LOCUS       NM_025690               3851 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SAFB-like, transcription modulator (Sltm), transcript
            variant 1, mRNA.
ACCESSION   NM_025690 XM_981515
VERSION     NM_025690.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3851)
  AUTHORS   Tsujio,G., Yashiro,M., Sakuma,T., Aoyama,R., Maruo,K., Yamamoto,Y.
            and Maeda,K.
  TITLE     Impact of SMAD2 and MET Expression on Lymph Node Metastasis of
            HER2-positive Gastric Cancer Cells
  JOURNAL   Anticancer Res 43 (10), 4359-4364 (2023)
   PUBMED   37772583
  REMARK    GeneRIF: Impact of SMAD2 and MET Expression on Lymph Node
            Metastasis of HER2-positive Gastric Cancer Cells.
REFERENCE   2  (bases 1 to 3851)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3851)
  AUTHORS   Zhang,Z., Zhan,X., Kim,B. and Wu,J.
  TITLE     A proteomic approach identifies SAFB-like transcription modulator
            (SLTM) as a bidirectional regulator of GLI family zinc finger
            transcription factors
  JOURNAL   J Biol Chem 294 (14), 5549-5561 (2019)
   PUBMED   30782847
  REMARK    GeneRIF: SLTM regulates GLI factor binding to chromatin and
            contributes to the transcriptional outcomes of SHH signaling via a
            novel molecular mechanism.
REFERENCE   4  (bases 1 to 3851)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 3851)
  AUTHORS   Chan,C.W., Lee,Y.B., Uney,J., Flynn,A., Tobias,J.H. and Norman,M.
  TITLE     A novel member of the SAF (scaffold attachment factor)-box protein
            family inhibits gene expression and induces apoptosis
  JOURNAL   Biochem J 407 (3), 355-362 (2007)
   PUBMED   17630952
  REMARK    GeneRIF: Inhibition of gene expression by STLM appears to result
            from generalized down-regulation of mRNA synthesis and initiation
            of apoptosis following SLTM overexpression.
REFERENCE   6  (bases 1 to 3851)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3851)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3851)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 3851)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3851)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158995.2.
            
            On Nov 10, 2017 this sequence version replaced NM_025690.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF462146.1, BC139202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AC158995.2         55854-56220         c
            368-455             AC158995.2         54878-54965         c
            456-520             AC158995.2         39834-39898         c
            521-718             AC158995.2         36962-37159         c
            719-766             AC158995.2         36074-36121         c
            767-794             AC158995.2         26759-26786         c
            795-1263            AC158995.2         25010-25478         c
            1264-1313           AC158995.2         24310-24359         c
            1314-1432           AC158995.2         22095-22213         c
            1433-1582           AC158995.2         19504-19653         c
            1583-1686           AC158995.2         18880-18983         c
            1687-1850           AC158995.2         18605-18768         c
            1851-1936           AC158995.2         18067-18152         c
            1937-2100           AC158995.2         17471-17634         c
            2101-2281           AC158995.2         14823-15003         c
            2282-2406           AC158995.2         14058-14182         c
            2407-2571           AC158995.2         12847-13011         c
            2572-2886           AC158995.2         11986-12300         c
            2887-3031           AC158995.2         11740-11884         c
            3032-3192           AC158995.2         9818-9978           c
            3193-3851           AC158995.2         6698-7356           c
FEATURES             Location/Qualifiers
     source          1..3851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.53 cM"
     gene            1..3851
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /note="SAFB-like, transcription modulator"
                     /db_xref="GeneID:66660"
                     /db_xref="MGI:MGI:1913910"
