LOCUS       NM_199065               4266 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus SLIT and NTRK-like family, member 1 (Slitrk1), mRNA.
ACCESSION   NM_199065 XM_127898
VERSION     NM_199065.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4266)
  AUTHORS   Matsumoto,Y., Miwa,H., Katayama,K.I., Watanabe,A., Yamada,K.,
            Ito,T., Nakagawa,S. and Aruga,J.
  TITLE     Slitrk4 is required for the development of inhibitory neurons in
            the fear memory circuit of the lateral amygdala
  JOURNAL   Front Mol Neurosci 17, 1386924 (2024)
   PUBMED   38736483
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4266)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4266)
  AUTHORS   Hatayama,M., Katayama,K.I., Kawahara,Y., Matsunaga,H.,
            Takashima,N., Iwayama,Y., Matsumoto,Y., Nishi,A., Yoshikawa,T. and
            Aruga,J.
  TITLE     SLITRK1-mediated noradrenergic projection suppression in the
            neonatal prefrontal cortex
  JOURNAL   Commun Biol 5 (1), 935 (2022)
   PUBMED   36085162
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4266)
  AUTHORS   Markenscoff-Papadimitriou,E., Binyameen,F., Whalen,S., Price,J.,
            Lim,K., Ypsilanti,A.R., Catta-Preta,R., Pai,E.L., Mu,X., Xu,D.,
            Pollard,K.S., Nord,A.S., State,M.W. and Rubenstein,J.L.
  TITLE     Autism risk gene POGZ promotes chromatin accessibility and
            expression of clustered synaptic genes
  JOURNAL   Cell Rep 37 (10), 110089 (2021)
   PUBMED   34879283
REFERENCE   5  (bases 1 to 4266)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4266)
  AUTHORS   Katayama,K., Yamada,K., Ornthanalai,V.G., Inoue,T., Ota,M.,
            Murphy,N.P. and Aruga,J.
  TITLE     Slitrk1-deficient mice display elevated anxiety-like behavior and
            noradrenergic abnormalities
  JOURNAL   Mol Psychiatry 15 (2), 177-184 (2010)
   PUBMED   18794888
  REMARK    GeneRIF: These results lead us to conclude that noradrenergic
            mechanisms are involved in the behavioral abnormalities of
            Slitrk1-deficient mice. Elevated anxiety due to Slitrk1 dysfunction
            may contribute to the pathogenesis of neuropsychiatric diseases
REFERENCE   7  (bases 1 to 4266)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   8  (bases 1 to 4266)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 4266)
  AUTHORS   Aruga,J., Yokota,N. and Mikoshiba,K.
  TITLE     Human SLITRK family genes: genomic organization and expression
            profiling in normal brain and brain tumor tissue
  JOURNAL   Gene 315, 87-94 (2003)
   PUBMED   14557068
REFERENCE   10 (bases 1 to 4266)
  AUTHORS   Aruga,J. and Mikoshiba,K.
  TITLE     Identification and characterization of Slitrk, a novel neuronal
            transmembrane protein family controlling neurite outgrowth
  JOURNAL   Mol Cell Neurosci 24 (1), 117-129 (2003)
   PUBMED   14550773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO430912.1, AK173296.1 and BE956915.1.
