LOCUS       NM_015748               5300 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus slit guidance ligand 1 (Slit1), mRNA.
ACCESSION   NM_015748 XM_129317
VERSION     NM_015748.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5300)
  AUTHORS   Delpech,C., Schaeffer,J., Vilallongue,N., Delaunay,A., Benadjal,A.,
            Blot,B., Excoffier,B., Plissonnier,E., Gascon,E., Albert,F.,
            Paccard,A., Saintpierre,A., Gasnier,C., Zagar,Y., Castellani,V.,
            Belin,S., Chedotal,A. and Nawabi,H.
  TITLE     Axon guidance during mouse central nervous system regeneration is
            required for specific brain innervation
  JOURNAL   Dev Cell 59 (24), 3213-3228 (2024)
   PUBMED   39353435
REFERENCE   2  (bases 1 to 5300)
  AUTHORS   Grudet,F., Martinot,E., Godin,P., Berube,M., Chedotal,A. and
            Boerboom,D.
  TITLE     Slit1 inhibits ovarian follicle development and female fertility in
            micedagger
  JOURNAL   Biol Reprod 111 (4), 834-844 (2024)
   PUBMED   38943353
  REMARK    GeneRIF: Slit1 inhibits ovarian follicle development and female
            fertility in micedagger.
REFERENCE   3  (bases 1 to 5300)
  AUTHORS   Curran,B.M., Nickerson,K.R., Yung,A.R., Goodrich,L.V., Jaworski,A.,
            Tessier-Lavigne,M. and Ma,L.
  TITLE     Multiple guidance mechanisms control axon growth to generate
            precise T-shaped bifurcation during dorsal funiculus development in
            the spinal cord
  JOURNAL   Elife 13, 94109 (2024)
   PUBMED   39159057
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5300)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 5300)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   6  (bases 1 to 5300)
  AUTHORS   Vargesson,N., Luria,V., Messina,I., Erskine,L. and Laufer,E.
  TITLE     Expression patterns of Slit and Robo family members during
            vertebrate limb development
  JOURNAL   Mech Dev 106 (1-2), 175-180 (2001)
   PUBMED   11472852
REFERENCE   7  (bases 1 to 5300)
  AUTHORS   Erskine,L., Williams,S.E., Brose,K., Kidd,T., Rachel,R.A.,
            Goodman,C.S., Tessier-Lavigne,M. and Mason,C.A.
  TITLE     Retinal ganglion cell axon guidance in the mouse optic chiasm:
            expression and function of robos and slits
  JOURNAL   J Neurosci 20 (13), 4975-4982 (2000)
   PUBMED   10864955
REFERENCE   8  (bases 1 to 5300)
  AUTHORS   Niclou,S.P., Jia,L. and Raper,J.A.
  TITLE     Slit2 is a repellent for retinal ganglion cell axons
  JOURNAL   J Neurosci 20 (13), 4962-4974 (2000)
   PUBMED   10864954
REFERENCE   9  (bases 1 to 5300)
  AUTHORS   Bertuzzi,S., Hindges,R., Mui,S.H., O'Leary,D.D. and Lemke,G.
  TITLE     The homeodomain protein vax1 is required for axon guidance and
            major tract formation in the developing forebrain
  JOURNAL   Genes Dev 13 (23), 3092-3105 (1999)
   PUBMED   10601035
REFERENCE   10 (bases 1 to 5300)
  AUTHORS   Yuan,W., Zhou,L., Chen,J.H., Wu,J.Y., Rao,Y. and Ornitz,D.M.
  TITLE     The mouse SLIT family: secreted ligands for ROBO expressed in
            patterns that suggest a role in morphogenesis and axon guidance
  JOURNAL   Dev Biol 212 (2), 290-306 (1999)
   PUBMED   10433822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145557.3 and BC062091.1.
