LOCUS       NM_001042660            4441 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus SMAD family member 7 (Smad7), mRNA.
ACCESSION   NM_001042660 XM_986975
VERSION     NM_001042660.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4441)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4441)
  AUTHORS   Yong,M., Zhou,H., Zeng,Y., Yao,Y., Zhu,H. and Hu,J.
  TITLE     Reduced expression of SMAD7 and consequent reduction of autophagy
            promotes endometrial stromal-myofibroblast transition and fibrosis
  JOURNAL   Mol Hum Reprod 30 (10) (2024)
   PUBMED   39412480
  REMARK    GeneRIF: Reduced expression of SMAD7 and consequent reduction of
            autophagy promotes endometrial stromal-myofibroblast transition and
            fibrosis.
REFERENCE   3  (bases 1 to 4441)
  AUTHORS   Humeres,C., Shinde,A.V., Tuleta,I., Hernandez,S.C., Hanna,A.,
            Huang,S., Venugopal,H., Aguilan,J.T., Conway,S.J., Sidoli,S. and
            Frangogiannis,N.G.
  TITLE     Fibroblast Smad7 Induction Protects the Remodeling
            Pressure-Overloaded Heart
  JOURNAL   Circ Res 135 (3), 453-469 (2024)
   PUBMED   38899461
  REMARK    GeneRIF: Fibroblast Smad7 Induction Protects the Remodeling
            Pressure-Overloaded Heart.
REFERENCE   4  (bases 1 to 4441)
  AUTHORS   Li,W., Bai,P. and Li,W.
  TITLE     UHRF1 inhibition mitigates vascular endothelial cell injury and
            ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1
            axis
  JOURNAL   Mol Immunol 170, 119-130 (2024)
   PUBMED   38657333
  REMARK    GeneRIF: UHRF1 inhibition mitigates vascular endothelial cell
            injury and ameliorates atherosclerosis in mice via regulating the
            SMAD7/YAP1 axis.
REFERENCE   5  (bases 1 to 4441)
  AUTHORS   Li,Z., Zhao,J., Wu,Y., Fan,S., Yuan,H., Xia,J., Hu,L., Yang,J.,
            Liu,J., Wu,X., Lin,R. and Yang,L.
  TITLE     TRAF2 decrease promotes the TGF-beta-mTORC1 signal in MAFLD-HCC
            through enhancing AXIN1-mediated Smad7 degradation
  JOURNAL   FASEB J 38 (4), e23491 (2024)
   PUBMED   38363556
  REMARK    GeneRIF: TRAF2 decrease promotes the TGF-beta-mTORC1 signal in
            MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.
REFERENCE   6  (bases 1 to 4441)
  AUTHORS   Nagarajan,R.P., Zhang,J., Li,W. and Chen,Y.
  TITLE     Regulation of Smad7 promoter by direct association with Smad3 and
            Smad4
  JOURNAL   J Biol Chem 274 (47), 33412-33418 (1999)
   PUBMED   10559222
REFERENCE   7  (bases 1 to 4441)
  AUTHORS   Nakao,A., Fujii,M., Matsumura,R., Kumano,K., Saito,Y., Miyazono,K.
            and Iwamoto,I.
  TITLE     Transient gene transfer and expression of Smad7 prevents
            bleomycin-induced lung fibrosis in mice
  JOURNAL   J Clin Invest 104 (1), 5-11 (1999)
   PUBMED   10393693
REFERENCE   8  (bases 1 to 4441)
  AUTHORS   Christian,J.L. and Nakayama,T.
  TITLE     Can't get no SMADisfaction: Smad proteins as positive and negative
            regulators of TGF-beta family signals
  JOURNAL   Bioessays 21 (5), 382-390 (1999)
   PUBMED   10376010
  REMARK    Review article
REFERENCE   9  (bases 1 to 4441)
  AUTHORS   Nakao,A., Afrakhte,M., Moren,A., Nakayama,T., Christian,J.L.,
            Heuchel,R., Itoh,S., Kawabata,M., Heldin,N.E., Heldin,C.H. and ten
            Dijke,P.
  TITLE     Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta
            signalling
  JOURNAL   Nature 389 (6651), 631-635 (1997)
   PUBMED   9335507
REFERENCE   10 (bases 1 to 4441)
  AUTHORS   Imamura,T., Takase,M., Nishihara,A., Oeda,E., Hanai,J., Kawabata,M.
            and Miyazono,K.
  TITLE     Smad6 inhibits signalling by the TGF-beta superfamily
  JOURNAL   Nature 389 (6651), 622-626 (1997)
   PUBMED   9335505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120156.9 and AJ000550.1.
