LOCUS       NM_020519                531 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus secreted Ly6/Plaur domain containing 1 (Slurp1), mRNA.
ACCESSION   NM_020519
VERSION     NM_020519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 531)
  AUTHORS   Weinberg,R.L., Kim,S., Pang,Z., Awad,S., Hanback,T., Pan,B.,
            Bettin,L., Chang,D., Polydefkis,M.J., Qu,L. and Caterina,M.J.
  TITLE     Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models
            of Hereditary Palmoplantar Keratoderma
  JOURNAL   J Neurosci 44 (28), e0260232024 (2024)
   PUBMED   38866482
  REMARK    GeneRIF: Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse
            Models of Hereditary Palmoplantar Keratoderma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 531)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 531)
  AUTHORS   Swamynathan,S., Campbell,G., Tiwari,A. and Swamynathan,S.K.
  TITLE     Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a
            pro-differentiation factor that stalls G1-S transition during
            corneal epithelial cell cycle progression
  JOURNAL   Ocul Surf 24, 1-11 (2022)
   PUBMED   34923162
  REMARK    GeneRIF: Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a
            pro-differentiation factor that stalls G1-S transition during
            corneal epithelial cell cycle progression.
REFERENCE   4  (bases 1 to 531)
  AUTHORS   He,X., Wang,L., Liu,L., Gao,J., Long,B., Chi,F., Hu,T., Wan,Y.,
            Gong,Z., Li,L., Zhen,P., Zhang,T., Cao,H. and Huang,S.H.
  TITLE     Endogenous alpha7 nAChR Agonist SLURP1 Facilitates Escherichia coli
            K1 Crossing the Blood-Brain Barrier
  JOURNAL   Front Immunol 12, 745854 (2021)
   PUBMED   34721415
  REMARK    GeneRIF: Endogenous alpha7 nAChR Agonist SLURP1 Facilitates
            Escherichia coli K1 Crossing the Blood-Brain Barrier.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 531)
  AUTHORS   Ertle,C.M., Rommel,F.R., Tumala,S., Moriwaki,Y., Klein,J.,
            Kruse,J., Gieler,U. and Peters,E.M.J.
  TITLE     New Pathways for the Skin's Stress Response: The Cholinergic
            Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine
            Production in Mice
  JOURNAL   Front Immunol 12, 631881 (2021)
   PUBMED   33815383
  REMARK    GeneRIF: New Pathways for the Skin's Stress Response: The
            Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter
            Cytokine Production in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 531)
  AUTHORS   Swamynathan,S. and Swamynathan,S.K.
  TITLE     SLURP-1 modulates corneal homeostasis by serving as a soluble
            scavenger of urokinase-type plasminogen activator
  JOURNAL   Invest Ophthalmol Vis Sci 55 (10), 6251-6261 (2014)
   PUBMED   25168896
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 531)
  AUTHORS   Adeyo,O., Allan,B.B., Barnes,R.H. 2nd, Goulbourne,C.N., Tatar,A.,
            Tu,Y., Young,L.C., Weinstein,M.M., Tontonoz,P., Fong,L.G.,
            Beigneux,A.P. and Young,S.G.
  TITLE     Palmoplantar keratoderma along with neuromuscular and metabolic
            phenotypes in Slurp1-deficient mice
  JOURNAL   J Invest Dermatol 134 (6), 1589-1598 (2014)
   PUBMED   24499735
  REMARK    GeneRIF: Slurp1 in mice has a role in neuromuscular and metabolic
            phenotypes in addition to its role in palmoplantar keratoderma
REFERENCE   8  (bases 1 to 531)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 531)
  AUTHORS   Narumoto,O., Horiguchi,K., Horiguchi,S., Moriwaki,Y.,
            Takano-Ohmuro,H., Shoji,S., Misawa,H., Yamashita,N., Nagase,T.,
            Kawashima,K. and Yamashita,N.
