LOCUS       NM_023908               4697 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 3a1 (Slco3a1), transcript variant 1, mRNA.
ACCESSION   NM_023908 XM_906837 XM_920094 XM_920111
VERSION     NM_023908.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4697)
  AUTHORS   Li,S., Zeng,L., Miao,F., Li,N., Liao,W., Zhou,X., Chen,Y., Quan,H.,
            He,Y., Zhang,H., Li,J. and Yuan,X.
  TITLE     Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by
            Enhancing the Proliferation of Granulosa Cells in Mammals
  JOURNAL   Int J Mol Sci 25 (5), 2468 (2024)
   PUBMED   38473715
  REMARK    GeneRIF: Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular
            Growth by Enhancing the Proliferation of Granulosa Cells in
            Mammals.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4697)
  AUTHORS   Ikegami,K., Saigoh,K., Fujioka,A., Nagano,M., Kitajima,K., Sato,C.,
            Masubuchi,S., Kusunoki,S. and Shigeyoshi,Y.
  TITLE     Effect of expression alteration in flanking genes on phenotypes of
            St8sia2-deficient mice
  JOURNAL   Sci Rep 9 (1), 13634 (2019)
   PUBMED   31541165
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4697)
  AUTHORS   Pan,Q., Zhang,X., Zhang,L., Cheng,Y., Zhao,N., Li,F., Zhou,X.,
            Chen,S., Li,J., Xu,S., Huang,D., Chen,Y., Li,L., Wang,H., Chen,W.,
            Cai,S.Y., Boyer,J.L. and Chai,J.
  TITLE     Solute Carrier Organic Anion Transporter Family Member 3A1 Is a
            Bile Acid Efflux Transporter in Cholestasis
  JOURNAL   Gastroenterology 155 (5), 1578-1592 (2018)
   PUBMED   30063921
REFERENCE   4  (bases 1 to 4697)
  AUTHORS   Selmi-Ruby,S., Bouazza,L., Obregon,M.J., Conscience,A., Flamant,F.,
            Samarut,J., Borson-Chazot,F. and Rousset,B.
  TITLE     The targeted inactivation of TRbeta gene in thyroid follicular
            cells suggests a new mechanism of regulation of thyroid hormone
            production
  JOURNAL   Endocrinology 155 (2), 635-646 (2014)
   PUBMED   24265449
REFERENCE   5  (bases 1 to 4697)
  AUTHORS   Ferrara,A.M., Liao,X.H., Gil-Ibanez,P., Marcinkowski,T., Bernal,J.,
            Weiss,R.E., Dumitrescu,A.M. and Refetoff,S.
  TITLE     Changes in thyroid status during perinatal development of
            MCT8-deficient male mice
  JOURNAL   Endocrinology 154 (7), 2533-2541 (2013)
   PUBMED   23696569
REFERENCE   6  (bases 1 to 4697)
  AUTHORS   Hatoum,I.J., Greenawalt,D.M., Cotsapas,C., Daly,M.J., Reitman,M.L.
            and Kaplan,L.M.
  TITLE     Weight loss after gastric bypass is associated with a variant at
            15q26.1
  JOURNAL   Am J Hum Genet 92 (5), 827-834 (2013)
   PUBMED   23643386
  REMARK    GeneRIF: Expression of St8sia2 and Slco3a1 was significantly
            altered in metabolically active tissues in Roux-en-Y gastric
            bypass-treated compared to weight-matched, sham-operated mice.
REFERENCE   7  (bases 1 to 4697)
  AUTHORS   Di Cosmo,C., Liao,X.H., Dumitrescu,A.M., Philp,N.J., Weiss,R.E. and
            Refetoff,S.
  TITLE     Mice deficient in MCT8 reveal a mechanism regulating thyroid
            hormone secretion
  JOURNAL   J Clin Invest 120 (9), 3377-3388 (2010)
   PUBMED   20679730
REFERENCE   8  (bases 1 to 4697)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   9  (bases 1 to 4697)
  AUTHORS   Sekine,T., Miyazaki,H. and Endou,H.
