LOCUS       NM_001402925            6397 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SLX4 structure-specific endonuclease subunit homolog
            (S. cerevisiae) (Slx4), transcript variant 4, mRNA.
ACCESSION   NM_001402925 XM_030249179
VERSION     NM_001402925.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6397)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6397)
  AUTHORS   Elango,R., Panday,A., Lach,F.P., Willis,N.A., Nicholson,K.,
            Duffey,E.E., Smogorzewska,A. and Scully,R.
  TITLE     The structure-specific endonuclease complex SLX4-XPF regulates
            Tus-Ter-induced homologous recombination
  JOURNAL   Nat Struct Mol Biol 29 (8), 801-812 (2022)
   PUBMED   35941380
  REMARK    GeneRIF: The structure-specific endonuclease complex SLX4-XPF
            regulates Tus-Ter-induced homologous recombination.
REFERENCE   3  (bases 1 to 6397)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6397)
  AUTHORS   Alavattam,K.G., Kato,Y., Sin,H.S., Maezawa,S., Kowalski,I.J.,
            Zhang,F., Pang,Q., Andreassen,P.R. and Namekawa,S.H.
  TITLE     Elucidation of the Fanconi Anemia Protein Network in Meiosis and
            Its Function in the Regulation of Histone Modifications
  JOURNAL   Cell Rep 17 (4), 1141-1157 (2016)
   PUBMED   27760317
REFERENCE   5  (bases 1 to 6397)
  AUTHORS   Thongthip,S., Bellani,M., Gregg,S.Q., Sridhar,S., Conti,B.A.,
            Chen,Y., Seidman,M.M. and Smogorzewska,A.
  TITLE     Fan1 deficiency results in DNA interstrand cross-link repair
            defects, enhanced tissue karyomegaly, and organ dysfunction
  JOURNAL   Genes Dev 30 (6), 645-659 (2016)
   PUBMED   26980189
REFERENCE   6  (bases 1 to 6397)
  AUTHORS   Lyndaker,A.M., Lim,P.X., Mleczko,J.M., Diggins,C.E., Holloway,J.K.,
            Holmes,R.J., Kan,R., Schlafer,D.H., Freire,R., Cohen,P.E. and
            Weiss,R.S.
  TITLE     Conditional inactivation of the DNA damage response gene Hus1 in
            mouse testis reveals separable roles for components of the
            RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance
  JOURNAL   PLoS Genet 9 (2), e1003320 (2013)
   PUBMED   23468651
REFERENCE   7  (bases 1 to 6397)
  AUTHORS   Garaycoechea,J.I., Crossan,G.P., Langevin,F., Daly,M., Arends,M.J.
            and Patel,K.J.
  TITLE     Genotoxic consequences of endogenous aldehydes on mouse
            haematopoietic stem cell function
  JOURNAL   Nature 489 (7417), 571-575 (2012)
   PUBMED   22922648
REFERENCE   8  (bases 1 to 6397)
  AUTHORS   Vannier,J.B., Pavicic-Kaltenbrunner,V., Petalcorin,M.I., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 dismantles T loops and counteracts telomeric G4-DNA to
            maintain telomere integrity
  JOURNAL   Cell 149 (4), 795-806 (2012)
   PUBMED   22579284
REFERENCE   9  (bases 1 to 6397)
  AUTHORS   Holloway,J.K., Mohan,S., Balmus,G., Sun,X., Modzelewski,A.,
            Borst,P.L., Freire,R., Weiss,R.S. and Cohen,P.E.
