LOCUS       NM_008540               7614 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus SMAD family member 4 (Smad4), transcript variant 1,
            mRNA.
ACCESSION   NM_008540 XM_916691 XM_924395 XM_924397 XM_924399 XM_924401
            XM_924404
VERSION     NM_008540.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7614)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7614)
  AUTHORS   Hashemi,Z., Hui,T., Wu,A., Matouba,D., Zukowski,S., Nejati,S.,
            Lim,C., Bruzzese,J., Lin,C., Seabold,K., Mills,C., Wrath,K.,
            Wang,H., Wang,H., Verzi,M.P. and Perekatt,A.
  TITLE     Epithelial-specific loss of Smad4 alleviates the fibrotic response
            in an acute colitis mouse model
  JOURNAL   Life Sci Alliance 7 (12), e202402935 (2024)
   PUBMED   39366762
  REMARK    GeneRIF: Epithelial-specific loss of Smad4 alleviates the fibrotic
            response in an acute colitis mouse model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7614)
  AUTHORS   Yang,D., Sun,X., Moniruzzaman,R., Wang,H., Citu,C., Zhao,Z.,
            Wistuba,I.I., Wang,H., Maitra,A. and Chen,Y.
  TITLE     Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic
            cancer in the absence of an oncogenic KRAS mutation
  JOURNAL   Cell Rep Med 5 (9), 101711 (2024)
   PUBMED   39232498
  REMARK    GeneRIF: Loss of p53 and SMAD4 induces adenosquamous subtype
            pancreatic cancer in the absence of an oncogenic KRAS mutation.
REFERENCE   4  (bases 1 to 7614)
  AUTHORS   Xin,X., Li,Z., Yan,X., Liu,T., Li,Z., Chen,Z., Yan,X., Zeng,F.,
            Hou,L. and Zhang,J.
  TITLE     Hepatocyte-specific Smad4 deficiency inhibits hepatocarcinogenesis
            by promoting CXCL10/CXCR3-dependent CD8+- T cell-mediated
            anti-tumor immunity
  JOURNAL   Theranostics 14 (15), 5853-5868 (2024)
   PUBMED   39346534
  REMARK    GeneRIF: Hepatocyte-specific Smad4 deficiency inhibits
            hepatocarcinogenesis by promoting CXCL10/CXCR3-dependent CD8[+]- T
            cell-mediated anti-tumor immunity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7614)
  AUTHORS   Chen,X., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Wu,H. and
            Qi,Y.
  TITLE     SENP3-regulated Nodal signaling plays a potential role in cardiac
            left-right asymmetry development
  JOURNAL   Int J Biol Macromol 274 (Pt 2), 133294 (2024)
   PUBMED   38925188
REFERENCE   6  (bases 1 to 7614)
  AUTHORS   Sirard,C., de la Pompa,J.L., Elia,A., Itie,A., Mirtsos,C.,
            Cheung,A., Hahn,S., Wakeham,A., Schwartz,L., Kern,S.E., Rossant,J.
            and Mak,T.W.
  TITLE     The tumor suppressor gene Smad4/Dpc4 is required for gastrulation
            and later for anterior development of the mouse embryo
  JOURNAL   Genes Dev 12 (1), 107-119 (1998)
   PUBMED   9420335
REFERENCE   7  (bases 1 to 7614)
  AUTHORS   Heldin,C.H., Miyazono,K. and ten Dijke,P.
  TITLE     TGF-beta signalling from cell membrane to nucleus through SMAD
            proteins
  JOURNAL   Nature 390 (6659), 465-471 (1997)
   PUBMED   9393997
  REMARK    Review article
REFERENCE   8  (bases 1 to 7614)
  AUTHORS   Chen,X., Weisberg,E., Fridmacher,V., Watanabe,M., Naco,G. and
            Whitman,M.
  TITLE     Smad4 and FAST-1 in the assembly of activin-responsive factor
  JOURNAL   Nature 389 (6646), 85-89 (1997)
   PUBMED   9288972
REFERENCE   9  (bases 1 to 7614)
  AUTHORS   Devereux,T.R., Anna,C.H., Patel,A.C., White,C.M., Festing,M.F. and
            You,M.
