LOCUS       NM_010754               8752 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus SMAD family member 2 (Smad2), transcript variant 1,
            mRNA.
ACCESSION   NM_010754
VERSION     NM_010754.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8752)
  AUTHORS   Hrncir,H.R., Goodloe,B., Bombin,S., Hogan,C.B., Jadi,O. and
            Gracz,A.D.
  TITLE     Sox9 inhibits Activin A to promote biliary maturation and branching
            morphogenesis
  JOURNAL   Nat Commun 16 (1), 1667 (2025)
   PUBMED   39955269
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8752)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   3  (bases 1 to 8752)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8752)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8752)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8752)
  AUTHORS   Dick,A., Risau,W. and Drexler,H.
  TITLE     Expression of Smad1 and Smad2 during embryogenesis suggests a role
            in organ development
  JOURNAL   Dev Dyn 211 (4), 293-305 (1998)
   PUBMED   9566949
REFERENCE   7  (bases 1 to 8752)
  AUTHORS   Waldrip,W.R., Bikoff,E.K., Hoodless,P.A., Wrana,J.L. and
            Robertson,E.J.
  TITLE     Smad2 signaling in extraembryonic tissues determines
            anterior-posterior polarity of the early mouse embryo
  JOURNAL   Cell 92 (6), 797-808 (1998)
   PUBMED   9529255
REFERENCE   8  (bases 1 to 8752)
  AUTHORS   Devereux,T.R., Anna,C.H., Patel,A.C., White,C.M., Festing,M.F. and
            You,M.
  TITLE     Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1):
            candidates for murine lung tumor resistance and suppressor genes
  JOURNAL   Carcinogenesis 18 (9), 1751-1755 (1997)
   PUBMED   9328171
REFERENCE   9  (bases 1 to 8752)
  AUTHORS   Chen,Y., Lebrun,J.J. and Vale,W.
  TITLE     Regulation of transforming growth factor beta- and activin-induced
            transcription by mammalian Mad proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12992-12997 (1996)
   PUBMED   8917532
REFERENCE   10 (bases 1 to 8752)
  AUTHORS   Baker,J.C. and Harland,R.M.
  TITLE     A novel mesoderm inducer, Madr2, functions in the activin signal
            transduction pathway
  JOURNAL   Genes Dev 10 (15), 1880-1889 (1996)
   PUBMED   8756346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU058005.1, AK007817.1, AC164009.3, BC058713.1, CN456711.1 and
            BM248478.2.
            
            On Nov 16, 2011 this sequence version replaced NM_010754.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007817.1, BC021342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               BU058005.1         32-255
            225-2475            AK007817.1         2-2252
            2476-3184           AC164009.3         66141-66849
            3185-7968           BC058713.1         1-4784
            7969-8414           CN456711.1         248-693
            8415-8752           BM248478.2         1-338               c
FEATURES             Location/Qualifiers
     source          1..8752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 51.42 cM"
     gene            1..8752
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="SMAD family member 2"
                     /db_xref="GeneID:17126"
                     /db_xref="MGI:MGI:108051"
     exon            1..279
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..567
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1735