  TITLE     Molecular physiology of renal organic anion transporters
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F251-F261 (2006)
   PUBMED   16403838
  REMARK    Review article
REFERENCE   10 (bases 1 to 4697)
  AUTHORS   Melia,M.J., Bofill,N., Hubank,M. and Meseguer,A.
  TITLE     Identification of androgen-regulated genes in mouse kidney by
            representational difference analysis and random arbitrarily primed
            polymerase chain reaction
  JOURNAL   Endocrinology 139 (2), 688-695 (1998)
   PUBMED   9449642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031280.1, AK152488.1 and AK046945.1.
            
            On Jan 7, 2006 this sequence version replaced NM_023908.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152488.1, AF226324.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AK031280.1         1-166
            167-2028            AK152488.1         1-1862
            2029-4622           AK046945.1         1389-3982
            4623-4697           AK152488.1         4459-4533
FEATURES             Location/Qualifiers
     source          1..4697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 42.95 cM"
     gene            1..4697
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="solute carrier organic anion transporter family,
                     member 3a1"
                     /db_xref="GeneID:108116"
                     /db_xref="MGI:MGI:1351867"
     exon            1..370
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2323
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 21 (organic anion transporter),
                     member 11; organic anion-transporting polypeptide D;
                     sodium-independent organic anion transporter D; androgen
                     regulated protein 1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 3A1 isoform 1"
                     /protein_id="NP_076397.2"
                     /db_xref="CCDS:CCDS21367.1"
                     /db_xref="GeneID:108116"
                     /db_xref="MGI:MGI:1351867"
                     /translation="MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLV
                     SECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGAR
                     GHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCATNGSSSDEG
                     PDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGIL
                     FTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLF
                     FSSLLMFGFPQSLPPHSDPGMESEQAMLPEREYERPKPSNGVLRHPLEPDSSASCFQQ
                     LRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLG
                     MTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAG
                     VTVRYGNNSARGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG
                     CACLTTVPPENASVVPGKCPSPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIRTVS
                     PELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRY
                     LYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFFASTLTLDNLGRDP
                     VPAHQTHRTKFIYNLEDHEWCENMESVL"
     exon            371..836
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     exon            837..935
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1199
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1364
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1563
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1702
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1878
