LOCUS       NM_008542               2971 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SMAD family member 6 (Smad6), mRNA.
ACCESSION   NM_008542
VERSION     NM_008542.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2971)
  AUTHORS   Quilez,S., Dumontier,E., Baim,C., Kam,J. and Cloutier,J.F.
  TITLE     Loss of Neogenin alters branchial arch development and leads to
            craniofacial skeletal defects
  JOURNAL   Front Cell Dev Biol 12, 1256465 (2024)
   PUBMED   38404688
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2971)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2971)
  AUTHORS   Kulikauskas,M.R., Oatley,M., Yu,T., Liu,Z., Matsumura,L.,
            Kidder,E., Ruter,D. and Bautch,V.L.
  TITLE     Endothelial cell SMAD6 balances Alk1 function to regulate adherens
            junctions and hepatic vascular development
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37787089
REFERENCE   4  (bases 1 to 2971)
  AUTHORS   Wang,R., Yang,X., Chen,J., Zhang,L., Griffiths,J.A., Cui,G.,
            Chen,Y., Qian,Y., Peng,G., Li,J., Wang,L., Marioni,J.C., Tam,P.P.L.
            and Jing,N.
  TITLE     Time space and single-cell resolved tissue lineage trajectories and
            laterality of body plan at gastrulation
  JOURNAL   Nat Commun 14 (1), 5675 (2023)
   PUBMED   37709743
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2971)
  AUTHORS   Liu,H., Lu,P., He,S., Luo,Y., Fang,Y., Benkaci,S., Wu,B., Wang,Y.
            and Zhou,B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2971)
  AUTHORS   Flanders,K.C., Kim,E.S. and Roberts,A.B.
  TITLE     Immunohistochemical expression of Smads 1-6 in the 15-day gestation
            mouse embryo: signaling by BMPs and TGF-betas
  JOURNAL   Dev Dyn 220 (2), 141-154 (2001)
   PUBMED   11169847
REFERENCE   7  (bases 1 to 2971)
  AUTHORS   Galvin,K.M., Donovan,M.J., Lynch,C.A., Meyer,R.I., Paul,R.J.,
            Lorenz,J.N., Fairchild-Huntress,V., Dixon,K.L., Dunmore,J.H.,
            Gimbrone,M.A. Jr., Falb,D. and Huszar,D.
  TITLE     A role for smad6 in development and homeostasis of the
            cardiovascular system
  JOURNAL   Nat Genet 24 (2), 171-174 (2000)
   PUBMED   10655064
REFERENCE   8  (bases 1 to 2971)
  AUTHORS   Christian,J.L. and Nakayama,T.
  TITLE     Can't get no SMADisfaction: Smad proteins as positive and negative
            regulators of TGF-beta family signals
  JOURNAL   Bioessays 21 (5), 382-390 (1999)
   PUBMED   10376010
  REMARK    Review article
REFERENCE   9  (bases 1 to 2971)
  AUTHORS   Datta,P.K., Chytil,A., Gorska,A.E. and Moses,H.L.
  TITLE     Identification of STRAP, a novel WD domain protein in transforming
            growth factor-beta signaling
  JOURNAL   J Biol Chem 273 (52), 34671-34674 (1998)
   PUBMED   9856985
REFERENCE   10 (bases 1 to 2971)
  AUTHORS   Imamura,T., Takase,M., Nishihara,A., Oeda,E., Hanai,J., Kawabata,M.
            and Miyazono,K.
  TITLE     Smad6 inhibits signalling by the TGF-beta superfamily
  JOURNAL   Nature 389 (6651), 622-626 (1997)
   PUBMED   9335505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046602.1, AC114674.10, AI415735.1 and AC135672.4.
            
            On Jul 24, 2009 this sequence version replaced NM_008542.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046602.1, BC047280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849387,
                                           SAMN01164134 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-902               AK046602.1         1-902
            903-1199            AK046602.1         904-1200
            1200-1278           AC114674.10        67238-67316         c
            1279-1618           AK046602.1         1281-1620
            1619-2901           AK046602.1         1622-2904
            2902-2948           AI415735.1         32-78               c
            2949-2971           AC135672.4         40253-40275
FEATURES             Location/Qualifiers
     source          1..2971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 34.4 cM"
     gene            1..2971
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /note="SMAD family member 6"
                     /db_xref="GeneID:17130"
                     /db_xref="MGI:MGI:1336883"
     exon            1..1855
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1912
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1990