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mothers against decapentaplegic homolog 2; mad-related
                     protein 2; mothers against DPP homolog 2; Smad 2; MAD
                     homolog 2"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 2
                     isoform 1"
                     /protein_id="NP_034884.2"
                     /db_xref="CCDS:CCDS29350.1"
                     /db_xref="GeneID:17126"
                     /db_xref="MGI:MGI:108051"
                     /translation="MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKA
                     VKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLY
                     SFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEV
                     CVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIP
                     ETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCS
                     IAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGR
                     GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAA
                     LLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLD
                     KVLTQMGSPSVRCSSMS"
     exon            568..657
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..851
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..986
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1061
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1115
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1328
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1466
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1611
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..8752
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="hexamer: TATAAA"
     polyA_site      2155
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="major polyA site"
     regulatory      2277..2282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="hexamer: AACAAA"
     polyA_site      2294
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="major polyA site"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="hexamer: AATAAA"
     polyA_site      2732
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="major polyA site"
     regulatory      7951..7956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="hexamer: AATAAA"
     polyA_site      7971
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
     regulatory      8564..8569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /note="hexamer: AAGAAA"
     polyA_site      8587
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
ORIGIN      
        1 cgccccgctc ggcccccggc cctgcccgcg gcgcccggcc tccttccgtc cctgccgtgc
       61 tccctccgtc ttccgtgcgc gcccgctcgg ccggcgtgcc tcacgcctaa cgggcggccg
      121 cgggcgccaa tcagcgggcg gcagggtgcc agcccggggc tgcgccggcg aatcggcggg
      181 gtccgcggct cggggaggga ggcggggcta ccgcgcgcgg cggtggagga gcagctcgcc
      241 aagcctgcag ctcgcgagcg ccgagcgagc ctcccggagg gtagatttac cgggcttttt
      301 ctgagtgtgg attgttacct ttggtaagaa aatgtcgtcc atcttgccat tcactccgcc
      361 agtggtgaag agacttctgg gatggaaaaa atcagccggt gggtctggag gagcaggtgg
      421 tggagagcag aatggacagg aagaaaagtg gtgtgaaaaa gcagtgaaaa gtctggtgaa
      481 aaagctaaag aaaacaggac ggttagatga gcttgagaaa gccatcacca ctcagaattg
      541 caatactaaa tgtgtcacca taccaagcac ttgctctgaa atttggggac tgagtacagc
      601 aaatacggta gatcagtggg acacaacagg cctttacagc ttctctgaac aaaccaggtc
