LOCUS       NM_183201               5989 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus schlafen 5 (Slfn5), mRNA.
ACCESSION   NM_183201
VERSION     NM_183201.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5989)
  AUTHORS   Nakagawa,K., Matsuki,T., Zhao,L., Kuniyoshi,K., Tanaka,H.,
            Ebina,I., Yoshida,K.J., Nabeshima,H., Fukushima,K., Kanemaru,H.,
            Yamane,F., Kawasaki,T., Machida,T., Naito,H., Takakura,N., Satoh,T.
            and Akira,S.
  TITLE     Schlafen-8 is essential for lymphatic endothelial cell activation
            in experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 30 (2), 69-78 (2018)
   PUBMED   29528433
REFERENCE   2  (bases 1 to 5989)
  AUTHORS   Mavrommatis,E., Arslan,A.D., Sassano,A., Hua,Y., Kroczynska,B. and
            Platanias,L.C.
  TITLE     Expression and regulatory effects of murine Schlafen (Slfn) genes
            in malignant melanoma and renal cell carcinoma
  JOURNAL   J Biol Chem 288 (46), 33006-33015 (2013)
   PUBMED   24089532
  REMARK    GeneRIF: several mouse Slfn genes are up-regulated in response to
            IFN treatment of mouse melanoma and renal cell carcinoma cells,
            including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8.
REFERENCE   3  (bases 1 to 5989)
  AUTHORS   Bustos,O., Naik,S., Ayers,G., Casola,C., Perez-Lamigueiro,M.A.,
            Chippindale,P.T., Pritham,E.J. and de la Casa-Esperon,E.
  TITLE     Evolution of the Schlafen genes, a gene family associated with
            embryonic lethality, meiotic drive, immune processes and
            orthopoxvirus virulence
  JOURNAL   Gene 447 (1), 1-11 (2009)
   PUBMED   19619625
REFERENCE   4  (bases 1 to 5989)
  AUTHORS   Neumann,B., Zhao,L., Murphy,K. and Gonda,T.J.
  TITLE     Subcellular localization of the Schlafen protein family
  JOURNAL   Biochem Biophys Res Commun 370 (1), 62-66 (2008)
   PUBMED   18355440
REFERENCE   5  (bases 1 to 5989)
  AUTHORS   Geserick,P., Kaiser,F., Klemm,U., Kaufmann,S.H. and Zerrahn,J.
  TITLE     Modulation of T cell development and activation by novel members of
            the Schlafen (slfn) gene family harbouring an RNA helicase-like
            motif
  JOURNAL   Int Immunol 16 (10), 1535-1548 (2004)
   PUBMED   15351786
REFERENCE   6  (bases 1 to 5989)
  AUTHORS   Le Bras,S., Cohen-Tannoudji,M., Guyot,V., Vandormael-Pournin,S.,
            Coumailleau,F., Babinet,C. and Baldacci,P.
  TITLE     Transcript map of the Ovum mutant (Om) locus: isolation by exon
            trapping of new candidate genes for the DDK syndrome
  JOURNAL   Gene 296 (1-2), 75-86 (2002)
   PUBMED   12383505
REFERENCE   7  (bases 1 to 5989)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036486.1, AK040359.1 and AL603745.16.
