LOCUS       NM_001166028            3704 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus schlafen 14 (Slfn14), mRNA.
ACCESSION   NM_001166028 XM_894124 XM_913679
VERSION     NM_001166028.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3704)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3704)
  AUTHORS   Stapley,R.J., Smith,C.W., Haining,E.J., Bacon,A., Lax,S.,
            Pisareva,V.P., Pisarev,A.V., Watson,S.P., Khan,A.O. and Morgan,N.V.
  TITLE     Heterozygous mutation SLFN14 K208N in mice mediates
            species-specific differences in platelet and erythroid lineage
            commitment
  JOURNAL   Blood Adv 5 (2), 377-390 (2021)
   PUBMED   33496736
  REMARK    GeneRIF: Heterozygous mutation SLFN14 K208N in mice mediates
            species-specific differences in platelet and erythroid lineage
            commitment.
REFERENCE   3  (bases 1 to 3704)
  AUTHORS   Seong,R.K., Seo,S.W., Kim,J.A., Fletcher,S.J., Morgan,N.V.,
            Kumar,M., Choi,Y.K. and Shin,O.S.
  TITLE     Schlafen 14 (SLFN14) is a novel antiviral factor involved in the
            control of viral replication
  JOURNAL   Immunobiology 222 (11), 979-988 (2017)
   PUBMED   28734654
  REMARK    GeneRIF: SLFN14 is a novel antiviral factor for both DNA and RNA
            viruses
REFERENCE   4  (bases 1 to 3704)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   5  (bases 1 to 3704)
  AUTHORS   Pisareva,V.P., Muslimov,I.A., Tcherepanov,A. and Pisarev,A.V.
  TITLE     Characterization of Novel Ribosome-Associated Endoribonuclease
            SLFN14 from Rabbit Reticulocytes
  JOURNAL   Biochemistry 54 (21), 3286-3301 (2015)
   PUBMED   25996083
REFERENCE   6  (bases 1 to 3704)
  AUTHORS   Bustos,O., Naik,S., Ayers,G., Casola,C., Perez-Lamigueiro,M.A.,
            Chippindale,P.T., Pritham,E.J. and de la Casa-Esperon,E.
  TITLE     Evolution of the Schlafen genes, a gene family associated with
            embryonic lethality, meiotic drive, immune processes and
            orthopoxvirus virulence
  JOURNAL   Gene 447 (1), 1-11 (2009)
   PUBMED   19619625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603711.6.
            
            [WARNING] On May 7, 2024 this sequence was replaced by
            NM_001166028.2.
            
            On or before Oct 4, 2009 this sequence version replaced
            XM_913679.3, XM_894124.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. There are no full-length
            transcripts supporting this RefSeq in mouse; however, it is
            predicted based on partial transcript alignments and on full-length
            transcript support from the human homolog (GeneID: 342618,
            NM_001129820.1, BC157877.1) and rat homolog (AY539914.1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: KY467412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL603711.6         119490-119582
            94-1155             AL603711.6         122018-123079
            1156-1290           AL603711.6         124263-124397
            1291-2005           AL603711.6         126562-127276
            2006-3704           AL603711.6         129406-131104
FEATURES             Location/Qualifiers
     source          1..3704
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..3704
                     /gene="Slfn14"
                     /gene_synonym="Gm20; Slfn14-ps"
                     /note="schlafen 14"
                     /db_xref="GeneID:237890"
                     /db_xref="MGI:MGI:2684866"
     exon            1..93
                     /gene="Slfn14"
