LOCUS       NM_019483               5380 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus SMAD family member 9 (Smad9), mRNA.
ACCESSION   NM_019483 XM_915671
VERSION     NM_019483.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5380)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   2  (bases 1 to 5380)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5380)
  AUTHORS   Kibalnyk,Y., Afanasiev,E., Noble,R.M.N., Watson,A.E.S.,
            Poverennaya,I., Dittmann,N.L., Alexiou,M., Goodkey,K.,
            Greenwell,A.A., Ussher,J.R., Adameyko,I., Massey,J., Graf,D.,
            Bourque,S.L., Stratton,J.A. and Voronova,A.
  TITLE     The chromatin regulator Ankrd11 controls cardiac neural crest
            cell-mediated outflow tract remodeling and heart function
  JOURNAL   Nat Commun 15 (1), 4632 (2024)
   PUBMED   38951500
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5380)
  AUTHORS   Wang,Y., Wang,J., Xu,T., Yang,S., Wang,X., Zhu,L., Li,N., Liu,B.,
            Xiao,J. and Liu,C.
  TITLE     Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor
            Agenesis and Molar Microdontia
  JOURNAL   Int J Mol Sci 25 (13), 7045 (2024)
   PUBMED   39000154
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5380)
  AUTHORS   Huang,Z., Wang,D., Ihida-Stansbury,K., Jones,P.L. and Martin,J.F.
  TITLE     Defective pulmonary vascular remodeling in Smad8 mutant mice
  JOURNAL   Hum Mol Genet 18 (15), 2791-2801 (2009)
   PUBMED   19419974
  REMARK    GeneRIF: Smad8 loss of function resulted in changes in pulmonary
            arteries including medial thickening and smooth muscle hyperplasia
            observed in patients with pulmonary artery hypertension.
REFERENCE   6  (bases 1 to 5380)
  AUTHORS   Faber,S.C., Robinson,M.L., Makarenkova,H.P. and Lang,R.A.
  TITLE     Bmp signaling is required for development of primary lens fiber
            cells
  JOURNAL   Development 129 (15), 3727-3737 (2002)
   PUBMED   12117821
REFERENCE   7  (bases 1 to 5380)
  AUTHORS   Oxburgh,L. and Robertson,E.J.
  TITLE     Dynamic regulation of Smad expression during mesenchyme to
            epithelium transition in the metanephric kidney
  JOURNAL   Mech Dev 112 (1-2), 207-211 (2002)
   PUBMED   11850197
  REMARK    GeneRIF: Dynamic regulation of Smad expression during mesenchyme to
            epithelium transition in the metanephric kidney.
REFERENCE   8  (bases 1 to 5380)
  AUTHORS   Tremblay,K.D., Dunn,N.R. and Robertson,E.J.
  TITLE     Mouse embryos lacking Smad1 signals display defects in
            extra-embryonic tissues and germ cell formation
  JOURNAL   Development 128 (18), 3609-3621 (2001)
   PUBMED   11566864
REFERENCE   9  (bases 1 to 5380)
  AUTHORS   Yoshida,Y., Tanaka,S., Umemori,H., Minowa,O., Usui,M., Ikematsu,N.,
            Hosoda,E., Imamura,T., Kuno,J., Yamashita,T., Miyazono,K., Noda,M.,
            Noda,T. and Yamamoto,T.
  TITLE     Negative regulation of BMP/Smad signaling by Tob in osteoblasts
  JOURNAL   Cell 103 (7), 1085-1097 (2000)
   PUBMED   11163184
REFERENCE   10 (bases 1 to 5380)
  AUTHORS   Kawai,S., Faucheu,C., Gallea,S., Spinella-Jaegle,S., Atfi,A.,
            Baron,R. and Roman,S.R.
  TITLE     Mouse smad8 phosphorylation downstream of BMP receptors ALK-2,
            ALK-3, and ALK-6 induces its association with Smad4 and
            transcriptional activity
  JOURNAL   Biochem Biophys Res Commun 271 (3), 682-687 (2000)
   PUBMED   10814522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK137411.1 and CK636610.1.