  TITLE     Mammalian BTBD12 (SLX4) protects against genomic instability during
            mammalian spermatogenesis
  JOURNAL   PLoS Genet 7 (6), e1002094 (2011)
   PUBMED   21655083
  REMARK    GeneRIF: these data indicate that BTBD12 functions throughout
            gametogenesis to maintain genome stability, possibly by
            co-ordinating repair processes and/or by linking DNA repair events
            to the cell cycle via ATM
REFERENCE   10 (bases 1 to 6397)
  AUTHORS   Crossan,G.P., van der Weyden,L., Rosado,I.V., Langevin,F.,
            Gaillard,P.H.L., McIntyre,R.E., Gallagher,F., Kettunen,M.I.,
            Lewis,D.Y., Brindle,K., Arends,M.J., Adams,D.J. and Patel,K.J.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Disruption of mouse Slx4, a regulator of structure-specific
            nucleases, phenocopies Fanconi anemia
  JOURNAL   Nat Genet 43 (2), 147-152 (2011)
   PUBMED   21240276
  REMARK    GeneRIF: mouse Slx4, a regulator of structure-specific nucleases,
            disruption phenocopies Fanconi anemia
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087900.19.
            
            On Mar 23, 2022 this sequence version replaced XM_030249179.1.
            
            Summary: This gene encodes a protein containing a BTB (POZ) domain
            that comprises a subunit of structure-specific endonucleases. The
            encoded protein aids in the resolution of DNA secondary structures
            that arise during the processes of DNA repair and recombination.
            Knock out of this gene in mouse recapitulates the phenotype of the
            human disease Fanconi anemia, including blood cytopenia and
            susceptibility to genomic instability. [provided by RefSeq, Dec
            2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.19144.1,
                                           SRR17784644.1001241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AC087900.19        45864-46148
            286-1011            AC087900.19        47997-48722
            1012-1239           AC087900.19        50330-50557
            1240-1423           AC087900.19        53798-53981
            1424-1636           AC087900.19        54755-54967
            1637-1842           AC087900.19        57554-57759
            1843-2159           AC087900.19        57887-58203
            2160-2373           AC087900.19        58759-58972
            2374-2459           AC087900.19        59359-59444
            2460-2606           AC087900.19        60556-60702
            2607-2773           AC087900.19        61594-61760
            2774-4959           AC087900.19        62499-64684
            4960-5062           AC087900.19        67988-68090
            5063-5236           AC087900.19        68681-68854
            5237-5347           AC087900.19        68984-69094
            5348-6397           AC087900.19        69503-70552
FEATURES             Location/Qualifiers
     source          1..6397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.34 cM"
     gene            1..6397
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /note="SLX4 structure-specific endonuclease subunit
                     homolog (S. cerevisiae)"
