LOCUS       NM_001355218            2993 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 4a1 (Slco4a1), transcript variant 2, mRNA.
ACCESSION   NM_001355218 XM_006500547
VERSION     NM_001355218.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Jiang,Y., Zhou,X., Li,Y. and Gao,X.
  TITLE     Solute carrier organic anion transporter family member 4A1 promotes
            colorectal cancer progression and is regulated by miR-1224-5p
  JOURNAL   Neoplasma 69 (4), 776-784 (2022)
   PUBMED   35331000
  REMARK    GeneRIF: Solute carrier organic anion transporter family member 4A1
            promotes colorectal cancer progression and is regulated by
            miR-1224-5p.
REFERENCE   2  (bases 1 to 2993)
  AUTHORS   Zhang,Y., Li,F., Wang,Y., Pitre,A., Fang,Z.Z., Frank,M.W.,
            Calabrese,C., Krausz,K.W., Neale,G., Frase,S., Vogel,P., Rock,C.O.,
            Gonzalez,F.J. and Schuetz,J.D.
  TITLE     Maternal bile acid transporter deficiency promotes neonatal demise
  JOURNAL   Nat Commun 6, 8186 (2015)
   PUBMED   26416771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2993)
  AUTHORS   Braun,D., Kinne,A., Brauer,A.U., Sapin,R., Klein,M.O., Kohrle,J.,
            Wirth,E.K. and Schweizer,U.
  TITLE     Developmental and cell type-specific expression of thyroid hormone
            transporters in the mouse brain and in primary brain cells
  JOURNAL   Glia 59 (3), 463-471 (2011)
   PUBMED   21264952
REFERENCE   4  (bases 1 to 2993)
  AUTHORS   Wirth,E.K., Roth,S., Blechschmidt,C., Holter,S.M., Becker,L.,
            Racz,I., Zimmer,A., Klopstock,T., Gailus-Durner,V., Fuchs,H.,
            Wurst,W., Naumann,T., Brauer,A., de Angelis,M.H., Kohrle,J.,
            Gruters,A. and Schweizer,U.
  TITLE     Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral
            phenotype of mice deficient in Mct8, the neuronal T3 transporter
            mutated in Allan-Herndon-Dudley syndrome
  JOURNAL   J Neurosci 29 (30), 9439-9449 (2009)
   PUBMED   19641107
REFERENCE   5  (bases 1 to 2993)
  AUTHORS   Sekine,T., Miyazaki,H. and Endou,H.
  TITLE     Molecular physiology of renal organic anion transporters
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F251-F261 (2006)
   PUBMED   16403838
  REMARK    Review article
REFERENCE   6  (bases 1 to 2993)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669926.6 and AK033598.1.
            
            On Sep 13, 2017 this sequence version replaced XM_006500547.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033598.1, SRR9219382.192533.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AL669926.6         43398-43486
            90-298              AK033598.1         2-210
            299-299             AL669926.6         51263-51263
            300-2993            AK033598.1         212-2905
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.99 cM"
     gene            1..2993
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /note="solute carrier organic anion transporter family,
                     member 4a1"
                     /db_xref="GeneID:108115"
                     /db_xref="MGI:MGI:1351866"
     exon            1..129
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            130..1017
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..2387
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /note="solute carrier family 21 (organic anion
                     transporter), member 12; solute carrier family 21 member
                     12; organic anion-transporting polypeptide E;
                     sodium-independent organic anion transporter E"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 4A1"
                     /protein_id="NP_001342147.1"
                     /db_xref="CCDS:CCDS17176.1"
                     /db_xref="GeneID:108115"
                     /db_xref="MGI:MGI:1351866"
                     /translation="MPQHAMGDTHFLSLPKHLFTSTSSATDSGCDTPPSSRASPASLR
                     SAHGTLGSSSQPLFEPQAEKRSSQTAREVQYVSSGPQNSLCGWQAFTPKCLQVFNTPK
                     GFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVS
                     YFGGNGHKPRWLGWGVLVLGIGSLVFALPHFTAGRYEVEMDEGLGTGTCLTNQSHVEC
                     KDSASGLSNYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAIL
                     GPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYP
                     RQLPGSQRYVVMRAAETQQLKDHSRGAVSNPAFGKTVRDLPLSIWLLLRNPTFILLCL
                     AGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFK
                     LRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNA
                     IYCCQPKHYSPLCGSDGTMYYSPCYAGCPADAETDLGGQKVYRGCSCILEKASSGWGN
