LOCUS       NM_028834               5106 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SLX4 interacting protein (Slx4ip), transcript variant
            1, mRNA.
ACCESSION   NM_028834
VERSION     NM_028834.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5106)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5106)
  AUTHORS   Robinson,N.J., Miyagi,M., Scarborough,J.A., Scott,J.G., Taylor,D.J.
            and Schiemann,W.P.
  TITLE     SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere
            maintenance through NF-kappaB and Notch signaling
  JOURNAL   Sci Signal 14 (689) (2021)
   PUBMED   34187905
  REMARK    GeneRIF: SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate
            telomere maintenance through NF-kappaB and Notch signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5106)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5106)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731706.14, AK008687.1, BC067037.1 and AL713981.17.
            
            On Sep 23, 2017 this sequence version replaced NM_028834.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 2 both encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.81673.1, BC071202.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AL731706.14        65358-65452
            96-1532             AK008687.1         2-1438
            1533-2928           BC067037.1         1350-2745
            2929-2929           AL713981.17        49679-49679
            2930-5106           BC067037.1         2746-4922
FEATURES             Location/Qualifiers
     source          1..5106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.65 cM"
     gene            1..5106
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /note="SLX4 interacting protein"
                     /db_xref="GeneID:74243"
                     /db_xref="MGI:MGI:1921493"
     exon            1..194
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /inference="alignment:Splign:2.1.0"
     exon            195..252
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1467
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0492 protein C20orf94 homolog; protein SLX4IP"
                     /codon_start=1
                     /product="protein SLX4IP isoform 1"
                     /protein_id="NP_083110.1"
                     /db_xref="CCDS:CCDS16795.1"
                     /db_xref="GeneID:74243"
                     /db_xref="MGI:MGI:1921493"
                     /translation="MASKKFAVKCGNFAVLVDLHVLPQGSNRDSSWFSEQKKEEVCLL
                     LKETIDSRVKEYVGIYKQRKPSSAEFTRSSPLSLKGYGFQITAYFLKRGIHLHCIQNS
                     QNTELRVFPERFVVCVSQLAFGHDIWANQNEKSTKKALHGVSDYFPECAESSPSPGTK
                     LKRNALKEIVRRTKSKGTDVSKPQPSGDLVGRSSDSVITVVPWRRDASAILLSESVGQ
                     AQDDIRAAKSHQELPVQKLENVSQTQPGDTRSQQQLHPGEWLKTGLLSRSPAYNYESA
                     SPGPKQSLRAAKTQQKHRNCGSVEDCDHRRRVSLGNEGLVPEDADRERSTAVRVLPAL
                     ELSDPGLLLKQDLAKAKAKEELHALENLSSRHLVTNNPGQAQQSDSAAITEQLATDQG
                     GPSKKRKKLQSYNRGCSGKKN"
     exon            253..342
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /inference="alignment:Splign:2.1.0"
     exon            343..463
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /inference="alignment:Splign:2.1.0"
     exon            464..541
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /inference="alignment:Splign:2.1.0"
     exon            542..630
