LOCUS       NM_008539               3040 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus SMAD family member 1 (Smad1), mRNA.
ACCESSION   NM_008539
VERSION     NM_008539.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3040)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   2  (bases 1 to 3040)
  AUTHORS   Lehr,S., Bruckner,D.B., Minchington,T.G., Greunz-Schindler,M.,
            Merrin,J., Hannezo,E. and Kicheva,A.
  TITLE     Self-organized pattern formation in the developing mouse neural
            tube by a temporal relay of BMP signaling
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39603235
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 3040)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3040)
  AUTHORS   Kibalnyk,Y., Afanasiev,E., Noble,R.M.N., Watson,A.E.S.,
            Poverennaya,I., Dittmann,N.L., Alexiou,M., Goodkey,K.,
            Greenwell,A.A., Ussher,J.R., Adameyko,I., Massey,J., Graf,D.,
            Bourque,S.L., Stratton,J.A. and Voronova,A.
  TITLE     The chromatin regulator Ankrd11 controls cardiac neural crest
            cell-mediated outflow tract remodeling and heart function
  JOURNAL   Nat Commun 15 (1), 4632 (2024)
   PUBMED   38951500
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3040)
  AUTHORS   Wang,Y., Wang,J., Xu,T., Yang,S., Wang,X., Zhu,L., Li,N., Liu,B.,
            Xiao,J. and Liu,C.
  TITLE     Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor
            Agenesis and Molar Microdontia
  JOURNAL   Int J Mol Sci 25 (13), 7045 (2024)
   PUBMED   39000154
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3040)
  AUTHORS   Foley,K.P., McArthur,G.A., Queva,C., Hurlin,P.J., Soriano,P. and
            Eisenman,R.N.
  TITLE     Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle
            exit during granulocyte differentiation
  JOURNAL   EMBO J 17 (3), 774-785 (1998)
   PUBMED   9451002
REFERENCE   7  (bases 1 to 3040)
  AUTHORS   Meersseman,G., Verschueren,K., Nelles,L., Blumenstock,C., Kraft,H.,
            Wuytens,G., Remacle,J., Kozak,C.A., Tylzanowski,P., Niehrs,C. and
            Huylebroeck,D.
  TITLE     The C-terminal domain of Mad-like signal transducers is sufficient
            for biological activity in the Xenopus embryo and transcriptional
            activation
  JOURNAL   Mech Dev 61 (1-2), 127-140 (1997)
   PUBMED   9076683
REFERENCE   8  (bases 1 to 3040)
  AUTHORS   Zhao,G.Q. and Hogan,B.L.
  TITLE     Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in
            the initiation and maintenance of spermatogenesis in the mouse
  JOURNAL   Mech Dev 61 (1-2), 63-73 (1997)
   PUBMED   9076678
REFERENCE   9  (bases 1 to 3040)
  AUTHORS   Yingling,J.M., Das,P., Savage,C., Zhang,M., Padgett,R.W. and
            Wang,X.F.
  TITLE     Mammalian dwarfins are phosphorylated in response to transforming
            growth factor beta and are implicated in control of cell growth
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 8940-8944 (1996)
   PUBMED   8799132
REFERENCE   10 (bases 1 to 3040)
  AUTHORS   Katagiri,T., Yamaguchi,A., Komaki,M., Abe,E., Takahashi,N.,
            Ikeda,T., Rosen,V., Wozney,J.M., Fujisawa-Sehara,A. and Suda,T.
  TITLE     Bone morphogenetic protein-2 converts the differentiation pathway
            of C2C12 myoblasts into the osteoblast lineage
  JOURNAL   J Cell Biol 127 (6 Pt 1), 1755-1766 (1994)
   PUBMED   7798324
  REMARK    Erratum:[J Cell Biol 1995 Feb;128(4):following 713]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058693.1.