  TITLE     Down-regulation of secreted lymphocyte antigen-6/urokinase-type
            plasminogen activator receptor-related peptide-1 (SLURP-1), an
            endogenous allosteric alpha7 nicotinic acetylcholine receptor
            modulator, in murine and human asthmatic conditions
  JOURNAL   Biochem Biophys Res Commun 398 (4), 713-718 (2010)
   PUBMED   20621062
  REMARK    GeneRIF: Those findings suggest that diminished expression of
            SLURP-1 in asthma attenuates its negative regulation of airway
            inflammation, and that perhaps changes in SLURP-1 expression could
            serve as a marker of airway damage in asthma.
REFERENCE   10 (bases 1 to 531)
  AUTHORS   Mastrangeli,R., Donini,S., Kelton,C.A., He,C., Bressan,A.,
            Milazzo,F., Ciolli,V., Borrelli,F., Martelli,F., Biffoni,M.,
            Serlupi-Crescenzi,O., Serani,S., Micangeli,E., El Tayar,N.,
            Vaccaro,R., Renda,T., Lisciani,R., Rossi,M. and Papoian,R.
  TITLE     ARS Component B: structural characterization, tissue expression and
            regulation of the gene and protein (SLURP-1) associated with Mal de
            Meleda
  JOURNAL   Eur J Dermatol 13 (6), 560-570 (2003)
   PUBMED   14721776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003904.1 and BY704159.1.
            
            On Jul 12, 2018 this sequence version replaced NM_020519.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY704159.1, AK029079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-520               AK003904.1         2-521
            521-531             BY704159.1         522-532
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.26 cM"
     gene            1..531
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
                     /note="secreted Ly6/Plaur domain containing 1"
                     /db_xref="GeneID:57277"
                     /db_xref="MGI:MGI:1930923"
     exon            1..83
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..358
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
                     /note="secreted Ly-6/uPAR-related protein 1; Ars component
                     B"
                     /codon_start=1
                     /product="secreted Ly-6/uPAR-related protein 1 precursor"
                     /protein_id="NP_065265.1"
                     /db_xref="CCDS:CCDS27528.1"
                     /db_xref="GeneID:57277"
                     /db_xref="MGI:MGI:1930923"
                     /translation="MTLRWAMWLLLLAAWSMGYGEAFRCYTCEQPTAINSCKNIAQCK
                     MEDTACKTVLETVEAAFPFNHSPMVTRSCSSSCLATDPDGIGVAHPVFCCFRDLCNSG
                     FPGFVAGL"
     exon            84..203
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..522
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      501..506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
                     /note="hexamer: AATAAA"
     regulatory      506..511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
                     /note="hexamer: AATAAA"
     polyA_site      519
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
     polyA_site      522
                     /gene="Slurp1"
                     /gene_synonym="1110021N19Rik; ARS; ArsB; Slurp-1"
                     /note="major polyA site"
ORIGIN      
        1 gctcctagct cctgagcact gaagaatgac ccttcgctgg gccatgtggc tgctgctctt
       61 ggcagcctgg agcatgggct atggtgaggc cttccgatgc tatacctgtg agcagcccac
      121 ggccattaac tcatgcaaga atattgctca gtgcaagatg gaagacacag cctgtaagac
      181 tgtactggag acagtggaag cagcgttccc cttcaaccac agtcccatgg tgacccgctc
      241 ctgctccagc tcgtgtctgg ccaccgaccc tgatggcatt ggcgttgccc atcctgtctt
      301 ctgttgcttc cgtgacctct gcaactcagg gtttccaggc ttcgtggcag gcctctagcc
      361 acacagggag cctcctcgtt ccttctctat ccactctccc ggcagggccc ggtgctgcct
      421 gcagtcgtct ctacatgcct ggatctatga gcagagctca ctgagcctca ggtcactcac
      481 tgtccaccaa gcttgtggaa aataaaataa accaagggcg aaaaaaaaaa a
//