            
            On Aug 21, 2009 this sequence version replaced NM_015748.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062091.1, AF144627.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-645               AC145557.3         161962-162606
            646-5300            BC062091.1         452-5106
FEATURES             Location/Qualifiers
     source          1..5300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.99 cM"
     gene            1..5300
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /note="slit guidance ligand 1"
                     /db_xref="GeneID:20562"
                     /db_xref="MGI:MGI:1315203"
     exon            1..645
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..5044
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /note="slit homolog 1 protein; slit-1"
                     /codon_start=1
                     /product="slit homolog 1 protein precursor"
                     /protein_id="NP_056563.2"
                     /db_xref="CCDS:CCDS29812.1"
                     /db_xref="GeneID:20562"
                     /db_xref="MGI:MGI:1315203"
                     /translation="MALTPQRGSSSGLSRPELWLLLWAAAWRLGATACPALCTCTGTT
                     VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVER
                     GAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENFLQAVPRKAFRGATDLK
                     NLQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLF
                     CDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKGEFSCSGQGEAAGAPACT
                     LSSGSCPAMCSCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK
                     LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANK
                     INCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWL
                     ADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECT
                     SDVACPHKCRCEASVVECSSLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSH
                     LKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNR
                     ISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCHLSWL
                     GDWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQCPQECAC
                     LDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISS
                     LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVT
                     SLSHLAIGANPLYCDCRLRWLSSWVKTGYKEPGIARCAGPPEMEGKLLLTTPAKKFEC
                     QGPPSLAVQAKCDPCLSSPCQNQGTCHNDPLEVYRCTCPSGYKGRHCEVSLDGCSSNP
                     CGNGGTCHAQEGEDAGFTCSCPSGFEGPTCGVDTDDCVKHACVNGGVCVDGVGNYTCQ
                     CPLQYTGRACEQLVDFCSPDMNPCQHEAQCVGTPDGPRCECMLGYTGDNCSENQDDCK
                     DHKCQNGAQCVDEVNSYACLCVEGYSGQLCEIPPAPRSSCEGTECQNGANCVDQGSRP
                     VCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNG
                     DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGG
                     SPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNEL
                     QDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPVDGPC
                     HGHKCVHGKCVPLDALAYSCQCQDGYSGALCNQVGAVAEPCGGLQCLHGHCQASATKG
                     AHCVCSPGFSGELCEQESECRGDPVRDFHRVQRGYAICQTTRPLSWVECRGACPGQGC
                     CQGLRLKRRKLTFECSDGTSFAEEVEKPTKCGCAQCA"
     exon            646..717
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..789
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..861
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..933
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1005
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1077
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1241
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1389
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1461
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1533
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1605
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1749
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1913
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..1937
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2082