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /inference="alignment:Splign:2.1.0"
     exon            631..731
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /inference="alignment:Splign:2.1.0"
     exon            732..5089
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5062..5067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /note="hexamer: AATAAA"
     polyA_site      5089
                     /gene="Slx4ip"
                     /gene_synonym="2210009G21Rik; 2410004I22Rik; Slxip"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttgggc gctggttgca ttctctaacg tgcgagggga cgctgggaaa cgggaagtaa
       61 gccaaagctg ctgaagcttg gtctgccgcc tttttagtct gagttttccc gttcaggtac
      121 tatactagtc caccagtgac cccggacagt aacaaagcat tacagcccga acccacctcc
      181 cgccaccatc gtaggttctg tacctcactt gggaatcagt aaaccatggc atctaagaaa
      241 tttgccgtta aatgtgggaa cttcgcagtc ctggtggatc ttcatgtatt gccacaaggt
      301 tcaaacagag actccagttg gttttctgaa cagaagaaag aggaagtttg tttgctgtta
      361 aaagaaacca ttgattccag agttaaggag tatgtgggca tttataaaca gcgcaagcca
      421 tcaagtgcag aattcacaag atccagtccc ttgtccttaa aaggttatgg ctttcagatc
      481 acagcttatt tcctcaagag agggatacac cttcactgta tccagaactc ccagaatact
      541 gaacttcgtg tatttcctga aagatttgtg gtgtgtgtta gtcagcttgc atttggtcat
      601 gatatttggg caaaccagaa tgaaaaatcg acaaaaaaag ccctccatgg agtgtctgat
      661 tattttcctg agtgtgcaga gagttcaccg tctcctggta caaagctcaa gaggaacgct
      721 ctgaaggaaa ttgtgagaag aactaaatca aaaggcactg atgtgagcaa accacagccc
      781 agcggggacc tcgtgggaag atctagtgac tcagtaatta ctgtggtacc atggaggagg
      841 gatgcctcag ccattctcct gtcagaatct gtgggtcaag cacaagatga cataagagca
      901 gccaagagcc accaggagct tcctgttcaa aagctggaaa atgtttctca gactcagcca
      961 ggagacactc gcagccagca gcaacttcat cctggggagt ggttgaagac ggggcttcta
     1021 agcaggagcc ctgcgtataa ctatgagtca gcatcaccag gtccaaagca aagtctgaga
     1081 gcagccaaga cacagcagaa acacaggaat tgtggctctg tggaagactg tgaccaccgc
     1141 aggagagttt ctcttggaaa tgaaggatta gtcccggagg acgcggatag ggaaaggagc
     1201 acagctgtca gggttttacc agccttagag ttgtcagatc ctgggttgct tttgaaacaa
     1261 gatttggcaa aagccaaggc taaggaagag ctacatgctt tggaaaatct ctcctccaga
     1321 catcttgtga caaacaaccc ggggcaggca cagcagagcg actcagctgc aattactgaa
     1381 caattagcta cagatcaggg cggccccagc aagaaaagaa agaaactaca aagttacaac
     1441 agaggatgta gtggcaagaa aaactgagga tacagtacct ggggtattgg aaggaattag
     1501 gacaattact ttaaataaat aaatttagga gctggagtta agtctcagct tttaagagca
     1561 cttagtgctc ttgcagagga accaagttta ggttccaagc acctagaagg tgacttacaa
     1621 ccatgatgaa ctccagatcc agaagaccca acacactctt tgacctccat gggcaccagg
     1681 catgcgcatg gtatgcatat ataccaggca aaacacacat acatgtaaat ctttttgtaa
     1741 aattgtttat gttggaattg gccttcatgg tcacctcctg gaggctgttt tcctaacagg
     1801 cttgttactt tttcatcatt ttagaactgt ctccagaaaa tactatattg acaaagagcc
     1861 atccactggt caaggagtaa actatgtatc taggacccca aggagaaatc agtaatggtg
     1921 gccttctcac cccatcacta tgaagacctc ctgattgggg gggggggggg ggcagagaca
     1981 gtgccaggta cttctggcca catcttgggc tgcagtcctc tgacttctca aactgagtac
     2041 ctgacagtaa gaataagtca gcagtctcag catgtgattc tgtgaggaat gcaggtattt
     2101 gggtctcaga catatggaat gaagaactgt gattctgaaa tggactaaag ttgaaaacag
     2161 ctccctagaa cttacatcct acagcctagt taccatggct tccatcagct ggcgacacat
     2221 gtggaaatgt acacccccgt gcttccttca gacttagatt tggggtgtga gtcactttgt
     2281 tcccaggttc atatactata ggatggacag aatgcctagg tctctcttat atctggagtt