     exon            1..367
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..3301
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /note="isoform a is encoded by transcript variant 1;
                     modulator of estrogen induced transcription; SAF-like
                     transcription modulator"
                     /codon_start=1
                     /product="SAFB-like transcription modulator isoform a"
                     /protein_id="NP_079966.2"
                     /db_xref="CCDS:CCDS23322.1"
                     /db_xref="GeneID:66660"
                     /db_xref="MGI:MGI:1913910"
                     /translation="MAAAAGAVVASAASGPAEGKKITELRVIDLRSELKRRNLDINGV
                     KTVLVSRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKQEADELSGDASVEDDS
                     FVKDCELENQETHDQDGNEELKDLEEFGENEEEIVHSQELLSTEENKTTQEFVEAEAI
                     EDREKEDIESQETEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSL
                     AEADHTAHEEMEANATGKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEA
                     SKPKDVQDAIAQSPEKEAKDYEMNPNHKDGKKEDSVKGEPVEKEARESAKKAESGDKE
                     KDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTGSAGGSSGSSTKNIWVSGLS
                     SNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCVAHLHRTEL
                     HGQLISVEKVKGDPSKKEMKKENDEKSSSRSAGDKKNASDRSAKTQASIKKEEKRSSE
                     KSEKKESKDTKKIEKDEKNDDGPSGQTSESLKKSEEKKRISSKSPGHMVILNQTKGDH
                     CRPSRRGRYEKGHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERL
                     KQAVEFRRRKEIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERER
                     LERERIRIEQERRREAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYW
                     SENKKLSLDTEARFGHGSDYRQQSRFLDFSHRERARFPDTASVQSSFERRERFVGQSE
                     GKKPRPAARREEPSFERYPKNFSDSRRNEPPPPRNELRETDRREVRGERDERRTVILH
                     DRPEVAHPRHPRETVPNPSRPTSWKSEANMSTEKRESRVERPERSGREVSGHTVRGAP
                     PGNRSSASGYGTREGERGVIADRGSGTQHYPEERHVVERHGRDTSGPRKEWHGPPSQG
                     PSYHDTRRMGDGRAGAGMITQHSSTASPVNRIVQMSGNSLPRGSSSGFKPFKSGPPRR
                     F"
     exon            368..455
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            456..520
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            521..718
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            719..766
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            767..794
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1263
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1313
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1432
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1582
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1686
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1850
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1936
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2100
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2281
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2406
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2571
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2886
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3031
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3192
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3851
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /note="hexamer: AATAAA"
     polyA_site      3848
                     /gene="Sltm"
                     /gene_synonym="5730455C01Rik; 5730555F13Rik;
                     9130215G10Rik; Met"
                     /note="major polyA site"
ORIGIN      
        1 gcagagtcgg gggcgtggtc cccgtggggg ggcgtggtca gtggctcatt gtgcgcagcg
       61 tagcgcggcg ccgctggccg cccggggccc gggttggaag ttggtgctgc cgcggccacc
      121 gcctccaccg ccgctgcctc ctcctccgcc gccgccgccg ccctgcagcc cactagctgc
      181 ctcggcagcg cgttgctttc ccaaaatggc tgccgctgcc ggggccgtgg tagcctcggc
      241 cgcctctggg ccggcggaag ggaagaagat cacggagctg cgggttatcg acctcaggtc
      301 cgagctgaag cgccgcaact tggacatcaa cggggtcaag acggtactgg tctcccggct
      361 gaagcaggct attgaagagg aaggaggcga tccagataat attgaattaa ctgtttcaac
      421 tgatactcca aacaagaaac caaccaaagg caaaggtaaa aaacaagaag cagatgagtt