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2157
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2301
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2445
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2612
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2745
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2814
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2886
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2958
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3030
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3194
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3319
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3417
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3557
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3651
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3789
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..4018
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4149
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4304
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            4305..4593
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            4594..4805
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     exon            4806..5238
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5218..5223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /note="hexamer: AATAAA"
     polyA_site      5238
                     /gene="Slit1"
                     /gene_synonym="mKIAA0813; Slil1"
                     /note="major polyA site"
ORIGIN      
        1 gggggggagg gcgggaagga gtctggccct ggaagtgtgc ttttcgattg atggatgact
       61 gccgggtgtg agcgagcgtg cgggtgtgag tgtgtatgtg tgtgtgtgtg tgtgcgcgcg
      121 cgcgcgaggt gtgtgtgtgt gcgcgcgcgc ggggcctgcc cattttcctc ctcacagcag
      181 tcagttggga gctggaggga gagggagacg ccggcagcga gcactgggag aggagctgag
      241 cgccctccgc ttaagacgcc tttcctgggt ctacgcacag acgctgtcgc tgggagcatc
      301 taggtaccac tcgatccgca agggcgcatc gcacgattcc accggctctt cggtccttcg
      361 gtggggatag cacctggagc tagccccgga cggggatggt cagcggctgc ggccgtctgg
      421 cacgcgaacg ggacacggcg aaggcaccat ggcgctaacg ccccagcgcg ggtcctcttc
      481 ggggttgagc cgaccggagc tgtggctgct gctgtgggca gccgcgtggc gcctgggggc
      541 cacggcgtgc cccgccctct gcacctgcac cggcactacg gtggactgcc acggcacggg
      601 tttgcaggcc atccccaaga acatcccacg gaacaccgag cgcctggaac tcaacggcaa
      661 caacatcact cggatccaca agaatgactt tgctggcctc aagcagcttc gagtgttgca
      721 gctgatggag aaccagatcg gagctgtgga acgcggagct tttgatgaca tgaaggagct
      781 agagcgccta cggctgaacc gcaaccagct acaagtgttg cctgaactac tgttccagaa
      841 caaccaggct ctatccagac tggacctgag tgagaatttt ctccaggctg tgcccaggaa
      901 ggcttttcgg ggagccacag acctcaaaaa tctacagctg gacaagaacc ggatcagctg
      961 catcgaggaa ggggccttcc gtgccctacg gggactggag gttctgaccc tgaacaacaa
     1021 caacatcacc accatccctg tgtccagttt caaccatatg cccaagcttc ggaccttccg
     1081 gctgcactcc aaccacctgt tctgtgactg ccacctggcc tggctctctc agtggctgag
     1141 acagaggccc accatcggac tcttcaccca gtgctctggg cccgccagcc ttcggggcct
     1201 caacgtggca gaggtgcaaa agggcgagtt cagctgctca ggccaggggg aggctgcggg
     1261 agcacctgcc tgcaccctct cgtccggttc ctgcccagcc atgtgcagct gtagcagcgg
     1321 catcgtggac tgccgtggca agggcctcac tgccatccct gctaaccttc cagagaccat
     1381 gacagagatc cgcctggagt tgaacggtat caaatccatc ccacccggag ccttctctcc
     1441 ctacagaaag ctgcgcagga tagacctgag caacaaccag attgcagaga ttgcacccga
     1501 cgccttccaa ggcctgcgct ccttgaattc cctggtcctc tatggcaaca agattacaga
     1561 cctgccccga ggtgtatttg gaggcctgta cacactccag ctgctgcttc taaatgccaa
     1621 caagatcaac tgcatccggc ctgatgcctt ccaggacctg cagaacctct ctctgctctc
     1681 cctgtatgac aacaagatcc agagtctcgc caagggcacc ttcacctccc tacgggccat
     1741 ccagacactg catctggccc agaatccttt catctgtgac tgtaacctca agtggctggc
     1801 agacttctta cgtaccaacc ccatcgagac aactggggcc cgatgtgcca gcccccggcg
     1861 cctcgccaac aagcgtattg ggcagatcaa aagcaagaag tttcggtgct cagccaaaga
     1921 gcagtacttc attccaggga cagaggacta ccacctgaac agcgagtgta ccagcgacgt
     1981 ggcctgccca cacaagtgcc gttgtgaggc cagtgtggtg gagtgctcca gcctgaaact