                     /db_xref="GeneID:52864"
                     /db_xref="MGI:MGI:106299"
     exon            1..285
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            286..1011
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     CDS             657..5699
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /note="isoform 2 is encoded by transcript variant 4;
                     structure-specific endonuclease subunit SLX4; BTB/POZ
                     domain-containing protein 12"
                     /codon_start=1
                     /product="structure-specific endonuclease subunit SLX4
                     isoform 2"
                     /protein_id="NP_001389854.1"
                     /db_xref="GeneID:52864"
                     /db_xref="MGI:MGI:106299"
                     /translation="MEESDDDFKELCASFFQRVKRNGTKEASGERTRQKASGHTQNRG
                     KRKEGRQVAARSKALQGPSEKKPRLGSQTPRTTKQGAPKSQEGGPALPANGKGDVLAP
                     TPDQPVLCERAQSIQTESAPNGNSQPLPSCFTTTGVPSPSKPRVSELVLQRMKQFKRA
                     DPERLRHASEESPQKTALGDDVPRSPPEETVGENEYKLDATDSDAAMALALQQEFRRE
                     EASSHHDSLEEKGLFFCQMCQKNLSAMNVTRREQHVNRCLDEAEKAQRPASPRIPDCP
                     ICGKPFLTTKSRISHLKQCAVRMEVGPQLLLQAVRLQTAQPEVDGSPQVPSFSNNVGG
                     LKRKGVTTKREPRRRKVNKPEAPSEDLLVAMALSRSEVEHCPVVPPLRLENAFSEKIR
                     LGAEKKSRKKRPPVCPPQLVTQDSETTGRQIEDRVAQLLSEEAELSCTPPLLASKISK
                     EELEPAGWRARLPEGKRNFLWELSALTGAWAEESFYTVGLFPPIVSQCPSKEPQLPLE
                     LPKQGEPSPRRPPASQSSLPVSHSPKIRLLSSSQRERQALQDLVDLAVEGLSSSPQPG
                     SRGVPTGLDLVPSSLPLTGFVLPCKKTLKKDDSASLSLGLLVTDFGAMVNNPHLSDVQ
                     FQLDSGEVLYAHKFVLYARCPLLIQYVSTESFSSEEDGDLTQRALLSDVSSEAAHAFL
                     NYLYMADTDMPPSLVPDLRSLALRFGVSDLVQLCEQVPAVVDLEGEQPEETSEDCESR
                     AETFLELLRSVWVDNEEEVETLLKPELCEEERERVNEAEMEEIYEFAATQRKLLQWGR
                     AADPDGSTNPHGEDGAVSEPSLAGVQSNRQLENTEHMESSGLEKEEALASWEQEGHST
                     PLQDQCPDWAGKAEAQDALGEATDDPSFCSRHRRGKECLPLHPNKAHGCKQPLPSNPR
                     VSSELSQITVDHEEQSDHVRETQADMAQAPTPHSCSLVSQSSVDGSPSQSWLHLYHTS
                     HLSPSVSQSHSSISRVASPRSLSPTTPTKQRRGSNIVTLRKDAGHHRGQQSSPIAGHR
                     NRGILISPAKSPPIDLTQSVPEPLSPRAQDPLHFVKKEDEVILLLDSDEELEHTKTES
                     VSKDSPEGRKVPEFSPRSSELFSVIDVEEDHEHFQSPLKREAGLQHGEEGQLGNQSAL
                     GCRDIPWLLCSQKTSLDEDSATDTSWLVPATPGVSRSRDCSSQTQIKSLKTRIPSDET
                     AQQTPRPNLERRTMLETAQQFSVIMPHTQPITLGAFDSGRQAYRSPSHPYPRHHRLSS
                     SQPSCPGPDFTRWSQKSSAPRPCLPNLPAADDVVEVGDSDDEVASHQGNSSPVLDGDP
                     PGPMGDYCWNEPLSPIPIDHLNLERTGPLTTSSPSSQVLEALHSDDCHSPGLGTTPIR
                     GSCGTLRESQERSSLAGSPEALWDDWNEEEGQSPEAPPVAQMLSTRTRKPDRPETPKG
                     ANQKKNLPPKVPITPMPRYSIMETPVLKKELDRFGVRALPKRQMVLKLKEIFQYTHQT
                     LESDSEDEVQSPQIPAELPCRQASTTETCNPSRLPTGEPSHPDGDAQLPASQESMATS
                     VDGSDNSFSSKSSSAEFGAAFEYSDEDKDEEVGVTASQAAIQAADTEEAVRRYIRSKP
                     ALHRQVLRYQPVELAELQAELKQNGIPVAMGKLSDILDAQCITFTTAAARKEKLKHKR
                     RQPSGRKKKDQK"
     exon            1012..1239
