LOCUS       NM_181545               4011 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus schlafen 8 (Slfn8), transcript variant 1, mRNA.
ACCESSION   NM_181545 XM_204664
VERSION     NM_181545.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4011)
  AUTHORS   Alvi,E., Mochizuki,A.L., Katsuki,Y., Ogawa,M., Qi,F., Okamoto,Y.,
            Takata,M. and Mu,A.
  TITLE     Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11
            during the replication stress response
  JOURNAL   Commun Biol 6 (1), 1038 (2023)
   PUBMED   37833372
  REMARK    GeneRIF: Mouse Slfn8 and Slfn9 genes complement human cells lacking
            SLFN11 during the replication stress response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4011)
  AUTHORS   Yang,J.Y., Deng,X.Y., Li,Y.S., Ma,X.C., Feng,J.X., Yu,B., Chen,Y.,
            Luo,Y.L., Wang,X., Chen,M.L., Fang,Z.X., Zheng,F.X., Li,Y.P.,
            Zhong,Q., Kang,T.B., Song,L.B., Xu,R.H., Zeng,M.S., Chen,W.,
            Zhang,H., Xie,W. and Gao,S.
  TITLE     Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting
            RNase engaged in translational control
  JOURNAL   Nat Commun 9 (1), 1165 (2018)
   PUBMED   29563550
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4011)
  AUTHORS   Nakagawa,K., Matsuki,T., Zhao,L., Kuniyoshi,K., Tanaka,H.,
            Ebina,I., Yoshida,K.J., Nabeshima,H., Fukushima,K., Kanemaru,H.,
            Yamane,F., Kawasaki,T., Machida,T., Naito,H., Takakura,N., Satoh,T.
            and Akira,S.
  TITLE     Schlafen-8 is essential for lymphatic endothelial cell activation
            in experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 30 (2), 69-78 (2018)
   PUBMED   29528433
  REMARK    GeneRIF: We demonstrated that Slfn8-/- mice were resistant to the
            development of EAE.
REFERENCE   4  (bases 1 to 4011)
  AUTHORS   Mavrommatis,E., Arslan,A.D., Sassano,A., Hua,Y., Kroczynska,B. and
            Platanias,L.C.
  TITLE     Expression and regulatory effects of murine Schlafen (Slfn) genes
            in malignant melanoma and renal cell carcinoma
  JOURNAL   J Biol Chem 288 (46), 33006-33015 (2013)
   PUBMED   24089532
  REMARK    GeneRIF: several mouse Slfn genes are up-regulated in response to
            IFN treatment of mouse melanoma and renal cell carcinoma cells,
            including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8.
REFERENCE   5  (bases 1 to 4011)
  AUTHORS   Bustos,O., Naik,S., Ayers,G., Casola,C., Perez-Lamigueiro,M.A.,
            Chippindale,P.T., Pritham,E.J. and de la Casa-Esperon,E.
  TITLE     Evolution of the Schlafen genes, a gene family associated with
            embryonic lethality, meiotic drive, immune processes and
            orthopoxvirus virulence
  JOURNAL   Gene 447 (1), 1-11 (2009)
   PUBMED   19619625
REFERENCE   6  (bases 1 to 4011)
  AUTHORS   Neumann,B., Zhao,L., Murphy,K. and Gonda,T.J.
  TITLE     Subcellular localization of the Schlafen protein family
  JOURNAL   Biochem Biophys Res Commun 370 (1), 62-66 (2008)
   PUBMED   18355440
REFERENCE   7  (bases 1 to 4011)
  AUTHORS   Geserick,P., Kaiser,F., Klemm,U., Kaufmann,S.H. and Zerrahn,J.