            
            On Mar 22, 2013 this sequence version replaced NM_019483.4.
            
            Summary: This gene encodes a member of a family of proteins that
            act as downstream effectors of the bone morphogenetic protein (BMP)
            signaling pathway. The encoded protein is phosphorylated by BMP
            receptors, which stimulates its binding to SMAD4 and translocation
            into the nucleus, where it functions as a regulator of
            transcription. Activity of this protein is important for embryonic
            development. Mutation of this gene results in defects in pulmonary
            vasculature. [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137411.1, SRR7345562.2339542.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5368              AK137411.1         2-5369
            5369-5380           CK636610.1         77-88
FEATURES             Location/Qualifiers
     source          1..5380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.62 cM"
     gene            1..5380
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /note="SMAD family member 9"
                     /db_xref="GeneID:55994"
                     /db_xref="MGI:MGI:1859993"
     exon            1..113
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            114..731
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            732..989
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1211
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1468
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..5380
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4485..4490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /note="hexamer: AATAAA"
     polyA_site      4507
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /note="major polyA site"
     regulatory      5163..5168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /note="hexamer: ATTAAA"
     polyA_site      5184
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /note="major polyA site"
     regulatory      5351..5356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /note="hexamer: ATTAAA"
     polyA_site      5372
                     /gene="Smad9"
                     /gene_synonym="MADH6; Madh8; Madh9; Smad8"
                     /note="major polyA site"
ORIGIN      
        1 agcctgactg acgcctctgg agccgctgtc tcggtcccgc cgccgcccgg ccgaccctgc
       61 agctaccgcg caaccggagt gcgcgggggg cacgcgtggc acctctcgga cagagtaagc
      121 tggctccact ttccaagagc tttggaagac gtcagcccat ctcccagttt gaatcggacc
      181 ccactgcttc cagaaggaaa ggcaagcttg ttcctatgac atccgtggac aggtacttgc
      241 cgccgacctg cccggggccc tgcaagcctt gaaaggtctc atcctctttc cccgtgcagc
      301 agcctgagct ctgcctccta tgcaccccag cacccccatc agctccctct tctccttcac
      361 cagccccgca gtgaagcggc tgctgggctg gaagcaggga gatgaagagg agaagtgggc
      421 agagaaggcg gtggactctt tggtgaagaa gttaaagaag aagaaaggcg ccatggatga
      481 actggagagg gcgctgagct gcccgggtca gcctagcaag tgtgtcacca tcccacggtc
