LOCUS       NM_016769               5090 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus SMAD family member 3 (Smad3), mRNA.
ACCESSION   NM_016769
VERSION     NM_016769.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5090)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5090)
  AUTHORS   Ling,L., Luo,M., Yin,H., Tian,Y., Wang,T., Zhang,B., Yin,L.,
            Zhang,Y. and Bian,J.
  TITLE     Sinomenine Ameliorated Microglial Activation and Neuropathic Pain
            After Chronic Constriction Injury Via TGF-beta1/ALK5/Smad3
            Signalling Pathway
  JOURNAL   J Cell Mol Med 28 (22), e70214 (2024)
   PUBMED   39586784
REFERENCE   3  (bases 1 to 5090)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
REFERENCE   4  (bases 1 to 5090)
  AUTHORS   Tang,F., Gong,H., Ke,T., Yang,W., Yang,Y. and Liu,Z.
  TITLE     USP7 Promotes TGF-beta1 Signaling by De-Ubiquitinating Smad2/Smad3
            in Pulmonary Fibrosis
  JOURNAL   Discov Med 36 (187), 1616-1626 (2024)
   PUBMED   39190377
  REMARK    GeneRIF: USP7 Promotes TGF-beta1 Signaling by De-Ubiquitinating
            Smad2/Smad3 in Pulmonary Fibrosis.
REFERENCE   5  (bases 1 to 5090)
  AUTHORS   Ren,Y., Zhou,L., Li,X., Zhu,X., Zhang,Z., Sun,X., Xue,X. and Dai,C.
  TITLE     Taz/Tead1 Promotes Alternative Macrophage Activation and Kidney
            Fibrosis via Transcriptional Upregulation of Smad3
  JOURNAL   J Immunol Res 2024, 9512251 (2024)
   PUBMED   39108258
  REMARK    GeneRIF: Taz/Tead1 Promotes Alternative Macrophage Activation and
            Kidney Fibrosis via Transcriptional Upregulation of Smad3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5090)
  AUTHORS   Zhu,Y., Richardson,J.A., Parada,L.F. and Graff,J.M.
  TITLE     Smad3 mutant mice develop metastatic colorectal cancer
  JOURNAL   Cell 94 (6), 703-714 (1998)
   PUBMED   9753318
REFERENCE   7  (bases 1 to 5090)
  AUTHORS   Labbe,E., Silvestri,C., Hoodless,P.A., Wrana,J.L. and Attisano,L.
  TITLE     Smad2 and Smad3 positively and negatively regulate TGF
            beta-dependent transcription through the forkhead DNA-binding
            protein FAST2
  JOURNAL   Mol Cell 2 (1), 109-120 (1998)
   PUBMED   9702197
REFERENCE   8  (bases 1 to 5090)
  AUTHORS   Zhao,J., Lee,M., Smith,S. and Warburton,D.
  TITLE     Abrogation of Smad3 and Smad2 or of Smad4 gene expression
            positively regulates murine embryonic lung branching morphogenesis
            in culture
  JOURNAL   Dev Biol 194 (2), 182-195 (1998)
   PUBMED   9501027
REFERENCE   9  (bases 1 to 5090)
  AUTHORS   Massague,J.
  TITLE     TGF-beta signal transduction
  JOURNAL   Annu Rev Biochem 67, 753-791 (1998)
   PUBMED   9759503
  REMARK    Review article
REFERENCE   10 (bases 1 to 5090)
  AUTHORS   Zhang,Y., Feng,X., We,R. and Derynck,R.
  TITLE     Receptor-associated Mad homologues synergize as effectors of the
            TGF-beta response
  JOURNAL   Nature 383 (6596), 168-172 (1996)
   PUBMED   8774881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158515.2, AK048626.1 and AK083158.1.
