LOCUS       NM_011408               1684 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus schlafen 2 (Slfn2), mRNA.
ACCESSION   NM_011408
VERSION     NM_011408.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1684)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1684)
  AUTHORS   Warsi,S., Dahl,M., Smith,E.M.K., Rydstrom,A., Mansell,E.,
            Sigurdsson,V., Sjoberg,J., Soneji,S., Rorby,E., Siva,K.,
            Grahn,T.H.M., Liu,Y., Blank,U., Karlsson,G. and Karlsson,S.
  TITLE     Schlafen2 is a regulator of quiescence in adult murine
            hematopoietic stem cells
  JOURNAL   Haematologica 107 (12), 2884-2896 (2022)
   PUBMED   35615926
  REMARK    GeneRIF: Schlafen2 is a regulator of quiescence in adult murine
            hematopoietic stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1684)
  AUTHORS   Yue,T., Zhan,X., Zhang,D., Jain,R., Wang,K.W., Choi,J.H.,
            Misawa,T., Su,L., Quan,J., Hildebrand,S., Xu,D., Li,X., Turer,E.,
            Sun,L., Moresco,E.M.Y. and Beutler,B.
  TITLE     SLFN2 protection of tRNAs from stress-induced cleavage is essential
            for T cell-mediated immunity
  JOURNAL   Science 372 (6543) (2021)
   PUBMED   33986151
  REMARK    GeneRIF: SLFN2 protection of tRNAs from stress-induced cleavage is
            essential for T cell-mediated immunity.
REFERENCE   4  (bases 1 to 1684)
  AUTHORS   Omar,I., Guterman-Ram,G., Rahat,D., Tabach,Y., Berger,M. and
            Levaot,N.
  TITLE     Schlafen2 mutation in mice causes an osteopetrotic phenotype due to
            a decrease in the number of osteoclast progenitors
  JOURNAL   Sci Rep 8 (1), 13005 (2018)
   PUBMED   30158544
  REMARK    GeneRIF: Overall, these data suggest that Slfn2 is required for
            normal osteoclast differentiation and that loss of its function in
            mice results in an osteopetrotic phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1684)
  AUTHORS   Fischietti,M., Arslan,A.D., Sassano,A., Saleiro,D.,
            Majchrzak-Kita,B., Ebine,K., Munshi,H.G., Fish,E.N. and
            Platanias,L.C.
  TITLE     Slfn2 Regulates Type I Interferon Responses by Modulating the
            NF-kappaB Pathway
  JOURNAL   Mol Cell Biol 38 (16), e00053-18 (2018)
   PUBMED   29866656
  REMARK    GeneRIF: we provide evidence that targeted disruption of the Slfn2
            gene leads to increased transcription of IFN-stimulated genes
            (ISGs) and enhanced type I IFN-mediated antiviral responses
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1684)
  AUTHORS   Zhao,L., Neumann,B., Murphy,K., Silke,J. and Gonda,T.J.
  TITLE     Lack of reproducible growth inhibition by Schlafen1 and Schlafen2
            in vitro
  JOURNAL   Blood Cells Mol Dis 41 (2), 188-193 (2008)
   PUBMED   18479948
  REMARK    GeneRIF: Schlafen1 and Schlafen2 failed to inhibit cell
            proliferation, cause G1 cell cycle arrest, or affect Cyclin D1
            level in murine fibroblasts.
REFERENCE   7  (bases 1 to 1684)
  AUTHORS   Neumann,B., Zhao,L., Murphy,K. and Gonda,T.J.
  TITLE     Subcellular localization of the Schlafen protein family
  JOURNAL   Biochem Biophys Res Commun 370 (1), 62-66 (2008)
   PUBMED   18355440
REFERENCE   8  (bases 1 to 1684)
  AUTHORS   Sohn,W.J., Kim,D., Lee,K.W., Kim,M.S., Kwon,S., Lee,Y., Kim,D.S.
            and Kwon,H.J.
  TITLE     Novel transcriptional regulation of the schlafen-2 gene in
            macrophages in response to TLR-triggered stimulation
  JOURNAL   Mol Immunol 44 (13), 3273-3282 (2007)
   PUBMED   17434208
  REMARK    GeneRIF: The Slfn-2 transcriptional start site and transcription
            factor binding sites in the slfn-2 promoter have been identified.
REFERENCE   9  (bases 1 to 1684)
  AUTHORS   Cohen-Tannoudji,M., Vandormael-Pournin,S., Le Bras,S.,
            Coumailleau,F., Babinet,C. and Baldacci,P.