      661 tcttgatggc cgtcttcagg tttcacaccg gaaagggttg ccacatgtta tatattgccg
      721 gctctggcgc tggccggacc ttcacagtca tcatgagctc aaggcaatcg aaaactgcga
      781 atatgctttt aatctgaaaa aagatgaagt gtgtgtaaat ccgtaccact accagagagt
      841 tgagacccca gtcttgcctc cagtcttagt gcctcggcac acggagattc taacagaact
      901 gccgcccctg gatgactaca cccactccat tccagaaaac acaaatttcc cagcaggaat
      961 tgagccacag agtaattaca tcccagaaac accaccacct ggatatatca gtgaagatgg
     1021 agaaacaagt gaccaacagt tgaaccaaag tatggacaca ggctctccgg ctgaactgtc
     1081 tcctactact ctctctcctg ttaatcacag cttggatttg cagccagtta cttactcgga
     1141 acctgcattc tggtgttcaa tcgcatacta tgaactaaac cagagggttg gagagacctt
     1201 ccatgcgtca cagccctcgc tcactgtaga cggcttcaca gacccatcaa actcggagag
     1261 gttctgctta ggcttgctct ccaacgttaa ccgaaatgcc actgtagaaa tgacaagaag
     1321 acatatagga aggggagtgc gcttgtatta cataggtggg gaagtgtttg ctgagtgcct
     1381 aagtgatagt gcaatctttg tgcagagccc caactgtaac cagagatacg gctggcaccc
     1441 tgcaacagtg tgtaagatcc caccaggctg taacctgaag atcttcaaca accaagaatt
     1501 tgctgctctt ctggctcagt ctgtcaacca gggttttgaa gccgtttatc agctaacccg
     1561 aatgtgcacc ataagaatga gttttgtgaa gggctgggga gcagaatatc ggaggcagac
     1621 agtaacaagt actccttgct ggattgaact tcatctgaat ggccctctgc agtggctgga
     1681 caaagtatta actcagatgg gatccccttc agtgcgatgc tcaagcatgt cgtaaaccca
     1741 tcaaagactc gctgtaacag ctcctccgtc gtagtattca tgtatgatcc cgtggactgt
     1801 ttgctatcca aaaattccag agcaaaaaca gcacttgagg tctcatcagt taaagcacct
     1861 tgtggaatct gtttcctata tttgaatatt agatgggaaa attagtgtct agaaatgccc
     1921 tccccagcgg ggaaaaagaa gacttaaaga cttaatgatg tcttgttggg cataagacag
     1981 tatcccaaag gttattaata acagtagtag ttgtgtacag gtaatgtgtc cagacccagt
     2041 attgcagtac tatgctgttt gtatacattc ttagtttgca taaatgaggt gtgtgtgctg
     2101 cttcttggtc taggcaagcc tttataaaat tacagtatct aatctgttat tcccacttct
     2161 ccgttatttt tgtgtctttt ttaatatata atatatatat atcaagattt tcaaattatc
     2221 atttagaagc agattttcct tgtagaaact aatttttctg ccttttacca aaaataaaca
     2281 aactcttggg ggaagacaag tggattaact tggaagtcct tgaccttcat gtgtccagtg
     2341 gatcttagca gtcgttcttt tgtgagcctt ttctcctgag ttgcattaga aggaaacctt
     2401 actggaaccg tccaggctcc tcatcccatt cctgttctgg ttcagagcag tacagcagaa
     2461 tgacgtcgtg ctaaacagtt gcactgctgg cttctgggtt agttgtttct gagtccagga
     2521 aaggtttgtg tgggcagtaa gtccttttgt ctaataacca gacttcagca gatgataact
     2581 gatgtgtata accagttgtt ctgttgatta acttttgtct caaacatgca caggtggcag
     2641 tataattatt ttcagggcta ttctagaatc atctcagtct gtttccttct tccaaagcca
     2701 gtctaataat aaagtacctt tctgtaaagg cagccgacct tttgcctcat tttactttta
     2761 ctaccaggtt gtattacaga acagaccttt tgtaaatgtg ttagagtgac gctgaggtct
     2821 tgtcagcaga tagggccatc tgtttttaaa gtgtattgta tgtaatttat aagtagaatg
     2881 ttattttacc tagcttcaaa ggtttaaata ttgtgagcta agccatttag caagatttct
     2941 agcccgcagt tagctgtgga cttagctctt cctgacttac cctgggtgtg tggtttgctg
     3001 acctttcagc tctgcaggaa ggagatccca gctgtccttt ggtcctccct tctgcagcac
     3061 acgacagtca tgtccagtgt tgactccttt ctcgtttgca actccgtaca aatgcctggt
     3121 ctcctttttg taaactttca tatttttgca gacaaatact tttggtactt actctttgag
     3181 accattctca catgtatgta cagtaatcat ttttgatgct tttcaacatt ggttgttttc
     3241 tatttgatat ttctcatttt cctatatttg tgtttgtatg ttatgtgttc atgtaaattt
     3301 ggtatagtaa tttttattca aatatttatt gttcacctgt taatgtgcca tgaacttcct
