LOCUS       NM_001405134            6618 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus SWI/SNF related BAF chromatin remodeling complex
            subunit ATPase 2 (Smarca2), transcript variant 8, mRNA.
ACCESSION   NM_001405134 XM_006527284
VERSION     NM_001405134.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6618)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6618)
  AUTHORS   Pundhir,S., Su,J., Tapia,M., Hansen,A.M., Haile,J.S., Hansen,K. and
            Porse,B.T.
  TITLE     The impact of SWI/SNF and NuRD inactivation on gene expression is
            tightly coupled with levels of RNA polymerase II occupancy at
            promoters
  JOURNAL   Genome Res 33 (3), 332-345 (2023)
   PUBMED   36927987
  REMARK    GeneRIF: The impact of SWI/SNF and NuRD inactivation on gene
            expression is tightly coupled with levels of RNA polymerase II
            occupancy at promoters.
REFERENCE   3  (bases 1 to 6618)
  AUTHORS   Abedini,A., Landry,D.A., Macaulay,A.D., Vaishnav,H., Parbhakar,A.,
            Ibrahim,D., Salehi,R., Maranda,V., Macdonald,E. and
            Vanderhyden,B.C.
  TITLE     SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for
            female fertilitydagger
  JOURNAL   Biol Reprod 108 (2), 279-291 (2023)
   PUBMED   36440965
  REMARK    Erratum:[Biol Reprod. 2023 Apr 11;108(4):708. doi:
            10.1093/biolre/ioad023.. PMID: 36796029]
REFERENCE   4  (bases 1 to 6618)
  AUTHORS   Ke,C., Zhao,S., Wang,L., Zhang,M. and Gao,X.
  TITLE     Chromatin remodeler BRM is a key mediator of leucine-stimulated
            mTOR gene transcription in mouse mammary epithelial cells
  JOURNAL   Biochem Biophys Res Commun 643, 88-95 (2023)
   PUBMED   36587526
  REMARK    GeneRIF: Chromatin remodeler BRM is a key mediator of
            leucine-stimulated mTOR gene transcription in mouse mammary
            epithelial cells.
REFERENCE   5  (bases 1 to 6618)
  AUTHORS   Fulton,S.L., Wenderski,W., Lepack,A.E., Eagle,A.L., Fanutza,T.,
            Bastle,R.M., Ramakrishnan,A., Hays,E.C., Neal,A., Bendl,J.,
            Farrelly,L.A., Al-Kachak,A., Lyu,Y., Cetin,B., Chan,J.C.,
            Tran,T.N., Neve,R.L., Roper,R.J., Brennand,K.J., Roussos,P.,
            Schimenti,J.C., Friedman,A.K., Shen,L., Blitzer,R.D., Robison,A.J.,
            Crabtree,G.R. and Maze,I.
  TITLE     Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn
            mouse model of Down syndrome
  JOURNAL   Nat Commun 13 (1), 6384 (2022)
   PUBMED   36289231
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6618)
  AUTHORS   Reyes,J.C., Barra,J., Muchardt,C., Camus,A., Babinet,C. and
            Yaniv,M.
  TITLE     Altered control of cellular proliferation in the absence of
            mammalian brahma (SNF2alpha)
  JOURNAL   EMBO J 17 (23), 6979-6991 (1998)
   PUBMED   9843504
REFERENCE   7  (bases 1 to 6618)
  AUTHORS   LeGouy,E., Thompson,E.M., Muchardt,C. and Renard,J.P.
  TITLE     Differential preimplantation regulation of two mouse homologues of
            the yeast SWI2 protein
  JOURNAL   Dev Dyn 212 (1), 38-48 (1998)
   PUBMED   9603422
REFERENCE   8  (bases 1 to 6618)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   9  (bases 1 to 6618)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   10 (bases 1 to 6618)
  AUTHORS   Spies,T. and DeMars,R.
  TITLE     Restored expression of major histocompatibility class I molecules
            by gene transfer of a putative peptide transporter
  JOURNAL   Nature 351 (6324), 323-324 (1991)
   PUBMED   2034277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118249.11 and AC118472.8.