                     /gene_synonym="Gm20; Slfn14-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            94..1155
                     /gene="Slfn14"
                     /gene_synonym="Gm20; Slfn14-ps"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2828
                     /gene="Slfn14"
                     /gene_synonym="Gm20; Slfn14-ps"
                     /note="schlafen family member 14, pseudogene; Schlafen
                     family member 14, WSB_EiJ strain specific; Schlafen family
                     member 14, CAST_EiJ strain specific"
                     /codon_start=1
                     /product="protein SLFN14"
                     /protein_id="NP_001159500.1"
                     /db_xref="CCDS:CCDS70269.1"
                     /db_xref="GeneID:237890"
                     /db_xref="MGI:MGI:2684866"
                     /translation="MPYAEITVNLGKVTLGEENRKKMTNSCLKRHENSSLVQAVCALL
                     NSGGGVIKAEINDKSYSYRCHGLGQDLETSFQKLLPSGSQKHLDYMQQNHDLLIFVKS
                     WSPDASSLPLRICSLRSNLYQRDVTSAINLCANGALELLREKESRAQRGTPRLHSQDH
                     ILNRTIQEEEDIKMCALEFLKKDKLNFKEKLSFTESTHVEFKRFTTKKIVPRIKETLA
                     HYVSAFANTQGGYIIIGVDDKSKEVFGCKKEKVNPDSLKTEIKNCIEKLPTYHFCREK
                     PKVNFTTKILKVYQKEALYGFVCVVQVEPFCCVVFAEDPDSWIMENNIVTRLKVQQWV
                     EMMLDIQSDPSSGFPTINDSAHLMTPALSAPRRPAYLTKVLEHKETLQRHFFSVTQEN
                     LQFQPESLCKKLFSDHEGLEDLLKAQTHPCSHGIVIFSRSWAGDIGLMREEKVLCDAL
                     LVAVGSPLVLYTILTDPSSTGRADYTQNTALQLKRQLQTLGGYPGKICVIPRVIYLAS
                     RGSRPDQPPVYYPRPYTLSSKAEVEDLLQGLVLVSLCSRSVLSDQLGCEFFKQCLEEQ
                     ANTLSRNLQESRELFIHCLPGTRKTALAIKMVEKIKDVFHCKPKEILFVCENDSLRDF
                     VMQQVTCRAVTRRTFMREEFPKIKHIVMDETENFCSRHGDWYVKAKSTTHPKANGAAN
                     EHPHHGILWLFLDPFQVRHADGSGLPVPSAQFPRKMITSEIHCAVEIAKVMKDEMKRM
                     QENPPSMGLPDTLATFQEAPYEEAMRAGALPGVCEIKANLTPEQIANYVAEKCHSLFH
                     EGYLPQDIAILYRRREDRGQYKDVLLKAMARGTTEVAFNSAADVCADGIILDSVEQFS
                     GMVRNIVFGLCPESVHSEGVHKLCFASKAIKHLYLLYGGRTAF"
     exon            1156..1290
                     /gene="Slfn14"
                     /gene_synonym="Gm20; Slfn14-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..2005
                     /gene="Slfn14"
                     /gene_synonym="Gm20; Slfn14-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..3704
                     /gene="Slfn14"
                     /gene_synonym="Gm20; Slfn14-ps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatatcaca gggcagcagg gccctcaact taagacaaat attccaccca gagccagatg
       61 agctcaagca ccaggaggaa acaggagcac caggaacacc tttctgttat tgcttgggag
      121 tacagaaaat gccctacgcg gagatcaccg tgaatctggg caaagtgacg ctgggagaag
      181 agaacaggaa gaagatgacc aacagttgtt tgaaaaggca tgagaactcg agtctcgtcc
      241 aggctgtgtg cgcactgctg aattctgggg gaggtgtgat caaagccgag atcaatgaca
      301 aaagctacag ttaccgatgc cacgggctgg ggcaggatct ggaaacttcc tttcagaagc
      361 tcctcccatc ggggtcacag aagcacctgg actacatgca acagaaccac gacctcctga
      421 tttttgtaaa gtcatggagc ccagatgcgt ccagccttcc actgaggatt tgcagcttac
      481 gctccaattt atatcagaga gatgtgacct cagccatcaa cttgtgcgcc aacggtgccc
      541 tagagcttct cagagagaaa gagtctagag cccaaagagg tacccctagg ctacattctc
      601 aagaccacat cctcaacaga accattcagg aagaggaaga tattaagatg tgtgccttgg
      661 aatttttaaa aaaagataaa ctcaatttta aggagaagct tagcttcaca gagtcaactc
      721 acgttgagtt taaaaggttt accaccaaaa agattgtccc tcggattaaa gagacactgg
      781 ctcattatgt ttctgcattt gccaatactc aggggggata cataattatt ggggttgatg
