LOCUS       NM_029420               3692 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus SLX1 structure-specific endonuclease subunit homolog B
            (S. cerevisiae) (Slx1b), transcript variant 1, mRNA.
ACCESSION   NM_029420
VERSION     NM_029420.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3692)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3692)
  AUTHORS   Giannuzzi,G., Chatron,N., Mannik,K., Auwerx,C., Pradervand,S.,
            Willemin,G., Hoekzema,K., Nuttle,X., Chrast,J., Sadler,M.C.,
            Porcu,E., Herault,Y., Isidor,B., Gilbert-Dussardier,B.,
            Eichler,E.E., Kutalik,Z. and Reymond,A.
  CONSRTM   16p11.2 Consortium
  TITLE     Possible association of 16p11.2 copy number variation with altered
            lymphocyte and neutrophil counts
  JOURNAL   NPJ Genom Med 7 (1), 38 (2022)
   PUBMED   35715439
  REMARK    Erratum:[NPJ Genom Med. 2023 May 24;8(1):9. doi:
            10.1038/s41525-023-00354-z.. PMID: 37225732]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3692)
  AUTHORS   Lachaud,C., Slean,M., Marchesi,F., Lock,C., Odell,E., Castor,D.,
            Toth,R. and Rouse,J.
  TITLE     Karyomegalic interstitial nephritis and DNA damage-induced
            polyploidy in Fan1 nuclease-defective knock-in mice
  JOURNAL   Genes Dev 30 (6), 639-644 (2016)
   PUBMED   26980188
REFERENCE   4  (bases 1 to 3692)
  AUTHORS   Castor,D., Nair,N., Declais,A.C., Lachaud,C., Toth,R.,
            Macartney,T.J., Lilley,D.M., Arthur,J.S. and Rouse,J.
  TITLE     Cooperative control of holliday junction resolution and DNA repair
            by the SLX1 and MUS81-EME1 nucleases
  JOURNAL   Mol Cell 52 (2), 221-233 (2013)
   PUBMED   24076219
  REMARK    GeneRIF: Data indicate that SLX1 and MUS81-EME1 nucleases act
            together to resolve Holliday junctions (HJs) in a manner that
            requires tethering to SLX4.
REFERENCE   5  (bases 1 to 3692)
  AUTHORS   Vannier,J.B., Pavicic-Kaltenbrunner,V., Petalcorin,M.I., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 dismantles T loops and counteracts telomeric G4-DNA to
            maintain telomere integrity
  JOURNAL   Cell 149 (4), 795-806 (2012)
   PUBMED   22579284
REFERENCE   6  (bases 1 to 3692)
  AUTHORS   Crossan,G.P., van der Weyden,L., Rosado,I.V., Langevin,F.,
            Gaillard,P.H.L., McIntyre,R.E., Gallagher,F., Kettunen,M.I.,
            Lewis,D.Y., Brindle,K., Arends,M.J., Adams,D.J. and Patel,K.J.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Disruption of mouse Slx4, a regulator of structure-specific
            nucleases, phenocopies Fanconi anemia
  JOURNAL   Nat Genet 43 (2), 147-152 (2011)
   PUBMED   21240276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049139.1, AK014753.1, BY633939.1, AC124505.4, AK153779.1 and
            AK163709.1.
            
            On Apr 6, 2010 this sequence version replaced NM_029420.3.