            
            On May 24, 2007 this sequence version replaced NM_199065.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                CO430912.1         1-81
            82-3720             AK173296.1         1-3639
            3721-4266           BE956915.1         1-546               c
FEATURES             Location/Qualifiers
     source          1..4266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 56.78 cM"
     gene            1..4266
                     /gene="Slitrk1"
                     /gene_synonym="3200001I04Rik"
                     /note="SLIT and NTRK-like family, member 1"
                     /db_xref="GeneID:76965"
                     /db_xref="MGI:MGI:2679446"
     exon            1..4252
                     /gene="Slitrk1"
                     /gene_synonym="3200001I04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             963..3053
                     /gene="Slitrk1"
                     /gene_synonym="3200001I04Rik"
                     /note="slit and trk like gene 1; SLIT and NTRK-like
                     protein 1"
                     /codon_start=1
                     /product="SLIT and NTRK-like protein 1 precursor"
                     /protein_id="NP_951020.1"
                     /db_xref="CCDS:CCDS27325.1"
                     /db_xref="GeneID:76965"
                     /db_xref="MGI:MGI:2679446"
                     /translation="MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEK
                     KGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAF
                     LGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLI
                     LNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTC
                     DLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPA
                     QEETFAPGPLPTPFKTNGQDEHATPGAVPNGGTKIPGNWQLKIKPTPPIATGSARNKP
                     PVHGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRK
                     SHFVDYKNLILLDLGNNNIANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLE
                     YLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMY
                     LPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFR
                     KDFMLLSNEEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGL
                     LLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADG
                     SHRVYDCGSHSLSD"
     regulatory      4230..4235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slitrk1"
                     /gene_synonym="3200001I04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4252
                     /gene="Slitrk1"
                     /gene_synonym="3200001I04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gatctttcag agtgcaccag gctggaacca gcagagcttc ttagcaactc cccccctcct
       61 cccctttctc gcgctctctt cctccctcag acaactcgct ccccctctct cctcccccct
      121 cacgtaattc cgaaagagca gaagaaagag aaggagaaca agcaaagaag agctagtaag
      181 cgccggccgg agcacagaaa aaaagggctg aagacgacca aaggggagca aaggaacagg
      241 atggacatcc acaaaacgca gtgattgcgg aaattttcca gcgccattgg ctgggcagtg
      301 agtcttttgg gcgggcgtga tttcagcacc gggggcactg gacagcacct cgggggtact
      361 tctgggcaac ccgcaaccga gacaagaact ccaccagctg cctggaccac tgaagccgcc
      421 gaaagccctg ctttgtatcc gagaggcaag gtcagtccga cgcacagcca tcacaggcag
      481 tgcgcctgta ctacgctgca aacctgcttg tttctaacat gcacttgctt ctaattgcta
      541 gcattgttcc cttgctggtt agtgagaacc tctaaacatg attctgtaag ggtgcgtttc
      601 cttttaattg tacaggtata tatttaactt attttggtta tttttaaagg gttgaggggg
      661 agtagtttgc tttctctctc tctctctctc tttcctctac tttccacccc cctctctttt
      721 ctgcttgcct tgcactatgt gcctggatag tttgtggata taattattga ctggcgtctg
      781 ggctattgca gtacgggggg gttagggagg aaggaatcca cccccacccc cccaaaccct
      841 tcttttctct ttctctggga tcggacattg gagcactaaa tgaacttgaa ttgtgtctgt
      901 ggcgagcagg atggttgctg ttactttgtg atgagatctg ggatgaattg ctcgctttaa
      961 aaatgctgct ttggattctg ttgctggaga cgtctctttg ttttgccgct ggaaacgtta
     1021 caggggacgt ttgtaaagag aagatctgtt cttgcaatga gatagaaggg gacttacacg