      481 gagtggagat gcttctgtgg aagatgattc ttttgtcaag gactgtgaat tggagaatca
      541 agagacacat gaccaagatg gaaatgaaga gctaaaggac ttggaagaat ttggtgaaaa
      601 tgaagaggaa attgtgcatt cccaggagtt gctttctaca gaagagaaca agacaactca
      661 ggaatttgta gaggcagaag caatagaaga tagagaaaaa gaggacatcg aaagtcagga
      721 aactgaagct caagaaggtg aagatgacac ctttctaaca gctcaagatg gtgaggaaga
      781 agaaaatgag aaagatatag caggttctgg tgatggcaca caagaagtat ctaaacctct
      841 tccttcagaa gggagcctag ctgaggctga tcacacagct catgaagaga tggaagctaa
      901 tgcgactggg aaagaagctg aggatgacaa catctcggtc acaatccagg ctgaagatgc
      961 catcactctg gattttgatg gtgatgacct cctagaaaca ggtaaaaatg tgaaaattac
     1021 agattctgaa gcaagtaagc caaaagatgt gcaggacgcc attgcacaga gcccggagaa
     1081 ggaagccaag gattatgaga tgaacccgaa ccataaagat ggtaagaagg aagactccgt
     1141 gaagggtgag cctgtcgaga aggaagccag agaaagtgct aagaaagcag aatctggaga
     1201 caaagaaaag gatactttga agaaagggcc ctcgtctaca ggggcctctg gtcaagcaaa
     1261 gagctcttca aaggaatcta aagacagcaa gacatcatct aaagatgaca aagggagcac
     1321 aggcagtgct ggtgggagca gtggaagctc aaccaagaac atctgggtca gtggactgtc
     1381 ttctaatacc aaagctgctg atttgaagaa cctctttggc aaatatggaa aggttctaag
     1441 tgcaaaggta gttacaaatg ctcgaagtcc tggggcaaaa tgctatggca tcgtaaccat
     1501 gtcttcaagc acagaagtgt ccagatgtgt tgcacatctc catcgcacag agctgcatgg
     1561 acaactgatt tctgtggaga aagtcaaagg tgatccttct aagaaagaaa tgaagaaaga
     1621 aaatgatgag aagagtagct cacggagcgc tggtgataaa aagaacgcga gtgatcggag
     1681 tgccaagaca caagcatcta ttaaaaaaga agagaaaagg tcatctgaga aatcagaaaa
     1741 aaaagaaagc aaagatacta agaaaataga gaaagatgag aagaacgacg atggtccaag
     1801 tgggcagact tcagagtccc tgaaaaagag tgaagagaag aagcggataa gttcaaagag
     1861 tccaggacat atggtgatac taaaccaaac caagggagat cattgtaggc cgtcaagaag
     1921 gggcagatat gagaaaggtc atggaagaag caaagaaaag gagagggcta gcctagataa
     1981 aaaaagagac aaagactaca gaaggaaaga gatcttgcct tttgaaaaga tgaaggaaca
     2041 aagattgaga gaacatttag ttcgttttga aagactgaaa caagcagtgg aattcagaag
     2101 acgaaaagag attgcagaaa gagagcgtcg agagcgtgaa cgcattagaa taattcgtga
     2161 acgggaagaa cgggaacgct tacagagaga gagagagcgc ctagaaattg aaaggcaaaa
     2221 actagagaga gagagaatgg aacgcgaacg cttggaaagg gaacgcattc gtattgaaca
     2281 ggagcggcgc agggaagctg aaaggattgc tcgggagaga gaggagctca gaaggcagca
     2341 gcagcagctt cgctatgaac aagaaaaaag gaattctttg aaacgcccac gtgacgtaga
     2401 ccataggcga gatgaccctt actggagcga gaataaaaag ttatctctag atacagaggc
     2461 acgattcggc catgggtctg actatcgtca acagagcagg ttccttgact tcagtcaccg
     2521 agaacgggcc aggtttcctg acactgcatc tgtgcagtca tcctttgaaa gacgggaacg
     2581 gtttgttggt caaagtgaag gaaagaaacc gagaccagca gcccgaagag aagagccaag
     2641 ttttgaaagg taccctaaaa acttcagtga ttccagaaga aatgagcctc caccaccaag
     2701 aaatgaactt agagaaacag acagacgaga ggtccgaggg gagagagacg agagaagaac
     2761 agtaatcctt catgaccgac ctgaggtcgc tcaccccaga caccctcgag agactgtgcc
     2821 caatccttct agaccaactt cctggaaaag cgaagcgaat atgtccacag agaaacggga
     2881 gtcacgagtt gaaaggccag aaagatctgg gagagaagtc tctggacaca ctgtgagggg
     2941 agcgcccccc gggaatcgga gtagtgcctc aggctatgga acccgagagg gagagcgagg
     3001 agtcattgct gacagaggaa gcggaacaca gcactaccct gaagaacgac atgtcgtgga
     3061 acgtcatgga cgggacacaa gtggaccaag gaaagagtgg catggcccac cctctcaggg
     3121 gcctagctac catgacacaa gacgaatggg tgatggccga gcaggagcag gcatgataac
     3181 ccaacactca agcactgcgt ccccagtgaa caggattgta cagatgagtg gtaactcctt
     3241 gccaagagga agcagctcgg ggtttaagcc gtttaagagt ggacctccac ggcgatttta
     3301 acgcaagctt cctgctgtgg cttcaagata atttattgag atctcctgta aacgttccct
     3361 gactgcttac taggagaacc tctgactgct tgagagttct agctgactgt tgtttttctt
     3421 tataaaaaaa tttaacacga tttcttttct caactttaga gaagatgttt aaatagttct
     3481 gttgaaactt ttcatagttt tgtgtaccat tcaacctttt cttgcagcac tgagacccat
     3541 ttgaaaggat tggcacaagg ctgttctgtt tggcactgtg tgaacatgag tggtttgcag
     3601 ctgaatggta gtggtttcat ttgcagcgta gctctgtggt gtcaccagtg ttggctgcct
     3661 ccattttgaa ggctatttga gcttcaaaag cctgctgtct aatttttaga gaataagatt
     3721 gttccctgca tttcggagta ttatgtaacc tatttttgca gaaggtactg ttacattaag
     3781 tgcatctgtg tatcctggtt aaaaaaaaaa tgtaatcttt ttggaaataa accttcatat
     3841 tctgtatagt t
//