            
            Transcript Variant: This variant (1) represents the protein coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049139.1, BC055909.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1483              AK049139.1         2-1484
            1484-1870           AK014753.1         1606-1992
            1871-2112           BY633939.1         160-401
            2113-2157           AC124505.4         31230-31274         c
            2158-3669           AK153779.1         88-1599
            3670-3692           AK163709.1         1428-1450
FEATURES             Location/Qualifiers
     source          1..3692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..3692
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /note="SLX1 structure-specific endonuclease subunit
                     homolog B (S. cerevisiae)"
                     /db_xref="GeneID:75764"
                     /db_xref="MGI:MGI:1915220"
     exon            1..359
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..993
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /note="GIY-YIG domain containing 2; GIY-YIG
                     domain-containing protein 1"
                     /codon_start=1
                     /product="structure-specific endonuclease subunit SLX1"
                     /protein_id="NP_083696.2"
                     /db_xref="CCDS:CCDS21838.1"
                     /db_xref="GeneID:75764"
                     /db_xref="MGI:MGI:1915220"
                     /translation="MDHAARPGRFFGVYLLYCQNPRHRGRVYVGFTVNPARRVRQHNA
                     GRKKGGAWRTSGRGPWDMVLIIHGFPSAVAALRFEWAWQHPQASRRLTHVGPRLRSEA
                     AFAFHLRVLAHMLRVPPWVRLPLTLRWLRPDFRHELCPAPPAHMPIAFGPPPPQPLVP
                     KRPAVSEADSERQLDLGTKARCSLCARLLQDEEGPLCCPHPGCPLRAHIICLAEEFLQ
                     EEPGQLLPLEGHCPSCKKSLLWGNLVGQCHADTEEEEDLELEEEHWTDLLET"
     exon            360..411
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..750
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..878
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..963
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..3692
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /note="hexamer: AATAAA"
     polyA_site      1951
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /note="major polyA site"
     regulatory      3123..3128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /note="hexamer: AATAAA"
     polyA_site      3145
                     /gene="Slx1b"
                     /gene_synonym="1110030E23Rik; 2410170E21Rik;
                     4833422P03Rik; Giyd1; Giyd2"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcctgc cagcaggcgg cgcagcaagt cgctctgccg gctttccagg agtttgcagg
       61 accattctcc cgtgcttttt cctaaaccaa ggttttgcag tcctggctac ccagcccttt
      121 ccgaggtccg aggtcccaga aaccaccccc aactctggcc cttcaaccca gaaagtccgg
      181 atggaccatg cagcaagacc cgggcgcttc ttcggtgtct acttgctcta ctgccagaac
      241 cctcggcatc ggggccgcgt ttacgttgga ttcactgtca atcctgctcg tcgggtccgg
      301 caacacaacg cgggtcgcaa gaaaggtgga gcatggcgga ccagcgggcg aggaccctgg
      361 gacatggtgc tgatcataca cggtttcccg tctgctgtgg ccgcccttcg gtttgaatgg
      421 gcctggcaac atcctcaagc ttcacgccgc ctgacgcacg tggggccgcg cctgcgcagc
      481 gaggctgcct ttgccttcca cttgcgcgtt ctggcgcaca tgcttcgagt tcctccgtgg
      541 gtgcgccttc ctctaacact gcgttggctg cgacctgact tccgccatga actctgtcca
      601 gcgccaccgg cacacatgcc cattgccttt ggaccacctc caccccagcc cttagtccca
      661 aaacgaccag ctgtaagcga ggctgacagc gagcgacagc tggatctagg taccaaggcc
      721 agatgcagtc tgtgtgcgcg tctgctgcag gatgaagagg gccccttgtg ctgcccccac
