LOCUS       NM_011412               5017 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus slit guidance ligand 3 (Slit3), mRNA.
ACCESSION   NM_011412 XM_203363 XM_895370
VERSION     NM_011412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5017)
  AUTHORS   Delpech,C., Schaeffer,J., Vilallongue,N., Delaunay,A., Benadjal,A.,
            Blot,B., Excoffier,B., Plissonnier,E., Gascon,E., Albert,F.,
            Paccard,A., Saintpierre,A., Gasnier,C., Zagar,Y., Castellani,V.,
            Belin,S., Chedotal,A. and Nawabi,H.
  TITLE     Axon guidance during mouse central nervous system regeneration is
            required for specific brain innervation
  JOURNAL   Dev Cell 59 (24), 3213-3228 (2024)
   PUBMED   39353435
REFERENCE   2  (bases 1 to 5017)
  AUTHORS   Liu,X., Li,B., Wang,S., Zhang,E., Schultz,M., Touma,M., Monteiro Da
            Rocha,A., Evans,S.M., Eichmann,A., Herron,T., Chen,R., Xiong,D.,
            Jaworski,A., Weiss,S. and Si,M.S.
  TITLE     Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure
            Overload-Induced Cardiac Hypertrophy
  JOURNAL   Circ Res 134 (7), 913-930 (2024)
   PUBMED   38414132
  REMARK    GeneRIF: Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates
            Pressure Overload-Induced Cardiac Hypertrophy.
REFERENCE   3  (bases 1 to 5017)
  AUTHORS   Gong,L. and Si,M.S.
  TITLE     SLIT3-mediated fibroblast signaling: a promising target for
            antifibrotic therapies
  JOURNAL   Am J Physiol Heart Circ Physiol 325 (6), H1400-H1411 (2023)
   PUBMED   37830982
  REMARK    GeneRIF: SLIT3-mediated fibroblast signaling: a promising target
            for antifibrotic therapies.
            Review article
REFERENCE   4  (bases 1 to 5017)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5017)
  AUTHORS   Iskusnykh,I.Y., Fattakhov,N., Li,Y., Bihannic,L., Kirchner,M.K.,
            Steshina,E.Y., Northcott,P.A. and Chizhikov,V.V.
  TITLE     Lmx1a is a master regulator of the cortical hem
  JOURNAL   Elife 12, e84095 (2023)
   PUBMED   37725078
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5017)
  AUTHORS   Erskine,L., Williams,S.E., Brose,K., Kidd,T., Rachel,R.A.,
            Goodman,C.S., Tessier-Lavigne,M. and Mason,C.A.
  TITLE     Retinal ganglion cell axon guidance in the mouse optic chiasm:
            expression and function of robos and slits
  JOURNAL   J Neurosci 20 (13), 4975-4982 (2000)
   PUBMED   10864955
REFERENCE   7  (bases 1 to 5017)
  AUTHORS   Niclou,S.P., Jia,L. and Raper,J.A.
  TITLE     Slit2 is a repellent for retinal ganglion cell axons
  JOURNAL   J Neurosci 20 (13), 4962-4974 (2000)
   PUBMED   10864954
REFERENCE   8  (bases 1 to 5017)
  AUTHORS   Yuan,W., Zhou,L., Chen,J.H., Wu,J.Y., Rao,Y. and Ornitz,D.M.
  TITLE     The mouse SLIT family: secreted ligands for ROBO expressed in
            patterns that suggest a role in morphogenesis and axon guidance
  JOURNAL   Dev Biol 212 (2), 290-306 (1999)
   PUBMED   10433822
REFERENCE   9  (bases 1 to 5017)
  AUTHORS   Li,H.S., Chen,J.H., Wu,W., Fagaly,T., Zhou,L., Yuan,W., Dupuis,S.,
            Jiang,Z.H., Nash,W., Gick,C., Ornitz,D.M., Wu,J.Y. and Rao,Y.
  TITLE     Vertebrate slit, a secreted ligand for the transmembrane protein
            roundabout, is a repellent for olfactory bulb axons
  JOURNAL   Cell 96 (6), 807-818 (1999)
   PUBMED   10102269
REFERENCE   10 (bases 1 to 5017)
  AUTHORS   Holmes,G.P., Negus,K., Burridge,L., Raman,S., Algar,E., Yamada,T.
            and Little,M.H.
  TITLE     Distinct but overlapping expression patterns of two vertebrate slit
            homologs implies functional roles in CNS development and
            organogenesis
  JOURNAL   Mech Dev 79 (1-2), 57-72 (1998)
   PUBMED   10349621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB645429.1, BC150780.1, AK147292.1 and AF088902.1.