      541 cctcgatgga cgcctccagg tgtcccaccg aaaggggctg ccccacgtca tctactgccg
      601 cgtgtggcgc tggccagacc tgcagtccca tcatgagctg aagcccttgg agtgctgtga
      661 gttcccgttc ggctccaagc agaaggaggt ctgcatcaac ccataccatt accgcagagt
      721 ggagacccca gttctgcctc cagtgctggt accaagacac agcgagtaca accctcagct
      781 cagcctcctg gccaagttcc gaagtgcctc gctgcacagc gaacccctca tgccgcacaa
      841 cgccacctac cctgactctt tccagcagtc tctctgtccg gcaccgccct cctcgccagg
      901 ccatgtgttt ccgcagtctc catgccccac cagctacccg cactcccccg gaagtccttc
      961 cgagtcagac agtccctatc aacactcaga cttccggcca gtttgctacg aggaacccca
     1021 gcactggtgt tctgttgcct actacgaact aaacaaccgg gtcggagaga ctttccaggc
     1081 gtcctcgcgg agcgtgctca tagacggctt caccgaccct tccaataaca ggaataggtt
     1141 ctgccttggg cttctctcaa atgtaaacag aaactcgacc atagaaaaca ccaggaggca
     1201 cattggaaag ggtgtgcatt tgtactacgt tgggggcgag gtgtatgcgg agtgcgtgag
     1261 cgacagcagc atctttgtcc agagccggaa ctgcaactac cagcacggct tccacccggc
     1321 caccgtctgc aagatcccca gcggctgcag cctcaaggtc ttcaacaacc agctcttcgc
     1381 ccagctgctc gcccagtccg tgcaccacgg ctttgaagtg gtgtatgagc tgacgaagat
     1441 gtgcacgatt cggatgagct ttgtgaaggg ctggggagca gagtatcatc gccaggatgt
     1501 cacgagcacc ccctgctgga tcgagatcca tcttcatgga ccgctgcagt ggttggataa
     1561 ggtgctcact cagatgggct ccccacacaa ccctatctct tcagtgtctt aagtcacgtc
     1621 gtcagccacg ttgccacaga acagactcgg gcaggggctt ccatcgtggc aaccgcagct
     1681 aatgcagggt tccggatgca gatgtaaata cacgtgtaac gcatccgagt cacgtttata
     1741 tcaccgtttg ttttgtgcta cctacttaac ctggggccag tgcggtgtgg tcgaagaagc
     1801 gtggtttctc tctgatggga gccaagtctt ctgtgagagg gaaacagcac gtgagggcgt
     1861 cggcaggact caaggccacc gagtcagctc atcgtcactc cacaggaggt tgtgccccac
     1921 atggaaaaca caaagctgct tacacagaag gaataggagc actagagcaa aatcagtcac
     1981 acacaagtgg ttttaaaaag acctcacttg caatgtgagt gtcaagaaag aaaaccaagc
     2041 ttgtccaggg acctgtgaga taaagccaca gaaactttat ctccgaagct gaaatacaca
     2101 tagccaggta ctgtgctgac ggcaggtaca ttcaaccaga tctaaactgt gattggagag
     2161 ggagaaactg tgaagcttgg agtcagtggc ctcaatctaa aacaagcaag caggcaggca
     2221 ggcaggcggg cgggcgggcg ggcaggcggg tgggcaggca ggcaagcaaa gccaaggctc
     2281 ttaagggaaa ccggcctgag aggaggcttg atccagggtt agcccagaat tcaggcccgg
     2341 aagcacaggg aactcctgcg tccactctgg aagccatctt cccgtcttcc cgtccctcct
     2401 gtctgacctt gcagatggct gcctgccctg tgcacactac aaaccccgtg cagagatgaa
     2461 gctgtagact ggaaggttgg gagggaagtg caggctaggc agggcatccc ttgcctcatt
     2521 tttcctcctg gtgacaaata gcaattagtg acagatgatt caaacaagag caaagccttg
     2581 ggaaagctcg aggcatcttt ggatcttatt tatgcatctc tcagcctggc acctatgtta
     2641 agttattagc tggttacatc agtgcagcct cttctaaagc tattaaatac ctggatatag
     2701 cttcccaggt gaagtaggaa tgtttcatat gccctacatt tttttatttt tatgaggaaa
     2761 cagtggtagt gaataataaa gcatctttaa aaaacacctt atgtgtatat agacatgcat
     2821 atatcagctc attccctctg ttggatgata agggaaatat cctccagact tcaaggtaca
     2881 tgccactcat taggcacccc attgcttcta agtttacttc aagccctttg aaaaggatta
     2941 tgtaggatgg catttattgt ttaaaggata gagcttccat aatatgatag agatattata