  TITLE     Modulation of T cell development and activation by novel members of
            the Schlafen (slfn) gene family harbouring an RNA helicase-like
            motif
  JOURNAL   Int Immunol 16 (10), 1535-1548 (2004)
   PUBMED   15351786
  REMARK    GeneRIF: functional participation of slfn8 in the regulatory
            networks governing T cell development and growth appears to be cell
            type specific
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY261798.1 and AL603745.16.
            
            On Nov 17, 2009 this sequence version replaced NM_181545.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY261798.1, AY261799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3051              AY261798.1         1-3051
            3052-4011           AL603745.16        118336-119295       c
FEATURES             Location/Qualifiers
     source          1..4011
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..4011
                     /gene="Slfn8"
                     /gene_synonym="mSLFN8"
                     /note="schlafen 8"
                     /db_xref="GeneID:276950"
                     /db_xref="MGI:MGI:2672859"
     exon            1..234
                     /gene="Slfn8"
                     /gene_synonym="mSLFN8"
                     /inference="alignment:Splign:2.1.0"
     exon            235..350
                     /gene="Slfn8"
                     /gene_synonym="mSLFN8"
                     /inference="alignment:Splign:2.1.0"
     exon            351..1420
                     /gene="Slfn8"
                     /gene_synonym="mSLFN8"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..3090
                     /gene="Slfn8"
                     /gene_synonym="mSLFN8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Schlafen family member 8"
                     /codon_start=1
                     /product="schlafen family member 8 isoform 1"
                     /protein_id="NP_853523.2"
                     /db_xref="CCDS:CCDS25155.1"
                     /db_xref="GeneID:276950"
                     /db_xref="MGI:MGI:2672859"
                     /translation="METHPSLAVKWSCPDLTIYAGEVTIGEEDRNKMDSKKRKLEKTR
                     ITEAACALLNSGGGLIAMQMTNKSEHPVEMGQDLEKSLRELIMSPNMQAFFETKQQED
                     QFYIFVKSWSCRPEDGSTKPRICSLGSSLYCRSITSKVAMDSREAFEFLKDKKACIKY
                     RPTDDGAPPAKIPRAMCQNSLESNPAFEIFQSKKLEYGQCLLFSESTSIEFKQFSTKH
                     VQAYMKNIIPEYISAFANTQGGYLFIGVDDKRIILGCPKDNVDRDSLKTVANETISKV
                     PVFHFCSSKDKDKVSYETRVIDVFQEGNLYGYLCVIKVEPFCCAVFSEAPISWMVDKE
                     KGVYRLNTEEWVRMMVDFGPEASSKDLSKDFECQLSLCNSPPHCRPVYSKKGLQHKVD
                     LQQRLFQVSPDCLKYTPESLWKELCSQHKRLKGLVKQQIRSFSCGLLILYRSWAVDLN
                     LKEKQEVICDALLIAQNSPPILYTILGEQDEQGQDYCNHTAFTLKQKLVNTGGYTGRV
                     CVMTKVLCLSSQNNIETNGGSVSPINYPSSYNLANIQEMQDLLQALVIVLLNFRSFLS
                     DQLGCEILNLLTAQQYEILSKSLRKTRELFVHGLPGSGKTIIAMKIMEKIRNTFHCET