            
            On Apr 15, 2009 this sequence version replaced NM_011412.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147292.1, BC150780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB645429.1         350-372
            24-1874             BC150780.1         1-1851
            1875-3062           AK147292.1         1876-3063
            3063-3463           BC150780.1         3040-3440
            3464-4801           AK147292.1         3465-4802
            4802-5017           AF088902.1         506-721
FEATURES             Location/Qualifiers
     source          1..5017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 20.29 cM"
     gene            1..5017
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /note="slit guidance ligand 3"
                     /db_xref="GeneID:20564"
                     /db_xref="MGI:MGI:1315202"
     exon            1..256
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..4631
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /note="slit homolog 3 protein; slit-3"
                     /codon_start=1
                     /product="slit homolog 3 protein precursor"
                     /protein_id="NP_035542.2"
                     /db_xref="CCDS:CCDS24542.1"
                     /db_xref="GeneID:20564"
                     /db_xref="MGI:MGI:1315202"
                     /translation="MALGRTGAGAAVRARLALGLALASILSGPPAAACPTKCTCSAAS
                     VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSIIER
                     GAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGVTGVK
                     NLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLY
                     CDCHLAWLSDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNAN
                     SLSCPSACSCSNNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLK
                     RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANKIN
                     CLRVNTFQDLQNLNLLSLYDNKLQTISKGLFVPLQSIQTLHLAQNPFVCDCHLKWLAD
                     YLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRFSSECFMDLVCPEK
                     CRCEGTIVDCSNQKLARIPSHLPEYTTDLRLNDNDISVLEATGIFKKLPNLRKINLSN
                     NRIKEVREGAFDGAAGVQELMLTGNQLETMHGRMFRGLSSLKTLMLRSNLISCVSNDT
                     FAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHMAWLGRWLRKRR
                     IVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCVETVVRCSN
                     RGLHALPKGMPKDVTELYLEGNHLTAVPKELSAFRQLTLIDLSNNSISMLTNHTFSNM
                     SHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGT
                     NPLHCDCSLRWLSEWVKAGYKEPGIARCSSPESMADRLLLTTPTHRFQCKGPVDINIV
                     AKCNACLSSPCKNNGTCSQDPVEQYRCTCPYSYKGKDCTVPINTCVQNPCEHGGTCHL
                     SENLRDGFSCSCPLGFEGQRCEINPDDCEDNDCENSATCVDGINNYACLCPPNYTGEL
                     CDEVIDYCVPEMNLCQHEAKCISLDKGFRCECVPGYSGKLCETNNDDCVAHKCRHGAQ
                     CVDEVNGYTCICPQGFSGLFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCP
                     PGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPL
                     ALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSL
                     GKLQKQPAVGSNSPLYLGGIPTSTGLSALRQGADRPLGGFHGCIHEVRINNELQDFKA
                     LPPQSLGVSPGCKSCTVCRHGLCRSVEKDSVVCECHPGWTGPLCDQEARDPCLGHSCR
                     HGTCMATGDSYVCKCAEGYGGALCDQKNDSASACSAFKCHHGQCHISDRGEPYCLCQP
                     GFSGHHCEQENPCMGEIVREAIRRQKDYASCATASKVPIMECRGGCGSQCCQPIRSKR
                     RKYVFQCTDGSSFVEEVERHLECGCRACS"
     exon            257..328
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..400
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..472
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..544
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..616
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..688
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..852
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..994
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1066
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1138
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1210