            
            On Apr 20, 2022 this sequence version replaced XM_006527284.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.17821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-825               AC118249.11        65400-66224         c
            826-1086            AC118249.11        51458-51718         c
            1087-1216           AC118249.11        47392-47521         c
            1217-1678           AC118249.11        40271-40732         c
            1679-1940           AC118249.11        30753-31014         c
            1941-2067           AC118249.11        24255-24381         c
            2068-2241           AC118249.11        22245-22418         c
            2242-2415           AC118249.11        19680-19853         c
            2416-2586           AC118249.11        16891-17061         c
            2587-2640           AC118249.11        7298-7351           c
            2641-2771           AC118249.11        2519-2649           c
            2772-2829           AC118249.11        2231-2288           c
            2830-2930           AC118249.11        218-318             c
            2931-3078           AC118472.8         205702-205849       c
            3079-3242           AC118472.8         201751-201914       c
            3243-3309           AC118472.8         200166-200232       c
            3310-3420           AC118472.8         199364-199474       c
            3421-3663           AC118472.8         196435-196677       c
            3664-3777           AC118472.8         194626-194739       c
            3778-3885           AC118472.8         187096-187203       c
            3886-3972           AC118472.8         186281-186367       c
            3973-4019           AC118472.8         182326-182372       c
            4020-4186           AC118472.8         180036-180202       c
            4187-4350           AC118472.8         172317-172480       c
            4351-4578           AC118472.8         167863-168090       c
            4579-4656           AC118472.8         162356-162433       c
            4657-4875           AC118472.8         157601-157819       c
            4876-5093           AC118472.8         126507-126724       c
            5094-5147           AC118472.8         118617-118670       c
            5148-5253           AC118472.8         107505-107610       c
            5254-5355           AC118472.8         106939-107040       c
            5356-5488           AC118472.8         104243-104375       c
            5489-5631           AC118472.8         102305-102447       c
            5632-6618           AC118472.8         100227-101213       c
FEATURES             Location/Qualifiers
     source          1..6618
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 21.17 cM"
     gene            1..6618
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit ATPase 2"
                     /db_xref="GeneID:67155"
                     /db_xref="MGI:MGI:99603"
     exon            1..825
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1086
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             862..5667
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /note="isoform 4 is encoded by transcript variant 8;
                     probable global transcription activator SNF2L2; subunit of
                     the SWI/SNF chromatin remodeling complex; BRG1-associated
                     factor 190B; ATP-dependent helicase SMARCA2;
                     SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily A member 2; BAF190B;
                     SNF2-alpha; protein brahma homolog; SWI/SNF related,
                     matrix associated, actin dependent regulator of chromatin,
                     subfamily a, member 2"
                     /codon_start=1
                     /product="probable global transcription activator SNF2L2
                     isoform 4"
                     /protein_id="NP_001392063.1"
                     /db_xref="GeneID:67155"
                     /db_xref="MGI:MGI:99603"
                     /translation="MSTPTDPAAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMM
                     GPSPGPPSVSHPLSTMGSADFPQEGMHQLHKPMDGIHDKGIVEDVHCGSMKGTSMRPP
                     HPGMGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPISGGGPTPPQMPPSQPGALIPGD