                     ATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLRCVSDRQRSFALGIQWIVV
                     RTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAMSRYMLIAGLTFKVLGFL
                     FFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQLQSNV"
     exon            1018..1108
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1230
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1342
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1497
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1693
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1859
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2032
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2097
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2246
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2993
                     /gene="Slco4a1"
                     /gene_synonym="OATP-E; Slc21a12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggtggcg gtggtgaggc cactaccccc atccctgcgg gagcggcttg ggcgatgaat
       61 gaagcgggag tgggctgcgc gcgtagtcca gagcgcaggg cgcagcgcgg cagccgggtt
      121 cgtgggaaga tagacccagt gacaagacag tctctcggcc acctctactg cacctcggct
      181 gctgtgctgc caaagccttc cccacgaggc tggacatgcc ccagcacgcg atgggggaca
      241 cacatttcct ctccctcccg aagcacctct ttactagcac gtcctcagcc acggacagcg
      301 ggtgtgacac tccgcccagc agcagagcat ccccagcctc cctgcgctct gcccacggca
      361 ccctgggctc ctccagccaa cccctgtttg agccccaggc tgagaagcgg agtagccaga
      421 cagcccgtga ggtgcagtat gtgtcctcgg ggccacagaa ctcactgtgc ggctggcaag
      481 ccttcacgcc caagtgcttg caggtcttca acacccccaa gggcttcctc ttcttcctgt
      541 gtgcggcctc cttccttcag ggcatgacag tgaatggctt catcaatact gtcatcacct
      601 ccatcgaacg ccgcttcgat ctgcacagct accagagcgg gctcatcgcc agctcctatg
      661 acatcgctgc ctgcctatgc cttaccttcg tcagctactt tgggggcaat gggcacaaac
      721 cgcgatggct gggctggggt gtgctggtcc tgggaatcgg ctccctggta tttgcactgc
      781 cccatttcac tgccggccgc tatgaggtag agatggatga ggggctgggg actgggacgt
      841 gcctgactaa tcagagtcat gtggagtgta aagacagtgc ctcaggcctg tccaactacc
      901 ggctgatctt catgctgggc cagctcctgc acggtgtggg tgccacgccg ctctacacac
      961 tgggcgtcac gtacctggat gagaacgtca agtcaagtta ctcacccatc tatatcgcca
     1021 tcttctacac ggcagccatc cttggacctg cagcaggcta cctgattgga ggagccatgc
     1081 taaacgttta cacagaagtg ggccaacgga cggagctgac cactgacagc ccactgtggg
     1141 ttggtgcctg gtggatcggc ttcctaggaa ccgggattgc tgcattcctc atcgccatcc
     1201 ccatccttgg ctatccccgg cagctaccag gctcccagcg ctacgttgtt atgagagcgg
     1261 ctgaaacaca gcagctgaaa gaccacagcc gcggagcagt gagcaatcca gcttttggca
     1321 agactgtcag agacctgccc ctctccatct ggctccttct aagaaacccc acgttcatcc
     1381 tgctctgcct ggcaggggcc actgaagcca cactcattgc cggcatgtcc acattcggtc
     1441 ccaagttctt cgaggcccag ttcagcttga gtgcctccga ggctgccacc ctgttcggat
     1501 acctggtggt gccagcaggc ggtggtggta cactcctagg tggcttcctg gtaaacaagt
     1561 tcaagctccg tggctctggg atcatcaggt tctgtctatt ctgcaccttg accagcctac
     1621 tagccttctt tgtcttcctc atgcactgcc ccaatgtgca catggcaggt gtgaccaccg
     1681 gctacgttgg gagcctcctg cctaaaggac agctggacct aaaggcagct tgcaacgcca
     1741 tctactgttg ccagccgaag cactacagcc ccctgtgtgg ctcagatggc accatgtact
     1801 actctccctg ctacgcaggc tgccctgctg atgccgagac agacctgggt ggccagaagg
     1861 tataccgagg ctgtagctgt atccttgaga aggcttcctc tggctggggc aatgctaccg
     1921 cagggaagtg cgcttccacc tgtcagagca agcccttcct tctggttctc gtgttcgttg
     1981 taattatctt tacattcctc agcagcattc cagcgctaac tgctactcta cggtgtgtca
     2041 gtgatcggca aagatccttt gccctgggga tccagtggat cgtcgtaaga acactaggca
     2101 gtattccggg gcccattgcc tttggctggg tgattgacaa ggcctgcctg ctgtggcaag
     2161 accagtgtgg tcatcagggc tcctgcttcg tgtatgagaa tgaagccatg agccggtaca
     2221 tgctcatcgc agggctcact ttcaaggtgt tgggcttcct cttcttcgtc gccgcctact
     2281 ttctctacaa gtccccttcc gtgtcctcag atggtctaga ggcctccctg cccagccagt
     2341 cctcggcctc tgacagtccc acagaacagc tccagagcaa cgtgtgacag cgctggcctc
     2401 tccacatttc ctgaggactc ttcctggaaa ccctgaccca cccccacagg gcggtaacac
     2461 tgaggacctt gcaaaacctc acactgtgtt ctggggtctc gcactgcccc acactgtgac
     2521 tgagcagcct ctgaggcgtt aaggaggaag tcacgtgtgt cataggggtc acatatgaac
     2581 cagacacatt ccccaagccc tggagtctga aagggggtca ctacatttca tagaccatca
     2641 cctgatcctg atttcctgtg tctactgaga agccccatgc agggcagcag tgccctggga
     2701 atgatcctgt ggagccagct attgggtaat ttgcttgaat ctgcttactg cctgtcctgg
     2761 aagcccggtg gcctccatgc ggggcagcag cgacttgaat cgttatgtcc agacgtatat
     2821 tttgcactga atggtgttta tggaatcagt tttgtacttg atcatgtgac tcatgtccaa
     2881 gcaaactgca ctgaggattt gatcccatct gaggtgccac gcagcttgtg tggacagtgt
     2941 gtttctatgt ttttggttag agtgtgtaca taatatattt taatatttaa acc
//
