LOCUS       NM_025540                536 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus sarcolipin (Sln), mRNA.
ACCESSION   NM_025540
VERSION     NM_025540.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 536)
  AUTHORS   Skop,V., Liu,N., Xiao,C., Stinson,E., Chen,K.Y., Hall,K.D.,
            Piaggi,P., Gavrilova,O. and Reitman,M.L.
  TITLE     Beyond day and night: The importance of ultradian rhythms in mouse
            physiology
  JOURNAL   Mol Metab 84, 101946 (2024)
   PUBMED   38657735
REFERENCE   2  (bases 1 to 536)
  AUTHORS   Mareedu,S., Fefelova,N., Galindo,C.L., Prakash,G., Mukai,R.,
            Sadoshima,J., Xie,L.H. and Babu,G.J.
  TITLE     Improved mitochondrial function in the hearts of
            sarcolipin-deficient dystrophin and utrophin double-knockout mice
  JOURNAL   JCI Insight 9 (9), e170185 (2024)
   PUBMED   38564291
  REMARK    GeneRIF: Improved mitochondrial function in the hearts of
            sarcolipin-deficient dystrophin and utrophin double-knockout mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 536)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 536)
  AUTHORS   Su,K.N., Ma,Y., Cacheux,M., Ilkan,Z., Raad,N., Muller,G.K., Wu,X.,
            Guerrera,N., Thorn,S.L., Sinusas,A.J., Foretz,M., Viollet,B.,
            Akar,J.G., Akar,F.G. and Young,L.H.
  TITLE     Atrial AMP-activated protein kinase is critical for prevention of
            dysregulation of electrical excitability and atrial fibrillation
  JOURNAL   JCI Insight 7 (8), e141213 (2022)
   PUBMED   35451373
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 536)
  AUTHORS   Son,J.S., Chae,S.A., Zhao,L., Wang,H., de Avila,J.M., Zhu,M.J.,
            Jiang,Z. and Du,M.
  TITLE     Maternal exercise intergenerationally drives muscle-based
            thermogenesis via activation of apelin-AMPK signaling
  JOURNAL   EBioMedicine 76, 103842 (2022)
   PUBMED   35081489
REFERENCE   6  (bases 1 to 536)
  AUTHORS   Shimura,M., Minamisawa,S., Yokoyama,U., Umemura,S. and Ishikawa,Y.
  TITLE     Mechanical stress-dependent transcriptional regulation of
            sarcolipin gene in the rodent atrium
  JOURNAL   Biochem Biophys Res Commun 334 (3), 861-866 (2005)
   PUBMED   16036219
  REMARK    GeneRIF: we generated left-sided pressure-overload models by
            transverse aortic constriction (TAC) in ddY mice.  TAC
            significantly decreased the expression of sarcolipin, SERCA2a, and
            phospholamban mRNAs in the left atrium (LA) than those in the right
            atrium (RA).
REFERENCE   7  (bases 1 to 536)
  AUTHORS   Vangheluwe,P., Schuermans,M., Zador,E., Waelkens,E., Raeymaekers,L.
            and Wuytack,F.
  TITLE     Sarcolipin and phospholamban mRNA and protein expression in cardiac
            and skeletal muscle of different species
  JOURNAL   Biochem J 389 (Pt 1), 151-159 (2005)
   PUBMED   15801907
  REMARK    GeneRIF: The expression of SLN and PLB mRNA and protein relative to
            SERCA1 or SERCA2 was assessed in ventricle, atrium, and skeltal
            msucle of mouse, rat, rabbit and pig.
REFERENCE   8  (bases 1 to 536)
  AUTHORS   Gramolini,A.O., Kislinger,T., Asahi,M., Li,W., Emili,A. and
            MacLennan,D.H.
  TITLE     Sarcolipin retention in the endoplasmic reticulum depends on its
            C-terminal RSYQY sequence and its interaction with
            sarco(endo)plasmic Ca(2+)-ATPases
  JOURNAL   Proc Natl Acad Sci U S A 101 (48), 16807-16812 (2004)
   PUBMED   15556994
  REMARK    GeneRIF: retention of sarcolipin in the endoplasmic reticulum is
            mediated through its association with other components through the
            C-terminal RSYQY sequence
REFERENCE   9  (bases 1 to 536)
  AUTHORS   Asahi,M., Otsu,K., Nakayama,H., Hikoso,S., Takeda,T.,
            Gramolini,A.O., Trivieri,M.G., Oudit,G.Y., Morita,T., Kusakari,Y.,
            Hirano,S., Hongo,K., Hirotani,S., Yamaguchi,O., Peterson,A.,
            Backx,P.H., Kurihara,S., Hori,M. and MacLennan,D.H.