  TITLE     Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1):
            candidates for murine lung tumor resistance and suppressor genes
  JOURNAL   Carcinogenesis 18 (9), 1751-1755 (1997)
   PUBMED   9328171
REFERENCE   10 (bases 1 to 7614)
  AUTHORS   Anna,C.H. and Devereux,T.R.
  TITLE     Sequence and chromosomal mapping of the mouse homolog (Madh4) of
            the human DPC4/MADH4 gene
  JOURNAL   Mamm Genome 8 (6), 443-444 (1997)
   PUBMED   9166592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY742922.1, BC046584.1 and AC134447.2.
            
            On Jul 18, 2018 this sequence version replaced NM_008540.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046584.1, SRR7652917.333409.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY742922.1         2-51
            51-3391             BC046584.1         1-3341
            3392-7614           AC134447.2         161070-165292       c
FEATURES             Location/Qualifiers
     source          1..7614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 49.51 cM"
     gene            1..7614
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /note="SMAD family member 4"
                     /db_xref="GeneID:17128"
                     /db_xref="MGI:MGI:894293"
     exon            1..362
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            363..739
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..2146
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mothers against decapentaplegic homolog 4; mothers against
                     DPP homolog 4; deletion target in pancreatic carcinoma 4
                     homolog; MAD homolog 4"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 4
                     isoform 1"
                     /protein_id="NP_032566.2"
                     /db_xref="CCDS:CCDS29337.1"
                     /db_xref="GeneID:17128"
                     /db_xref="MGI:MGI:894293"
                     /translation="MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLV
                     KKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWP
                     DLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSMLVKDE
                     YVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPAESNATSTTNFPNIPV
                     ASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYT
                     PNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQV
                     GETFKVPSSCPVVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKG
                     EGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQA
                     ATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGW
                     GPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD"
     exon            740..914
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            915..944
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1154
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1274
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1391
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1442
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1626
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1795
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1934
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..7614
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3372..3377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /note="hexamer: AATAAA"
