LOCUS       NM_001412603             656 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus secretory leukocyte peptidase inhibitor (Slpi),
            transcript variant 4, mRNA.
ACCESSION   NM_001412603
VERSION     NM_001412603.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 656)
  AUTHORS   Rosen,A.L., Lint,M.A., Voelker,D.H., Gilbert,N.M., Tomera,C.P.,
            Santiago-Borges,J., Wallace,M.A., Hannan,T.J., Burnham,C.-A.D.,
            Hultgren,S.J. and Kau,A.L.
  TITLE     Secretory leukocyte protease inhibitor protects against severe
            urinary tract infection in mice
  JOURNAL   mBio 15 (2), e0255423 (2024)
   PUBMED   38270443
  REMARK    GeneRIF: Secretory leukocyte protease inhibitor protects against
            severe urinary tract infection in mice.
REFERENCE   2  (bases 1 to 656)
  AUTHORS   Kwiecinska,P., Kwitniewski,M., Kwiecien,K., Morytko,A.,
            Majewski,P., Pocalun,N., Pastuszczak,M., Migaczewski,M., Cichy,J.
            and Grygier,B.
  TITLE     Secretory leukocyte protease inhibitor modulates
            FcepsilonRI-dependent but not Mrgprb2-dependent mastocyte function
            in psoriasis
  JOURNAL   Int Immunopharmacol 122, 110631 (2023)
   PUBMED   37453153
REFERENCE   3  (bases 1 to 656)
  AUTHORS   Kwiecinska,P., Grygier,B., Morytko,A., Sanecka-Duin,A.,
            Majchrzak-Gorecka,M., Kwitniewski,M., Kapinska-Mrowiecka,M.,
            Porebski,G. and Cichy,J.
  TITLE     Secretory leukocyte protease inhibitor regulates nerve
            reflex-mediated skin barrier function in psoriasis
  JOURNAL   J Eur Acad Dermatol Venereol 36 (8), 1266-1274 (2022)
   PUBMED   35279880
REFERENCE   4  (bases 1 to 656)
  AUTHORS   Ozaka,S., Sonoda,A., Ariki,S., Kamiyama,N., Hidano,S., Sachi,N.,
            Ito,K., Kudo,Y., Minata,M., Saechue,B., Dewayani,A., Chalalai,T.,
            Soga,Y., Takahashi,Y., Fukuda,C., Mizukami,K., Okumura,R.,
            Kayama,H., Murakami,K., Takeda,K. and Kobayashi,T.
  TITLE     Protease inhibitory activity of secretory leukocyte protease
            inhibitor ameliorates murine experimental colitis by protecting the
            intestinal epithelial barrier
  JOURNAL   Genes Cells 26 (10), 807-822 (2021)
   PUBMED   34379860
  REMARK    GeneRIF: Protease inhibitory activity of secretory leukocyte
            protease inhibitor ameliorates murine experimental colitis by
            protecting the intestinal epithelial barrier.
REFERENCE   5  (bases 1 to 656)
  AUTHORS   Cui,C., Chakraborty,K., Tang,X.A., Zhou,G., Schoenfelt,K.Q.,
            Becker,K.M., Hoffman,A., Chang,Y.F., Blank,A., Reardon,C.A.,
            Kenny,H.A., Vaisar,T., Lengyel,E., Greene,G. and Becker,L.
  TITLE     Neutrophil elastase selectively kills cancer cells and attenuates
            tumorigenesis
  JOURNAL   Cell 184 (12), 3163-3177 (2021)
   PUBMED   33964209
REFERENCE   6  (bases 1 to 656)
  AUTHORS   Ashcroft,G.S., Lei,K., Jin,W., Longenecker,G., Kulkarni,A.B.,
            Greenwell-Wild,T., Hale-Donze,H., McGrady,G., Song,X.Y. and
            Wahl,S.M.
  TITLE     Secretory leukocyte protease inhibitor mediates non-redundant
            functions necessary for normal wound healing
  JOURNAL   Nat Med 6 (10), 1147-1153 (2000)
   PUBMED   11017147
REFERENCE   7  (bases 1 to 656)
  AUTHORS   Kikuchi,T., Abe,T., Hoshi,S., Matsubara,N., Tominaga,Y., Satoh,K.
            and Nukiwa,T.
  TITLE     Structure of the murine secretory leukoprotease inhibitor (Slpi)
            gene and chromosomal localization of the human and murine SLPI
            genes
  JOURNAL   Am J Respir Cell Mol Biol 19 (6), 875-880 (1998)
   PUBMED   9843921
REFERENCE   8  (bases 1 to 656)
  AUTHORS   Abe,T., Tominaga,Y., Kikuchi,T., Watanabe,A., Satoh,K., Watanabe,Y.
            and Nukiwa,T.