                     PQAMNQPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGMQQQ
                     QQQQQQQQQQQQQQQQQQQQQQQPQQPQQQAQAQPQQQQQQQQQPALVSYNRPSGPGQ
                     ELLLSGQSAPQKLSAPAPSGRPSPAPQAAVQPTATAVPGPSVQQPAPGQPSPVLQLQQ
                     KQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPGSLPPDLRTKATVELK
                     ALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIE
                     QERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETER
                     IEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKE
                     KKKRRRRKKKAEENAEGGEPALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPK
                     ASQLDAWLEMNPGYEVAPRSDSEESESDYEEEDEEEESSRQETEEKILLDPNSEEVSE
                     KDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQL
                     QGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSN
                     WTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRW
                     KYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIF
                     KSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEK
                     VEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHP
                     YMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTS
                     LMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNL
                     QAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLN
                     VDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFD
                     LFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSR
                     QRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKEDVEKAKKR
                     RGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDRCNVEKVPCNSQLEIEGNSSGRQLSE
                     VFIQLPSRKDLPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNL
                     EGSQIYEDSIVLQSVFKSARQKIAKEEESEEESNEEEEEDDEEESESEAKSVKVKIKL
                     NKKEEKGRDTGKGKKRPNRGKAKPVVSDFDSDEEQEENEQSEASGTDNE"
     exon            1087..1216
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1678
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1940
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2067
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2241
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2415
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2586
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2640
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2771
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2829
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2930
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3078
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3242
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3309
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3420
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3663
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3777
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3885
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..3972
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3973..4019
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4186
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4350
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            4351..4578
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            4579..4656
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            4657..4875
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            4876..5093
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            5094..5147
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            5148..5253
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            5254..5355
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            5356..5488
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            5489..5631
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            5632..6618
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6550..6555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /note="hexamer: AATAAA"
     polyA_site      6572
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /note="major polyA site"