                     DSILYICENQPLRDFIRAKRICQAVTRKTFMNYRFKTNSFQHIIVDEAQNFRTEDGNW
                     YGKAKAISRRVKSCPGMFWIFLDYFQTSHLKESGLPDFSRQYPREELTQVVRNGDKIA
                     EFLQKELQKIRDNPPCSIPRQSLNIVHEFKWSQSVSGNIKTEQFTLEDMVIYVADKCY
                     DFLRKGYSLQDIAVLFSTDKEKKTYESMFLGEMRKRRRASEMNHAYLCDSNMFDSIRR
                     FSGLERSIVFGINPIATEQPISHNLLLCLASRAMKHLYILYFSTPEGHSSTEAC"
     exon            1421..1555
                     /gene="Slfn8"
                     /gene_synonym="mSLFN8"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..2279
                     /gene="Slfn8"
                     /gene_synonym="mSLFN8"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..4011
                     /gene="Slfn8"
                     /gene_synonym="mSLFN8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagttcgctg ttaccactgc tagccaaact cacagtagaa ccagggctgc ttttctggac
       61 ttcacaggca ggtgactagt ccacaagtgg aacactaccc ggccacagac cagaaggatc
      121 ttgtcaggag gctggcttct ggaaagaaag ggagacttac attcctgtct gtttccaaat
      181 tctgctttcc aaggtggcca gggaacaggg atcaagagaa ctccactgga agtggtccag
      241 cacaccagaa ctgggacctg agcagcccag aagccagggt ggcaccactg tgtctctcct
      301 gtctgaagac ccggatattt tctcagactt ggcgacgcgt tcctttaaaa gatcagcatg
      361 gagacacatc cctccttagc agtgaaatgg tcgtgcccag acttgaccat ctacgcagga
      421 gaagtgacta tcggagaaga agatagaaat aaaatggact caaagaaaag aaagctggag
      481 aagacaagaa ttacagaggc tgcttgtgct ctgttaaact ctggaggagg attaattgct
      541 atgcaaatga ctaacaagag tgagcatcct gtggagatgg gacaggactt ggaaaagtct
      601 ttgagagagc ttattatgtc ccctaatatg caggctttct ttgagaccaa gcaacaagag
      661 gaccagttct acatttttgt taaatcttgg agctgcaggc ctgaagatgg ttctactaag
      721 cctcgaattt gcagcctggg ctcttctctg tactgtagat ctataacttc taaggttgcc
      781 atggattcaa gagaagcatt tgaatttctg aaagataaga aggcatgtat caaatacagg
      841 cctactgatg acggagctcc accggctaaa attccgagag ccatgtgtca gaacagcctt
      901 gaatcaaatc cagcttttga aattttccaa agtaagaaac ttgaatatgg ccaatgcttg
      961 cttttctctg aatccacatc tatagagttt aaacaattct ctaccaaaca cgtccaagca
     1021 tatatgaaaa acataattcc agaatacatc tccgcatttg caaacaccca gggaggctat
     1081 cttttcattg gagtggatga taagagaatc atcttgggat gcccaaaaga caacgttgac
     1141 cgtgactctt tgaaaactgt ggcgaatgaa acaatatcca aggtgccagt tttccatttt
     1201 tgttcatcta aagacaagga caaggtgtct tatgagacca gagtcataga tgtgtttcaa
     1261 gagggaaatt tgtatggtta tctctgtgtg atcaaagtag agccgttctg ctgtgcagtg
     1321 ttctcagagg ctcccatttc atggatggta gacaaggaga aaggtgtcta cagactgaac
     1381 actgaggaat gggtacgcat gatggtggat tttggcccag aggcatcttc caaagatcta
     1441 tctaaagatt ttgaatgtca gctgagtcta tgcaacagcc ccccacactg cagaccagtg
     1501 tattctaaaa aaggactgca gcataaagtt gacctgcagc agcgtttatt tcaagtgtca
     1561 ccagactgtt taaagtatac tcctgaatct ctctggaagg agctgtgttc ccagcataag
     1621 agactaaagg gtttagtaaa gcagcaaata cgttctttct cctgtggttt gctgatcctc