     3001 tcggaaactc atttcgtctc aaactaccac ttagagtgta taagaaaaaa aacccaagca
     3061 tgtcgattca ttaagtctgt cttgtgcatt tgtgtgtact gggtacagtg tcaggtacca
     3121 gggaatcaaa cgcacattag aggcagtccc cacctccata acgccagaca tctaacggta
     3181 aaccatttgc acagacatca ggtctcagaa ctttaaaaac cccacacatg tgaatcttct
     3241 tgggctcgaa aaataacata atcgagttct gaacaatagt taagaactct attgtaataa
     3301 ctatattggg attttatgtc tcctcagaac acttgagtaa tttatctttt cataactact
     3361 tccattccta gccaccccac ctcctggaat ccctattttt ttctgatatt tctcctggtt
     3421 tcttccttgg aaaagccatg tgtacccatc taaggacaca aagcattgtc ccagatttcc
     3481 caccgcccct ttgatctcct cacaagtggc caaatatccc tggcaatctg tagttgtaag
     3541 aaactattca ggagtaggag cttcagggtg tagtggtacc gtggtacctg cctttgatct
     3601 cagcagcagg gagacagagg caggtggatc cctgtgaatt caggcctgac ctggtctata
     3661 taaggagtta caggacagcc agggctatac actgaaaccc tgtctcaaaa caaaagtaga
     3721 agcttaaaaa caaaactaaa aaccaaacaa acaagtaaac tacttggact tccttgcagt
     3781 gttaagaaat caaaatattg aagcgtgtct gatttctttg agaaaggaat catgacctag
     3841 gttcatatgt atattatcag agaatttagc tttgaagaga tataagtcct atgcttgtat
     3901 agcagagtca cattttaatg aattttcccc ctttggctgt taagagatct aaacgtatca
     3961 taacgtaatc cttgacttca actcctctga gtgaccatgt ggcgatcatt ccatgaagct
     4021 gacaagcaaa cttatgctgc gtaggttgtt ttacagggtg aaggggaaag tgggcagcca
     4081 ggcctttgca cactgcaagt tgcctcaggc agggtcaggc aatggagatc tgtatcggtt
     4141 tggcttgccc acaagaccca gaatgtttat cactgtgtac aagtcagtat gtgtgagtct
     4201 tagcaaaaat aagacatgat cagtttgttt cagctaagtg attacaactg tttcagaact
     4261 aagaagacac caccttgtta acatacacac ttcggtgttg tgttgtagag tcagcaaaac
     4321 tctctagcat ttagaatatt cttttcattg tgttctaagg gtggagttat cctcataacg
     4381 acaacagaaa gaagagtagc aaaatcattt tataaaaatc gcttgctgga ctttaagctc
     4441 ctgcttaatg ctgagtatgt tccagatatt tcatgtatgt atttaataaa gtaaaatata
     4501 ccatgcattc cacatcgtct tacctgctag agtcaagagc cgaactttgc aagggtaggt
     4561 aaccctcaca tatgttcata ataagttctt tttttggggg gagagggagg ttcaagacag
     4621 ggtttctctg tatagccctg gctgtcctgg aactcgcttt gtagaacagg ctggcctcaa
     4681 actcagaaat ctgcttgcct ctgcctcccg agtgctggga ttaaaggcgt gcaccaccac
     4741 gtccggctct catgataaat tcgaatgtat ataaaacaga cagccaagat tactctttga
     4801 ttcccagaag ccttgccttc ctgaaatgcc acacaccaca ctttggtagt ctgtgctaga
     4861 caatgataca ccttttggct tatttttctt tcaaactcta ggaaatactt ctatgtatat
     4921 gatctatggc tccttaagat gcttaatcat aaactgttct acttagaaaa tgagcttttt
     4981 aagaagtctt catgctgtaa aaactttggt ggcactataa caaaaaagac atcttcgaat
     5041 atttggcatt aatgtgtaat tttaatgata ctttgcagaa tttttagagg tgtttaacta
     5101 ctgctcccca gcttagcacc aggacacaca actcaaaccc tttgtatggt aaagctgttg
     5161 ttattaaaaa gtgaatttaa tacacactgt cgtttgagca tcctacctta gcaactcaac
     5221 agccacgtcc atcaaggaac atgtctatag gaagatgttt agcatgtgat gcttaaaaca
     5281 cctggatata taggggaact ttcactaaaa actcatttat ttttcatatg ccatgaaata
     5341 tgtttaactg attaaaatgt tttctaagag aagcttgtga
//