            
            On May 30, 2009 this sequence version replaced NM_183201.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036486.1, AK040359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK036486.1         2-15
            15-2558             AK040359.1         2-2545
            2559-5989           AL603745.16        77598-81028
FEATURES             Location/Qualifiers
     source          1..5989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..5989
                     /gene="Slfn5"
                     /note="schlafen 5"
                     /db_xref="GeneID:327978"
                     /db_xref="MGI:MGI:1329004"
     exon            1..94
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     exon            95..160
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1188
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2843
                     /gene="Slfn5"
                     /note="expressesd sequence AI956840"
                     /codon_start=1
                     /product="schlafen family member 5"
                     /protein_id="NP_899024.3"
                     /db_xref="CCDS:CCDS25153.1"
                     /db_xref="GeneID:327978"
                     /db_xref="MGI:MGI:1329004"
                     /translation="MSFLEDLELNFAECIQDGGKATLGVRQREEMDTTHCMKQNEIIS
                     QAVCALLNSGGGVVRVEIENGDYNFERDGVGLNLPPLFRNHLDEMLYGKLFLIYVSSW
                     DVAASHVRLATLCSNLYHRCGTFTEVMDPEKALKFLKRVQDPRILGDSDSLNLQEAPV
                     DDAQMILASDLFHSPQLQYLEKLNFTKSSHVEFQMFSADLSQGIRERLPKCVSALANS
                     EGGYVFFGVHDETRHVIGCEKEKINCTNLKSTIDACIRKMPVYHFCGQNHKVQYELKF
                     LEVYDKEALHGYVCAIKVERFCCAAFAKAPDSWEIKDNNKKPLTANDWASRMIEINPD
                     LSSFPQMIPWKSMLNTTPCSKTVFTHKYLKCVEDLQKDYFPVSPNRITYTPESVYKDL
                     FADYRGLRNLINMEMRCFSQGILIFSHSWAVDLGLQRRQDVICDALLISPNNVPILYT
                     ICNKWDLGNRHYSMKVARTLKQKLVNMGGYPGRLGIIPLVLPLGSHQRVRNDLEMPVY
                     PESYNFITTQQVEALLQSLVIILFGFRPLLNEELNLESETVALLSDQQYGLLSTNLSK
                     HREMFVHGLPGSGKTTLALMIVGKIRNVFNCQADNILYICENQSLKRFIVRKNVCQAV
                     TRKTFMKNTFDNVQHIIVDEAQNFRTEDGNWYAKAKAITQRARDGPGVLYIFLDYFQI
                     NHLCCSGLPELQHQKPLLKLTRMLRSGDNITSYLQDIMHQIRENPPPNVPQEALMVGE
                     ELEWGPDVTGNLEITDNLNLEQMSVYVAEKCQSLWRSGYFTDVAVLFTRARDIEKCRD
                     KLLLAMRRRSMSQLAEEPSLLVQVREGLDSLGSHVVLESVHRFSGMERSIVFGIIPMG
                     SETAIFYNALLCLASRARTHLYIVKVVF"
     exon            1189..1314
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..2038
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..5989
                     /gene="Slfn5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagggtag aggtctccac tctggaccca ggacatcagc tctgattcca ggagacgggg
       61 cgccctgcgg gctgcggagg acagactccg gcggtttcct ggaggttcca gcaagacacc
      121 atctcaccac ttgccgctct agagctcaac ctttggccag gaaaagattt cagctaaagg
      181 cggagaagat gagtttcctg gaggatttgg aactgaactt tgcggaatgt atacaagatg
      241 gaggaaaagc gacccttggg gttaggcaaa gggaggaaat ggataccaca cactgcatga
      301 aacagaacga aatcatctcg caagccgtgt gcgctctgct gaattccggt ggcggagtgg
      361 tcagggttga gattgagaac ggagactata attttgagag ggatggagtt ggcttgaatc
      421 tgccaccatt gttcagaaac catttagacg agatgctgta tggaaagctc tttttaatat
      481 atgtgagttc gtgggacgtg gcagcctctc acgtgaggct cgctaccctg tgctccaatt