     regulatory      6596..6601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
                     /note="hexamer: AATAAA"
     polyA_site      6618
                     /gene="Smarca2"
                     /gene_synonym="2610209L14Rik; brahma; brm; SNF2alpha;
                     Snf2l2"
ORIGIN      
        1 gtactctggg tgactcagag agggaagatt cagccagcac actgctcgcg agcaaggtaa
       61 atataactta caactccttt ctcttctctc cacggctccg gccttacagc agccgcagcg
      121 gccgccgaac cccttgggca ccgcgccgcc ttcgccccgg attatgcatc cttatcctaa
      181 tcattattta ttgtgcatgc tggaagacca aaacaaacag gcgggccaac cgctacaaca
      241 acaaaaaagc ccgcctcttc cccgcgggcc tcaggtggaa tgctctaacc acagctcccg
      301 ggtggcgata aaagaaacaa agtttcaacc gaacctcgcc gttctaataa taacagtaat
      361 aattactact tcgagggggc aaggagaaga aatcccaaca tgtcacagcc ttgaccctgg
      421 gcaggttgac agtgatgcgc tgccaactca gggttgcaac acactctccg ccaggttgca
      481 tccccccccc cctcctatcc cctaaaaagc agaggtgggg agggctagtg gcaagaggag
      541 agggggattt gggaactccg ggccgggggg cggaggggtt gggaggcggg ggactggaaa
      601 cgcgacagtt caccccgagc catcctcccc gttagagttg gaagggaaca ggaaaggagg
      661 gaaggagggt gaggagcccg ggctggcggc agggcgccaa ccaacacggc tgctattcgc
      721 ctcccgggga cttgtttaaa gggctccggc tgcggggacg agagcagatc ttggcggtag
      781 tagtctggga tggcgcactg agcgggcggc ggccactacc acaggtgtca ctctgctaac
      841 tggcagagcc aggagaccta gatgtccaca cccacagacc cagcagcaat gccccatcct
      901 gggccctccc cggggcctgg accctctcct ggaccaattc tggggcctag tccaggacca
      961 ggaccatccc caggttctgt gcacagcatg atgggtccta gtcccggacc tcccagcgtc
     1021 tcacatcctc tgtcaacgat gggctctgca gacttcccac aggaaggcat gcaccaatta
     1081 cataagccca tggatgggat acatgacaaa gggattgtag aagatgtcca ctgtggatcc
     1141 atgaagggca ccagcatgcg ccccccacac ccaggaatgg gccctccaca gagccccatg
     1201 gaccagcaca gccaaggtta tatgtcacca catccgtctc ctctgggagc cccggagcac
     1261 gtctctagcc ctatatctgg aggaggccca accccacccc agatgccacc gagccagcca
     1321 ggggcactca tcccaggaga tccgcaggcc atgaaccagc ctaacagagg tccctcgcct
     1381 ttcagtcctg tgcagctgca tcagcttcga gctcagattt tagcttacaa aatgttggcc
     1441 aggggccagc ctctccctga aactctgcag ctggcagtcc agggaaaaag gaccttgcct
     1501 ggcatgcagc agcagcagca gcaacaacaa caacagcagc agcagcagca gcagcagcag
     1561 cagcaacagc agcaacaaca gcagccccag cagcctcagc agcaggctca ggcacagccc
     1621 cagcagcagc agcaacagca gcagcagcca gctcttgtta gctataatcg accatctggc
     1681 cccgggcagg agctgctact gagtggccag agcgctccgc agaagctgtc agcaccagca
     1741 ccaagcggcc gaccttcacc ggcaccccag gccgccgtcc agcccacggc cacagcggtg
     1801 cccgggccct ccgtgcagca gcccgcccca gggcagccgt ctccggtcct acagctgcaa
     1861 cagaagcaga gccgcatcag ccccatccag aaaccgcaag gcctggaccc ggtggagatc
     1921 ctgcaggaac gagagtacag acttcaagct cgcatcgctc ataggataca agaactggaa
     1981 agtctgcctg gttccttgcc accagattta cgcaccaaag caaccgtgga actgaaagca
     2041 cttcgcttac tcaacttcca acgtcagctg agacaggagg tggtggcctg catgcggagg
     2101 gacaccaccc tggagacggc cctcaactcc aaagcatata agcggagcaa gcgccagacc
     2161 ctgcgtgagg cacgcatgac agagaaactg gagaagcagc agaagataga acaggagagg
     2221 aaacgccggc agaaacacca ggaatacctg aacagtattt tgcaacatgc aaaagatttt
     2281 aaggaatatc accggtctgt ggccgggaag atccagaagc tctccaaagc agtggcgact
     2341 tggcatgcta acacagaaag ggagcagaag aaggagacgg agcggatcga gaaggagaga
     2401 atgcggaggc tgatggccga agatgaagag ggctacagga agcttattga ccaaaagaaa
     2461 gacagacgtc tcgcctacct attgcagcag accgatgagt atgtcgccaa tctgaccaac
     2521 ctggtgtggg agcacaagca ggcccaagca gccaaagaga agaagaagag gaggaggagg
     2581 aagaagaagg ctgaagagaa tgcagaggga ggggaacctg ccctgggacc agatggagag
     2641 ccaatagatg aaagcagcca gatgagtgac ctgcctgtca aagtgacaca cacagaaact
     2701 ggcaaggtcc tctttggacc agaagcaccc aaagcaagtc agctggatgc ctggctggag
     2761 atgaatcctg gttacgaagt tgcacccaga tctgacagtg aagagagtga atcggactac
     2821 gaggaggagg atgaagaaga agagtccagt aggcaggaaa ccgaggagaa gatactgctg
     2881 gatcccaaca gtgaagaagt ttccgaaaag gatgccaagc agatcattga gactgcgaag
     2941 caggacgtgg acgacgaata cagcatgcag tacagtgcca gaggctctca gtcctactac
     3001 acggtggctc acgctatctc tgagagggtg gagaagcagt ctgccctcct cattaacggc
     3061 accctaaagc attaccagct ccagggcctg gaatggatgg tttccctgta taataacaat
     3121 ctgaacggaa tcttagctga tgaaatgggg ctaggcaaga ccatccagac cattgcactc