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1943
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..4697
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2734..2739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="hexamer: ATTAAA"
     polyA_site      2757
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="major polyA site"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="hexamer: TATAAA"
     polyA_site      3258
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="major polyA site"
     regulatory      3371..3376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="hexamer: TATAAA"
     polyA_site      3398
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
     regulatory      4623..4628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="hexamer: AATAAT"
     polyA_site      4637
                     /gene="Slco3a1"
                     /gene_synonym="5830414C08Rik; Anr1; MJAM; OATP-D;
                     Slc21a11"
                     /note="major polyA site"
ORIGIN      
        1 gaagggagct agcgcggcgg cagcgaggag cggagccttc aacctctcta gccgcggcag
       61 gacgggggcg gccgccgcgg gcccggggcg gggacagtac gcagcctcgc ggcacgcacc
      121 cccgcccggc aacggccacg acacccgggg cgagcgggaa agcggcggcg gcggcggcgg
      181 cgggggaagg atgcagggaa agaagccggg cggctcgtcg ggcggcggcc ggagcggcga
      241 gctgcagggg gacgaggcgc agaggaacaa gaagaagaaa aagaaggtgt cctgcttctc
      301 caacatcaag atcttcctgg tgtctgagtg cgccttgatg ctggcgcagg gtacggtggg
      361 cgcctacctg gtgagcgtgt tgaccaccct ggaacgcagg ttcaacctcc agagcgccga
      421 tgtgggtgtg atcgccagca gctttgagat cggcaacctg gcgctgattc tcttcgtaag
      481 ttacttcgga gcacgtgggc accgaccgcg cctcatcggc tgtggtggaa ttgtcatggc
      541 actgggcgcc ctgctttcgg cactgcctga gttcctcacc caccagtaca agtacgaggc
      601 tggcgagatc cgatggggag cagaaggccg cgatgtctgt gccaccaatg ggtccagcag
      661 tgatgagggg cccgacccgg acctaatctg ccgtaaccgg acagccacga acatgatgta
      721 cttgctgctt attggggctc aggtgctcct gggcatcggt gctacccccg tgcagcccct
      781 gggggtctcc tatattgacg accacgtgcg gagaaaggac tcctcgctct acataggaat
      841 cctgttcacg atgttggtat ttggaccagc ctgtggattt attctgggct ctttctgtac
      901 caagatctat gtggatgcgg tcttcattga cacaagtaac ctggacatca ctccagatga
      961 cccgcgttgg atcggagcct ggtggggcgg ctttctgctc tgcggtgcct tgctcttctt
     1021 ctcgtccctc ctgatgtttg ggttcccaca atccctgccc ccacactcag accccggcat
     1081 ggagagtgag caggccatgc tcccagaaag agaatatgag aggcccaagc ccagcaatgg
     1141 ggtcctgaga caccctctgg agccagacag cagtgcctcc tgtttccagc aactgagagt
     1201 gatccccaag gtcaccaagc acctgctctc aaaccctgtg ttcacctgca tcgtcctggc
     1261 tgcttgcatg gagattgctg tggtggctgg cttcgctgcc ttcctcggca agtacctgga
     1321 acagcagttt aacctcacca cttcctctgc caaccagctg ctcgggatga cggcgatccc
     1381 ctgtgcctgc ctgggcatct ttctgggtgg ccttttggtg aagaagctga gcctgtctgc
     1441 cctgggggcc attcgaatgg ccatgctggt caacctggtg tccacagcct gctacgtctc
     1501 cttcctcttc ctgggctgtg acacaggccc tgtggctggg gtcactgttc gctacggaaa
     1561 caactcagca cgtggctcgg cccttgaccc ttactctccg tgcaacaaca actgtgaatg
     1621 ccagacggac tccttcacgc cagtgtgcgg ggccgatggc atcacctacc tgtcagcctg
     1681 cttcgccgga tgcaacagca cgaacctcac aggctgtgcg tgcctcacca ctgtcccccc
     1741 tgagaatgcc agcgtggttc caggaaaatg tcccagtcct gggtgccaag aggccttcct
     1801 caccttcctc tgtgtgatgt gtgtgtgcag cttgatcggg gccatggccc aaaccccttc
     1861 tgtcatcatc ctcatcagga cagtcagccc tgaactcaag tcttatgcgc tgggagttct