     1081 tagactgtga aaaaaagggc ttcacaagtc tgcagcgctt caccgccccg acttcccagt
     1141 tttaccattt atttctgcat ggcaattccc tcactcgact tttccctaat gagttcgcta
     1201 acttttataa tgcggttagt ttgcatatgg aaaacaatgg cttgcatgag atcgttccgg
     1261 gggcatttct ggggctgcag ctggtgaaac ggctgcacat caacaacaac aagatcaagt
     1321 cttttcgaaa gcagactttt ttggggctgg acgatctgga atacctccag gctgatttta
     1381 atttattacg ggatatagac ccgggggcct tccaggactt gaacaagttg gaagtcctca
     1441 ttttaaacga caatctcatc agcaccctac ctgctaatgt attccagtat gtgcccatca
     1501 cccacctcga cctccgtgga aacaggctga aaacactgcc ctatgaggag gtcttggagc
     1561 agatccctgg cattgccgag atcctgctag aggataaccc ttgggactgc acctgtgatc
     1621 tgctctccct gaaggaatgg ctagagaaca ttcccaaaaa cgccctaatc ggtcgagtgg
     1681 tctgcgaagc ccccaccagg ctccagggta aagacctcaa tgaaaccacg gaacaggacc
     1741 tgtgtccttt aaaaaacaga gtggattcta gtctcccggc tccccctgcc caggaagaaa
     1801 ccttcgctcc tggccccctg ccaactcctt tcaagacaaa tgggcaggat gagcatgcta
     1861 ccccaggggc tgttccaaat ggaggtacaa agatcccggg caactggcag ctcaaaatca
     1921 aacccacgcc accgatagca actgggagcg ccagaaacaa acccccagtg catggcttgc
     1981 cctgccccgg gggctgcagc tgtgaccaca tcccaggctc aggcttaaag atgaactgta
     2041 acaaccggaa cgtgagcagc ttggctgatt tgaagcctaa gctttccaac gtgcaggagc
     2101 ttttccttcg agataacaag atccatagca tccgaaaatc acactttgtg gattacaaga
     2161 acctcattct gttggatctg ggcaacaaca acatcgcaaa catagagaac aacactttca
     2221 agaacctttt ggacctcagg tggctctaca tggatagtaa ctacctggac actctgtccc
     2281 gggagaaatt tgctgggctg cagaacctgg agtatctgaa tgtggagtac aacgcgattc
     2341 agctcattct ccctggtact ttcaatgcca tgccgaaact gaggattctt attctcaaca
     2401 acaacttgct gaggtcccta ccggtggacg tctttgctgg ggtctccctg tctaagctca
     2461 gtctgcacaa taattacttc atgtacctcc ctgtggcagg ggtgctggac cagttaacct
     2521 ccatcatcca gatagacctg catggcaacc cctgggagtg ctcctgcacc attgtgcctt
     2581 tcaagcaatg ggcagaacgt ctgggctccg aggtgctgat gagcgacctc aagtgtgaga
     2641 caccggtgaa cttctttagg aaggatttca tgctgctctc caatgaggag atctgccccc
     2701 agctgtatgc gaggatctcg cccacgttaa cttcgcacag taaaaacagc actgggttgg
     2761 cggagaccgg gacacactcc aactcctacc tagacaccag cagggtgtcc atctccgtgt
     2821 tggtcccggg actgctgctg gtgttcgtca cctccgcctt caccgtggtg ggcatgctcg
     2881 tgtttatcct gaggaaccga aagcggtcca agagaaggga tgccaattcc tctgcgtccg
     2941 aaattaattc cctacagaca gtctgtgact cttcctactg gcacaatggg ccttacaatg
     3001 cagatgggtc ccatagggtg tatgactgtg gctctcactc actttcagac taagcccccg
     3061 accctaaagg ggaaggagtg caggaagacg tccatcctcc cctgccgcct gaatcgcggg
     3121 gggagtggga gaacattgac ccagatctag cgtgtcacaa gcaccgatgg acatgagtaa
     3181 ataaataact atgaactcac tcaactcaga ggctctggcc cttaagctcc catctgaaaa
     3241 caaagagcag actgtggacc tgtgagtgca gcgagctagc tctttgctct gagctccttt
     3301 tgactcaaag cccagcatgg ggcctgccag aagaattgag ccccctcgct ctgagccaaa
     3361 ggtcccctgg ggctggctgc agtggctcta tacatatata catatatcac atctatatag
     3421 agaaatagat atctattttt cccctgtgga tagcccgaag atggctccct gttggtaaag
     3481 cagggatggg cagttgcacg aaggcatgaa tgtattgtaa ataaataact ttgactcctg
     3541 acaagaacaa acaaacaaac aaaagtgctg catggctcgc atggaatcca cacgctccag
     3601 ggactctgcc ccccgccccc cctctaccgc cccgccccac tgcgactgga gacgctgtca
     3661 cagcacccat cctcttacct gataagtccc atcgtatcaa actttctata aacaaaatac
     3721 agtataatca gaaagtgcca tttcgccctt atttgtgatt ggtaggcagt tcagagcgta
     3781 tgtttactgt gaaaaaaaat gtaaaggttt atttaagaca tttgcatggc taagtcatcg
     3841 gtccatttta tgagttaaca atgtattttg ttgagcaaag tttttaaggg ttgttttggg
     3901 ttcttttatt ttgatggtga tgtttgattt tcttttagtt tctgaggggg aatatttttc
     3961 tatacatatc caataatgcc ttccatctga atgtaaaata agtacccatg atttctatta
     4021 tagtaccagt gtaattattt aagaaaaaaa gattctgggg cagttaagca tgaccaatta
     4081 atgtcactct agtgcttagg ctgcgaccct atggtagcaa ttgtgtgctg gtaaaagtct
     4141 tacttataaa gtaggaacaa agaaccgagg aagcacgtga aaacttacta attctattcg
     4201 aggattttat aatggcatat tttttcagta ttaaagtgaa aatgttttca aaaaaaaaaa
     4261 aaaaaa
//