     2341 accagaaatg tatgcgtaat tcatcccagt ctgagatgaa gacatggaag aggtgtgtcc
     2401 tgtgtagcac aagtttgacc ctgtccttgt ccacaccccc catattctgg ttgcagttaa
     2461 gacagaccag aatccaaagc tagggcagtg gccgttccag ttcccaattt ggaaaatttc
     2521 ccagggcatt taaatgacct cttcagttgt gtagtcagtc ctcaagaaag acaggaagcc
     2581 agagctatca gcctggacgc ttcatctgct caccccaacc tcaaaggacc agaaactgct
     2641 tgctggtgtc cctctccttt cccacctagc tttttttgtt ttcttgagag ctgattccaa
     2701 gatgttgagt cctcaatgta agcatgagta gtcacccttg tacagagcta agatattctg
     2761 acctggaata gacgggattt gaattgttta atggctaagg tcatattctg tacttaattg
     2821 tacttatacg aagaatatgc tttcaagaag tgttttgctt ttcaaatctg ttccattata
     2881 ttataggaaa tagtgattat tgtgaccaat aatttataaa aaaaaaaaag tatgttacgg
     2941 ttgtagatag atgtggcttt gtagcagcct tcatgcacaa tggattttaa caggattagc
     3001 agagctctgg gcttccatac tctgccatat gtttaaggaa ttttgccctt aatcattttc
     3061 cttcagcatg tttgaaacac ctctccatgt cctgtttctt gaatgatttt acaattcctt
     3121 gaatatatgc ataaaggggc aaattaatcc ccaatgtttt gttacttatc aggtgggaca
     3181 tgaagtattg tctactgttg ggaatggtat gagtttttat attcttaatt actgtaacaa
     3241 tttagcattt gaaagtctga gacagtgtca ggattgatag tcaaaaccaa gttcttcatc
     3301 aaaaccaagt tcttcaaccc tttcatcctc caaattaaat gtatatttag gtccctgtga
     3361 ttctgattct gagaggaagc gttcacccaa tccgtggata actgaactca agactccgca
     3421 gtacctgcga tgctaagccc ctccatgtac tatcaaatga catttcaata gatgaaagct
     3481 agtgaggtcc ttttgtattt tctttctttc tccctcctcc cccaatttaa aaacatggaa
     3541 aggctggcct ggtggcacat gcctttaatc ctagcacttg ggaggcagag gcaggtagat
     3601 ctctgagcca gactggtcta cataataagt tagtgaacag acaaaactac atagtgagac
     3661 cttgtctcag aacaaccaaa cagatcagta tgggaatcat ctgtgatttt tcttgcatac
     3721 gtgcttttct ttgccactgg aggttaactc accaagacat gcatatgact tgtgcagtgt
     3781 aaagaagcac ttggtgctgg aatagtatgg aaatgtattt aattttttaa aaaacaagac
     3841 tcatgagtct tgaatacttg gtgaagttgt gcatgtgcag tgatcactaa gacaccaata
     3901 agaaagaaaa agacacaaaa agtctctgta ttttgatgtt tgaagaatcc agttcatctc
     3961 tggatggacc ttctcaaagt ggatcttagt ggtgatgatg gggtctcagt ataattgttt
     4021 tatgtttgat gtcatgtttt gatttcagct gaaattgtac ctctcattgg cctttgactt
     4081 cagaaaaagc cccgactagg acggacacat agggaaggaa gcatctatgc ccaagagaat
     4141 gacctaggat cagtgtcagc cttcgtagtt ttttaagctc cttggcaggt cgtactgtaa
     4201 tatttccaca aaacagtagt gaacggccct ctgaataata agcaactttt caagagccaa
     4261 aacacgcact gtgcagcatg ctgggactag aatatggaaa ttgttttaat ttcttctttt
     4321 ctcttatgag gaaatcactg cacttggttt gtcaagacaa gacagttcat tcccctgtat
     4381 tgaaacagtg atgaattgaa acatgttgga gcaagttttt aaagaaaatc aaaattaaac
     4441 tggtttttct taaatagctt aaagcgttcc acagtacaca ataaatgaag cattgtaaaa
     4501 tgaacttaat gcaagtaatc acttaagaga gaagtttaag cagatagata tatatataca
     4561 tacacatata catcatcagt cttgcagttc caggctataa ttaattctca gaaacttgct
     4621 gaattccctc taattttgtt tctatatata cttaccaaga cagggagcaa atgtgtgtca
     4681 atatgtagca tgacaaagag aacttgggtg aagttttcta cttgtggaga cccatttgga
     4741 ctgggcttga aatatctctg ggtaaatctc atctgtggca gtgtccccac actacagtaa
     4801 ggcttccata accattctaa gcaaagactg cgcttttgtt tattgaagta aaatcagtaa
     4861 aagtgtgcag ttggctcccc aaggcagctg accggtgcta ataggtgcta atttgacaga
     4921 ttctcagaat gagtttccag atggaattag acagtaccac aatctccagg agagccctgg
     4981 tcctttcatt caagtatgct taatagactg agtgtccaca gaataaaaac acttttgttg
     5041 tgaaaatgta cctgttttat gaataaacat gtgggttttg tgaatttaaa aaaaaaaaaa
     5101 aaaaaa
//