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1354
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1518
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1669
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1744
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1888
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2032
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2196
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2329
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2398
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2470
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2542
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2614
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2778
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2903
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3001
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3141
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3235
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3373
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3614
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3745
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3900
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4186
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4395
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     exon            4396..4996
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4845..4850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /note="hexamer: AATATA"
     polyA_site      4866
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
     regulatory      4975..4980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /note="hexamer: AATAAA"
     polyA_site      4996
                     /gene="Slit3"
                     /gene_synonym="b2b2362.1Clo; Slil2; Slit1"
                     /note="major polyA site"
ORIGIN      
        1 gggctcctcg tgtcccgcct cgccaggcat cctcctctgg gtgcgggcgc ttgtgcacca
       61 tggccctcgg ccggaccggg gccggcgccg ctgtgcgcgc ccgcctggcg ctgggcttgg
      121 cgcttgcgag catcctgagc ggaccccctg ctgccgcctg ccccaccaag tgtacctgct
      181 ccgccgctag cgtggactgc cacgggctgg gcctgcgcgc cgttcctcgg ggcatccccc
      241 gcaacgcaga gcgccttgac ctggacagaa ataacatcac caggatcacc aaaatggact
      301 tcgctggcct gaagaatctt cgagtcttgc atctggaaga caatcaagtc agcatcatcg
      361 agagaggcgc cttccaggat ctgaagcagc tggagagatt acgtctgaac aagaacaagc
      421 tccaggtcct cccagaactg cttttccaga gcaccccgaa gctcaccaga ctagatctga
      481 gcgaaaacca gatccagggc atcccgagga aggcgttcag aggcgtcaca ggcgtgaaga
      541 acctgcaact ggacaataac cacatcagct gcattgaaga tggagccttc cgagcgctgc
      601 gcgatttgga gatcctcacc ctcaacaata acaacatcag ccgcatcctg gtcaccagct
      661 tcaaccacat gccgaagatc cggactctgc gtctacactc caaccacctg tactgtgact
      721 gtcatttggc ctggctctca gattggctgc gacaacggcg gaccattggc cagttcaccc
      781 tctgcatggc acctgtgcac ctgagaggct tcagtgtagc agatgtgcag aagaaagagt
      841 atgtgtgtcc aggtccccac tcggaggctc cagcctgcaa tgccaactcc ctctcctgcc
      901 cttccgcttg ctcatgcagt aataacattg tggactgccg agggaaagga ctgacagaga
      961 tccctgccaa cctgccagag ggcatcgtgg aaatacgcct agaacagaac tccatcaaat
     1021 ccattcctgc aggagccttc acccagtaca aaaaactgaa gcgaatagac atcagcaaga
     1081 atcagatatc ggacatcgct ccagatgcct tccagggcct gaaatcactc acgtcgctgg
     1141 tactctatgg gaacaagatc acagagattc ccaaaggact gtttgacggg ctggtgtccc
     1201 tgcagctgct cctcctcaat gctaacaaga tcaactgtct gcgggtgaac accttccagg
     1261 acctacagaa cctcaatctg ctctctctgt atgacaacaa gttgcagact atcagcaaag
     1321 ggctcttcgt tccactgcag tccatccaga ccctccactt agctcaaaac ccatttgttt
     1381 gcgactgcca cttgaagtgg ttggctgact acctccagga caaccctatt gagacaagcg
     1441 gggcccgctg cagcagccca cgccggctgg ccaacaagcg tatcagccag atcaaaagca
     1501 agaagttccg ctgctcaggc tctgaggatt atcgcaacag attcagcagt gagtgcttca
     1561 tggacctagt gtgccctgaa aagtgccgct gtgagggcac cattgtggac tgctccaacc
     1621 agaagctagc ccgcatccca agccacctcc ctgaatatac cactgacttg cgactgaacg
     1681 acaatgacat ctctgtgctg gaggccactg ggatcttcaa gaagctgccc aacctgcgga