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1423
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1636
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1842
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2159
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2373
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2459
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2606
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2773
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..4959
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            4960..5062
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            5063..5236
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            5237..5347
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     exon            5348..6397
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6347..6352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /note="hexamer: AATAAA"
     regulatory      6353..6358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /note="hexamer: AACAAA"
     polyA_site      6368
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /note="major polyA site"
     polyA_site      6380
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
     regulatory      6387..6392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /note="hexamer: AATAAA"
     polyA_site      6397
                     /gene="Slx4"
                     /gene_synonym="Btbd12; D16Bwg1016e"
                     /note="major polyA site"
ORIGIN      
        1 attctctgct cgcaagcctc agggcgcaag cgcagccccg cgcggttctc cgttaagaag
       61 gtgcggctga agcgcgggag gtaggaggag ctcggcatcg gcctagagtg tcccggtgcg
      121 ggggagtagt ggtgggggtt gtcacttccc gcggtttccc ctcttctgcg aggcctgaag
      181 ccgtctgtct tgtcagcctt ccccggacgc ccgatcttga ccggtccgcg gtggagtgac
      241 aggagctgca ccgggtagac gggggcagcg cctgccggga gggagatata aaattagatg
      301 aacctacgcc ctttatcact gtggagatct tggagaatca cctgatcaca gagttcacat
      361 gtgttctatc tcagaggcag ctgttggaca acaaaatgct ctctcacttg tgaagttttt
      421 aaacaactta tttagctacg ggtccaaatt gaaggaagat ataaaagtca catggagagg
      481 aggtcagtac aaagtctccg agtaaatcag agagaagagt tgctgagctg cagtgaggtc
      541 agaggcgtgg gaaggcctga gtgggctcac acacgagttc ctcatctgtg gacatggttc
      601 caggtcggtc ctcactcccc taaagacaaa ccggaaacct taaaacaggt caagtgatgg
      661 aggagtcaga tgacgatttc aaagaactct gtgccagctt tttccaaagg gtgaaaagaa
      721 atgggaccaa agaagcatca ggagagagga cgaggcagaa ggcctctggc cacactcaga
      781 accgaggcaa acggaaagaa ggccgccaag ttgccgccag gagcaaagct cttcaaggcc
      841 cttcagagaa gaaacctcga ttaggcagcc agacccctag gactacaaag caaggggcac
      901 ccaagtctca agaagggggc ccagctctcc ctgcgaatgg gaagggagac gttcttgctc
      961 ctaccccaga tcagccagtg ttgtgtgaga gagcacagag cattcagaca gagagtgctc
     1021 ccaatggcaa ctcccagcct cttccttcct gtttcacgac aactggtgta ccaagtccct
     1081 ccaaacccag agtctcagag ctggttctgc aacggatgaa gcagttcaag agagcagacc
     1141 ctgagcgcct gagacacgcc tcagaagaat ccccccaaaa gactgcactg ggagacgatg
     1201 tcccaaggag ccctccagag gagacagtgg gagaaaatga gtataaactt gatgccacag
     1261 acagtgatgc tgcaatggcc ctggccttac agcaggagtt tagaagggag gaagcatcct