     polyA_site      3395
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /note="major polyA site"
     regulatory      3635..3640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /note="hexamer: AATAAA"
     polyA_site      3654
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
     regulatory      7591..7596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
                     /note="hexamer: ATTAAA"
     polyA_site      7614
                     /gene="Smad4"
                     /gene_synonym="D18Wsu70e; DPC4; Madh4"
ORIGIN      
        1 agtgtccttc cgacaagttg gcagcaacaa cacggccctg gtcgtcgtcg ccgctgcggt
       61 aacggagcgg ctcgggtggc ggagcccgtg ttcgcgtccg tccgcccgcc cgcccgccgt
      121 cctccggagg cccttcccgc gccgcgctcc gctccgcggc cgtccccggg gcgggagcgc
      181 gtgaccggag ccggcgcccg cgagcgaggc cccccgcagc ggggcggctc cggagctcca
      241 gcggcccggc cggccggcgc ggtccgcggc gcggcgggga gagggggccg cctgggccgg
      301 acgccgcggg cggggcccgg gaagcgacag cgaggcgagg cgcggtgcgg cgcggagccc
      361 aggtcatcct gctcaccaga tgtcttgaca gtttttcttg caacattggc cattggtttt
      421 cactgccttc aaaagatcaa aattactcca gaaattggag agttggattt aaaagaaaaa
      481 acttgaacaa atggacaata tgtctataac aaatacacca acaagtaacg atgcctgtct
      541 gagcattgta catagtttga tgtgtcatag acaaggtggg gaaagtgaaa cctttgcaaa
      601 aagagcaatt gagagtttgg taaagaagct gaaagagaaa aaagatgaat tggattcttt
      661 aataacagct ataactacaa atggagctca tcctagcaag tgtgtcacca tacagagaac
      721 attggatgga cgacttcagg tggctggtcg gaaaggattt cctcatgtga tctatgcccg
      781 tctgtggagg tggcctgatc tacacaagaa tgaactaaag catgttaaat attgtcagta
      841 tgcgtttgac ttaaaatgtg acagtgtctg tgtgaatcca tatcactatg agcgggttgt
      901 ctcacctgga attgatctct caggattaac actgcagagt aatgctccaa gtatgttagt
      961 gaaggatgag tacgttcacg actttgaagg acagccgtcc ttacccactg aaggacattc
     1021 gattcaaacc atccaacacc cgccaagtaa tcgcgcatca acggagacgt acagcgcccc
     1081 ggctctgtta gccccggcag agtctaacgc caccagcacc accaacttcc ccaacattcc
     1141 tgtggcttcc acaagtcagc cggccagtat tctggcgggc agccatagtg aaggactgtt
     1201 gcagatagct tcagggcctc agccaggaca gcagcagaat ggatttactg ctcagccagc
     1261 tacttaccat cataacagca ctaccacctg gactggaagt aggactgcac catacacacc
     1321 taatttgcct caccaccaaa acggccatct tcagcaccac ccgcctatgc cgccccatcc
     1381 tggacattac tggccagttc acaatgagct tgcattccag cctcccattt ccaatcatcc
     1441 tgctcctgag tactggtgct ccattgctta ctttgaaatg gacgttcagg taggagagac
     1501 gtttaaggtc ccttcaagct gccctgttgt gactgtggat ggctatgtgg atccttcggg
     1561 aggagatcgc ttttgcttgg gtcaactctc caatgtccac aggacagaag cgattgagag
     1621 agcgaggttg cacataggca aaggagtgca gttggaatgt aaaggtgaag gtgacgtttg
     1681 ggtcaggtgc cttagtgacc acgcggtctt tgtacagagt tactacctgg acagagaagc
     1741 tggccgagca cctggcgacg ctgttcataa gatctaccca agcgcgtata taaaggtctt
     1801 tgatctgcgg cagtgtcacc ggcagatgca gcaacaggcg gccactgcgc aagctgcagc
     1861 tgctgctcag gcggcggccg tggcagggaa catccctggc cctgggtccg tgggtggaat
     1921 agctccagcc atcagtctgt ctgctgctgc tggcatcggt gtggatgacc tccggcgatt
     1981 gtgcattctc aggatgagct ttgtgaaggg ctggggccca gactacccca ggcagagcat
     2041 caaggaaacc ccgtgctgga ttgagattca ccttcaccga gctctgcagc tcttggatga
     2101 agtcctgcac accatgccca ttgcggaccc acagccttta gactgagatc tcacaccacg
     2161 gacgccctaa ccatttccag gatggtggac tatgaaatat actcgtgttt ataatctgaa
