LOCUS       NM_001252530            4635 bp    mRNA    linear   ROD 30-DEC-2022
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 2b1 (Slco2b1), transcript variant 1, mRNA.
ACCESSION   NM_001252530
VERSION     NM_001252530.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4635)
  AUTHORS   Unlu G, Prizer B, Erdal R, Yeh HW, Bayraktar EC and Birsoy K.
  TITLE     Metabolic-scale gene activation screens identify SLCO2B1 as a heme
            transporter that enhances cellular iron availability
  JOURNAL   Mol Cell 82 (15), 2832-2843 (2022)
   PUBMED   35714613
  REMARK    GeneRIF: Metabolic-scale gene activation screens identify SLCO2B1
            as a heme transporter that enhances cellular iron availability.
            Erratum:[Mol Cell. 2022 Oct 6;82(19):3750. PMID: 36206741]
REFERENCE   2  (bases 1 to 4635)
  AUTHORS   Marie S, Hernandez-Lozano I, Breuil L, Truillet C, Hu S, Sparreboom
            A, Tournier N and Langer O.
  TITLE     Imaging-Based Characterization of a Slco2b1(-/-) Mouse Model Using
            [11C]Erlotinib and [99mTc]Mebrofenin as Probe Substrates
  JOURNAL   Pharmaceutics 13 (6), 918 (2021)
   PUBMED   34205780
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4635)
  AUTHORS   Chen M, Hu S, Li Y, Gibson AA, Fu Q, Baker SD and Sparreboom A.
  TITLE     Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions
  JOURNAL   Drug Metab Dispos 48 (5), 419-425 (2020)
   PUBMED   32114507
  REMARK    GeneRIF: Role of Oatp2b1 in Drug Absorption and Drug-Drug
            Interactions.
            Erratum:[Drug Metab Dispos. 2020 Jun;48(6):446. PMID: 32398361]
REFERENCE   4  (bases 1 to 4635)
  AUTHORS   Medwid S, Li MMJ, Knauer MJ, Lin K, Mansell SE, Schmerk CL, Zhu C,
            Griffin KE, Yousif MD, Dresser GK, Schwarz UI, Kim RB and Tirona
            RG.
  TITLE     Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with
            Targeted Disruption of Organic Anion Transporting Polypeptide 2B1
  JOURNAL   Drug Metab Dispos 47 (8), 832-842 (2019)
   PUBMED   31123035
REFERENCE   5  (bases 1 to 4635)
  AUTHORS   Chen Y, Zhang J, Liu M, Zou Z, Wang F, Hu H, Sun B and Zhang S.
  TITLE     Risk of Developing Hepatocellular Carcinoma following Depressive
            Disorder Based on the Expression Level of Oatp2a1 and Oatp2b1
  JOURNAL   Biomed Res Int 2019, 3617129 (2019)
   PUBMED   31467884
  REMARK    GeneRIF: depression disorder (DD) was the adverse factors for the
            overall occurrence risk of hepatocellular carcinoma (HCC).
            Mechanistically, be the downregulation of Oatp2a1 and Oatp2b1 in
            liver tissue induced by DD might be involved
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4635)
  AUTHORS   Tuck E, Estabel J, Oellrich A, Maguire AK, Adissu HA, Souter L,
            Siragher E, Lillistone C, Green AL, Wardle-Jones H, Carragher DM,
            Karp NA, Smedley D, Adams NC, Bussell JN, Adams DJ, Ramirez-Solis
            R, Steel KP, Galli A and White JK.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   7  (bases 1 to 4635)
  AUTHORS   Pan J, Mor G, Ju W, Zhong J, Luo X, Aldo PB, Zhong M, Yu Y, Jenkins
            EC, Brown WT and Zhong N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   8  (bases 1 to 4635)
  AUTHORS   Boon AC, deBeauchamp J, Hollmann A, Luke J, Kotb M, Rowe S,
            Finkelstein D, Neale G, Lu L, Williams RW and Webby RJ.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   9  (bases 1 to 4635)
  AUTHORS   Lee J, Xu Y, Chen Y, Sprung R, Kim SC, Xie S and Zhao Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   10 (bases 1 to 4635)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132394.1, AK163542.1 and AK048120.1.