            
            On Jul 24, 2009 this sequence version replaced NM_016769.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048626.1, AK083158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC158515.2         167117-167147       c
            32-1539             AK048626.1         32-1539
            1540-3323           AK083158.1         1148-2931
            3324-5090           AK083158.1         2933-4699
FEATURES             Location/Qualifiers
     source          1..5090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 34.22 cM"
     gene            1..5090
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /note="SMAD family member 3"
                     /db_xref="GeneID:17127"
                     /db_xref="MGI:MGI:1201674"
     exon            1..523
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..717
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..849
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
     exon            850..924
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..975
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1188
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1326
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1471
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..5090
                     /gene="Smad3"
                     /gene_synonym="Madh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcaccc aaacagctac cccgtgcgga aacccaaact ttctactgcc acttggagtc
       61 tcgcggccgc cgcctccgcc ccgcgcgtcc ggggcctgcc cgtcagtccg tcggtccgcg
      121 tggagcagct cgggcgccgc cgtgctcccg atccccgcag ctgcagcgcc gcagtcctgg
      181 cccggacgcc cgggcaagtt ctccagagtt aaaagcgaag ttcgggcgag gcgcgggccg
      241 agctgcctct gagcgccccc ggcgtcccca gtgcgcccag ccccgccggg ggcgccggtg
      301 acccttcggt gccagccatg tcgtccatcc tgcccttcac ccccccgatc gtgaagcgcc
      361 tgctgggttg gaagaagggc gagcagaacg ggcaggagga gaagtggtgc gagaaggcgg
      421 tcaagagctt ggtgaagaag ctcaagaaga cggggcagtt ggacgagctg gagaaggcca
      481 tcaccacgca gaacgtgaac accaagtgca ttaccatccc caggtcactg gatggtcggc
      541 tgcaggtgtc ccatcggaag gggctccctc acgttatcta ctgccgcctg tggcgatggc
      601 ccgacctgca cagccaccat gaattacggg ccatggagct ctgtgagttt gccttcaaca
      661 tgaagaagga tgaagtgtgt gtaaatcctt accactatca gagagtagag acgccagttc
      721 tacctccagt gttggtgcca cgccacaccg agatcccggc cgagttcccc ccactggatg
      781 actacagcca ttccattccc gagaacacta acttccctgc tggcattgag ccccagagca
      841 atattccaga aaccccacct cctggctacc tgagtgaaga tggagaaacc agtgaccacc
      901 agatgaacca cagcatggac gcaggttctc caaacctctc cccgaatccg atgtccccag
      961 cacacaataa cttggaccta cagccagtca cctactgtga gccggccttc tggtgctcca
     1021 tctcctacta cgagctgaac cagcgagttg gggagacatt ccacgcctca cagccatcca
     1081 tgacagtaga tggcttcact gacccctcca actcggagcg cttctgcctg ggcctactgt
     1141 ccaatgtcaa ccggaatgca gccgtggaac ttacaaggcg acacattggg agaggtgtgc
     1201 ggctctacta catcggaggg gaggtctttg cggagtgcct cagtgacagt gctattttcg
     1261 tccagtctcc caactgcaac cagcgctatg gctggcaccc ggccactgtc tgcaagatcc
     1321 caccaggctg caacctgaag atcttcaaca accaggaatt tgctgccctc ctagctcagt
     1381 ctgtcaacca gggctttgag gctgtctacc agctgacgcg catgtgcacc atccgtatga
     1441 gcttcgtcaa aggctgggga gcagagtaca ggagacagac agtgaccagc accccctgct
     1501 ggattgagct acacctgaat ggacccttgc agtggcttga caaggtcctc acccagatgg
     1561 gttccccgag catccgctgt tccagtgtgt cttagagaca ctaggagtaa agggagcggg
     1621 ttggggaggg cgggcttggg gaaaatgacc ttggaagaga actccatcca acttggtctt
     1681 gtcaaagaac accgattcca ctcaactaag gcaccagcct gtttctgaga ccacagaaga
     1741 aaaccccagg gatggattta tgaacagctg tgtctgctac atacacgtgc ccctgtctga
     1801 aggccaagtg atggcttctg ttctggtggc ttgaactaac aggtggtgta tcgccacctg
     1861 actccttgtt taatgacaga ggtctgggat gtcacagtcc aaaaggaaag tgcctttctc
     1921 catggctgga gtatggagtt tacctttgga gaagttgtaa tggagcatgc cctgtcccac
