LOCUS       NM_011407               1907 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus schlafen 1 (Slfn1), mRNA.
ACCESSION   NM_011407
VERSION     NM_011407.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1907)
  AUTHORS   Nakagawa,K., Matsuki,T., Zhao,L., Kuniyoshi,K., Tanaka,H.,
            Ebina,I., Yoshida,K.J., Nabeshima,H., Fukushima,K., Kanemaru,H.,
            Yamane,F., Kawasaki,T., Machida,T., Naito,H., Takakura,N., Satoh,T.
            and Akira,S.
  TITLE     Schlafen-8 is essential for lymphatic endothelial cell activation
            in experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 30 (2), 69-78 (2018)
   PUBMED   29528433
REFERENCE   3  (bases 1 to 1907)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 1907)
  AUTHORS   Wang,Y., Hu,G., Liu,F., Wang,X., Wu,M., Schwarz,J.J. and Zhou,J.
  TITLE     Deletion of yes-associated protein (YAP) specifically in cardiac
            and vascular smooth muscle cells reveals a crucial role for YAP in
            mouse cardiovascular development
  JOURNAL   Circ Res 114 (6), 957-965 (2014)
   PUBMED   24478334
REFERENCE   5  (bases 1 to 1907)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1907)
  AUTHORS   Zhang,Y., Yang,Z., Cao,Y., Zhang,S., Li,H., Huang,Y., Ding,Y.Q. and
            Liu,X.
  TITLE     The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1
            nuclear localization which is critical for promotion of cell-cycle
            arrest in T-cells
  JOURNAL   Biochem J 413 (2), 239-250 (2008)
   PUBMED   18373498
  REMARK    GeneRIF: DnaJB6 is necessary for translocation of Slfn1 into the
            nucleus, where Slfn1 down-regulates cyclin D1, induces cell-cycle
            arrest and programmes a quiescent state of T-cells
REFERENCE   7  (bases 1 to 1907)
  AUTHORS   Neumann,B., Zhao,L., Murphy,K. and Gonda,T.J.
  TITLE     Subcellular localization of the Schlafen protein family
  JOURNAL   Biochem Biophys Res Commun 370 (1), 62-66 (2008)
   PUBMED   18355440
REFERENCE   8  (bases 1 to 1907)
  AUTHORS   Bell,T.A., de la Casa-Esperon,E., Doherty,H.E., Ideraabdullah,F.,
            Kim,K., Wang,Y., Lange,L.A., Wilhemsen,K., Lange,E.M., Sapienza,C.
            and de Villena,F.P.
  TITLE     The paternal gene of the DDK syndrome maps to the Schlafen gene
            cluster on mouse chromosome 11
  JOURNAL   Genetics 172 (1), 411-423 (2006)
   PUBMED   16172501
REFERENCE   9  (bases 1 to 1907)
  AUTHORS   Brady,G., Boggan,L., Bowie,A. and O'Neill,L.A.
  TITLE     Schlafen-1 causes a cell cycle arrest by inhibiting induction of
            cyclin D1
  JOURNAL   J Biol Chem 280 (35), 30723-30734 (2005)
   PUBMED   15946944
  REMARK    GeneRIF: Results suggest that Schlafen-1 causes a cell cycle arrest
            during G1 by inhibiting induction of cyclin D1 by mitogens.
            Erratum:[J Biol Chem. 2016 Nov 25;291(48):25278. doi:
            10.1074/jbc.A116.500435. PMID: 27888236]
REFERENCE   10 (bases 1 to 1907)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056716.1, AF099972.1 and BX518009.1.