     3361 taacttttgg gtgaaggtga acaagatagc tatagttcct gcctttgcta agagcagttg
     3421 gtttaaccca tactcaagtg tctgcatagg aggtaaacag ggtatacttt gagaatggca
     3481 gagacgatgc ttttggtagg atattaggaa ggcatctgga gagtgatgtg taagctaacc
     3541 cctgacctag gaagagaaag ccatgtgaag agccaagggc aatttaacac tgctggaaca
     3601 ttatcagcat ccaaaggctc aggctcatag agactcactg tcaggtatca tgattgtgca
     3661 cacacctgca cacacccaca cgtggtgatg aaaatgcttg ttcagtttag aatttgttga
     3721 aggtgggact gctttgtgac aggctgcttc tgtcatctca ctgtaatcta ttcctcagac
     3781 cttgtacagc tttcttacac caggtcagtg ccacttaatt taacaactcc cgttacgtaa
     3841 atgctcacca gtctggagcc tccctgcttg cttctggacg tgttgctgca tatcggctat
     3901 cactgcttcc cttccgctgc ccatcttgtg atagagcaat tgtcctgtgc attattgctg
     3961 ttgagcctac tggagatcct tgtacataaa ctgccccttc tctggaagtt tccacagact
     4021 agaaaacttg agctgttggg acagttctgg ggcagaggac agctttgaaa gtggtaggag
     4081 gttatcagac atgttaaagt gttgccaaca gtgagacaca gctccatggt tggggttcag
     4141 gaataggttt tctataccac cgagcgtgaa caagtcaccg tgtaaactca tgtgaaaaga
     4201 attcagtgct tatctttgct tttcaccgga atgctgtggg catgcgctac tgtcacctag
     4261 attttgttga tttcacctct tttgcaagac tgatttttgt tccagatgat tcctacggcc
     4321 tctcttggtt gatttatatt gatttaattt ctccacatta tttagcatca tgtctcagca
     4381 gtaatttgaa agcctttcta ccagattcaa acatttggtt gtattaggcc agtcttttgg
     4441 aatgccacta aactgggctg tgacttaagg accctttcct gctagggtct gagccacacc
     4501 agttagactt actatccatc gttatataca tttagtcagc atagttcctg cctattgttt
     4561 acccagccaa tgtgattctg ggaccatgtc ctggctctgg agttgggctt agtcctgtga
     4621 gagttcctgt tgttttcagg gcctatgact ttgccagaag gaatttgcat atgttttctt
     4681 gagagctgaa tcttctaatt gtgtacatat atgtatgtat atgtacagag ttccttcttt
     4741 gtttctttaa tttcaccttc atcacgcctt ggttgtcagt tcatcccgac taagagtcca
     4801 agtcagtcag gttagtaggc ttttgctggt tgaagtcaaa gaaagcagat gcccagttgc
     4861 cttccctacc tctgccaaga gctgcccgta tgtgttttta agccctcccc ctttttttaa
     4921 gattaactac ttggaacagt tgttctctta ggtgtcctct ttgctggaga gtagttgatt
     4981 tggtggtgag gtataaagta aggagacaat ctaagttgac ccttccagct tgcctgtgtg
     5041 ttgcacctct ctgtgcaact atctcaggta tgtcttcaca gggcagccaa gggcctttcc
     5101 ccatactgtg gcttaaggct ttggtgtcct gatagatcag acttattact tgtcatgctt
     5161 ttgcctgagc actttgctaa acccaggctt ccttgcacct taccctcccc agtcaatcag
     5221 ctctattttt ttttctgaat gcattctgta ttcttccctt agtgcgatgc atttccctgc
     5281 aggcaagcta gtattgttca ttcctggacc gttgttggag tctttcaaat gactctggaa
     5341 tttttgccca gttaaaatgt ccctgtgact gacaagtagc aaactcaaca ttatttatca
     5401 tagtttagat ggtaacagca tctccatcac agtttgggga cagtctagat cagcggtgtg
     5461 accctttagt gcagttcctc atgttgtggt gacccccagc cataaaatta ttttattgct
     5521 acttcattac tgtaattttg ctactgttat gaatcataat gtaaatatct ttgatttttg
     5581 atggtcttag gtgacccctg tgaaaaggtt gtttgaccac ccctccccca aggggttgca
     5641 acccacaggt tgagaaacca ctgttgtaaa gtgtccgatt tattccagtg atggtggtct
     5701 gtggtctgca gaggtagacc tctgccattg gctcctcttc tgttttccag cttgcttgat
     5761 tattttactt gttcagacta ccttttgtcc agggagattg agggacaagt tatttcttgg
     5821 attatagttt atgtgtttaa atacttggag ccagaaaatg ctgagttaat ctcatgagtg
     5881 cttttgcgat aagaattggc ctcatgtgtt atatcttgaa tagagacttt taccttggcc
     5941 attataggta gcttatatac atgagagttg cctcaaacat tttagtttta gtgtatatgt
     6001 gtgtgtgtgt tcaagtgtac acacatgtac cctcagaaaa caaacggtgg ggttatctta