     1921 ttttctgctc cttcgtttgt tgggtttcat ccccccacct ctcatcttcg gggccggcat
     1981 tgactccacc tgtctgttct ggagcacctt ctgcggggaa caaggcgcct gtgtcctcta
     2041 cgacaatgtg gtctacagat acctgtacgt cagcatcgcc attgcgctca agtcctttgc
     2101 cttcatcctc tacaccacca cgtggcagtg cctgcggaaa aactataaac gctacatcaa
     2161 aaaccacgag ggcgggctga gcaccagtga gttctttgcc tctactctga ccctagacaa
     2221 tctggggagg gaccctgtgc ccgcacacca gacacatagg acaaaattta tctataacct
     2281 ggaagaccat gagtggtgtg aaaacatgga atctgtttta tagtgactac aggagggctg
     2341 aactctgtat ttgtgaacaa agagtcattt tcttaaaaaa aaaaaaaaag aaagaaagaa
     2401 agaaggaaag aaagaaaagg aaagaaagaa aagaggtttt gaaaacagag atgcacactc
     2461 tctcacacac acacatacac acatacatac acataagacc tttgtccttt ttctaaaact
     2521 cagagccagt caggattcag aataaagaga gaaggggatg gccctggagg acatacacac
     2581 tgctgggctc agaatctgct tggaaggcac ctcatggttt tcacgatgcc gacagctaca
     2641 agcaagaggc actgccaaat tcagggaaca cttgtggcca gcttggagga tggacatctc
     2701 tggatatgca tacacataca aaacttaaaa ggcattaaaa aaatgagtct actaaaatca
     2761 caagttcaag ttgaaaaaca ttaccagatt aagcactaga gacaccctct ccctccagtg
     2821 gggtgggggg gggatacagg ttggagggat gggaacccca ctcctctttc caacttttgc
     2881 aatatgggtc actgtgtaga ccactcactc agtctatgtg tggttcaagc ccccagagtt
     2941 ctcaaagaga tgctgacggg ttatccggac tggagtctgt ggttggcacc tctcaccagc
     3001 tccatttcca tgttcaagac tgagggccca aaggaggggc tgggcgggga gcatctacct
     3061 ccccgcctcc taacacctcc tccctaccag ccccacagtg tgacctcagg aagctgtggg
     3121 cctcacctgg ctatgactga cccgctcaga gccggtgagc gccaatatag cccatgtcat
     3181 ttgcttacat ttgccaaaca ttttgccatt ttttttccaa aaacaacaac aaaaaatata
     3241 aagcgtacga atttccaact gttgtatgta taatcctcta atactatttt taactgcttc
     3301 tagaatctgt gttaaccctt cagtcactaa caaagctttt acttctctcc tttttttaat
     3361 gcaccaaaaa tataaaggga ttcgagggat gcagttaatc tattgtaatt ttcattctta
     3421 ctctgatacc atgaaaacaa acaaacaaac aaaatcaaaa acacaatgtg gtataagaaa
     3481 aagatactcc ggaaagagtg taaatgcatc ttgaaaataa tcacatctga gataatggga
     3541 taatgtgaca agctgcaaat ctgccttctg gctttatccc ctgtgatgat gttactgtca
     3601 caagaagccc ttttatagtc atgcttcagg tccaatgggc attcctctta gcctgtgaag
     3661 gagactcact caaatgtggg ttgatgtgga tgggagccgt gctcctgggg ataggagaga
     3721 gagggtgtgt ggctcctgcc tacgactgtt ttgtgagctg tgatacttgt gatcataaac
     3781 ccacaagctc ctaagtgatc actgtccagt ccatgaaaat gttagtgaca ggtcccaggt
     3841 cagtcctgaa ctctgtgcat tgaaagtggc tgaacctcag agcatcacct tgccatttgg
     3901 gataagaatc gtatgggtgt tggggggagg gaagatctct tgcaccagca cacttaagac
     3961 aatgtggcct ctctcatcag gggatggatc agatgggagc atatatatcc atagcaaagg
     4021 gtccagtcag ctcacccttc atacctcttt attgaccttt tttgtagaca tacatacggt
     4081 accaaagtcg accacaaagg atgcttggtt tcatttttcc accttaaaca tccactcacc
     4141 tgaagcaatg aaagaataag gccagaagag taaagacatg gatgttgtgc catattttct
     4201 ttttacagat agtataagtg gggaagacta ggtaatagcc tcaaagtaga gaagacatca
     4261 agcaaaggca actgagaaaa tgtctgtgtg gcattgtggc tatggttgac catctcattc
     4321 agggtgcttc taaaacagcc ctcccatctg tctaccagga gttagcctat ccttgttgat
     4381 gaacataggg tgctcatcag tatagtaact aggaatgggg aacagttctc caaacagttt
     4441 gtaaggtgat gttctgtcgc tctgaaggct ttgatcatgc tccaaacagg ttttggttca
     4501 gtcttgtttt gaaaatgaat gactaatggg tgaccgccct ctctgtcgtg tgtctttgca
     4561 aacggaggcc ctgggatgta ctctgtttca tgacatgatt tgatttgatt tttggaaaaa
     4621 aaaataatga tttttaagct ctttgtatct tggatttttt tccccttaaa atgttcttaa
     4681 agatagcaat ggaaccc
//
