LOCUS       NM_011409               1834 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Mus musculus schlafen 3 (Slfn3), mRNA.
ACCESSION   NM_011409
VERSION     NM_011409.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Vomhof-DeKrey,E.E., Rajpathy,O.K., Preszler,E. and Basson,M.D.
  TITLE     Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in
            lung, stomach, cecum, kidney, and proximal colon differentiation
            markers and Slfn family members expression levels
  JOURNAL   Biochem Biophys Rep 36, 101552 (2023)
   PUBMED   38076659
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Vomhof-DeKrey,E.E., Stover,A.D., Labuhn,M., Osman,M.R. and
            Basson,M.D.
  TITLE     Vil-Cre specific Schlafen 3 knockout mice exhibit sex-specific
            differences in intestinal differentiation markers and Schlafen
            family members expression levels
  JOURNAL   PLoS One 16 (10), e0259195 (2021)
   PUBMED   34710177
  REMARK    GeneRIF: Vil-Cre specific Schlafen 3 knockout mice exhibit
            sex-specific differences in intestinal differentiation markers and
            Schlafen family members expression levels.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Vomhof-DeKrey,E.E., Lansing,J.T., Darland,D.C., Umthun,J.,
            Stover,A.D., Brown,C. and Basson,M.D.
  TITLE     Loss of Slfn3 induces a sex-dependent repair vulnerability after
            50% bowel resection
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 320 (2), G136-G152 (2021)
   PUBMED   33237796
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Vomhof-DeKrey,E.E., Lee,J., Lansing,J., Brown,C., Darland,D. and
            Basson,M.D.
  TITLE     Schlafen 3 knockout mice display gender-specific differences in
            weight gain, food efficiency, and expression of markers of
            intestinal epithelial differentiation, metabolism, and immune cell
            function
  JOURNAL   PLoS One 14 (7), e0219267 (2019)
   PUBMED   31260507
  REMARK    GeneRIF: Study characterized the role of Slfn3 in the intestinal
            homeostasis. Slfn3KO mice have a phenotype of decreased weight gain
            that is unlikely caused by a single gene but instead multiple
            genes/pathways. This includes the metabolic pathways of
            glycerolipid, linoleic and arachidonic acid metabolism,
            sex-dependent disregulation of glucose transporters, Glut2 and
            SGLT1, and intestinal differentiation genes, Notch2 and Cdx2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1834)
  AUTHORS   Nakagawa,K., Matsuki,T., Zhao,L., Kuniyoshi,K., Tanaka,H.,
            Ebina,I., Yoshida,K.J., Nabeshima,H., Fukushima,K., Kanemaru,H.,
            Yamane,F., Kawasaki,T., Machida,T., Naito,H., Takakura,N., Satoh,T.
            and Akira,S.
  TITLE     Schlafen-8 is essential for lymphatic endothelial cell activation
            in experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 30 (2), 69-78 (2018)
   PUBMED   29528433
REFERENCE   6  (bases 1 to 1834)
  AUTHORS   Berger,M., Krebs,P., Crozat,K., Li,X., Croker,B.A., Siggs,O.M.,
            Popkin,D., Du,X., Lawson,B.R., Theofilopoulos,A.N., Xia,Y.,
            Khovananth,K., Moresco,E.M., Satoh,T., Takeuchi,O., Akira,S. and
            Beutler,B.
  TITLE     An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due
            to loss of immune cell quiescence
  JOURNAL   Nat Immunol 11 (4), 335-343 (2010)
   PUBMED   20190759
REFERENCE   7  (bases 1 to 1834)
  AUTHORS   Bustos,O., Naik,S., Ayers,G., Casola,C., Perez-Lamigueiro,M.A.,
            Chippindale,P.T., Pritham,E.J. and de la Casa-Esperon,E.
  TITLE     Evolution of the Schlafen genes, a gene family associated with
            embryonic lethality, meiotic drive, immune processes and
            orthopoxvirus virulence
  JOURNAL   Gene 447 (1), 1-11 (2009)
   PUBMED   19619625
REFERENCE   8  (bases 1 to 1834)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF099974.1.