  TITLE     Bacterial pneumonia causes augmented expression of the secretory
            leukoprotease inhibitor gene in the murine lung
  JOURNAL   Am J Respir Crit Care Med 156 (4 Pt 1), 1235-1240 (1997)
   PUBMED   9351627
REFERENCE   9  (bases 1 to 656)
  AUTHORS   Zitnik,R.J., Zhang,J., Kashem,M.A., Kohno,T., Lyons,D.E.,
            Wright,C.D., Rosen,E., Goldberg,I. and Hayday,A.C.
  TITLE     The cloning and characterization of a murine secretory leukocyte
            protease inhibitor cDNA
  JOURNAL   Biochem Biophys Res Commun 232 (3), 687-697 (1997)
   PUBMED   9126337
REFERENCE   10 (bases 1 to 656)
  AUTHORS   Jin,F.Y., Nathan,C., Radzioch,D. and Ding,A.
  TITLE     Secretory leukocyte protease inhibitor: a macrophage product
            induced by and antagonistic to bacterial lipopolysaccharide
  JOURNAL   Cell 88 (3), 417-426 (1997)
   PUBMED   9039268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590429.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.8043142.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AL590429.10        98164-98268         c
            106-267             AL590429.10        97427-97588         c
            268-412             AL590429.10        96857-97001         c
            413-656             AL590429.10        96046-96289         c
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.16 cM"
     gene            1..656
                     /gene="Slpi"
                     /gene_synonym="ALP"
                     /note="secretory leukocyte peptidase inhibitor"
                     /db_xref="GeneID:20568"
                     /db_xref="MGI:MGI:109297"
     exon            1..105
                     /gene="Slpi"
                     /gene_synonym="ALP"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..635
                     /gene="Slpi"
                     /gene_synonym="ALP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4; antileukoproteinase; secretory leukocyte
                     protease inhibitor"
                     /codon_start=1
                     /product="antileukoproteinase isoform 2 precursor"
                     /protein_id="NP_001399532.1"
                     /db_xref="GeneID:20568"
                     /db_xref="MGI:MGI:109297"
                     /translation="MKSCGLLPFTVLLALGILAPWTVEGGKNDAIKIGACPAKKPAQC
                     LKLEKPQCRTDWECPGKQRCCQDACGSKCVNPVPIRKPVWRKPGRCVKTQARCMMLNP
                     PNVCQRDGQCDGKYKCCEGICGKVCLPPILIPDIGAGSGLVLGVLWKLLPCSQASLLR
                     VPWLPAPCIPGLDPVDQGYCFTTNISFWLSIHRSLGKCCWRANK"
     exon            106..267
                     /gene="Slpi"
                     /gene_synonym="ALP"
                     /inference="alignment:Splign:2.1.0"
     exon            268..412
                     /gene="Slpi"
                     /gene_synonym="ALP"
                     /inference="alignment:Splign:2.1.0"
     exon            413..656
                     /gene="Slpi"
                     /gene_synonym="ALP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      631..636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slpi"
                     /gene_synonym="ALP"
                     /note="hexamer: AATAAA"
     polyA_site      656
                     /gene="Slpi"
                     /gene_synonym="ALP"
                     /note="major polyA site"
ORIGIN      
        1 agagctcccc tgccttcacc atgaagtcct gcggcctttt acctttcacg gtgctccttg
       61 ctctggggat cctggcaccc tggactgtgg aaggaggcaa aaatgatgct atcaaaatcg
      121 gagcctgccc tgctaaaaag cctgcccagt gccttaagct tgagaagcca caatgccgta
      181 ctgactggga gtgcccggga aagcagaggt gctgccaaga tgcttgcggt tccaagtgcg
      241 tgaatcctgt tcccattcgc aaaccagtgt ggaggaagcc tgggaggtgc gtcaaaactc
      301 aggcaagatg tatgatgctt aaccctccca atgtctgcca gagggacggg cagtgtgacg
      361 gcaaatacaa gtgctgtgag ggtatatgtg ggaaagtctg cctgcccccg atcctgatcc
      421 ctgacattgg cgccggctct ggactcgtgc tcggtgtgct ctggaaacta cttccctgct
      481 cccaggcgtc cctgctccgg gttccatggc tcccggctcc ctgtatccca ggcttggatc
      541 ctgtggacca gggttactgt tttaccacta acatctcctt ttggctcagc attcaccgat
      601 ctttagggaa atgctgttgg agagcaaata aataaacgca ttcatttctc tatgca
//