     2221 gatctattgc attttgttct gctctgtctt ttcctaaagg gttgagagat gtgtttgctg
     2281 ccttgctctt agcagacaga aactgaatta aaacttcttt tctattttag aactttcagg
     2341 tgtggctcag tgcttgaaga tcagaaagat gcagttcttg ctgagtcttc cctgctggtt
     2401 ctgtatggag gagtcggcca gtgctgggcg ctcagccctt tagtgtgtgc gagcgccttg
     2461 catgccgagg agagtcagag ctgctgattg taaggctgag aagttctcac agttaagcca
     2521 cctgcccctt agtgggcgag ttattaaacg cactgtgctc acgtggcgct gggccagcca
     2581 gctctaccaa gagcaacttt actctccttt aaaaaccttt tagcaacctt tgattcacaa
     2641 tggtttttgc aagttaaaca gtgaaggtga attaaattca tactgtcttg cagacttcag
     2701 ggtttcttcc ccaagacaaa acactaatct gtgtgcatat tgacaattcc ttacaattat
     2761 cagtcaaaga aatgccattt aaaattacaa tttttttaat ccctaatgga tgaccactat
     2821 caagatgtat actttgccct gttaaacagt aaatgaattc ttctatattt ctaggcacaa
     2881 ggttagttat ttaaaaaaaa aaaaaaaagc ctaggggagg gatttttccc ttaattccta
     2941 gggagaaggt tttgtataaa acactaaaag cagtgtcact ctgcctgctg cttcactgtt
     3001 ctgcaaggtg gcagtacttc aactgaaata atgaatattt tggaaactgc taaattctat
     3061 gttaaatact gtgcagaata atggaaacag tgcagttggt aacaggtggt ttggatattt
     3121 ttgtacttga tttgatgtgt gacttctttt catatactgt taaaatcatg tatgttttga
     3181 cattgtttaa aattcagttt ttgtatctta gggcaagact gcagactttt ttataccttt
     3241 tggttataag ccctgtgttt gccatccttg atcacttggc ggtgactttg tagagattga
     3301 agtggaggag ttaagacaca ttgactgtac cacagacaca catgtatact ttctacctag
     3361 ttactagcgt aaataaaact gagtcactat acgaagtgga attctagatt tggtttttaa
     3421 aatgctttcc ttttgcactt ttgagtccag tctcagtggc aagacacctt ctgctaaatg
     3481 acaggtggca gccagttgta ccatgcagcg ctggttccct cccactctac caggactttc
     3541 ccatggacac tgtgcatcat gtgtagttgg ttattttttg agtttttatt ttactgtagc
     3601 aaaaaaaaaa aaaaaaactt ggataaatag tgtgaataaa atcaagacca tggagatgtt
     3661 tttaccctga gagttttctg tgagttttaa attgcagtag gcatttgagc tctggaaacc
     3721 ccgtgcatag cagttctctt tgtgccaaca gaaatgacca cgtcctgcag cctgctgcgg
     3781 aaggttccag aggctctgag aaaccagagt gctgcagtga ctggggtcca tctcagccca
     3841 gcgcacacag cgtgcgttgt aaaagctgcc tctgtgtctt gtcttctgta cttagggatg
     3901 ctttgtctcg ggcctaatct tatctgtaga agtttggtga tttttttttt ttaaatgttg
     3961 tattgacaga attataaaaa gataccttct ctagaaatgc ttgtcttcag atccgtttca
     4021 cgatggccgg ggaacaggag tgagaagaga gagtaagctg tagtgtaacg ggtttttaag
     4081 acccagctca tctgaccagg cagtgctgta acttgatgct tcctgttgta ccttatggaa
     4141 cctttcccat atttaatcat cttcagaaag taggtgggaa atatttgctg ggaagtatct
     4201 cttcagagcc aagccacttg tcttggtttt cttactaaga gccatagaaa tgatttctgg
     4261 ttattgatga aatttgtaat ttgcctgtcc tagtcttttt tcctttcact tcgctatctt
     4321 tgaataagac ttttaaaaac ttccctgagt tgaaaaattt tgggataaaa tagtttccct
     4381 agttcttaga gactgattat gatgtgggta tggttctggg tgggtttttt ttctaagtca
     4441 tagctcaaaa gtctcccaag attaaatttc agtgggcacc cagtttgaaa ccattctact
     4501 tttgtcttgt gcctttcttt gcatgattaa agagaatctg taatggtatt gcctttattt
     4561 gcttggaagt agattctttt ctgggataga gtctacctta atcgttgtcc tttaccgccc
     4621 ctgctgtaca gatagatgct aagccactgc cgggaacttg cttttccata gacagtcttt
     4681 ttatactgcc tgaacccatt gctcctgttc acagtataag ttcacagaca gggtgagccg
     4741 gccgaggcgc acacctgcag aatccagcaa caaccatgct taactgtgtg tatttcaaag
     4801 ttagaaatcc agttttgtgg ggaatggtgt ggtttatatt agcagctttg aaggcgaagt
     4861 aactcagagg ttttacagtc tggagaaggg aagcttcctg gaatgcttgt gaagtatctg