      541 tgtaccacag atgtggaaca tttactgagg tcatggatcc tgaaaaagcc ctgaaattcc
      601 tcaaaagggt ccaggatcct aggattcttg gtgactctga ctcgctaaat ctacaggaag
      661 ctcctgtaga tgacgctcag atgatcttag cttctgattt gtttcatagc ccgcagctcc
      721 agtacctgga aaaactcaac ttcacaaagt cctcacacgt tgaatttcaa atgttctcgg
      781 cagacctttc ccagggcatt agagagagac ttcccaagtg tgtttctgca cttgccaatt
      841 ctgaaggggg ctatgtgttt tttggtgtgc atgatgagac ccgtcatgtc attggatgtg
      901 aaaaggaaaa gataaattgt accaacttga aatctactat cgatgcctgt atcaggaaga
      961 tgcctgtcta ccacttctgt ggacaaaacc acaaagtgca atatgagctt aaattccttg
     1021 aagtgtatga taaggaggcc ctccatgggt atgtctgtgc aatcaaggtc gaacgattct
     1081 gctgtgcagc atttgccaaa gcgcccgatt cctgggagat aaaggacaat aataagaagc
     1141 cgctaactgc gaatgactgg gcctctcgga tgatagaaat caacccagac ctttccagtt
     1201 tccctcagat gatcccctgg aagagtatgt taaacaccac accctgcagc aagaccgtgt
     1261 tcacacataa atatttgaaa tgtgtggaag acctgcagaa ggattacttt ccagtgtcac
     1321 ccaacaggat tacatatact ccagagagcg tctacaagga cctcttcgca gattacagag
     1381 gactaagaaa cttaataaat atggaaatgc gctgtttctc tcaagggata ttgatcttct
     1441 cccacagctg ggctgtagat ctaggtcttc agaggaggca agatgtcatc tgtgacgctc
     1501 ttctgatttc cccgaacaac gttccaatcc tgtacaccat ttgcaacaag tgggatctgg
     1561 ggaacaggca ctattccatg aaagttgccc gtaccctgaa gcagaagctg gtgaacatgg
     1621 gtggctaccc tggaagatta ggcatcattc ccttggtctt accactgggt tctcaccaaa
     1681 gagtaaggaa tgacttagaa atgccagtgt accccgaatc ctataacttc ataaccacac
     1741 agcaggtgga agctctgttg caatctcttg tgatcatctt gtttgggttc agacccctgt
     1801 taaatgaaga gttaaacttg gagtctgaga ctgtggccct gctctcagac caacagtacg
     1861 ggttgctttc aactaacctg agcaagcaca gagagatgtt tgttcacggc ttacctggat
     1921 cagggaagac cactctagct ctcatgatcg tggggaagat caggaatgtg ttcaactgtc
     1981 aagctgacaa cattctttac atctgtgaga accagtcctt gaagaggttc attgtgagga
     2041 aaaacgtttg ccaggcagtg acacggaaaa ccttcatgaa aaataccttt gataatgtgc
     2101 aacatatcat cgtggacgaa gctcagaatt tccgaacgga ggacgggaac tggtacgcaa
     2161 aggccaaagc catcactcag agagcgagag atggcccagg agttctctac atttttctgg
     2221 attactttca gatcaatcac ttgtgttgca gtggcctccc tgagctccaa caccagaagc
     2281 cgttattgaa gctcaccaga atgctccgca gcggagacaa cataaccagc taccttcagg
     2341 atataatgca tcaaatcaga gaaaatcctc ccccaaatgt cccccaagaa gccttgatgg
     2401 tgggtgaaga acttgaatgg ggtccagatg tcacaggcaa cttagagatt actgataact
     2461 tgaatttgga gcagatgtca gtctatgtag cagagaaatg ccagagtctt tggaggtctg
     2521 gctatttcac ggatgttgct gttcttttca ctagagccag agatatagaa aaatgtagag
     2581 acaagcttct gctagcaatg aggaggaggt ccatgtctca gctcgctgag gagcccagtt
     2641 tactagtgca ggtcagggag gggttggata gtctgggtag tcacgtcgtg ttggagagtg
     2701 ttcaccgatt ttcaggcatg gaaagaagta ttgtgtttgg gatcattcca atgggatctg
     2761 agacggccat tttctacaat gctctgctct gtctggcttc cagggcaagg acacatctgt
     2821 atattgtaaa ggttgtgttt tgataggaag atgccagttt tcagttagct tgggttggtc
     2881 tctagctgtc tttgaagctc tttgatctaa acatttaagc accaaaaaca tttcatgtac
     2941 aatcagccac actcagggca agcaaatatg agtatggggg atgtagacag taggaagaga
     3001 cagcagagca attagctggc actgagatat cctttctctc tctctctctc tctctctctc
     3061 tctctctctg tgtgtgtgtg tgtatgtgtg tgtgtgtatc aggaaggact ggttgtttga
     3121 ggtaggcagg aaagagctaa ttatgagatg actgctgact tctcgtagac tcagatattt
     3181 tccttgtttt taacacagcc accggcagaa atgcttgatc ttggtgtgtg gagggagcat
     3241 gaaggggaga gggggagaga gtgtgtccat ctttagcagg acatagtttg aaatgtaagt