            
            [WARNING] On Feb 7, 2025 this sequence was replaced by NM_011409.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF099974.1, SRR7345562.1531951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..1834
                     /gene="Slfn3"
                     /note="schlafen 3"
                     /db_xref="GeneID:20557"
                     /db_xref="MGI:MGI:1329005"
     exon            1..79
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
     exon            80..1149
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1763
                     /gene="Slfn3"
                     /codon_start=1
                     /product="schlafen 3"
                     /protein_id="NP_035539.1"
                     /db_xref="CCDS:CCDS25159.1"
                     /db_xref="GeneID:20557"
                     /db_xref="MGI:MGI:1329005"
                     /translation="MKDIQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDG
                     MGLDLVNSLPGIMHLPHDYLDFMQHKDYFFVFVKPLKPNQKGPGITTLKTNLYRRINS
                     ISDEVKVANAVQLLKSRTDPEEKAESRPSSPGKIVCNETLNECLSLFNRDWLAYEETF
                     CFTKSIHAEVKLTPKEKIFPKEKILELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFE
                     AEKSNLVLLESEIEKCIQQLPVTHFCGEKEKIKYTCKFIEVRKSGAVCAYVCALRVER
                     FCCAVFAAEPESWHVEGGCVKRFTTEEWVKRQMDATAVMPGKVICCPEALYMKPFSQH
                     EGYEHLVRTELGSLLKGTLVISKSWALDLGLQEKQEVIWDVLHISQGSLLTLYVFVQG
                     DENLEGNSSLLGELGAELKGYYKQIALTLKQMLLNHCGYTAEIGIIVKITYLGHKTMC
                     LYDTSTKIRYPQKYYLSAKAVKDLEKALVEILGSYESFYSLPRRNWDSFMSAFLNVGS
                     YIVPVLRNV"
     exon            1150..1816
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaaaaatg cctggggcct cggagatgaa agacggacct gaacaggagc agagacacag
       61 agctggccac acatggaagg aaaggacttc atctgggaaa cagaggcagt gattggaaaa
      121 caaacatcat tgttgatcag gacacagact atgctgaact ggttctgttt attggagaaa
      181 tcacacttgg agagaaaaat aggaattcaa tgaaagatat tcaactgaga agaaaagaag
      241 ccaaaagtat attacaggct gtgtgcaccc tgctgaattc tggagggggc gtggtcaagg
      301 ctcacattaa aaatcaaaac tacagcttca ccagagatgg aatgggactg gatttggtaa
      361 attccttacc cggtatcatg caccttcctc atgactatct agacttcatg cagcacaaag
      421 actacttttt cgtttttgtg aaaccattga agccgaatca gaaagggccg gggatcacca
      481 ccttgaaaac gaacttgtac agaagaatca actcaatctc agatgaagtg aaagtagcga
      541 atgcagtgca gctcctcaaa tccaggacag atcccgaaga gaaagcagaa tccagaccaa
      601 gttcacctgg gaaaatcgtc tgtaatgaaa cactaaatga atgtctttcc ttatttaaca
      661 gagactggct tgcctatgag gagacattct gtttcactaa atccatacat gctgaagtaa
      721 aattgactcc taaggaaaag atttttccta aggaaaagat tttagagctc ctccctcaaa
      781 ctgtttctgc atttgcaaac actgatgggg gatttttgtt cattggcttg gatggcaaaa
      841 cgcagcaaat tattggtttt gaagcagaga agagcaatct cgtgcttcta gagagtgaaa
      901 tagaaaagtg catccaacag ctgcctgtca ctcacttctg tggggagaag gagaagatca
      961 agtacacgtg caaattcatc gaagtgcgca aatccggagc tgtgtgtgca tatgtgtgtg
     1021 cgctcagagt ggagaggttc tgctgtgcag tgttcgctgc agagcccgag tcctggcacg
     1081 tggaaggtgg ctgtgtgaag aggtttacca cagaggaatg ggtgaagcgc cagatggatg
     1141 ccactgcagt gatgcctgga aaggtgatat gctgtccaga agccctctat atgaaaccat
     1201 tctcacaaca tgaaggctat gagcacttag tccggacaga attgggctcc ctgcttaaag
     1261 gaacactggt tatctccaag agctgggctt tggatctggg cttgcaagag aagcaggaag
     1321 ttatctggga tgtgcttcat atttcccagg gcagtctcct gaccctgtat gtctttgtcc
     1381 agggagatga gaacctggaa ggcaacagca gtcttcttgg ggaactaggc gccgagttaa
     1441 agggctatta taaacaaatt gccctaacat taaagcagat gttgttaaac cattgtggtt
     1501 acactgcgga aataggtatt atagtaaaga taacatactt gggtcataag acaatgtgtc
     1561 tttatgacac aagcacaaaa atacgttacc cccaaaaata ttatctgtcg gccaaggcag
     1621 taaaggactt agaaaaagct ctcgttgaaa tcttaggaag ttatgagtct ttctacagtt
     1681 tacccaggag aaactgggat tcttttatgt ctgcattttt aaatgtggga agttatatag
     1741 tccctgtttt gagaaatgta tgagaaatgt cttaactcat attcgaatct gacaagacat
     1801 aaaaaaaaca aatggaaaaa aaaaaaaaaa aaaa
//