            
            On Feb 24, 2018 this sequence version replaced NM_011407.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052869.1, AF099972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CJ056716.1         2-26
            26-1882             AF099972.1         1-1857
            1883-1907           BX518009.1         412-436
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..1907
                     /gene="Slfn1"
                     /note="schlafen 1"
                     /db_xref="GeneID:20555"
                     /db_xref="MGI:MGI:1313259"
     exon            1..243
                     /gene="Slfn1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..1893
                     /gene="Slfn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1864..1869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slfn1"
                     /note="hexamer: AATAAA"
     polyA_site      1893
                     /gene="Slfn1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcaatcc actaaggtcg gtcaagacaa aagccgagag caaccacagg cactgtagct
       61 catccctcaa atccaagtgc tgagaaggac ttctggagac agccaccact cccactgctg
      121 tgggtgtctc aagcttttgc cttacttcct ctggcccgca agtgtccaca gcacagctag
      181 ctcacagcta gctcgcagtt gacttcaagc agctgaggga acgtgctcag tagagcagct
      241 taggtgagga tttcagctcg ggagcagcaa gactgctgga aaatgaacat caccgatgaa
      301 gggacccctg tgctgattct aaatgcagga gggatcacac ttgggacaga aagtaggaaa
      361 accatggaga atcatgacag ggtagaagag aacaggaaca ttacaaaagc tctgtgtgct
      421 ctgattaatt ctggagaggg aaaggtcaag gctcacatta aaaatccaga ctacattttg
      481 tctaaacatg gaataggaga agatttggaa acctctttca agaacatttt gccatctagg
      541 cccctagact ttaagcaata tcaatcctac tttttcatct gtgtagaaaa atcacagagt
      601 ccagatgtct ctgttgggaa gcctgccacc attgcaacca atttgtacat gagaaatggg
      661 gcatcatcag ttgaaatgaa cttggatgct gctcagaagt tcttagacaa tatcaaggtt
      721 gcaggaggaa ggtcgccttc agcaaggcct tcagataggc caggcgatga tacgcaagag
      781 gaaggccaca ttcaggagtt ggctgctgct ttttttaaac agtcaaaact tacaaagaag
      841 gaaaatttct tatttagtga atccaaaaat gttgaatata aatcctttga aacaaaaaag
      901 ttgctacaac gagttaaaga gattctccct cgaactgttt ctgcctttgc caacactgac
      961 gggggatatt tgtttattgg tttagatgaa aaaaaacagg aaatagttgg ttttgaagca
     1021 aagaattgcc agcctaagtg cttagagagt gaaatagaaa agtgcatcca acagctgcct
     1081 gtcactcact tctgtgagga gagggagaag atcaagtaca agtgcaaatt catcgaagtc
     1141 cacgattccg gagttgtgtg taaatatgtg tgtgcgctca gagtggagag gttctgctgc
     1201 gcagtgtttg ctgcagagcc cgagtcctgg cacatgaaag atggtggtgt taaaaggttt
     1261 accatagagg aatggatcaa gctcctcatg tcttagctag tcaggttcag gaaggagagc
     1321 tggcaattgg aatacgttta gctggggatg ttggaagggt ttttcttttg gatttgagac
     1381 aagatcaata gtcttgatta ttcagctact gatctggatt gcatctgtaa cctacctggg
     1441 agcccagatc cctctctcgc tggtgttacc tcaactccca gtactcactt gtaaaaaacc
     1501 cacccccaac cccaacatct ccccagttga gctctgtttc tggagctggc atgtcttcta
     1561 gaaatcctcg attcagtttc actcctaccc cttccccatg ctcctttctc cctaaccttc
     1621 tctcctctca gtcaccttat tagataatac gcgccctgat ggtttatgat gtggaaagtg
     1681 ctgtactgct atctcaggct ttgcaagaag aagctctgag atgaggccag accagcacct
     1741 gcacaccgag tctgcagagt tcccagcagc tgcttctgtc gccccccaag ctcactgctg
     1801 cttcatgagc cccctccaac ctcttgcttt tcgtaacatt ttcaataaat agattggtaa
     1861 gcaaataaaa gcctcaacaa tgtgcacact gtaaaaaaaa aaaaaaa
//