            
            On Aug 5, 2006 this sequence version replaced XM_986975.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ000550.1, BC137638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1149              AC120156.9         82965-84113         c
            1150-2949           AJ000550.1         995-2794
            2950-4441           AC120156.9         55544-57035         c
FEATURES             Location/Qualifiers
     source          1..4441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 51.06 cM"
     gene            1..4441
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /note="SMAD family member 7"
                     /db_xref="GeneID:17131"
                     /db_xref="MGI:MGI:1100518"
     exon            1..2204
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2258
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2333
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..4441
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4414..4419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /note="hexamer: ATTAAA"
     polyA_site      4435
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /note="major polyA site"
ORIGIN      
        1 ttcgctcgct gatcggcgca cagaggatct tgtccccgag ctgcgccagc agagccagcc
       61 gggcgcctcg ctcggtccgc tcgccgcgcc ggagagagct gcctgagacg cagccagcca
      121 gccagccggc gccacgccgc cgagcgctcg gccccggagt ccctgagtgc ggcgcggcga
      181 gcccccagcg gcggcagaag gactcgagcg ccaggagagg gcggacgggg gacgaggagg
      241 ctccggggcg cgacgaagag agtctccgag gaagaggctg cgagaggaca cccgggcctc
      301 ctgccgccac tgtcgggtcg gggccagcag ctcatgagag cagccccggc ggccacccgc
      361 ggccaggaga aggagcaccg gaggccccca cactagcctg tgccctcggg ggcgagagct
      421 tgcgacccgc cggagcccgc cgccgcgccg ccctcccccg cgctgacagc cccccggggc
      481 gcagccgccg ccgcagcatc ttctgtccct gcttccccag cgcggaggaa gtccccgccg
      541 aggacctggg cccccgggaa cgcaggagga aagaccagag actctaaaac acccagatac
      601 gcaagattga agcagcctag ccagaccttt ctgtggatta aaagaaatac gatttttttt
      661 ttttttttgg cagaagaaaa ggaaaggaag accggctggg ttcagcaagg aaaaaaaggg
      721 ggatgtaact cgtggatacg gtttttttcc cccacccttc caacatcttg ttttactttg
      781 taaacatttt ctcttttaaa cccgggctcc atccggtgcc ctccagacct ccgaggtgcg
      841 aggaggtggt gtgttttttc attgggggct ttgcatattt tggttttggg ggttttgaga
      901 gaccctccag acatctcacg aggggtgaag tctactcggt cccctccctc aagtcttcgc
      961 gtgcacagaa ttcgaggaga tccggttact aaggatatag aagaaaaaaa ataaatcgtg
     1021 cctgcctttt ttttttaatt gcctgcttct ccccaccccc aaattaagtt gcttagcaag
     1081 ggggaaagag gctttttcct ccctttagta gctcagccta acgtctttcg tttttttttt
     1141 tttttttttg cccccgagga tcttccatgt aggaagccga ggctggcgag cccgacactc
     1201 gggagccact gtaggggggc cttttttggg ggaggcgtct accggggttg cctcggccgc
     1261 ccccagggaa gcggcggccg cgttcctcca gggcacgccg gggcccgaaa gccgcgcagg
     1321 gcgcgggccg cgccgggtgg ggcagccgaa gcgcagcccc ccgatccccg gcaggcgccc
     1381 ctgggccccc gcgcgcgccc cggcctctgg gagactggcg catgccacgg agcgcccctc
     1441 gggccgccgc cgcttctgcc cgggcccctg ctgttgctgc tgtcgcctgc gcctgctgcc
     1501 ccaactcggc gcccgacttc ttcatggtgt gcggaggtca tgttcgctcc ttagccggca
     1561 aacgactttt ctcctcgcct cctcgccccg catgttcagg accaaacgat ctgcgctcgt
     1621 ccggcgtctc tggaggagcc gtgcgcccgg cggcgaggac gaggaggagg gcgtgggggg
     1681 tggcggcgga ggaggcgagc tgcggggaga aggggcgacg gacggccggg cttatggggc