     3181 atcacgtatc tgatggagca caaaaggctc aatggtccct acctcatcat cgtccccctc
     3241 tcgactctgt ctaactggac atatgaattt gacaaatggg ctccttctgt ggtgaaaatt
     3301 tcttacaagg gtacccctgc catgcgacgc tccctcgttc cccagctacg gagtggcaaa
     3361 ttcaatgtcc tcctgactac ttacgagtac attataaaag acaagcacat tcttgcaaag
     3421 attcggtgga agtacatgat cgtggacgaa ggccaccgga tgaagaatca ccactgcaag
     3481 ctaacccagg tcctgaacac acactatgtg gcccccaggc ggatccttct gactgggacc
     3541 ccactgcaga ataagcttcc ggaactctgg gccctcctca acttcctcct ccctacaatc
     3601 ttcaagagtt gcagcacatt tgagcagtgg tttaatgctc catttgccat gaccggtgaa
     3661 agggtggacc tgaacgaaga agaaacgatt ttgatcatca ggcgtctaca caaggtgctg
     3721 agaccctttt tactgaggag gctgaagaaa gaggttgagt ctcagcttcc ggaaaaggtt
     3781 gagtatgtga tcaagtgtga catgtcagct ctgcagaaga ttctgtaccg tcacatgcaa
     3841 gccaagggga tcctcctcac ggacgggtct gagaaagata agaaggggaa aggaggtgcc
     3901 aagacactta tgaacaccat catgcagctg agaaaaatat gcaaccaccc atatatgttt
     3961 cagcacattg aggaatcctt tgctgaacac ctgggctatt cgaatggggt catcaatggg
     4021 gctgagctgt atcgggcctc gggaaagttt gagctgcttg atcgtattct gcccaaattg
     4081 agagcgacta accaccgcgt gctgcttttc tgccagatga cgtcactcat gaccattatg
     4141 gaggattact ttgcttttcg gaacttcctg tacctgcgcc ttgacggcac caccaagtct
     4201 gaagatcgtg ctgctttgct aaagaaattc aatgaacctg ggtcccagta tttcattttc
     4261 ttgctgagca caagagcagg gggcctgggc ttaaatcttc aggcggcaga cacggtggtc
     4321 atatttgaca gcgactggaa tcctcaccag gatctgcagg cccaagaccg agctcaccgc
     4381 attggccaac aaaacgaggt ccgggtgctg aggctttgca ccgtcaacag tgtggaggaa
     4441 aagattctcg cggctgccaa gtacaagctg aacgtggatc agaaggttat ccaagcaggc
     4501 atgtttgacc agaagtcatc cagccacgag cggagggcct tcctgcaggc cattctggag
     4561 cacgaggagg agaatgagga agaagatgag gtaccagacg acgagaccct gaaccagatg
     4621 attgctcgcc gggaggaaga atttgatctt tttatgcgca tggacatgga ccggcggagg
     4681 gaggatgccc ggaacccgaa gcgcaaaccc cgcttgatgg aggaagatga gctgccctcc
     4741 tggattatca aggatgacgc cgaagtggaa aggctcacct gtgaagaaga ggaggagaag
     4801 atatttggga ggggctctcg ccagcgccgg gatgtggact acagtgatgc cctcaccgag
     4861 aagcaatggc tcagggccat cgaagacggc aatttggaag aaatggaaga ggaggtacgg
     4921 cttaagaaga gaaaaagacg aagaaatgtg gataaagacc ccgtgaagga agatgtggaa
     4981 aaagcgaaga aaagaagagg ccgccctccg gctgagaagt tgtcaccaaa tcccccaaaa
     5041 ctaacgaagc agatgaacgc catcattgat actgtgataa actacaaaga caggtgtaac
     5101 gtggagaagg tgccctgtaa ttctcagttg gaaatagaag gaaacagttc agggcgacag
     5161 ctcagtgaag tcttcattca gttaccttcc aggaaagact taccagaata ctatgaatta
     5221 attaggaagc cagtggattt caaaaagata aaggagcgaa tccgtaatca taagtatcgg
     5281 agcctgggag acctggagaa agacgtcatg cttctctgtc acaacgcaca gacattcaac
     5341 ttggaaggat cccagatcta cgaagactcc attgtcctac agtcagtgtt taagagtgct
     5401 cggcagaaaa ttgccaaaga agaagagagt gaggaagaaa gcaatgaaga agaggaagaa
     5461 gatgatgaag aggagtcgga gtcagaggcg aaatctgtga aggtgaaaat caagctgaat
     5521 aaaaaggaag agaaaggccg ggacacaggg aagggcaaga agcggccaaa ccgaggcaaa
     5581 gccaaacccg tcgtgagcga ttttgacagt gacgaggaac aggaagagaa cgaacagtca
     5641 gaagcaagtg gaactgataa cgagtgacca tcctggacgt gagcttcccg cggtggcaga
     5701 accgaatgct ttcttccccc tctccttcct ccccagtgag ttcacttgcc attcgggcac
     5761 actgggttat ttctccgtcc tcattgtcat ctagaactag ctttagggta gtgccagaca
     5821 aacatatgat atcatggtgt aaaaaaagaa acacatgcgt gcagacacac tacacacaca
     5881 cacacacaca cacacacaca cacacacaca tatttgtaac atattgtgac caaatgggcc
     5941 tcaaagattc aaagattaaa aacaaaaagc ttttgatgga aaagatgtgg gtggatagta
     6001 tatttctaca ggtgggtcag gtttggtagc agtttgatgt gctgggttct gtcatctgtt
     6061 ctgatgagaa gatttttatc ttctgcagtg ctgatggccg ggaggaacca ttcaaagcca
     6121 ctggttattt tgtttttcat caggcgattt tcaagatttt catttgtttc agtattgttg
     6181 gttttctctt ttctcttttt tacactgtgg tacatataag caacttgact agtgacaaat
     6241 gtacagtagt tagatatcac ctacatatac atttttccat tttatgctct atgatctgaa
     6301 gaacaaaaaa aaaagctttt tgacttgtat aagatttatg tctactgtaa acattgcgga
     6361 attttttttt gttcttgttt tattgacaat gctattgagt attacagtgt ctagaatacc
     6421 ctggatggct tctcttgtcc acccgatctc ccgtgttacc aatgtgtatg gtctccttct
     6481 cccgaaagtg tacttaatct ttgctttctt tgcacaatgt ctttggttgc aagtcataag
     6541 cctgaggcaa ataaaattcc agtaatttcc aagaatgtgg tgttggtact ttcctaataa
     6601 accgataacg taccttga
//
