 agcaacagat gccaacacta cctccaccct cagtgtccgc cacaggaccc ggacctggac
      961 ccggccctgg ccctggccct ggcccaggac cagcccctcc aaattacagt agaccccatg
     1021 gtatgggagg gcccaacatg cctcccccag gaccctcagg tgtgcccccc gggatgcctg
     1081 gtcagccgcc tggagggcct cccaagccat ggcctgaagg acccatggcc aatgctgctg
     1141 cccccacaag caccccacag aagctgattc ctccgcaacc aacaggccgt ccttcacctg
     1201 cacctcctgc tgtcccgcct gctgcctcac ctgtaatgcc accacaaaca cagtccccag
     1261 ggcagccagc ccagcctgct ccattggtgc cactgcacca gaagcagagc cgaatcaccc
     1321 ccatccagaa gccccgaggc cttgaccctg tggagatcct acaagagcgg gagtacaggc
     1381 ttcaggctcg aatcgcacac agaattcagg aacttgaaaa cctccctggg tccctggctg
     1441 gggaccttcg aaccaaagca accatcgaac tcaaggccct taggttgctg aacttccaga
     1501 ggcagctgcg ccaggaggtg gtggtgtgca tgcgaagaga cacagccctg gagacagccc
     1561 tcaatgccaa ggcctacaag cgcagcaaac gtcagtcact acgggaggcc cgcatcactg
     1621 agaagttgga gaagcagcag aagattgaac aggagcgcaa gcgccgccag aagcaccagg
     1681 agtacctcaa cagcattctg cagcatgcca aggacttcag ggagtatcac agatcagtca
     1741 caggcaaact ccagaaactc accaaggctg tggccaccta ccatgccaac actgagcggg
     1801 agcagaagaa agaaaatgag cgcattgaga aggagcgaat gcggaggctt atggctgaag
     1861 atgaggaggg ctaccgcaaa ctcattgacc agaagaagga caagcgcctg gcctaccttc
     1921 tgcagcagac agatgagtat gtggccaacc tcacagagct ggtgcggcag cacaaagctg
     1981 cccaggttgc caaggagaag aagaagaaaa agaaaaagaa gaaggcagaa aatgctgaag
     2041 gacagacacc tgctattgga ccagatggtg agcctctgga tgagaccagc cagatgagtg
     2101 acctccctgt gaaggtgatc cacgtggaga gtggcaagat cctcactggc acagatgccc
     2161 caaaagccgg gcagctggaa gcctggcttg aaatgaaccc agggtatgaa gtagccccca
     2221 ggtcagacag tgaagaaagt ggctctgaag aggaggagga ggaggaggaa gaggagcagc
     2281 ctcagcccgc acagccccct acactgcctg tggaagaaaa gaagaagatt ccagacccag
     2341 acagcgatga tgtctctgag gtggacgccc gacacattat tgagaacgcc aagcaagatg
     2401 tggacgatga gtacggtgtg tcccaggccc ttgctcgtgg cctgcagtct tactatgctg
     2461 tggcccatgc agtcacagag agagtagata agcagtccgc cctcatggtc aacggtgtcc
     2521 tcaaacagta ccagatcaag ggtttggagt ggctggtgtc cctgtacaac aacaacctga
     2581 atggcatcct ggctgatgag atggggctgg ggaagaccat ccagaccatc gcgctcatca
     2641 catacctcat ggagcacaag cgcatcaacg ggcctttcct catcatcgtg cctctctcga
     2701 cactgtcaaa ctgggcgtat gaatttgaca agtgggcccc ctctgtggtg aaggtttctt
     2761 acaagggctc tccagctgca aggcgagctt ttgtcccaca gcttcgcagt gggaagttca
     2821 acgtcttact gaccacctat gaatatatca tcaaagacaa gcatatccta gccaagatcc
     2881 gctggaagta catgattgtg gatgaaggcc accgcatgaa aaaccaccac tgcaagttga
     2941 cgcaggtcct taacacacac tacgtggccc ctcggcgcct gcttcttaca ggcacaccac
     3001 tgcagaacaa gctaccggag ctctgggccc tgcttaactt cctgctcccc actatcttca
     3061 agagctgcag caccttcgaa cagtggttca atgcaccctt tgccatgact ggagaaaagg
     3121 tggacctgaa tgaagaggag actatcctca ttattcgtcg cctacacaaa gttctgcggc
     3181 ccttcctgct gcggcggctc aagaaggaag ttgaagccca gctccctgag aaggtagagt
     3241 atgtcatcaa atgcgacatg tcagccctgc agcgtgtgct gtaccgtcac atgcaggcca
     3301 aaggtgtgct gctgactgac ggctccgaga aggacaagaa gggcaaaggt ggcaccaaga
     3361 cactgatgaa cactattatg caactgcgta agatctgcaa ccacccctac atgttccagc
     3421 acatcgagga gtccttttct gagcacttgg ggttcaccgg cggcatcgtg caaggattgg
     3481 acctttaccg tgcctcaggg aaatttgaac ttcttgatag aattctaccc aaactccgtg
     3541 caacgaacca taaagtgctc ctcttttgcc aaatgacctc cctcatgacc atcatggaag
     3601 actactttgc ataccgtggc ttcaaatacc tcaggcttga tggaaccaca aaagcagaag
