LOCUS       NM_026958                427 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SRA stem-loop interacting RNA binding protein (Slirp),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026958 XM_354684
VERSION     NM_026958.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 427)
  AUTHORS   Gineste,C., Youhanna,S., Vorrink,S.U., Henriksson,S., Hernandez,A.,
            Cheng,A.J., Chaillou,T., Buttgereit,A., Schneidereit,D.,
            Friedrich,O., Hultenby,K., Bruton,J.D., Ivarsson,N., Sandblad,L.,
            Lauschke,V.M. and Westerblad,H.
  TITLE     Enzymatically dissociated muscle fibers display rapid
            dedifferentiation and impaired mitochondrial calcium control
  JOURNAL   iScience 25 (12), 105654 (2022)
   PUBMED   36479146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 427)
  AUTHORS   Siira,S.J., Spahr,H., Shearwood,A.J., Ruzzenente,B., Larsson,N.G.,
            Rackham,O. and Filipovska,A.
  TITLE     LRPPRC-mediated folding of the mitochondrial transcriptome
  JOURNAL   Nat Commun 8 (1), 1532 (2017)
   PUBMED   29146908
  REMARK    GeneRIF: Study demonstrated that the LRPPRC-SLIRP complex is a
            global RNA chaperone that stabilizes RNA structures to expose the
            required sites for translation, stabilization, and polyadenylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 427)
  AUTHORS   Lagouge,M., Mourier,A., Lee,H.J., Spahr,H., Wai,T., Kukat,C., Silva
            Ramos,E., Motori,E., Busch,J.D., Siira,S., Kremmer,E.,
            Filipovska,A. and Larsson,N.G.
  CONSRTM   German Mouse Clinic Consortium
  TITLE     SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and
            Protects LRPPRC from Degradation
  JOURNAL   PLoS Genet 11 (8), e1005423 (2015)
   PUBMED   26247782
  REMARK    GeneRIF: both LRPPRC and SLIRP are required for maintaining mt-mRNA
            steady-state levels independent of their roles in stabilizing the
            other partner of the LRPPRC-SLIRP complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 427)
  AUTHORS   Colley,S.M., Wintle,L., Searles,R., Russell,V., Firman,R.C.,
            Smith,S., Deboer,K., Merriner,D.J., Genevieve,B., Bentel,J.M.,
            Stuckey,B.G., Phillips,M.R., Simmons,L.W., de Kretser,D.M.,
            O'Bryan,M.K. and Leedman,P.J.
  TITLE     Loss of the nuclear receptor corepressor SLIRP compromises male
            fertility
  JOURNAL   PLoS One 8 (8), e70700 (2013)
   PUBMED   23976951
  REMARK    GeneRIF: SLIRP regulates male fertility, wherein its loss results
            in asthenozoospermia associated with compromised sperm structure
            and mitochondrial morphology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 427)
  AUTHORS   Ruzzenente,B., Metodiev,M.D., Wredenberg,A., Bratic,A., Park,C.B.,
            Camara,Y., Milenkovic,D., Zickermann,V., Wibom,R., Hultenby,K.,
            Erdjument-Bromage,H., Tempst,P., Brandt,U., Stewart,J.B.,
            Gustafsson,C.M. and Larsson,N.G.
  TITLE     LRPPRC is necessary for polyadenylation and coordination of
            translation of mitochondrial mRNAs
  JOURNAL   EMBO J 31 (2), 443-456 (2012)
   PUBMED   22045337
REFERENCE   6  (bases 1 to 427)
  AUTHORS   Baughman,J.M., Nilsson,R., Gohil,V.M., Arlow,D.H., Gauhar,Z. and
            Mootha,V.K.
  TITLE     A computational screen for regulators of oxidative phosphorylation
            implicates SLIRP in mitochondrial RNA homeostasis
  JOURNAL   PLoS Genet 5 (8), e1000590 (2009)
   PUBMED   19680543
  REMARK    GeneRIF: SLIRP plays an essential role in maintaining
            mitochondrial-localized mRNA transcripts that encode OxPhos protein
            subunits.
            Erratum:[PLoS Genet. 2010;6(3). doi:
            10.1371/annotation/36fe7624-0904-46d4-a013-4be6195245c4]
REFERENCE   7  (bases 1 to 427)
  AUTHORS   Hatchell,E.C., Colley,S.M., Beveridge,D.J., Epis,M.R., Stuart,L.M.,
            Giles,K.M., Redfern,A.D., Miles,L.E., Barker,A., MacDonald,L.M.,
            Arthur,P.G., Lui,J.C., Golding,J.L., McCulloch,R.K., Metcalf,C.B.,
            Wilce,J.A., Wilce,M.C., Lanz,R.B., O'Malley,B.W. and Leedman,P.J.
  TITLE     SLIRP, a small SRA binding protein, is a nuclear receptor
            corepressor
  JOURNAL   Mol Cell 22 (5), 657-668 (2006)
   PUBMED   16762838
REFERENCE   8  (bases 1 to 427)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU850988.1, BC116741.1 and CK372908.1.
            
            On Jan 5, 2010 this sequence version replaced NM_026958.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV462870.1, BU850369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BU850988.1         4-19
            17-408              BC116741.1         4-395
            409-427             CK372908.1         379-397
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 41.67 cM"
     gene            1..427
                     /gene="Slirp"
                     /gene_synonym="1810035L17Rik"
                     /note="SRA stem-loop interacting RNA binding protein"
                     /db_xref="GeneID:380773"
                     /db_xref="MGI:MGI:1916394"
     exon            1..131
                     /gene="Slirp"
                     /gene_synonym="1810035L17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..373
                     /gene="Slirp"
                     /gene_synonym="1810035L17Rik"
                     /codon_start=1
                     /product="SRA stem-loop-interacting RNA-binding protein,
                     mitochondrial"
                     /protein_id="NP_081234.2"
                     /db_xref="CCDS:CCDS36503.1"
                     /db_xref="GeneID:380773"
                     /db_xref="MGI:MGI:1916394"
                     /translation="MAASAIKGLSALRSSTGRPIAFVRKIPWTAAASELREHFAQFGH
                     VRRCTVPFDKETGFHRGMGWVQFSSQEELQNALQQEHHIIDGVKIHVQAQRAKALHGA
                     QTSDEERFLR"
     exon            132..190
                     /gene="Slirp"
                     /gene_synonym="1810035L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            191..298
                     /gene="Slirp"
                     /gene_synonym="1810035L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            299..419
                     /gene="Slirp"
                     /gene_synonym="1810035L17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      392..397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slirp"
                     /gene_synonym="1810035L17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      413
                     /gene="Slirp"
                     /gene_synonym="1810035L17Rik"
                     /note="major polyA site"
ORIGIN      
        1 acgactccag ggtttcgatt cattccgttt taacatggca gcctccgcca taaaggggct
       61 aagcgcactg cgttccagta ctggtcggcc tattgcgttt gtcagaaaaa ttccttggac
      121 cgcggcagcg agtgagctga gagaacattt tgcacagttt ggccatgtaa gaaggtgcac
      181 tgtacctttt gacaaagaga ctggctttca cagaggcatg ggttgggttc agttttcctc
      241 tcaggaagaa cttcagaatg cactacaaca agaacatcat attattgatg gagtaaaaat
      301 ccacgttcaa gctcaaagag caaaggcttt gcacggagct caaacatctg atgaagaaag
      361 atttctgaga tgatcagtgt accgtccact aaataaacag aattgagact ttttctacaa
      421 aaaaaaa
//