     1681 tatagaagct gggctgtgga cctgaacctg aaggagaagc aggaagtcat ctgtgatgct
     1741 ctgctgattg cacagaatag ccccccaatc ctctacacca tccttgggga gcaggatgag
     1801 cagggtcagg actactgcaa ccacactgcc tttactctga agcagaagct ggtgaacact
     1861 ggtggctaca ctgggagagt gtgtgtcatg accaaggttc tctgcctgag ttctcagaac
     1921 aatattgaga ccaatggggg ctcagtctct cctattaatt acccaagttc ctataacctt
     1981 gcaaacatcc aggaaatgca ggacttgctg caggcccttg tgattgtctt gctcaacttc
     2041 agatctttct tgagcgacca gcttggctgt gaaattttga atcttctcac agcccaacag
     2101 tatgagattc tctcaaaaag tctccgcaaa accagagaac tatttgtgca tggcttgccg
     2161 ggctcaggga agacaatcat agccatgaaa atcatggaaa agatcagaaa cacatttcac
     2221 tgtgaaacag atagtatcct ctacatctgt gaaaatcagc cattgaggga cttcatccgg
     2281 gcaaaaagaa tctgccaggc agtgacccgg aaaaccttca tgaattatag atttaagaca
     2341 aacagtttcc aacacatcat tgttgatgaa gcccagaatt tccgcactga ggatggaaac
     2401 tggtatggga aggcaaaagc aatctctcga agagtgaaaa gttgtcctgg aatgttctgg
     2461 atatttctag actattttca gaccagtcat ttgaaggaga gtggcctccc agatttctca
     2521 cgccagtatc caagggaaga gctcacacaa gtagtacgca atggagataa aatagctgag
     2581 ttcctacaaa aagagttgca aaaaatcaga gataaccctc catgcagcat cccccgacag
     2641 tccctaaaca ttgtccatga atttaagtgg tcccaaagtg tatcaggcaa cattaaaact
     2701 gaacaattca ctttggaaga catggtaatc tatgtagcag ataagtgtta tgatttcttg
     2761 cgtaaaggct attctctcca agatattgca gtgcttttca gcacagataa ggagaagaaa
     2821 acctatgagt ctatgttcct cggagaaatg aggaagagga ggagagcatc tgagatgaat
     2881 cacgcgtatc tctgtgattc taacatgttt gacagcatcc gtcgattctc aggactggaa
     2941 agaagcattg tgtttggtat caatcccatt gcaactgagc agcccatttc ccacaaccta
     3001 ttgctctgcc tggcttccag agcaatgaaa catctatata tcctgtattt ttcaactcct
     3061 gaggggcata gctcaacgga ggcatgctga atgggatgta tgaggaccta ggttcaatcc
     3121 ctgatgatga gaaagttaaa tcaagtcgag gtccttcagg acaagaagaa agataaagat
     3181 ataacaaaac cttgtgctgt agttttgaca catgtaggaa aaaaattacc aatgtgtata
     3241 tcgtaactaa ctgaggctga aaacaaagct ggagagaagg ctggcaaggc aatgtacaca
     3301 tgacataggc tatgggaacg ttgagaccat aaggactgaa accagagatg aagacaactc
     3361 aatacagtaa gtcatatcca aatcttaaaa cagacttcca ttttaaattg ttgaaaacat
     3421 ttatgaaaat attgtataca gttaaagaaa aagactaaaa acacaatatt aagtagtact
     3481 ggggtctgtg cctggagctg atcctgtgcc acagtgctca atacccaaac accgctggga
     3541 aagaactggc ctcccacaag tgtggacaag cctgtgagcg caggtaagtc caccactcct
     3601 gctcagaggt acgcacctgg aaccctccgg acacaggaac cagatgatga gaggcaacag
     3661 caagaacata aacaacagac accaaggcca cttggcatca tcagaacccg gttctcccac
     3721 cacagtgagc catcgatacc acaacacacc agaaaaacaa gactctgatt taaaatcaca
     3781 tctcatgatg atgatagaga actttaagaa ggacataaat aattccctta aagaaataca
     3841 gggacaggag ggatggctta gtggttataa gcactgactt aggtcctgag ttcaattccc
     3901 agaaaagaca tcgtggctca caaccatctc taatggggat ctaatactct cttctagtgt
     3961 gtctgaaggc tgggaccgtg tactcacata catgaaataa ataaaataag g
//