     4921 tggtggccaa atgtgtttgc tcctggcctt gcttgtaact ggctaattgt cactcttcag
     4981 atttttaaaa atttttaatg agctgagacc cccttggaag gagcttgttt ggagctggcc
     5041 agagatgttt ttggtagttc ctgtcttcat ccggtcttca tcactgtttt ctttaatggt
     5101 cagttagtaa agtataagtt aggtcactgt catgagtgga gcaggaacaa ctctcccagg
     5161 tgggggcctg gaagggactc gttacatgga gccatctgta actagccctt taaatcctcc
     5221 tttgcatgac atagagaaaa ggctgtgaga ctcctgccca ggcctttcta gttttccctt
     5281 ctagtaacca agcaatcgca tctctgcggt gcagtaggct gtatgtaaaa agccgtggcc
     5341 ttactcctag cagcaccctt ggcagggcct ttttctcagc gcagtgaggc tgtgcatctg
     5401 gcactcctga ggaatgaaag ttttcatcat cttgccttat taagcagtaa aacttttgaa
     5461 aaatgagccg tttattggca ggagctattt acacaaatca gaatattata ccatttcttt
     5521 ttctctctct cctgtctctg tggacctccg gggcttctga gatagacagt actgcctagc
     5581 cattcgaaat gcccaagcca gctggggttg ttgggctctc ctctcccttc ctccttcctc
     5641 acagctcctg ctcttgcgtg gttagtgagc ctctactcag tgtttcctgt cctcgctgct
     5701 caggcgaggg aagacgacaa ctgatagtct tagagttcac ctttctgtcg ggggcggcat
     5761 tgttctgatt gctgccatcg tctccgatcc ttgatgagtt ttatacgatt gatgtggaga
     5821 gaatttaatt gatattcata gcccatagct gctcccctct ccctggtgtt gtggaagatt
     5881 tagtttccac cgaattcact caaaaagctg tcctgttggc accagcaaac cacacgctct
     5941 tttagaaaac atctttgctt gttttgtgtc ctgaccctgc tctctggcct ccttcctctg
     6001 tagatacttc tgacctatag gtgcctttat gagaattgag ggtctgatac cgtgccccaa
     6061 ggaatagctg atgcaatgag tgatgttttt cagggatttt agcatcaaat taaataaatg
     6121 aatgaaactt ttaagtcctt cttttctttt atttttttaa tgcaggaagg actgaggaga
     6181 cgtcgggtga cgacaatcat ttctctgtgt tgctgtaaag gctttcacac agtttaagat
     6241 gcttttctca gtagctccag agttgatgtt cttgttcaac ctaaagcagg ctctggactc
     6301 gcccagaccg ttgcacttgt agtttacgac ttcatgtgtc ctccctcggc aagtcattcc
     6361 cttctctggg cctcagctgc ctcgtctgtg aaatgagggg ttggactatt gtgccagctc
     6421 tggcttctaa gtgaccttgc ccgccctgca gcaggttgag atgcgctctt tacctttttt
     6481 ctgctgtgtg agggggaatc ttactttttc ctttgttact cagtgagact aggcttgatc
     6541 tttgagtacc cgctctcctg tggacaagta gttacatatg tccttatgac ttatttttaa
     6601 ccaaaggccg agcaccacct taggggctgc cgtaagtacc atacagaaca ctggggtggg
     6661 gggcgggggg caccttcatt tcactgtgtc atcgtctgtg ttcagagcct ctgcaaaggc
     6721 cttcatctgt catgacattc tgactttgaa gttagtatgt gtatgattct gtcctcctaa
     6781 gtgctggcaa ttcttcatct aaactggact gaaatcctgt tgtaaatgcc tggtaatatt
     6841 agagggcctt tctttgggtc ttttgtagct taattcctct atgttcaaaa caggaagttc
     6901 ttcagaaatt atatcaatat tttaattgat gctatgaaag acagtcccag tgaatgactg
     6961 tccactttat ttttgcctct tttatatcca ttttgattga caacttttgg ctggatcatg
     7021 cctttcagag agttttcttc cagcctgctt ggatgagtat aataaccgac tttgttattt
     7081 ttacggacct gggaaccttt ctagggggtg gggtggggtg gggtggggtg gggagtcctg
     7141 gtagaggcca catctgtggc agctgtgaag aagggatgaa gccagctgct cttgctaagg
     7201 ctgcttgtca ttggtagaag gactcaccgg tttgggttac ttaaaaggct aaatatagag
     7261 ttggcaaact tctccaagcg gggagggttt tttttttgtt ccatgcatct aacgtgattt
     7321 aaaagcatga cttcctatag gttatgaaaa ctggtgtgct gcagatccag tgtggaagag
     7381 gtgactgggc gttggggaca gctttgatgg tgacacttct agctctgaga gtctcctact
     7441 ctgggtccac tcttagcttg gctcttagga aaaactggtc agctaaaggc ccaccacttt
     7501 ctttctatag acttttgcct ggttgaagtc tgtggcttaa aaaaaatagt tgaatctttc
     7561 ttgagaactc tgtaacaaag tatgtttttg attaaaaaga gaaagccaac taaa
//
