LOCUS       NM_001357395            2434 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus small ArfGAP 1 (Smap1), transcript variant 4, mRNA.
ACCESSION   NM_001357395 XM_006496362
VERSION     NM_001357395.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Sumiyoshi M, Masuda N, Tanuma N, Ogoh H, Imai E, Otsuka M, Hayakawa
            N, Ohno K, Matsui Y, Hara K, Gotoh R, Suzuki M, Rai S, Tanaka H,
            Matsumura I, Shima H and Watanabe T.
  TITLE     Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit
            embryonic lethality
  JOURNAL   FEBS Lett 589 (19 Pt B), 2754-2762 (2015)
   PUBMED   26296315
  REMARK    GeneRIF: either SMAP1 or SMAP2, is required for proper
            embryogenesis
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Kon S, Minegishi N, Tanabe K, Watanabe T, Funaki T, Wong WF,
            Sakamoto D, Higuchi Y, Kiyonari H, Asano K, Iwakura Y, Fukumoto M,
            Osato M, Sanada M, Ogawa S, Nakamura T and Satake M.
  TITLE     Smap1 deficiency perturbs receptor trafficking and predisposes mice
            to myelodysplasia
  JOURNAL   J Clin Invest 123 (3), 1123-1137 (2013)
   PUBMED   23434593
  REMARK    GeneRIF: Enhanced endocytosis of transferrin in Smap1-targeted mice
            might facilitate the active iron metabolism and c-KIT-induced
            growth of erythroblasts and myelodysplastic syndrome/acute myeloid
            leukemia cells.
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Tanabe K, Torii T, Natsume W, Braesch-Andersen S, Watanabe T and
            Satake M.
  TITLE     A novel GTPase-activating protein for ARF6 directly interacts with
            clathrin and regulates clathrin-dependent endocytosis
  JOURNAL   Mol Biol Cell 16 (4), 1617-1628 (2005)
   PUBMED   15659652
REFERENCE   4  (bases 1 to 2434)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 2434)
  AUTHORS   Sato Y, Hong HN, Yanai N and Obinata M.
  TITLE     Involvement of stromal membrane-associated protein (SMAP-1) in
            erythropoietic microenvironment
  JOURNAL   J Biochem 124 (1), 209-216 (1998)
   PUBMED   9644265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123790.4, AC153649.4 and AC121857.2.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_001357395.2.
            
            On Oct 26, 2017 this sequence version replaced XM_006496362.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.14672.1,
                                           SRR7345562.3639247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AC123790.4         152765-153108
            345-478             AC153649.4         25905-26038
            479-564             AC121857.2         10680-10765
            565-640             AC121857.2         12025-12100
            641-721             AC121857.2         16956-17036
            722-802             AC121857.2         22177-22257
            803-893             AC121857.2         29361-29451
            894-1021            AC121857.2         34924-35051
            1022-1187           AC121857.2         39006-39171
            1188-1495           AC121857.2         39903-40210
            1496-2434           AC121857.2         41911-42849
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 9.79 cM"
     gene            1..2434
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /note="small ArfGAP 1"
                     /db_xref="GeneID:98366"
                     /db_xref="MGI:MGI:2138261"
     exon            1..344
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1630
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /note="isoform 3 is encoded by transcript variant 4;
                     stromal membrane-associated protein 1"
                     /codon_start=1
                     /product="stromal membrane-associated protein 1 isoform 3"
                     /protein_id="NP_001344324.1"
                     /db_xref="GeneID:98366"
                     /db_xref="MGI:MGI:2138261"
                     /translation="MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWA
                     SWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQIQCMQDMGNTKARLLYEANL
                     PENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNISSSDAPLQPLVSSPSLQAAVD
                     KNKLEKEKEKKKDEKKREKEPEKPAKPLTTEKLPKKEEQQLEPKKSTSPKNAAEPTID