  TITLE     Cardiac-specific overexpression of sarcolipin inhibits
            sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and
            impairs cardiac function in mice
  JOURNAL   Proc Natl Acad Sci U S A 101 (25), 9199-9204 (2004)
   PUBMED   15201433
  REMARK    GeneRIF: SLN overexpression inhibits SERCA2a through stabilization
            of SERCA2a-phospholamban interaction in the absence of PLN.
REFERENCE   10 (bases 1 to 536)
  AUTHORS   Minamisawa,S., Wang,Y., Chen,J., Ishikawa,Y., Chien,K.R. and
            Matsuoka,R.
  TITLE     Atrial chamber-specific expression of sarcolipin is regulated
            during development and hypertrophic remodeling
  JOURNAL   J Biol Chem 278 (11), 9570-9575 (2003)
   PUBMED   12645548
  REMARK    GeneRIF: sarcolipin is likely to be an atrial chamber-specific
            regulator of Ca2+ cycling in heart
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK008896.1, BC028496.1 and
            CA460968.1.
            
            On Feb 1, 2007 this sequence version replaced NM_025540.1.
            
            Summary: Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane
            proteins that catalyze the ATP-dependent transport of Ca(2+) from
            the cytosol into the lumen of the sarcoplasmic reticulum in muscle
            cells. This gene encodes a small proteolipid that regulates several
            sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein
            interacts with Ca(2+)-ATPases and reduces the accumulation of
            Ca(2+) in the sarcoplasmic reticulum without affecting the rate of
            ATP hydrolysis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA460968.1, CB596554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK008896.1         2-20
            20-517              BC028496.1         1-498
            518-536             CA460968.1         556-574
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.24 cM"
     gene            1..536
                     /gene="Sln"
                     /gene_synonym="2310045A07Rik"
                     /note="sarcolipin"
                     /db_xref="GeneID:66402"
                     /db_xref="MGI:MGI:1913652"
     exon            1..76
                     /gene="Sln"
                     /gene_synonym="2310045A07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            77..520
                     /gene="Sln"
                     /gene_synonym="2310045A07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..239
                     /gene="Sln"
                     /gene_synonym="2310045A07Rik"
                     /codon_start=1
                     /product="sarcolipin"
                     /protein_id="NP_079816.1"
                     /db_xref="CCDS:CCDS40640.1"
                     /db_xref="GeneID:66402"
                     /db_xref="MGI:MGI:1913652"
                     /translation="MERSTQELFINFTVVLITVLLMWLLVRSYQY"
     regulatory      488..493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sln"
                     /gene_synonym="2310045A07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      517
                     /gene="Sln"
                     /gene_synonym="2310045A07Rik"
                     /note="major polyA site"
ORIGIN      
        1 agacagccgg ggagacagct ggaggtggag agactgaggt ccttggtagc ctgagtgtgc
       61 ccctgctcct cttcaggaag tgaagacaag ccttggtgtg caatcacaag tccttctgga
      121 gttctcatcc agacattctg aagatggaga ggtctactca ggagctgttt atcaacttca
      181 cagttgtcct catcaccgtt ctccttatgt ggctcctcgt gaggtcctac caatactgag
      241 gggccatgct atactccagg gagtgactgc tgtgtgcccc gagcttccaa tgctctattg
      301 tcatgagatg ctgcttctgg ctcctccagc atctctgacc cacactcaca atgcctgaca
      361 caccgctgca ctaggtcctt ggcatgtttt ctaaagatgc tgttcttgta ggctgcccaa
      421 agcttgccag ccagtgagcc ttagctttgt tccctagcaa atgtactatt caagtcacca
      481 ggttaaaatt aaactggatt cttatgatgc agagtaacaa aaaaaaaaaa aaaaaa
//