     1981 cactctcaga gagggtgtac ctgtcaaact ggatggccta cataggtact cccccctacc
     2041 cctaggatgc agagagacgg gaacacgccg gagggtagag ctggggagaa cccattcttc
     2101 cttggaagga tccgctgaag gtcagcgtat aggtgatgta cagttcctaa tatcacatca
     2161 gtctcagagt gttcacagga agcagcaagg gcactcgtgg agtatgtgtc ctgggtgagg
     2221 tggcaccaca ccgaatgaat gcatctctgg gagctggcac cacaaccctg atgtataggc
     2281 tgtgttggtt tatggagaca agttgcatca atgaattcac ctagcatagg ctctttgaaa
     2341 tgtcctctgt ttgataaaaa acaatcctgg gtacgtatgt tggctggaaa accacaatgg
     2401 accctgccac tgcttcttgc cctgaggttt ggaagctgag agttatagaa gccaattcac
     2461 caggaggtaa gacatcccag gctgacatgg gcaaatgaaa agggctatta aaattttttt
     2521 acaccttgga aaattgcagg cttggtgcag agcgctctgt catcttcacc ctgggatgta
     2581 ggattaccta gctatggtaa aggattgcca cagcaaactg tgacactgtg taatgagcac
     2641 tgttcccagc ggcaattaca gagaaaacga gtgtaaatta tttcaactgg aaaaaagtcc
     2701 ctttcttggc tgttttagaa cagggtacac aggatcgcca cctgcaactg gtactcgctt
     2761 cttggctgct gcttctgttg tgaaaagacg agcccatgtt tctgcatgga tttcccatgg
     2821 aagtcctgtc ctgctacaga ggggaagaaa gtgtaccctc caatgtgata aatcttctga
     2881 tgcccccaga ctcttggagc acatcctggt gcccctcctg caggagcctg tggcatattt
     2941 ccagctgggc atgctgatcc tccttgagac acagatgcct gtgtgagtct ccgttgatac
     3001 aattctgaac ccctcaggtt ctctgaaagg gcacagacca tgggcgtgaa cattgtgccg
     3061 tacctgagat ggtctgtgga ctgctgcttc agacacacga gtcctcggaa ctgcctggct
     3121 gcctgtcacg catgctctga gtcagaacac accaacgctc tgctgtggct cctagggaag
     3181 cattcatggt cctctgttat cagcaggggt ttatgtcact tgctgtccgg tttcctaggg
     3241 gcttcctgtg ccccttcccc agctatcctc caggtggcta gggacagtct attctgctgc
     3301 aactggaaag tagagggaac cggcactgct cagagcagat ggcggcttct ggaggcacac
     3361 agtgggagta caccccttca tgttattggc cagttgctgg agaatgctgt aggagaaaat
     3421 tctaggcagg tctactcttg gcatccctga gagtcaaagg cttggagtct aggaaaggtc
     3481 acaccatgat ggagaacaca ggtcatttgg gtacgtgtaa tcaaagtgcc ctcccaaatc
     3541 agttctcctt ttcgtatgaa cagcatctct acttttaaag aggagttgag gatcgagaag
     3601 atgacagtgc agcagtgggt gtggcctgac tacatgtgct gttccagccc tgggtgccca
     3661 ctgacaccga cccccaggca gaggcctttg tcttcagcac tcctgagaag ttggctcttt
     3721 accccttctc ctctgctgcc cctccttcct gctggttcag gtagccccag ccacgtgggt
     3781 tagagtcctg tgctggcctg ccatggcagc tggctacctt ccagaccaac tgtagagata
     3841 cctggcattt tgaagaaagc ctagactgga gagcagggcc tctcttggga aggacacaag
     3901 gcgggcaagg ctgctggcag acttctccac tgacctgagt gtgctttttt tttcccctaa
     3961 atgtattgca tcaagcctca gtgcttatgg agtgcagtgg tcttcatctt ccccaacttg
     4021 cttctcagag ctgggatgta ttccagagcc tgatgttttt attcaaacca cagaaaagtt
     4081 ttctttaagt agcctgtgca gtcatgcatg tgcctgagtt gtctggagca gaggcaaaca
     4141 tctgacttca ttcttagccc caagctgcca tttctgagtc cttgagaggc tgagaaggct
     4201 ctagctttgt actgtattct tactgtgtga ctagatgcgt gagcgcttta cattagaagg
     4261 aacctggtta gagctcgctc ctcctgtctt tgtgtggcat ttgtgttcca ttaccggccc
     4321 ctttaagtaa cggccttcac agcaccttcc cagtgggtag aaagccacac accaggatgt
     4381 gggtcaacca tgaagatgtg gcattgcaga cgggggaaca tgtggatgca tggctatcgc
     4441 cctgaacagt ccctgcagct acttgtgtta acacagaact gatgtttagc attctgccgc
     4501 tttcgtattt atgtaacaat tccttaaagc cattcaaatg gctaactatt taatttcttt
     4561 aggacagttg taaaggtctc tctcctgagg acaatgactt ggaagaactg gggcacagcc
     4621 agtcccagac actggtggag gctgcagtga ctttttttgg ctcaagatcc acaagcatta
     4681 gagtagactg ggccaacaag tcaacaagtg gtggcgtgtg caaacgggct gccctagtca
     4741 agcccagtcc cttcaacagt atgtctgatg caccacaggc cctccctact ggaagtggga
     4801 acttcaaatg gaaattggag ccatctttta tcccagaagc ctttgctgct gccagggcaa
     4861 gtgggctggt gtggactctt gtttaggagg ctgaggttct tgtcactcct tagccagcca
     4921 ggcctttagt gtctttgtaa aaagcatgta tttatagtgt tttagatttt tctaactttt
     4981 gtatcttaca gcattgtacc ccattgttaa agagccgtgt cccctcttct tataaacgcc
     5041 cttctaataa acttttcacc gtaaagctcc tgagacagga gcacagtctg
//
