LOCUS       NM_198936               3653 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SLU7 splicing factor homolog (S. cerevisiae) (Slu7),
            transcript variant 2, mRNA.
ACCESSION   NM_198936
VERSION     NM_198936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Garate-Rascon,M., Recalde,M., Jimenez,M., Elizalde,M., Azkona,M.,
            Uriarte,I., Latasa,M.U., Urtasun,R., Bilbao,I., Sangro,B.,
            Garcia-Ruiz,C., Fernandez-Checa,J.C., Corrales,F.J., Esquivel,A.,
            Pineda-Lucena,A., Fernandez-Barrena,M.G., Avila,M.A.,
            Arechederra,M. and Berasain,C.
  TITLE     Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte
            Nuclear Factor 4alpha Degradation, Preserving Hepatic
            Differentiation and Protecting From Liver Damage
  JOURNAL   Hepatology 74 (5), 2791-2807 (2021)
   PUBMED   34170569
  REMARK    GeneRIF: Splicing Factor SLU7 Prevents Oxidative Stress-Mediated
            Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic
            Differentiation and Protecting From Liver Damage.
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Wang,J., Kainrad,N., Shen,H., Zhou,Z., Rote,P., Zhang,Y.,
            Nagy,L.E., Wu,J. and You,M.
  TITLE     Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates
            Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice
  JOURNAL   Am J Pathol 188 (8), 1807-1819 (2018)
   PUBMED   29870742
  REMARK    GeneRIF: Knockdown of hepatic Slu7 by adenovirus-Slu7shRNA
            treatment ameliorated inflammation and attenuated liver injury in
            mice after ethanol administration.
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   Elizalde,M., Urtasun,R., Azkona,M., Latasa,M.U., Goni,S.,
            Garcia-Irigoyen,O., Uriarte,I., Segura,V., Collantes,M., Di
            Scala,M., Lujambio,A., Prieto,J., Avila,M.A. and Berasain,C.
  TITLE     Splicing regulator SLU7 is essential for maintaining liver
            homeostasis
  JOURNAL   J Clin Invest 124 (7), 2909-2920 (2014)
   PUBMED   24865429
  REMARK    GeneRIF: SLU7 knockdown in liver resulted in profound changes in
            pre-mRNA splicing and gene expression, leading to impaired glucose
            and lipid metabolism, refractoriness to key metabolic hormones, and
            reversion to a fetal-like gene expression pattern.
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Alberstein,M., Amit,M., Vaknin,K., O'Donnell,A., Farhy,C.,
            Lerenthal,Y., Shomron,N., Shaham,O., Sharrocks,A.D.,
            Ashery-Padan,R. and Ast,G.
  TITLE     Regulation of transcription of the RNA splicing factor hSlu7 by
            Elk-1 and Sp1 affects alternative splicing
  JOURNAL   RNA 13 (11), 1988-1999 (2007)
   PUBMED   17804646
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Chua,K. and Reed,R.
  TITLE     An upstream AG determines whether a downstream AG is selected
            during catalytic step II of splicing
  JOURNAL   Mol Cell Biol 21 (5), 1509-1514 (2001)
   PUBMED   11238888
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   Chua,K. and Reed,R.
  TITLE     The RNA splicing factor hSlu7 is required for correct 3'
            splice-site choice
  JOURNAL   Nature 402 (6758), 207-210 (1999)
   PUBMED   10647016
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY243619.1, AK047597.1 and
            AK029117.1.