     1741 aaataaacct gagcaataat aggatcaagg aagtgcggga gggtgccttc gatggagcgg
     1801 ccggcgtgca ggagctgatg ctgacgggga accagctgga gaccatgcac ggacgcatgt
     1861 tccggggcct cagtagcctc aagacgctga tgttgcggag caacctgatc agctgcgtaa
     1921 gcaacgatac ctttgctggc ttaagttctg tgagactgct gtctctctat gacaaccgaa
     1981 tcaccaccat cacccctgga gccttcacca cacttgtctc cctgtccacc ataaacctcc
     2041 tgtctaaccc tttcaactgc aactgccaca tggcgtggct cggccgctgg ctgaggaaac
     2101 gccgcatcgt cagcgggaac cccagatgcc agaagccctt tttcctcaag gagattccca
     2161 tccaagacgt ggccatccag gactttacct gcgacggcaa tgaggagagc agctgccagc
     2221 tgagtccacg ctgccctgag cagtgcacct gtgtggagac ggtggtccga tgcagcaaca
     2281 ggggtctcca tgccctcccc aaaggcatgc caaaggatgt gactgaactg tacctggaag
     2341 gaaaccattt aacagcagtg cccaaagagt tgtctgcctt ccgacagctg acccttattg
     2401 acctgagcaa caacagcatc agcatgctga ccaatcacac cttcagcaac atgtcccacc
     2461 tctccacgct gatcctgagc tacaaccggc tgagatgcat ccctgtccat gccttcaacg
     2521 ggctaagatc cctccgagtg ctgaccctcc atggaaatga catttccagt gttcctgaag
     2581 gctccttcaa tgatctgaca tccctttccc acctggccct gggaaccaac cctctccact
     2641 gtgactgcag tctgcgttgg ttatcagagt gggtaaaggc tggatacaag gagcctggca
     2701 ttgccagatg cagcagcccc gagtccatgg cagacagact cctgctcacc acccccactc
     2761 accggttcca gtgcaaaggg ccagtggaca ttaacatcgt ggccaagtgc aacgcctgcc
     2821 tctctagccc gtgcaagaac aacggcactt gcagtcagga tcccgtggag cagtaccgct
     2881 gcacctgccc ctacagctac aagggcaagg actgcaccgt acccatcaac acctgcgtcc
     2941 agaacccctg tgagcacgga ggcacctgcc acctcagtga gaacctcaga gatggattca
     3001 gctgctcctg ccctctgggc tttgagggac agcgatgtga gatcaaccca gatgactgtg
     3061 aggataacga ctgtgaaaac agtgccacct gtgtggatgg gatcaacaac tacgcatgcc
     3121 tgtgcccgcc gaactacaca ggggagctgt gtgatgaggt gattgactac tgtgtgcccg
     3181 agatgaacct ctgtcagcac gaggccaagt gcatctccct ggacaaagga ttcaggtgcg
     3241 aatgtgtccc tggctacagt ggaaagctgt gtgagacaaa caacgatgac tgtgtggctc
     3301 acaagtgtcg ccatggagcc cagtgtgtgg acgaggtcaa tggctacaca tgcatctgcc
     3361 cccagggctt cagtgggctc ttctgtgagc atcccccacc catggttctg ctacaaacca
     3421 gcccctgcga ccagtacgag tgccagaatg gggcgcagtg cattgtggta cagcaggagc
     3481 ccacttgccg ctgtccccca ggctttgctg gacccaggtg tgagaagctc atcactgtga
     3541 acttcgtggg caaggactct tatgtggaac tggcctccgc caaggtccgg ccccaggcca
     3601 acatctccct gcaggtggcg actgacaagg acaatggcat ccttctttac aagggagaca
     3661 atgacccctt ggcactggag ctgtaccagg gccacgtgag gctggtgtat gacagcctga
     3721 gctcccctcc aaccacggtg tacagtgtgg agacggtgaa tgatggccag tttcacagtg
     3781 tggagctggt gatgctaaac cagaccctga acctggtggt agacaaagga gctcccaaga
     3841 gcctggggaa gctgcagaag caaccagcag tgggcagcaa cagccccctc taccttggag
     3901 gcatccccac ctctacgggc ctctcagcct tacgccaggg tgcagacagg ccgctgggcg
     3961 gcttccacgg ctgcatccac gaggtgcgca tcaacaacga gttgcaggat ttcaaggccc
     4021 tccccccaca gtccctgggg gtctctcctg gctgcaaatc ctgcactgtg tgtcgtcatg
     4081 gcctgtgtcg ctccgtggag aaggacagcg tagtgtgtga gtgccacccg ggatggaccg
     4141 gtccgctatg tgatcaggaa gctcgggacc cctgccttgg tcacagctgc aggcacggga
     4201 catgcatggc gactggggac tcctacgtgt gcaagtgtgc cgagggctac ggaggggctt
     4261 tgtgtgacca gaagaatgac tctgccagtg cctgctcagc cttcaagtgc caccatgggc
     4321 agtgtcacat ctcagatcga ggggagccct attgcctatg ccagcctggc ttcagtggcc
     4381 atcactgtga gcaagagaat ccatgtatgg gggagatagt ccgtgaagcc atccgccgcc
     4441 agaaagacta cgcctcttgt gccacggcgt ccaaggtgcc catcatggaa tgccgcgggg
     4501 gctgcgggag ccagtgctgc cagccgattc gaagcaagcg gcggaaatat gtcttccagt
     4561 gcacggacgg ctcctcattc gtggaagagg tggagagaca cttggaatgt ggctgccgcg
     4621 cgtgttcctg agcccccctc tgccacccac ccatcctccg ccttgcggac cccagctcat
     4681 tgggctgagg aacagccaca tggaacctct ttgagattca gaacgaagga gagaaatctg
     4741 gagagcaaga ggcaaaagag agaatattaa gtatattgta aaataaacaa aaatagaact
     4801 tatttttatt atggaaagtg actattttca tcttttatta tataaatata tcacaccgtc
     4861 tgagtatatg gactatacag tgagttattt ttaccaagtt ttgttttgtg ttgtgtattt
     4921 gttgtgtttt tataaacagc tgtttataaa attttaagac aaagaaaaaa cactaataaa
     4981 aatgttttaa acacaaaaaa aaaaaaaaaa aaaaaaa
//