     3301 tcacaaactg caagctatga tttcagggtg agtccagttc agtttagctt gtcgagttgc
     3361 ttcctgtttt gcctttcatc ggcattgctg tttctgatct ttgccttcta catgacttat
     3421 ttattcagaa tctttgactc cgccttaata ctattcctgt ggggacccag agttactacc
     3481 gtcaaagtgc caaagtgtgg gtgcagtggt ttggaaggta gagggccgaa gaggaagaat
     3541 gtacagagtc taagcctggc atcactccac acttaattta gtaaccacag tatgcaaaca
     3601 taagtcaaat atctctgctc tctgtgcgct ccccagttca aacagccttt cgaaggccgt
     3661 tgctgaaaaa atactcattt gtcatttgct ttaggtctct gtatagccct ggctgtcctg
     3721 gaactcactc tgtagaccag gctggcctcg aactcagaaa tccacctgcc tctgcctccc
     3781 gagtgctggg attaaaggca tgtgccacca cgctcggctt ctctgaaact caatatttag
     3841 agccaaacag agcaaacttt tctgggagac acaaacaaac aaaaatccag agttcatttc
     3901 cagggatgat ttgcaggagc aaatcatgaa aacttaagga aaatgaataa acatagagag
     3961 tatgatataa attgaataac ttagagaaaa aaaatcacac attctaatgg gtggatcgga
     4021 acctaccatg tttatcagag agtgtgtggg tatgggtgag tgtgggtgtg gataataatc
     4081 agaaaaaaaa gacaaagaag cttggggaaa tggagggctg gagagtaggg catcaggaca
     4141 catgtgctat gaagcagaaa ggatgctgtg gggagatgga agtggagtca caagggaagg
     4201 ctcagggagg ggaggggcac agatattagc aaaatactgt aaaaaaataa acttgaacat
     4261 agaatcggtt tgctttaggc atctagttac attcttagag aatttatatc aaagaaattt
     4321 acttctagcc aggaagtgat ggcacacacc tttaacccca gaactcagaa ggcagaggca
     4381 ggtggatctc tgagttggag gccagcctgg tttacagagt gagttctagg acatctaagg
     4441 ttatacagaa aacccctgtc tcaaaaagca aagctgagcc aagccaagcc aagccaaacc
     4501 aaaccaaacc aaaccaaacc aaatcaaacc caaaaaccac catcaacaaa aaaactccaa
     4561 acaaatgaca aagagccagg tagtggtggt gcatagcttt aatctcagca ctatggagac
     4621 agagacagaa ggatctctta agtttgagct agcctggtct acagagtgag tgtcaggata
     4681 gccagaaagg tcaagaaaca atatgctggg gaaatgctgg cagcaaatgt cataaatatt
     4741 ttttccctaa agtttctatt catggtagtt taatcccagc actcaggagg cagaggcaag
     4801 tggatctccg tgagtttgag tccaacctgg tccacatagt gagtttcggg ctaaccaggg
     4861 ttacatactg agaccttgtc tcaaaatttt tttttataca taaaagaaaa atttccgggc
     4921 tggtgagatg gctcagtggg taagagcacc cgactgctct tccgaaggtc aggagttcaa
     4981 atcccagcaa ccacatggtg gctcacaacc atctgtaacg agatctgact ccctcttctg
     5041 gagtgtctga ggacagctac agtgtactta catataataa ataaataaat aaataaatct
     5101 taaaaaaaaa aaaatataaa aaaaaaaaaa aaaaaaaaag aaaaatttcc aagattaaag
     5161 gaaaactgga caaagaattt gacaggaaga gcacagaagg agtttaaaaa gctcctacac
     5221 atgggggaga catcccttac ggtggcatga gtgtcacata accaggtgtg tgacaacatg
     5281 ctgtttggag agaaagacct ggcaatggcc atgatatgct tggatgtttg taacctttta
     5341 ccctgagatt cattcctaag gaacttattc tgcacagaca gcttgcacac atgtaaaaag
     5401 cttctgggtc gacgtataga gttttgcttc tagtagcaga aagcacagca gtagtaaaca
     5461 caatacagat gagttgaagg gagtaattta cagaaaatca caacacacca tcatatcacg
     5521 aagccataaa aagtgagatc gcccttgtat ttatgtgggg ccatctctaa gatgttctgt
     5581 attgtgacca aagtctacct atcctgtgcc tctagggccg acacacatgc ttgcagatgc
     5641 tttcaggatt tttttttttt aaataaacct taaaatctct ggagcagggg catcggtgcc
     5701 cagggagaaa gacagcttct gctcttttgg actctaggtt ctctaccatg tggcacttga
     5761 tgaagttttg ctttgcatat gtttttactt ataaatgtaa tggatttata aatgactttc
     5821 tcagttttta tcaacctgta tcctggtaaa catttcataa tcatagtggg tattaatagt
     5881 gggtagtgaa tggggaattt gaaaactata caatgtagga tgtagaagtg ctgacacact
     5941 gttcaagctt tttttaaaaa ataaaataaa ggacataaga tattgcaac
//