      841 ataagagcaa agaagtgttt ggatgtaaga aagaaaaagt gaaccccgac tcactaaaaa
      901 cagaaataaa aaactgcata gaaaagttgc ccacatacca cttctgtcgt gaaaagccca
      961 aggtgaattt cacaactaag attttgaaag tttatcaaaa agaggccctg tatggttttg
     1021 tctgtgttgt tcaagtagag cccttctgtt gtgtcgtgtt tgcagaggac ccagattcct
     1081 ggatcatgga gaacaatatt gtcacaaggc tgaaggttca acagtgggtg gaaatgatgc
     1141 tggacattca gtcagatcct tcttcaggct ttcccaccat caatgacagt gctcacctga
     1201 tgacaccagc tttgtctgca ccaagaagac cagcgtatct cacaaaagtc ctggaacata
     1261 aggaaactct gcagcgccat ttcttttcag tgacacaaga aaacctacaa tttcagccag
     1321 aatccctctg taagaagctg ttctcagatc acgaaggact ggaagactta ctgaaggcac
     1381 agacacaccc ttgttctcac ggcattgtga tattttcgag aagctgggct ggcgatattg
     1441 gtttaatgag agaagagaag gtcctatgtg atgcactcct ggtagcagtt ggcagccctc
     1501 tggtactcta tacaatccta acagacccca gttcgactgg aagagccgac tatactcaaa
     1561 acaccgccct tcagttaaag aggcagctac aaactcttgg aggctaccca gggaaaatat
     1621 gtgtcattcc aagggtgata tacctggcca gcagagggtc cagacctgat caaccccctg
     1681 tgtactaccc cagaccctac acactgtcca gcaaagctga agtggaggat ttgctacagg
     1741 gcctggtgtt ggtctcactg tgttccagat ctgtgctgag tgaccagcta ggctgtgagt
     1801 tcttcaagca gtgcttagaa gagcaagcca acacactctc caggaacctc caggaaagcc
     1861 gggaactgtt catccattgc cttcctggaa ccaggaagac agctcttgcc ataaagatgg
     1921 tggagaaaat caaggatgtg ttccactgca aaccaaaaga gatcctcttt gtttgtgaaa
     1981 atgactccct aagggatttt gtgatgcagc aagtcacctg ccgagctgtg acccgcagga
     2041 ccttcatgag ggaagagttc ccaaagatta aacacatagt gatggatgag actgagaact
     2101 tctgcagtag acatggtgac tggtacgtga aggctaagag caccacccat ccaaaagcaa
     2161 acggggctgc aaatgaacac cctcaccacg ggatcctctg gctttttctg gatcctttcc
     2221 aagttcggca cgcagatggt agtggccttc cagttccttc tgctcagttt cctcggaaaa
     2281 tgatcaccag tgagatccac tgtgctgtgg aaattgctaa ggtcatgaaa gatgaaatga
     2341 agaggatgca agaaaaccct ccctccatgg gccttccaga caccctggca acgttccagg
     2401 aggctcccta tgaggaagca atgcgtgctg gggctttgcc tggcgtgtgt gagatcaagg
     2461 ctaacctgac accagaacaa atagccaact atgtggcaga aaaatgtcac agcctgtttc
     2521 atgagggcta tctgccccaa gacatagcaa ttctgtacag gagacgagaa gacagaggac
     2581 agtataagga tgtgttgcta aaagcaatgg cccgtgggac aacggaggtc gccttcaaca
     2641 gcgctgctga tgtttgtgct gatggcatca ttttagacag tgtagaacag ttctcaggca
     2701 tggtaaggaa tattgtgttt gggctttgcc ctgaatctgt gcactcagaa ggcgttcata
     2761 aactctgctt tgcctcaaaa gccattaaac acctctacct gctgtatgga ggaaggacag
     2821 ctttttaaaa ctgttgtaaa taatacagga agccaaacaa gaacactctc cttccaaatg
     2881 agtggtagct cctttttaat atgacaagtg aatgaatgaa ggcgcatcat tatggcttgg
     2941 agcctcagag atgtgtttct ggtccagcgg tgtggctgga ccctttgctc agtccactac
     3001 tttttaccag tgacaagata agtatgactg attctctgcc tccaatcttc ccgactcaat
     3061 ccagctctca ttctgtcacc caaagagcct aaaacagaat gtgaatttta tgaaattctc
     3121 tgctccaggg agttcctgtg accctcgaat gcaatacatt tctgaggctc tccatggtac
     3181 ctacttcctc tcctgactcc atccttgatc acacccccga ctcccagcgt ttctaatgca
     3241 gtccctgatc tgtagctgct ttgggagtga tggtaggata tcctttagac caaatacttg
     3301 gattgggtgt cttgaaggca gtacctgggc taacatctca tgtgggctgt ggggctcaag
     3361 ctttgcagag acatccttgg tttttcctct ctctctctct ctccctccct ccctctctat
     3421 cccttctctt cctctttttc ttttctcttc ttttttctct ctctttgtat tgctacactg
     3481 ccataatgct acaactagtg taataaaata atcaagataa agagttgctt gtggtgtgat
     3541 gctcctaaga cattgttgga gggcaacaga atattatcac accagcttaa gaaatagaaa
     3601 aagaaaaagc tcctaaacat ctcatgaccc aggtgtattc tttttcattt ttgcttgata
     3661 ttttacacac attgcaagtt ctgcaataaa ttttatattc taca
//