  TITLE     A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus
            region on mouse chromosome 11
  JOURNAL   Genomics 68 (3), 273-282 (2000)
   PUBMED   10995569
REFERENCE   10 (bases 1 to 1684)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF099973.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF099973.1, BC138750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..1684
                     /gene="Slfn2"
                     /gene_synonym="Shlf2"
                     /note="schlafen 2"
                     /db_xref="GeneID:20556"
                     /db_xref="MGI:MGI:1313258"
     exon            1..232
                     /gene="Slfn2"
                     /gene_synonym="Shlf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1319
                     /gene="Slfn2"
                     /gene_synonym="Shlf2"
                     /note="schlafen family member 12-like"
                     /codon_start=1
                     /product="schlafen family member 2"
                     /protein_id="NP_035538.1"
                     /db_xref="CCDS:CCDS25156.1"
                     /db_xref="GeneID:20556"
                     /db_xref="MGI:MGI:1313258"
                     /translation="MGTRLEATEQSNHRTQRNDIQLENAKAAGKMGISVDLEAKYAKL
                     GLNLGAITFGEKDRKKMKNSHLRKQENANISLAVCALLNSGGGAIKVKIENENYSLTR
                     DGLGLDLEASLCKCLPFVQWHLDFTESEGYIYIYVKSWSQEIFGLPIGTLRTNLYVRS
                     MSSSVQVSAAAALEFLQDLEETGGRPCVRPELPASIAFPEVEGEWHLEDLAAALFNRT
                     EFQYEETFPFTRSRYVEVTLLSAKRLRKRIKELLPQTVSAFANTDGGFLFIGLDGKTQ
                     QIIGFEAEKSDLVLLESEIEKHIRQLPVTHFCEEKEKIKYTCKFIEVHKSGAVCAYVC
                     ALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKLQMNAPSG"
     exon            233..1664
                     /gene="Slfn2"
                     /gene_synonym="Shlf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slfn2"
                     /gene_synonym="Shlf2"
                     /note="hexamer: CATAAA"
     polyA_site      1664
                     /gene="Slfn2"
                     /gene_synonym="Shlf2"
                     /note="major polyA site"
ORIGIN      
        1 gctttaatgc agcaaggaac aaagaactca catgggctta gaggtgaaca cacaaccagg
       61 gctgcagtta gaactcttcc aagtgccaaa gcccaccggc gaagacatct gctggccagg
      121 acttgttgca gacagagggt ctttctcagg tgacactagc ctgctttacc aagactgctg
      181 acatgggtac tagacttgag gcaactgagc aaagcaacca cagaactcag aggaatgaca
      241 ttcagctgga aaatgcaaag gctgctggga aaatgggcat cagtgttgat ctggaagcca
      301 aatatgctaa gctgggtcta aatctcggag caatcacttt tggagagaag gataggaaga
      361 aaatgaagaa ttctcacctc agaaaacagg agaatgcaaa catctctcta gctgtatgtg
      421 ctctcctgaa ttcgggaggt ggagcaatca aggttaaaat tgaaaatgaa aattatagtc
      481 tcactaggga tggcctggga ctagatttgg aagcctctct ttgtaaatgt ctgccctttg
      541 tccagtggca cctggacttc acggagagcg aaggctacat ttatatctac gtgaaatcgt
      601 ggagccaaga aatctttggg ctgcctattg gcaccctaag aaccaatttg tatgtaagga
      661 gcatgtcatc ttctgtacaa gtgagcgccg ctgctgccct ggaatttctc caggacctgg
      721 aggaaactgg agggagaccc tgtgtcagac cagagttgcc tgcaagcata gccttccctg
      781 aagtggaagg agaatggcac ctggaggatt tggctgctgc attgtttaac aggacagaat
      841 ttcagtacga ggaaactttc ccctttacca gatccagata tgttgaagtt acattgcttt
      901 cagcgaaacg cctgcgaaaa cgcatcaaag agctcctccc tcaaactgtt tctgcttttg
      961 caaacacgga tgggggattt ttgttcattg gtttggatgg caaaacccag caaattattg
     1021 gttttgaagc agagaagagc gatctcgtgc ttctagagag tgaaatagaa aagcacatcc
     1081 ggcagctgcc tgtcactcac ttctgtgagg agaaggagaa gatcaagtac acgtgcaaat
     1141 tcatcgaagt gcacaaatcc ggagctgtgt gtgcatatgt gtgtgcgctc agagtggaga
     1201 gattctgctg tgcagtattc gctgcagagc ccgagtcctg gcatgtggaa ggcggctgtg
     1261 tgaagaggtt taccacagag gaatgggtga aactccagat gaatgcccca tcaggttgaa
     1321 gggggattaa taatctgtat gagggcggca gagatggctc agtggctaag agcactgact
     1381 gctcttccag agatctgagc tgtaaccccc cccccccagc ctgaaacctg gttgctcagg
     1441 tttcactgtt agcaagaaga gagcatggga gaggggggag gagcctgccg ccctatcgtt
     1501 catcctaccc tttgtccacc cgagactaga ggggtgtgtc cgttccacgc agacaaaggg
     1561 gcccagaggg tctgtggcag tggtcacctg aaactggact ccaggatgat ttggcgggaa
     1621 tgggcccctt ccccctcctt cataaaattg agctttgctc agaaaaaaaa aaaaaaaaaa
     1681 aaaa
//