            
            Summary: Pre-mRNA splicing occurs in two sequential
            transesterification steps. The protein encoded by this gene is a
            splicing factor that has been found to be essential during the
            second catalytic step in the pre-mRNA splicing process. It
            associates with the spliceosome and contains a zinc knuckle motif
            that is found in other splicing factors and is involved in
            protein-nucleic acid and protein-protein interactions.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains an additional segment
            in its 5' UTR when compared to variant 1. Variants 1 and 2 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029117.1, SRR1660819.71811.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY243619.1         2-26
            26-32               AK047597.1         14-20
            33-3653             AK029117.1         3-3623
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.68 cM"
     gene            1..3653
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /note="SLU7 splicing factor homolog (S. cerevisiae)"
                     /db_xref="GeneID:193116"
                     /db_xref="MGI:MGI:2385598"
     exon            1..89
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            90..275
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            276..429
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            430..510
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            511..675
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            676..744
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            745..792
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            793..924
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1022
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1090
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1230
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1392
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1497
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1569
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1683
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..3653
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /note="hexamer: AATAAA"
     polyA_site      1983
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /note="major polyA site"
     regulatory      2678..2683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /note="hexamer: AATAAA"
     polyA_site      2707
                     /gene="Slu7"
                     /gene_synonym="D11Ertd730e; D3Bwg0878e"
                     /note="major polyA site"
ORIGIN      
        1 gccggaagaa ggcagggaac ccggaagtaa acattgccga gtcgcttcgt ttctggcgga
       61 tggttttgag tggtctgcgg cgcgactgga ggataccagt tcaccatgtc ggcggccgct
      121 gtggacccag ttagtgcgac acccatgacg ggatcaaagg agatgagttt ggaggagccg
      181 aaaaagatga cccgagagga ctggaggaag aagaaggagc tagaagaaca gaggaaactg
      241 ggcaatgctc ctgcagaagt cgatgaagag ggaaaagata tcaaccctca tattcctcag
      301 tatatttctt cggttccatg gtacattgat ccatcaaaga gacccacttt aaagcatcag
      361 agaccacagc cagagaaaca gaagcagttc agttcatctg gggagtggta caagcgaggc
      421 gtaaaggaga attctataac taccaagtac cgcaaaggtg catgtgagaa ttgtggagcc
      481 atgacacaca agaggaaaga ttgctttgag agaccgaggc gggttggagc taaattcaca
      541 ggaactaaca ttgctccaga cgagcacgtc cagccccagc tgatgtttga ctatgatggg
      601 aagagagacc gctggaatgg ctacaatccg gaagagcaca tgaagattgt cgaggaatac
      661 gccaaggttg atctggcaaa acggacattg aaagcacaga aactgcaaga agagttagcc
      721 tctggaaaat tagtggagca agctaactct ccgaaacacc agtggggaga agaggaaccc