     6061 acaatgatga aagatacatt gtttaaatct cagatctcag taaagagatc ccatttgctt
     6121 gtagactcat gacacaatca gtgtatttaa aatgaaatta ccagtcctta tttgacagtg
     6181 cagctggtat gctggtgttc gggcactggt gaaaatcata agaaatcaat taccgccaat
     6241 aaagctttcc atatacctca tccctaaact acacccagca ctgagggtta acttgaaaat
     6301 ctgtctcttc ttcatttggg tctccccatg aaattccaga gacccgggaa gtacctccat
     6361 gaagtcagag tcccacacct aatgctactc taaaggaagg tagttcaggc ctgtcttggc
     6421 agtgaactac caagaaatga ttttccaaga cttcttagaa cctctgtata ctaaccacct
     6481 atgtgttcat tggctagctt ctgagtctta gagtggaccc caggtttcac aaatgctaga
     6541 gatgtaggat cccttgggaa aaggggtgtt ttttggtttg ctattttggg atggaaggta
     6601 aggatttgta ccttttttct gtcttgaagt aatttttaaa caaccaaata cgcaacataa
     6661 gaacagatac aaagctttag cgtgttggaa aacgctctga ttagtgtaca acttccaaac
     6721 cagctgttac ccttcctctc tctggcttta aggttcctgg ctggttgcag tggtaaacac
     6781 taagtaactt tatgtttcta aggctgtatt aaattgtgcc cttcacagtg ttgtgtcata
     6841 gggggttggc tttggggagc tgagaagaaa cctgccttga agggccagtg cctagctggt
     6901 tgcacatttg tccttgcctc tgtagggtgg tggattattg gcttatagag gtagtttaca
     6961 gagactggtt taaatcacga gaataactaa ccaacccctg gcctctgaac catgtatgta
     7021 catataccga tccagcctat ttcttggtaa aatgcagaat tcaaattggg cacacattag
     7081 accagcttta ccttcgactt catttacgct tttattgact ctgacataag gtgtgagtat
     7141 ttgactttct ttgttggtgg cagtgatctg taacactcag cactttctag gtgagctaaa
     7201 ccaagaaaat ccacagtgac tggctaaggc tgcaacttca ttggaaggca agtgaaaaag
     7261 catcagaggc ctcctgcctc aaggctggcc tcctgggagc tcagtacaca gtagtgtggc
     7321 tctgggcctc tgcaagggcc ttcaagcttg gctgtcctca tacacgaaat tagaatgtgg
     7381 gagtagttgg cgttgaaggt cttcacattt aaagggatat aaaacgatac atgaaactag
     7441 aatattcatt tagctcagaa aatctcaaca cgtggtaggt aagatgctat gtaacttacg
     7501 ggaacaggag actcgggacg tcttgtctga aagtgggttt caagagtgaa gtctgataca
     7561 ctaccactaa atgtacttgg tctgagttaa ataaccttaa ggtatttccc agcttccagc
     7621 tggttagcct ttagcaagag agctacaagt gcattgtcct taaggagcct tatgtacaca
     7681 gacgttcttt tctctgcacg tgtcaaggga aggtgaccag tcccagccat gcctgggaca
     7741 agggtcccag atatgcaatg ctaagtgcca accaaagtga gtcctagggg tcctgggagg
     7801 agttgtcccc ttaggtgtcc tcaggactta ttctcatact gatgtcatcc tagctgataa
     7861 ctgtgttggg ttatgccatg gctgtcaata tttttaggac tcaacccctg tattctgtat
     7921 tcattactgt ggatgcaacc taagatttac aataaataac acaaagaaca atggagttga
     7981 gtatggaatg aaaagaggca acgagctagg gatgatctgt gtaggtgtaa gtacactttg
     8041 tgtccttagg agttcttgta acagaaaccg tgtgaaacta tagatgtctt ctcctataag
     8101 ggaaaacatg gtgtttgatg ctttggtctc tatttcccag tctgtcctgc ttaagaagcc
     8161 agaatgtggt ttctatttgg tggatgctgt cttaaaatta ctaaatgtgt catccggaag
     8221 caggtaaagg agtcagtatc cctgtggagt tctgtcctac tctcacggtg cttaccagct
     8281 aagctgagct caggagccaa gggaaaccct gctcctgctc tctggtggtc ctcagtggct
     8341 gatgcagtgc actgtgatgg agatactaaa acaagtgtgt tatttgtaag tcttctctca
     8401 gtgattgtca gacaactgtg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     8461 gagaaacagt gagctgaggc tttattatag ctgatttcca gttaaaattg tgaaatacgt
     8521 atttcttgtc cacaccaaat atttcagtct atttaatgta ttaaagaaat agttctgctt
     8581 aagaaaatgt tgcttaaatg ttctgtgatt tctggtgcat ttttatacag atctgtgtgt
     8641 gtctgtgcat tcactttctg cctttgctct ctgtgttaac tgtcctgttg ccctcggaag
     8701 gtggacacta ttcgtagcat taaaaagaaa tatttgagtt atttaccatg tc
//