     1321 cacaccatga cagcctggag gagaaggggt tgttcttctg tcaaatgtgt cagaaaaacc
     1381 tctcagcaat gaatgtaacc cggagggagc aacatgtgaa cagatgccta gatgaggcag
     1441 agaaggcaca gagacctgct tcacctcgga tccctgattg cccaatatgt gggaaaccgt
     1501 tcctcaccac caagagccga atcagtcact tgaagcagtg tgcggtgagg atggaagtgg
     1561 gtccccaact cctgcttcag gctgtgaggc tacagacagc tcagccagag gtggatggca
     1621 gccctcaggt acccagtttc agcaacaacg ttggaggttt gaaacggaaa ggagtcacca
     1681 ccaaaaggga gccaaggagg aggaaagtca ataagcctga ggctccgtct gaagatctgt
     1741 tggtggccat ggctctgtct cgctctgagg tggagcactg tccagttgtg cccccgctca
     1801 gactggaaaa tgctttttct gagaagataa ggctaggagc agagaagaaa agtcgcaaga
     1861 agagaccccc ggtgtgtccc ccacagttgg taacccaaga ctctgagacc acaggtagac
     1921 agattgaaga tcgtgttgcc cagcttctgt cagaggaagc agaactatct tgcaccccac
     1981 cacttcttgc cagcaagatt tctaaggaag aattggaacc tgcaggctgg cgagcacggc
     2041 tgcctgaagg gaagcggaac tttctgtggg aactcagcgc tctcacagga gcctgggctg
     2101 aggagtcctt ctacacagtg ggactgtttc ctccaattgt gtcccaatgc ccttccaagg
     2161 aaccccagct accattggag ctgcccaagc aaggagagcc gagtccacgg cggccacctg
     2221 cttcccagag cagccttcct gtgagccaca gccccaagat ccggctgctg tcctccagcc
     2281 agagggagcg tcaagccctt caggaccttg tggacttggc agtggaaggg ctgagctcta
     2341 gcccacagcc cgggagtcgg ggcgtaccca cagggttgga cctggtacct agcagccttc
     2401 cgctgacggg gtttgtcctt ccatgtaaga agaccctgaa gaaggatgac agtgcctcac
     2461 tctctcttgg gttattggtg acagactttg gggccatggt caataatcca cacctgagtg
     2521 atgtccagtt ccagcttgac agtggagagg tgctttatgc acacaagttt gttctttatg
     2581 cgagatgccc acttcttatt cagtatgtaa gcactgaaag cttttcttct gaagaggacg
     2641 gggatctgac ccagcgtgct ctgctgagtg atgtgagctc ggaggccgcc catgcatttc
     2701 tgaactacct ctacatggca gacactgaca tgcctcccag cctggttccg gatctgcgtt
     2761 ccctggccct aaggtttggt gtgagtgacc ttgttcagct gtgtgaacaa gtgcccgccg
     2821 tggtggactt agagggagaa cagccagaag agaccagtga ggactgtgaa agccgagcag
     2881 agactttcct ggaactcctg aggtcggtgt gggtagacaa tgaggaggaa gtggagactc
     2941 tgctgaaacc tgagctctgt gaagaagaga gagaaagagt gaatgaagca gaaatggaag
     3001 agatatatga atttgctgct acgcagagga agcttctcca gtgggggaga gcagcagacc
     3061 cagatgggag cactaacccg catggggaag acggtgcagt ttctgagcct tccctggcag
     3121 gtgtccagag taacagacag ctagaaaata cagagcacat ggagtcatct gggttagaaa
     3181 aagaagaggc actagccagc tgggaacaag aaggacattc cactccactg caggaccagt
     3241 gcccagactg ggcagggaaa gcagaggccc aggatgcatt gggggaggca actgacgacc
     3301 ccagcttctg cagccgccac aggaggggga aagagtgctt gcctttgcac ccaaacaagg
     3361 cccatggctg caaacagccc cttccatcaa atccaagagt gtcatctgaa ctgtcacaaa
     3421 taacagttga tcatgaagag cagagtgacc atgtcaggga gacgcaggca gacatggccc
     3481 aggcacctac tccacactcc tgcagccttg tgtcacagtc ttctgtggat ggaagtccca
     3541 gccagtcatg gcttcaccta taccacacaa gtcatttgtc cccctcagtg tcccagtcac
     3601 acagtagcat ttccagggtg gcatccccaa gatcactgtc tccaactaca ccaactaagc
     3661 agaggagggg cagtaacatt gtcacattac ggaaagatgc tggccaccac agaggccaac
     3721 aaagtagccc catagcggga cacagaaata ggggcatcct gatttcccca gcaaagtctc
     3781 cacccattga cctcacacag tcagtacccg agcccctgag ccccagggcc caggatcctc