                     LLGLDGPAEAPVTNGNPATAPALSDDLDIFGPMISNPLPAAVMPPAQGTASVPAPATL
                     STVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGAQQSTPGVFMGPTNIPFTSQ
                     APTAFQGFPSMGVPVPAAPGLIGNMMGQNTGMMVGMPMHNGFMGNAQTGVMPLPQNVV
                     GPQGGMVGQMGAPQSKFGLPQAQQPQWNLSQMNQQMAAMNLSSANASAGFGQPPSTTA
                     GWSGSSSGQTLSTQLWK"
     exon            345..478
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            479..564
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            565..640
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            641..721
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            722..802
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            803..893
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1021
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1187
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1495
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..2434
                     /gene="Smap1"
                     /gene_synonym="1700056O10Rik; 4921514B13Rik;
                     4921525H11Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcgtgcg gcgggcccgg cgaggaggcg ggacacgtcg gcgctggctc ggccgccgcc
       61 gcccctcctc cggttccagc cgccgccgcc accgccgctg ccgccgcttc ctgggccgag
      121 tccgtccgcg gccccagcgg cgtcaggtgc cctcgcccgc ccggcctcgc cagcgccgtc
      181 cgcccgtccg ctcgcccgcg tccgggcccg ccgccccgcc gccgacatgg cgacacgctc
      241 ctgtcgggag aaggctcaga agctgaacga gcagcaccag ctcatcctgt ccaaactgct
      301 gagggaggag gacaacaagt actgcgccga ctgcgaggcc aaaggtcccc gatgggcttc
      361 ctggaatatt ggtgtgttta tttgcatcag atgtgctgga attcatagaa atcttggggt
      421 tcatatatcc agagtcaagt cagtcaacct agaccaatgg acaccagaac agatacagtg
      481 catgcaagat atgggaaata ctaaagcaag actactttat gaagccaatc ttccagagaa
      541 ctttcgaaga ccacagacag atcaagcagt agagtttttc atcagagata aatatgaaaa
      601 gaagaaatac tatgataaaa atgcaatagc tatcacaaat atttcctctt ctgatgcccc
      661 tcttcagcct ttggtatcct ctccttctct gcaagctgct gttgataaaa acaagttaga
      721 gaaagaaaag gaaaaaaaaa aggacgagaa aaagagagaa aaggagccag aaaagcctgc
      781 aaaaccacta acaacggaaa agctgccgaa gaaagaagag caacaacttg agcctaagaa
      841 aagcaccagc ccaaaaaatg ctgcagagcc cactattgat cttctaggac ttgatggtcc
      901 tgctgaggca cccgtgacca atggaaaccc agccacagcg ccagccctga gtgatgatct
      961 ggacattttt ggaccaatga tttctaaccc tttacctgca gctgtcatgc ccccggctca
     1021 ggggactgcc tccgtaccag cacctgctac cctgtctacc gttacatctg gggacctgga
     1081 tctgtttact gagcaaacta caaagtcaga agaagtagca aagaaacaac tctccaaaga
     1141 ctccatctta tctctgtatg gtacaggagc acagcaaagc actcctggtg tgtttatggg
     1201 acccacaaat ataccattta cctcacaagc accgactgca tttcaaggtt ttccttccat
     1261 gggcgtccca gtgcctgcag ctcccggtct tataggaaat atgatgggac agaatactgg
     1321 catgatggtg ggcatgccca tgcacaatgg gttcatggga aacgcacaga ctggagtgat
     1381 gccacttcct cagaatgttg ttggccctca gggaggaatg gtgggacaaa tgggtgcacc
     1441 acagagtaag ttcggcttgc cacaagccca gcagcctcag tggaacctct cacagatgaa
     1501 tcagcagatg gctgccatga acctcagtag tgctaacgct agtgcaggtt ttggccagcc
     1561 tcccagcacg acagcagggt ggtctggaag ctcatcgggg cagacgctga gcacacagct
     1621 gtggaagtaa gaagctgtca cagagttcca tccagaaccg accccaacat tcctcgctgc
     1681 aaaggcatct agttcccatt tattcatgta cataacgtat tttttctttc ccccatttgc
     1741 tcacattaag aatgacctga ttgaccgtgt tggtctgtgc tgattaaatt ggatgtgaaa
     1801 gcaggttgag aaaccatctg tgtggagggc agctttgctc atactcccca tgatgtccta
     1861 agccacattg ggaagctgct cagttaactt gcataatcag ttttatttgc aaaattatag
     1921 ctctaacgtt tgcatataag ggaagtagtt atcatgttag taatacctct aacagtataa
     1981 accccacccc caaattagcc agtaatcctg tagaaaggta ctgtatgatc aaatgtttaa
     2041 tcatataaat agaatgtaaa tgtatcactg agcactgttt tctagtgtat caaattcttt
     2101 tattcatcac tcactccact gtgctgttgt tatgatgtgc ttaacaggga acgtggttag
     2161 tgaacggaga taaacctgga tgctactgta aaactcaatg aaggtttcag aattcaaatt
     2221 tccattgcct cttgtaatgt gggcctcttc tcatgtacat agtgctaata tgaagacctt
     2281 tttctgcact atatgcacac agggtaacta aaacaaagcc acttttaatc cttgaaggta
     2341 tatccaggtt tatgacagta attgtgttta cattttatgg tgcctagtat tgacaaaatg
     2401 ttatttccct atattaaaca gatgaatcca caca
//