      781 aactctcaga tggaaaagga tcataacagt gaggatgaag acgaagacaa atatgcggat
      841 gacattgaca tgcctgggca gaatttcgac tctaagagac gcattactgt tcgcaatctc
      901 cggattcgtg aagatattgc aaaatatttg agaaatttag atccaaattc tgcctattat
      961 gatccaaaaa ccagagcgat gagagagaat ccttacgcca atgcagggaa gaatccagat
     1021 gaagtgagct acgctggaga taactttgtt cgatacacag gagataccat ctccatggct
     1081 caaacacaac tgtttgcttg ggaagcctac gacaaggggt ctgaagtgca tctccaggca
     1141 gatccgacaa aactagagct gctgtataag tccttcaaag tcaaaaaaga agacttcaaa
     1201 gagcagcaga aggaaagcat cctggaaaag tacggtggcc aagaacacct ggacgcccct
     1261 ccagctgagc tgctcttagc ccagacagaa gactacgtgg agtactccag gcatggcaca
     1321 gtcattaaag gccaggagcg ggctgtcgcc tgctccaagt acgaggaaga cgtgaagatc
     1381 aataaccaca cgcatatctg gggatcttac tggaaagaag gccgctgggg atacaaatgt
     1441 tgtcactcgt tttttaagta ttcctactgt actggagaag ctgggaagga gagcgttaac
     1501 tcagaggagt gtattataac tggtgcgact gcagaagagt ctgtgaagaa acctcaggcc
     1561 ctcctggagc tacatcagga gaaactaaaa gaggagaaga agaagaaaaa gaagaagaag
     1621 aaacaccgca agagcagttc tgacagcgac gatgaggaac ggaagcagga gaaactgaaa
     1681 aaggcactga atgcagagga ggctcgcctt cttcacgtga aggagatcat gcagattgac
     1741 gagcggaagc ggccctacaa cagcatctat gaaacccgag agcccacaga agaggagatg
     1801 gaggcctaca ggatgaaacg gcagaggccc gatgacccca tggcctcttt cctaggacag
     1861 tgactcgtca ggattggaca catacacagc atgttctttc cagctccttg tcaccgagag
     1921 atagaaaatc tttatctgtc cttcttgctc cctgacatta ataaattttt ctgaagtctc
     1981 aaagtcttct caacagtcaa gaaaccaagc aagcaagcaa gagcatccag ttgtgattag
     2041 ggttaaaatc atccatccta attaatgatt tggaaagttt gactctcttc ctctcaagtg
     2101 tcttgtggag tctgcatgat ggctcgtctt gtaatgccgg cacctgagag tggtggagac
     2161 aggggggtca agagttcaag gtcagccgag tatggtagtg cacacctgta atcctggcac
     2221 tcaggagact gaggcaagag cctcgtagca ttagctgcat agcaagtttg aaaccagtct
     2281 gcactacatg aggctttgtc tcaaaatgaa aaagtttgag attatcctag gctacatagc
     2341 aaggtgattt caagaaagag atgaaggaag gaaggaagag aaaaacaaag tcatttgttc
     2401 atagtgaggt ctccagctat gtacatgccg tcagtcctct ggtctcttga atgtagcccc
     2461 accctgtagg tcctctcaaa gccagagccc tgttcttaaa ttactagtga ttctagtagt
     2521 gacatcgtta gtaatttaac tctataattg cagttacagc atttggtttt tgccatctaa
     2581 gattttcttg gttttaaaca aaaatattct atctttatct gcagcacaga gggaaatctg
     2641 ccgggcatca aatatctgtg tcccccataa tcctaataat aaatctattt ttcattcagt
     2701 tgttaaacgt tggattttcg tacacttcct tataccttac atcttttaat ggtcgttgac
     2761 tgcttcacac ttaccttgct gaacatgaac tttcagacct agaagtcact tttatgattt
     2821 atgatatatg atgtgttttt tactattgta tgtcatttaa ttctgatctg tttaatgcta
     2881 caaaagtaaa gttgaaaaga tctaagacat ctagttacct agactgtacc cagcaggtat
     2941 cacttggtaa aaatacaaga gcaaagccac ttgagactga aggttcttta aagaccgtaa
     3001 ggatggcttc cgacgtgtca tgctgctgct gtgatcttca gcctgccttg cctggaaaca
     3061 tggcaaagac aatgctgaca ccactccact gtgagagcat agtctgggga cactgactca
     3121 gcgagtgtgt tccagactga cttccaggac actgtgtgac gtcagcatct cagacaggca
     3181 ggagaaaagc accagatacc tggctttcca tggtgtgagc attcagactg agattagaac
     3241 cgcaatgcag gcttggggaa ttggctcagt cagagaaggc cttgctttgc aaggatggta
     3301 aagagaaagc agaccagcca gatgcagtca gtggtgtatg cttgtaatcc cagccctggg
     3361 gaggcagaga aaaataccta aggctcaggc tcaccagctc agccaaatct gcaagtacca
     3421 gaccagtgaa cagctccgga ggaacaggtt gttctctgac ctctacacgt atgccacgct
     3481 tgtacccaca cacgcgcaca cacacagact tataatgcaa atggatctct gatcataaag
     3541 gccaaaattg tgttctatct ctacctcgac atgggtggtt caacacaaag tcggttattg
     3601 gtgtctattt tgtgtatttt cttttgttaa taaagatgca attgagaata ttt
//