     3841 tgcatttcgt gaaaaaggag gatgaggtca tcctgttact ggactcagat gaggagctgg
     3901 agcacaccaa gacagagtca gtttctaaag attccccaga aggaaggaaa gttccagaat
     3961 ttagccccag gtcctctgaa ctgttttcag tcattgatgt tgaagaagat catgaacatt
     4021 tccaaagccc actgaagaga gaggccgggc tacagcacgg ggaggaagga cagctgggaa
     4081 accagtctgc gctgggctgc agagacatcc cctggctgct ctgcagccag aaaaccagcc
     4141 tggatgagga cagtgctaca gacacctctt ggctggtgcc tgccactcca ggggtcagca
     4201 ggagtcgtga ttgctcatca cagacccaaa tcaaaagcct taagaccagg attccgtcag
     4261 atgagactgc tcagcaaaca cctagaccta acttagaacg caggaccatg ctggaaacag
     4321 cccagcagtt ctctgtgatc atgccacaca cacagcctat tactctagga gcctttgaca
     4381 gcggaagaca ggcctacaga agcccttccc atccctaccc caggcaccac agactctctt
     4441 cttcacagcc atcatgtcct ggccctgatt ttaccaggtg gtcccagaaa tcttccgcac
     4501 ctagaccatg cctgccaaat ctgcctgcag ctgatgatgt ggtagaagtt ggggacagtg
     4561 atgatgaggt ggcttcccat caaggaaaca gcagccccgt gctagatggt gaccccccag
     4621 gtcccatggg tgactactgt tggaatgagc ctctctcacc aattccaatt gaccacttga
     4681 atctggagcg gaccggcccc ctgaccacaa gcagtcccag cagtcaggtc ctggaggctt
     4741 tgcacagtga tgactgccac tccccgggac ttggtaccac ccccatccga ggaagctgtg
     4801 gtacgctgag agagtctcag gaacggtcct cactggctgg ctctccagag gctctgtggg
     4861 acgactggaa tgaggaggaa ggacagtctc cagaggcccc acctgtggct caaatgctga
     4921 gtaccagaac tcggaagcca gacaggccag agacaccaaa aggtgctaac cagaaaaaga
     4981 acttgcctcc caaagtgcct ataactccaa tgccaaggta ttcgatcatg gagaccccgg
     5041 tgctgaagaa agaactggac aggtttggag tccgtgctct gcccaaacgc cagatggttc
     5101 taaaactgaa ggagattttc cagtacactc accagactct ggagtcggac tctgaggatg
     5161 aggtccagtc cccccagata cccgcagaac taccttgtcg ccaggcatct accactgaga
     5221 cctgcaaccc ttcaaggttg ccaactgggg agccttcaca tcctgatggt gacgcccagc
     5281 tcccagcctc ccaggaatcc atggctacct ctgtggacgg cagtgacaac tcctttagct
     5341 ctaaaagctc ctctgctgag tttggagctg cgtttgagta ttcagatgaa gacaaggatg
     5401 aggaggtcgg ggtcactgca tcacaggccg caatccaggc cgcagacaca gaggaggcag
     5461 tgaggcgcta tatccgctct aagcctgccc tgcacaggca ggtcctgagg taccagcctg
     5521 tggagctggc cgagctgcag gctgagctga aacagaatgg catccctgtg gccatgggca
     5581 agctgtcgga catcctggac gctcagtgca tcaccttcac cactgctgca gcccgaaagg
     5641 agaaactcaa acacaagaga cggcagccct caggccgaaa gaaaaaggat cagaaatgac
     5701 aggcctccac ccagtagacc tgccagagga cctgggcacc tagcataagt caggcctctg
     5761 cagtatgtcg taggatatgg gcctatgtct gtgtaaagga caagaactcg agcgtacttt
     5821 cctgcactcc agctccgttg tcccctttgg actcagagca cacccttccc ccctcagtca
     5881 gtgccagttt tccccctttg gcccaaccag ggtccccatc ctgtgtgttc ctgaaaggca
     5941 gtgggccaca ccagcgacca gagcaagacc tgagccttct tcacttgcct ctctgtgtcc
     6001 agcacaccca agcacagctg ccctatattc tgggacaggc aactgggtcc agccttctca
     6061 gcattgaaac cagcccagcc gccatggcag accagacacc gacgggcggc ctgcaccctg
     6121 tgcttgccca gatacttgcc actgtcacca gcatcctaca agtagggccc agcacagcta
     6181 tgaagacccc caaagtaagc atgtttgtgg gctccaccca tttgtgttaa gcctccttga
     6241 cccagtgtgg actctgggac cagaaaaaaa cagaagtttg ggttttcaca gcctgtgagt
     6301 gtccttgtgt gttttaaata cagtgaagtt gttttatata atgtgcaata aaaacaaaga
     6361 agactttatt taaaaataaa taaataaata aactaga
//