            
            On Jun 9, 2018 this sequence version replaced NM_008539.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058693.1, AK054104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3040              BC058693.1         41-3080
FEATURES             Location/Qualifiers
     source          1..3040
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 37.56 cM"
     gene            1..3040
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /note="SMAD family member 1"
                     /db_xref="GeneID:17125"
                     /db_xref="MGI:MGI:109452"
     exon            1..176
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            177..757
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1015
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1132
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1354
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1611
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..3009
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2726..2731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /note="hexamer: AATAAA"
     polyA_site      2748
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /note="major polyA site"
     regulatory      2972..2977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /note="hexamer: AATAAA"
     polyA_site      3009
                     /gene="Smad1"
                     /gene_synonym="dwf-A; Mad1; Madh1; Madr1; Mlp1; mMad1;
                     MusMLP"
                     /note="major polyA site"
ORIGIN      
        1 agatcaatcc aggctcgggg agcgagcggg cgcaccaagg cgaggccggg gccgaggcgc
       61 ggggacggcg gcccggagct aagcagagcg cggggacggc ggccgggagc ggatcggagc
      121 acgggacccg gcgccgggtc tcgtgcgtcc ctgcggatgg gcgcgccgcc gagccggcgc
      181 taactgggat cctcgctgga acaggaggga cagtattttc tacctttcca aaccgcagac
      241 caagaagcta aggagaatct atgtaaatat actgaaatct ctgttggctc tgcgcccaac
      301 accccggagc tggcacctca ccctgtctga ggagcgtgta gaactagacc agccgctatg
      361 aatgtgacca gcttgttttc attcacaagt ccagctgtga agagactcct tgggtggaaa
      421 cagggcgatg aagaagagaa atgggcagag aaagctgtgg acgctttggt gaagaaactg
      481 aagaagaaga aaggggccat ggaagagctg gagaaggccc tgagctgccc tggacagccg
      541 agtaactgcg tcaccattcc tcgctccctg gatggcaggt tgcaggtgtc ccaccggaag
      601 ggactacctc atgtcattta ttgccgtgtg tggcgctggc ccgacctcca gagccaccat
      661 gaactgaagc ctctggaatg ctgtgagttc ccatttggtt ccaagcagaa ggaggtctgc
      721 atcaacccct accactataa gcgagtggag agcccggttc tcccgccggt gctggttccg
      781 aggcacagcg agtacaatcc tcagcacagc cttctggctc agttccgcaa cctgggacaa
      841 aatgagcctc acatgccact gaacgccacg ttcccagact ctttccagca gcccaacagc
      901 cacccgttcc cccactcccc caacagcagc taccccaact ctcctggcgg cagcagcagc
      961 acctaccctc actccccaac cagctcagac ccgggcagcc cttttcagat gccagctgac
     1021 acacccccac ctgcttacct gcctcctgaa gaccccatgg cccaggatgg ctctcagccc
     1081 atggacacga acatgatggc gcctccactg cccgctgaaa tcagcagagg agatgttcag
     1141 gcagttgctt acgaggaacc aaaacactgg tgctctattg tgtactatga gctcaacaac
     1201 cgtgtgggtg aagcgttcca cgcctcgtcc accagcgtgc tggtggatgg tttcacagat
     1261 ccgtccaaca ataagaaccg cttctgcctt ggcttgctct ccaacgttaa ccggaattcc
     1321 actattgaaa acaccaggcg acatattggg aaaggagtcc acctttatta cgttggagga
     1381 gaggtgtatg cggaatgcct cagtgacagc agcatcttcg tgcagagccg gaactgcaac
     1441 taccaccacg gctttcaccc caccaccgtc tgcaagatcc ccagcgggtg cagcttgaaa
     1501 atcttcaaca accaagagtt tgctcagcta ctggcgcagt ctgtgaacca cgggttcgag
     1561 accgtgtatg aactcaccaa aatgtgcact attcggatga gcttcgtgaa gggttgggga
     1621 gccgaatacc accggcagga tgttaccagc accccctgct ggattgagat ccatctgcat
     1681 ggccctctcc agtggctgga taaggttctg acccagatgg gctcacccca caatcctatt
     1741 tcatccgtgt cttaaaagac ctgtggcttc cgtctcttgc aaactatcga gccttgcatg
     1801 tacttgaagg atggacaagt cagacaggat ggagacctga cgaaggagcc acgataatac
     1861 ttgacctctg tgaccaacta ttggattgag aaactgacaa gccttggttg atagcaagaa
     1921 ccctttcagt ttacattgtg acattctgtt gtaaaaatca actaaaatgc tgactttcag
     1981 caggactttt gtgtatagtt aaaaaaaaaa gagatggcca agccagggac aaattatcta
     2041 ttaggaaaaa agaaaaaaat gattgtaatc aatccttttg tgtggggtgt tggcagaagg
     2101 ttggcgctga tagtctttct gaagtgggct ttcatcaggc tcagagccca cgttgaatca
     2161 tcttctcatg ggttttctta atattttaaa actacttgtt tagaaatgaa tgggtttttt
     2221 gtttgttttt aaagtacagg ttaatcgtta tgacatgcat agtaatcttt ctgaaactgt
     2281 atgctggctg tattactgtc agaatgatgg caggcatatg ctctttgcta aatatgtata
     2341 tacagaatat ttggaggtta tgaatagtct aaatggctag tgggtttaca gagtatctga
     2401 ggggcggggt cgggaagaaa acgacggctg caaatgtaga ctataccgta aagctcagct
     2461 tgctgcctta aacagacaag ctggtgtctg aatttgctgt gtttcagttt ttgtagagtt
     2521 ttatctgact tcttttcttc tgtcttatcc gctccacggc acagttaagc agctggttaa
     2581 ttcctctaac tgtgagagca gatgagtaat tccttctgtt cgcaaatcaa ctggcttcgt
     2641 gtttcagtac ccagtatatg aaaagcttga attgaatgag cagtttttat ggagtttaca
     2701 gtacagacat aggctttgat ttccaaataa attgtttgcc aaacctggta actctgttca
     2761 ttattcgcag gattaaagat ctctctattg gaatccattt caaaggttgt tttttttgtt
     2821 tttgtttttg ttttttgttt tattttgatt tgtttttttt tgtactattt ggtttctttt
     2881 cttctgttaa tttttttatt ctcctttgct cttatacagc gagtactttt attccaacac
     2941 tagcagggtt tttctctact ggaaattttt aaataaaacc tgtcattatt gcttactttg
     3001 attaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