     1741 tggtggcggc ggtgcgggca gggctggctg ctgcctgggc aaggcagtcc gaggtgccaa
     1801 aggtcaccac catccccatc ccccaacctc gggtgccggg gcggccgggg gcgccgaggc
     1861 ggatctgaag gcgctcacgc actcggtgct caagaaactc aaggagcggc agctggagct
     1921 gctgcttcag gccgtggagt cccgcggcgg tacgcgcacc gcgtgcctcc tgctgcccgg
     1981 ccgcctggac tgcaggctgg gcccgggggc gcccgccagc gcgcagcccg cgcagccgcc
     2041 ctcgtcctac tcgctccccc tcctgctgtg caaagtgttc aggtggccgg atctcaggca
     2101 ttcctcggaa gtcaagaggc tgtgttgctg tgaatcttac gggaagatca accccgagct
     2161 ggtgtgctgc aacccccatc accttagtcg actctgtgaa ctagagtctc cccctcctcc
     2221 ttactccaga tacccaatgg attttctcaa accaactgca ggctgtccag atgctgtacc
     2281 ttcctccgcg gaaaccgggg gaacgaatta tctggcccct ggggggcttt cagattccca
     2341 acttcttctg gagcctgggg atcggtcaca ctggtgcgtg gtggcatact gggaggagaa
     2401 gactcgcgtg gggaggctct actgtgtcca agagccctcc ctggatatct tctatgatct
     2461 acctcagggg aatggctttt gcctcggaca gctcaattcg gacaacaaga gtcagctggt
     2521 acagaaagtg cggagcaaga tcggctgtgg catccagctg acgcgggaag tggatggcgt
     2581 gtgggtttac aaccgcagca gttaccccat cttcatcaag tccgccacac tggacaaccc
     2641 ggactccagg acgctgttgg tgcacaaagt gttccctggt ttctccatca aggcttttga
     2701 ctatgagaaa gcctacagcc tgcagcggcc caatgaccac gagttcatgc agcaaccatg
     2761 gacgggtttc accgtgcaga tcagctttgt gaagggctgg ggccagtgct acacccgcca
     2821 gttcatcagc agctgcccgt gctggctgga ggtcatcttc aacagccggt agtcggtcgt
     2881 gtggtgggga gaagaggaca gggcggatcg tgagccgagc aggccaccgt tcaaactact
     2941 tgctgctaac ctttcccgag tgattgcttt tcatgcaaac tctttggttg gtgttgttat
     3001 tgccattcat tgttggtttt gttttgttct gttctggttt gttttttttt ttttttcctc
     3061 ctcctttctc gtcatccgtg tgtcccgctt gtcttgttct ttgagaaatt agcttatggt
     3121 gcggattttt gttgggttgt gtgtgtgtgt tttgtttttg ttttgaggtg gtgggtgtgg
     3181 ttggcaggac accccctccc cccatatacg aagacaggaa acgagagtca gcactgccaa
     3241 gcatggtgtg tgaaagtggg caccaccttc cctttggatc agcgtttcgg ttgtccgtgc
     3301 gtaggggtgt acccgagcga cagatggggg aagtgctttt ttgtgtgtgt gttctttatg
     3361 gatgcccccg gctgagaggc tcatagtgcc aagctgtgtg tctctctagc cttttggaca
     3421 cgctcggtgg ggcagaggca gtacctgggc agactggcag caggtgccaa gctctgctcc
     3481 agcctgccga agctgccccg ccccgccccg cccccgcccc cacaggacac gggcctatcc
     3541 acaggcttct gagaagccag cctgctagaa ggctgaacca gaaccaattg ttttcatccc
     3601 tgtcttactg ccgcctgtca cccgctgcca ttgtcgagtc tgtctttttt ggccatctgc
     3661 tcctggatct ctctcttgag atgggcttcc caagggctgc cgggacagcc ccagtcacag
     3721 tattgctacc ccagtaccct ctcaggccct tccaccgggt cccagccgtg gtggtttttt
     3781 catcaggttt ctcccagatg tggaaagtca gctcagcacc ccatccccca tcctgtgtgc
     3841 tgagctctgt agaccagcga ggggcatcag ggagggacct gcgcagtgcc cccccttcct
     3901 gctgagaagg gtgtagcccc gtcacaacaa aggtaccatc ccttggctgg ctcccagccc
     3961 ttctctcagc tcatacgctc gctcgtatga tactttgaca ctgttcttag ctcaatgagc
     4021 atgtttagaa tttaacataa gctatttttc taactacaaa ggtttaaatg aacaagagaa
     4081 gcattctcat tggaaattta gcattgtagt gctttgagag aggaaaggac tccttaaaag
     4141 aaaaaaaaag ctgagattta ttaaagaaaa atgtatttta tgttatatat aaatatatta
     4201 ttacttgtaa atataaagac gttttataag catcattatt tatgtattgt gcaatgtgta
     4261 taaacgagaa gaataaagaa aagatgcact ttgctttaat ataaatgcaa ataacatgcc
     4321 aaattaaaaa aaaaaagata aacacaagat tggtgttttt ttctatgggt gttatcacct
     4381 agctgaatgt ttttctaaag gagtttatgt tccattaaac aatttttaaa atgtatactg
     4441 c
//