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2971
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2779..2784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /note="hexamer: AATACA"
     polyA_site      2802
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /note="major polyA site"
     regulatory      2952..2957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /note="hexamer: AATAAA"
     polyA_site      2971
                     /gene="Smad6"
                     /gene_synonym="b2b390Clo; Madh6"
                     /note="major polyA site"
ORIGIN      
        1 agactggcat atgatgggag gcagccaatg actccgcggc gctcctccgg gggccctcag
       61 tgtgcgtttg aggagaacaa aaaagagaga gagcgccgag agggggaacg agcgagggag
      121 ctgagtccag agaaagagcc gccgggcgct gcctcgccaa acctcgctgg gaccgcgggg
      181 ccaccaggag gcactttggt gaaggggggg gggggcgacc tcggcagccg cggcgcccga
      241 agcgacccag cgcagcgtgg ggcgggctgc gacctctgct tcggtggatt gcatttttaa
      301 ttaaggattc ctagcagctc tttgggattt tttttttccg gcttccactc atgtgttgac
      361 acccgcgttc aggagagact tgccccaagt gcaccgagcg cccgggacct gagacggaat
      421 tgcttttcgt gcgtgcaaaa tccaagcatt ttgagttttg tttgggacct ttttcttgct
      481 ttgcttttat ttctattttt attttgttgc agggatatgg gagttatcca caagccttag
      541 tttcggatcc tgcagggaaa gcccatgtag catagcttgg cttttgaagg cagagttgtg
      601 cagacacatt tgggggcacg acgcaagcgc tttgtgctcg tgtaccagcc gcgcaacttt
      661 tgaaggctcg ccggcccatg cagggtgtct ctagcatcgt ttcgctggtg gcttccctaa
      721 ggctccaaag cagctggagt tgagcggtcc cggcccatcg tgatccatgt agcccgctgg
      781 tccctcgcgg actgaggctc aacacgcgcg tgttcccggc ccggcccggc ccggcttggc
      841 ccggcgcgag ctccctcatg ttgcagccct gcggtgcccc ttcgacgaca ggctgtgcgc
      901 ggtctgcacg gcgccccgcg gcagagcttc atgtggggct gcggcccgct cagccggcgc
      961 ctcgttgagg gaacggaccc ccggtaaccg gagaccgcct cccctcccac caccccaggc
     1021 gccaaagggt atcgtatgtt caggtctaaa cgttcggggc tggtgcggcg actttggcga
     1081 agtcgtgtgg tccctgatcg ggaggaaggc agcggcggcg gcggtggtgt cgacgaggat
     1141 gggagcctgg gcagccgagc tgagcctgcc ccgcgggcac gagagggcgg aggctgcagc
     1201 cgctccgaag tccgctcggt agccccgcgg cggccccggg acgcggtggg accgcgaggc
     1261 gccgcgatcg cgggcaggcg ccggcgcaca gggggcctcc cgaggcccgt gtcggagtcg
     1321 ggggccgggg ctgggggctc cccgctggat gtggcggagc ctggaggccc aggctggctg
     1381 cctgagagtg actgcgagac ggtgacctgc tgtctcttct ccgaacggga cgcagcaggc
     1441 gcgccccggg actctggcga tccccaagcc agacagtccc cggagccgga ggagggcggc
     1501 gggcctcgga gtcgcgaagc ccgctcgcga ctgctgcttc tggagcagga gctcaagacg
     1561 gtcacgtact cgctgctcaa gaggctcaag gagcgttcgc tggacacgct gttggaggct
     1621 gtggagtccc gaggcggcgt accgggcggc tgcgtgctgg tgccgcgcgc cgacctccgc
     1681 ttgggcggcc agcccgcgcc accgcagctg ctgctcggcc gcctcttccg ctggccagac
     1741 ctgcagcacg cagtggagct gaaacccctg tgcggctgcc acagctttac cgccgccgcc
     1801 gacgggccca cggtgtgttg caacccctac cacttcagcc ggctctgcgg gccagaatca
     1861 ccgccgcccc cctattctcg gctgtctcct cctgaccagt acaagccact ggatctgtcc
     1921 gattctacat tgtcttacac tgaaaccgag gccaccaact ccctcatcac tgctccgggt
     1981 gaattctcag atgccagcat gtctccggat gccaccaagc cgagccactg gtgcagcgtg
     2041 gcgtactggg agcaccggac acgcgtgggc cgcctctatg cggtgtacga ccaggctgtc
     2101 agcattttct acgacctacc tcagggcagc ggcttctgcc tgggccagct caacctggag
     2161 cagcgcagtg agtcggtgcg gcgcacgcgc agcaagatcg gttttggcat actgctcagc
     2221 aaggagccag acggcgtgtg ggcctacaac cggggcgagc accccatctt cgtcaactcc
     2281 ccgacgctgg atgcgcccgg aggccgcgcc ctggtcgtgc gcaaggtgcc accgggttac
     2341 tccatcaagg tgttcgactt tgagcgctca gggctgctgc agcacgcaga cgccgctcac
     2401 ggcccctacg acccgcacag tgtgcgcatc agcttcgcca agggctgggg accctgctac
     2461 tcgcgacagt tcatcacctc ctgcccctgt tggctggaga tcctactcaa caaccacaga
     2521 tagcaatgcg gctgccactg tgccgcagcg tcccccaacc tctggggggc cagcgcccag
     2581 agacaccacc ccagggacaa cctcgccctc cccccagata tcatctacct agatttaata
     2641 taaagtttta tatattatat ggaaatatat attatacttg taattatgga gtcattttta
     2701 caacgtaatt atttatatat ggtgcaatgt gtgtatatgg agaaacaaga aagacgcact
     2761 ttggcttgta attctttcaa tacagatata tttttttctt tctttccctc tttccttttt
     2821 taaagagaat tatacagtag aactaggtgg aaagcctagg tttggtgtat ggctttttta
     2881 aaaaatatta atgcccagac caaaaaaaaa caaaacaaaa aacaaaaaaa ctaataccag
     2941 tcactcttga taataaagtg tttgcattat a
//