     3661 accggggcat gctgttgaaa acctttaatg aacctggctc tgagtatttc attttcctgc
     3721 tcagtacccg tgctgggggg ctgggcctga atctgcagtc agctgacact gtgatcatct
     3781 ttgacagtga ctggaatccc caccaggacc tgcaagcaca ggatcgagcc catcgcattg
     3841 gacagcagaa tgaggtgcgt gttcttcgcc tgtgcacggt caacagtgtg gaagagaaga
     3901 tactggctgc tgccaaatac aaactcaatg tggatcagaa ggtgatccag gcaggcatgt
     3961 tcgaccagaa gtcgtccagc catgagaggc gtgccttcct gcaggccatc ctggagcacg
     4021 aggagcagga tgaggaggaa gatgaggtgc ctgatgatga gaccgtcaac cagatgattg
     4081 cccggcacga agaagagttt gacctcttca tgcgcatgga cttggaccgc cggcgtgaag
     4141 aagcccgcaa ccccaagcgg aagccacgcc tgatggaaga ggatgagctc ccatcctgga
     4201 tcatcaagga tgatgccgag gtggagcggc tgacatgtga agaggaagag gagaagatgt
     4261 tcggccgtgg ttctcgccac cgcaaggagg tagactacag cgactcactg acagagaagc
     4321 agtggctcaa gaccctgaag gctatcgagg agggcacgct ggaggagatc gaagaggagg
     4381 tccggcagaa gaaatcttca cgtaagcgta agcgagacag cgaggccggc tcctccaccc
     4441 cgaccaccag cacccgcagc cgtgacaagg atgaggagag caagaagcag aagaaacgtg
     4501 ggcggccacc tgctgagaag ctgtccccaa acccacctaa cctcaccaag aagatgaaga
     4561 agatcgtgga tgctgtgatc aagtacaaag acagcagcag tggacgtcag ctcagcgagg
     4621 tgttcatcca gctcccctct cgcaaggagc ttcctgagta ctatgagctc atccgaaagc
     4681 ctgtggactt caagaagatc aaggaacgca tccgaaacca caagtaccgc agcctcaatg
     4741 acctggagaa ggatgtgatg ctgctgtgcc agaacgctca gacgttcaac ctcgagggtt
     4801 ccctgatcta tgaggactcc atcgtcctgc agtctgtctt caccagcgta cggcagaaga
     4861 ttgagaagga ggacgacagt gaaggcgagg aaagcgagga ggaggaggag ggcgaggagg
     4921 aaggctccga gtctgagtcc cgctccgtca aggtgaagat caagctgggc cgcaaggaga
     4981 aggcccagga ccgactcaag gggggccgcc ggcggccaag ccggggatcc cgggccaagc
     5041 cggttgtgag tgacgatgac agtgaggagg agcaggagga ggaccgctca ggaagtggca
     5101 gtgaggaaga ctgaaccaga cattcctgag tcctgacccc gaggcgctcg tcccagccaa
     5161 gatggagtag cccttagcag tgatgggtag caccagatgt agtttcgaac ttggagaact
     5221 gtacacatgc aatcttccac atttttaggc agagaagtat aggcctgtct gtcggccctg
     5281 gcctggcctc gagtctctac cagcattaac tgtctagaga ggggacctcc tgggagcacc
     5341 atccacctcc ccaggcccca gtcactgtag ctcagtggat gcatgcgcgt gccggccgct
     5401 ccttgtactg tatcttactg gacagggcca gctctccagg aggctcacag gcccagcggg
     5461 tatgtcagtg tcactggagt cagacagtaa taaattaaag caatgacaag ccaccactgg
     5521 ctccctggac tccttgctgt cagcagtggc tccggggcca cagagaagaa agaaagactt
     5581 ttaggaactg ggtctaactt atgggcaaag tacttgcctt gccaggtgta tgggttttgc
     5641 attcccatca cccacacacc ctaaacaagc caagtcagtg agcttcaagt tagagcctcc
     5701 acctcaatgt gtacgtggaa agcaatcaaa gatgatgcct agcatccacc tctggccctc
     5761 atgtgcagat gtacacacac tgaattacat acacgggaca cacacatcca cacggaggca
     5821 gtccatgact tgcactgggg agatggtacc ataggcgaaa gtgccacagg cacagggcca
     5881 ggctaattta gtcctgcagt cctgtgctct taagatgaag gcacaaagag gaaccccagg
     5941 cgctccaact agcatgccag gcagtgacaa gaccctgctt caaatgaatc agagcccaca
     6001 ttcagtattg ccctcttacc cgatgcgatg cccatgccct cacatatgaa tgtgtatata
     6061 tacatacata cgtaaaataa ttctttttta aattatagac atttttgtgt gaatgttttg
     6121 cctgaatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatcaagtac
     6181 attcctagag cctacagagg tcaagggagg gcattggatc tggaactgga gtcacatgag
     6241 gctgtgagca actgtgtggg ttcctgggcc tttgcaacag cagttagtac tcttcaccac
     6301 tgagccattt ctccaatctc aaaaagaagc attcttttaa atgaagactg aaataaataa
     6361 gtaggacttg ccttgg
//