     2041 ctctaagatc cctgagcgaa tcccccagtc cacgactgag ctacgactga acaacaatga
     2101 gatttctatc ctagaggcca ctgggttgtt taagaagctc tcacatctga agaaaataaa
     2161 cctgagcaat aacaaggtgt ccgagatcga agacgggacg tttgagggtg ccgcctctgt
     2221 cagtgagctg cacctgactg ctaaccagct ggagtccatt agaagtggca tgttccgggg
     2281 tctagatggc ttgcggaccc tgatgctgag gaacaaccgt atcagctgta tccacaacga
     2341 cagcttcacc gggctgcgca acgtgcggct cctgtctctc tatgacaacc acatcaccac
     2401 catctcccct ggagcctttg acactctcca ggccctgtcc acactaaacc tcctggccaa
     2461 cccgttcaac tgcaactgcc atctgtcatg gctgggcgac tggctccgga agaggaagat
     2521 tgtgacgggg aaccctcgct gtcagaaccc agacttcctg cggcagattc ctctgcagga
     2581 tgtggccttc cctgacttca ggtgtgagga aggccaggag gaggtgggct gcctgccccg
     2641 cccacagtgc ccccaggagt gtgcctgcct ggacacagtg gtccgctgca gcaacaagca
     2701 cctccaggct ctgcccaagg gcatccccaa gaatgtcaca gaactctatt tggatgggaa
     2761 ccagttcaca ctcgttccgg gacagctgtc taccttcaag tatctgcagc tcgtggactt
     2821 gagcaacaac aagatcagtt ccttgagcaa ttcttccttc accaacatga gccagctgac
     2881 cacgctgatc ctcagctaca atgccctcca gtgcatccct cctctggcct ttcaaggact
     2941 tcgttcgctg cgcctgctgt ctttgcatgg caatgatgtc tccaccctcc aagagggcat
     3001 ctttgcagac gtgacgtctc tgtctcacct ggccattggt gccaaccccc tgtactgcga
     3061 ctgccgcctc cggtggctct ccagttgggt gaagactggc tacaaggaac ctggcattgc
     3121 ccgctgtgct ggacccccag agatggaggg caaactgtta ctcaccacac ctgccaagaa
     3181 gtttgaatgc caaggtcccc ccagcctggc agttcaggcc aagtgtgatc cctgcttgtc
     3241 cagcccatgc cagaaccagg gcacctgcca caatgaccct cttgaggtat acaggtgtac
     3301 ctgccccagt ggctacaagg gccgacactg tgaggtgtct ctggacggct gttccagcaa
     3361 cccatgtgga aatgggggga cctgccatgc ccaggagggc gaggatgctg gcttcacgtg
     3421 ctcctgtccc tccggctttg aagggccgac ctgtggagtg gacacagatg actgtgttaa
     3481 gcatgcctgt gtcaacgggg gtgtctgtgt agatggcgtg gggaattaca catgtcagtg
     3541 ccccctgcag tacacaggaa gggcctgtga gcagctggtg gacttctgct ccccggatat
     3601 gaacccgtgt cagcatgagg cccaatgtgt tggcaccccg gatgggccca ggtgtgagtg
     3661 catgctaggt tacacgggtg acaactgcag cgaaaatcag gatgactgca aggaccacaa
     3721 gtgtcagaac ggggcccagt gtgtggatga agtcaacagc tacgcctgcc tctgtgttga
     3781 gggctacagt ggacagctct gtgagatccc acctgccccc aggagctcct gtgaggggac
     3841 ggagtgccag aatggagcca actgcgtaga ccagggaagc cggcccgtat gccagtgcct
     3901 accaggcttt ggtggccctg aatgtgagaa attgctcagt gtcaactttg tggaccggga
     3961 cacttatctg cagttcactg acctgcagaa ctggcctcgg gccaacatca ctcttcaggt
     4021 ctccacagca gaggacaatg ggattctcct atataatggg gacaatgacc acattgcagt
     4081 tgagctgtac cagggccatg tccgtgttag ttatgaccca ggcagctacc ccagctctgc
     4141 tatctacagc gctgagacga tcaacgatgg gcagttccac accgttgagc tggtcacctt
     4201 cgaccagatg gtgaacctct ccatcgatgg cggcagcccc atgaccatgg acaactttgg
     4261 caagcactac accctcaaca gcgaggcccc cctctatgtg ggagggatgc ctgtggacgt
     4321 gaactcagct gccttccgcc tgtggcagat cctcaatggt accagcttcc acggttgcat
     4381 ccggaacctg tacatcaaca atgaactgca ggacttcacc aagacacaga tgaagccagg
     4441 cgtggtgcca ggctgtgagc cgtgccgcaa actctactgt ctacatggca tttgccagcc
     4501 caacgccacc ccagggcctg tgtgccactg tgaggctggc tgggggggcc tgcactgtga
     4561 ccagccagtg gatggcccct gccatggcca caagtgtgtc catgggaaat gcgtgccgct
     4621 cgacgctctt gcctacagct gccagtgcca ggatgggtac tcgggggctc tgtgcaacca
     4681 ggtcggggct gtggcagagc cctgtggggg cttgcagtgc ctgcatggtc actgccaggc
     4741 ctctgccacc aaaggggcac actgtgtgtg cagcccaggc ttttcaggcg agctgtgtga
     4801 gcaagagtcc gagtgccggg gggaccctgt ccgggacttt caccgggtcc agaggggcta
     4861 tgccatctgc cagaccacac gcccgctgtc gtgggtggaa tgccggggcg cgtgcccggg
     4921 ccagggctgc tgccagggcc tgcggctgaa gcggaggaag ctcaccttcg agtgcagcga
     4981 tgggacttcg tttgctgagg aggtggagaa gcccaccaag tgtggctgtg cccagtgcgc
     5041 ataatgtgcg ggtggcacac tagccgggct ggggcgggca tcaccaggat agcgcctgga
     5101 tcctggtggg cacggggtca ctgagctgcc ttcccagcgg actgcactgc cggggcagag
     5161 gagcaaggcc cgggctgcca tgccctctct caaagtgcct tgcacagata ggcgcttaat
     5221 aaatatttgt tgaatgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     5281 aaaaaaaaaa aaaaaaaaaa
//