      781 cctggttgtc ccctaagggc ccatatcatc tgcttggcag aggagttcct gcaggaagag
      841 cccgggcagc ttctgcccct agagggacat tgtcctagct gcaagaaatc actactttgg
      901 ggaaacctgg ttgggcagtg ccacgcggac acagaggagg aagaggattt ggagttagag
      961 gaggaacact ggacagactt gctggagact tgatcctaag tgtccccctg tacctttcct
     1021 gcttctctct tcagtaactg gcagctttta cttgagcacc acacaaaggc tgggataagg
     1081 gtaccttctg atgttttctc agagctgggc gggaaaggaa ggcgtgaagt ggaggctttg
     1141 gcctaaccat gtggccttgc ttcctccctt acctttctca gaggtaacag ctactgtctt
     1201 cagttgcttt cccatggcga tgattaatgt tgggaccagc aacttggggg aggagggggc
     1261 ttgtcccatg ttacacttcc agtccatcag cgagggaagg ttgggtggga actcaaagca
     1321 ggaacctaga aaccatgcag ggggttgcct attggcgcca tctctctggc tggtgcttca
     1381 ttcaatcaac acttatatga cccagaaccc cctgcctagg ggtggcactg tccacagtgg
     1441 gctgggcctt ctcacatcaa tcagcaataa agaaaatgcc cgcacagatg tgcccacagg
     1501 caagtctggc tgagacagtt tcccggttga ggagccctcc gaaaatgcag ggctgggtga
     1561 agttgacaac tgaaaccaaa caagataata attagaggct cagagggtag cacctgtgac
     1621 ttggagcctc agttgggagc acaaaggtcc ttgtgttcac acataagcac caggcatccc
     1681 ttggaaagct accaaacttt tcgactggac tctaccccca agagtccatt gatgggggct
     1741 ggagagccag ctcagaggtt aagtggctgt tcttgcagag gactcaaatt caattcccaa
     1801 caccacatgg tctctcacaa ccacctacaa ctccaattcc aagggatcca atggcatctt
     1861 ctggcttctg agggaccagg cagactggtg gtttacaatg caggcaaaac actcacataa
     1921 ataaaataat aaagttaaat taaaaacaaa agttctagcc gggcgtggtg gcgcacgcct
     1981 ttaatcccag cactcgggag gcagaggcag gcggatttct gagttcgagg ccagcctggt
     2041 ctacaaagtg agctccagga cagccagggc tatacagaga aaccctgtct cgaaaaacca
     2101 aaaaaaaaaa ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaacaa
     2161 aagttcttta atggtctgaa tacctgtggg atactgagaa cataggatgt tctacaggtg
     2221 agctactgta cagccacacg ggtgatcact gccctgaaga cagacctgcc ttccaggcag
     2281 ctaccactag ctggctctgt gagctccagc agagtgctct tcccccaaag cctcctggtc
     2341 tttctcttga agccaagagc acctcaaatg gtagtggtgt gcttctaatg gaggtggctg
     2401 gctgtttctg caacatggag ctggggtggg gcatcccagt gtcaaagact gcagagggga
     2461 ttgctgcact gcacagcttg caagcctttc ctgatgacca ggagagttcc ataaccaggt
     2521 ctgtagttcc caccttggca gacacagcca agccctcagc cccagtcact tcccactccc
     2581 tgctctccag gtaccacccg ggtcagtgag atacttggca tggtctatca ggatgctgac
     2641 ctagagaaat gtctctaggc ttccatctgg tttcaggttc ccttcctaga gctcagaagc
     2701 cctggtgacc ccctcatgta tgtgaagaaa tagtaggaaa atgaccaggg tcttgaagct
     2761 ctggaaagca ctccagccct gaggttcctc aaaactcact ggcctgtgtc tctggtcccc
     2821 cagagttcgc tggatgaagg tcaaggtgag agccagggca gtgctagcca atcctggata
     2881 gacccttggt cctgtgctgc tgaggtctct gctgtctcat ggagtaagag gccatctgcc
     2941 tgtcagtgtt gtggggttca ggatggagat ctgagagaag gggagtcaca gaaaaaggcg
     3001 ctcacagaac atggaagaga gctggctaga cccagatctg ccttgttcta gtacaggtat
     3061 ggtggcccct caggggacca acctgatcta gttgtttgta taggtggctt gtccttgctg
     3121 taaataaaat agaactccag gtgcattctg actcttggct tcaggccaca atatgtgtgt
     3181 gtgtatgtgt gtgtgtgtgt gtttggttgt actgaggcag gacatcacag tgaaagttca
     3241 tggggaacag taaggaatga gaccccccag aatgccatcc atacatgagt catgagcgga
     3301 tcaatctcca cgttaggtca gttctcatga actagccatt gcacaacagt gctgcccagc
     3361 tagagtgaag ccttcagcaa gagtgatacc cgagccagga acaaccaaat tccagatcaa
     3421 cagcacccat atcacaaggt tgcaacagtc cagcctttga ccctgtttct cctttgccat
     3481 cacaggagaa aattccctca gtgtgttgtg atgggtgaca ggaactcagg atggtttaga
     3541 catggggtca gatgccttta atattggagc attggagaag cagacaggtc tttatgattt
     3601 tgaggctagc ctggtctaca tattgaattt cagatcaccc cgagctactc cccaactctc
     3661 aaaccaaaca acaaaataaa acacaacacg gc
//