            
            [WARNING] On Apr 25, 2023 this sequence was replaced by
            NM_001252530.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132394.1, AK163542.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-675               AK132394.1         2-676
            676-1103            AK163542.1         672-1099
            1104-4026           AK132394.1         1105-4027
            4027-4635           AK048120.1         3774-4382
FEATURES             Location/Qualifiers
     source          1..4635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..4635
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /note="solute carrier organic anion transporter family,
                     member 2b1"
                     /db_xref="GeneID:101488"
                     /db_xref="MGI:MGI:1351872"
     exon            1..332
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..2398
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 21 member 9; solute carrier family
                     21 (organic anion transporter), member 9; organic anion
                     transporting polypeptide 2B1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 2B1 isoform 1"
                     /protein_id="NP_001239459.1"
                     /db_xref="CCDS:CCDS57567.1"
                     /db_xref="GeneID:101488"
                     /db_xref="MGI:MGI:1351872"
                     /translation="MGPRIGEGPRMPDRSTKTTMGTEDMHERKVSVEPQDSHQDAQPR
                     GMFHNIKFFVLCHSLLQLTQLMISGYLKSSISTVEKRFGLSSQISGLLAAFNEVGNVS
                     LILFVSYFGSRVHRPRMIGYGALLVATAGLLMALPHFISEPYRYDHSSSDNRSLDFEA
                     SLCLPTTMAPASALSNGSCSSHTETKHLTMVGIMFAAQTLLGIGGVPIQPFGISYIDD
                     FAHHSNSPLYIGILFGITTMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTPKDPRWVG
                     AWWLGFLISSGLVVLASSPYFFFPREMPKEKHEFHFRRKVLASAASTASKGEDLSSQH
                     EPLKKQAGLAQIAPDLTLVQFVKVFPRVLLRNLRHPIFLLVVLSQVCTSSMVAGMATF
                     LPKFLERQFSITASFANMLLGCLTIPLVIVGIMMGGVLVKRLHLSPVQCSALCLLGSL
                     LCLLFSVPLFFIGCSTHQIAGITQDLGAQPGPSLFPGCSEPCSCQSDDFNPVCDTSAY
                     VEYTTPCHAGCTGRVVQEALGKSQVFYTNCSCVAGNGTVPAGSCESACSRLVLPFIVL
                     FSLGAGLASITHTPSFMLILRGVKKEDKTLAVGMQFMLLRVLAWMPSPVIHGSAIDTT
                     CVHWALTCGRRAVCRYYDHDLLRNRFIGLQFFFKSGSLVCFTLVLAILRQQSREASTR
                     TTVKSSELQQL"
     exon            333..469
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            470..607
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            608..770
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1004
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1103
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1294
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1388
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1746
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1912
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2076
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2141
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2262
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..4635
                     /gene="Slco2b1"
                     /gene_synonym="OATP-B; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagatcagag gaattcatgg aaccaaagaa acagacactg caagggttgg ggggtctaaa
       61 gctagataaa ggagcaagtt cccagaagag ctctcaggga ggggtcagtt tgagcagggc
      121 ttctaccaca cctgacctgg aggcagctgc tgtctagtgt ggccaaataa atatagccta
      181 gtgagggaca gtcctacctt gatggtccct gctgctctct caggagctgt ctcccgttgt
      241 ccactggcag gctcacttcc tctctgctaa gctccaggtt ggactggggg ccacaattct
      301 ctgcatttcc ccagccatgg ggcccagaat aggtgagggg ccccggatgc cagacaggag
      361 caccaagacc acaatgggca cagaagatat gcatgaaagg aaagtcagtg tggagcctca
      421 ggactcacat caggatgcac agccccgcgg gatgttccac aacatcaagt tctttgtcct
      481 atgtcacagt ctactgcagc tgacacagct catgatctct ggctacctca agagctccat
      541 ctccacagtg gaaaagcgct ttgggctgtc cagccagatc tcagggctgc tagctgcttt
      601 caatgaggta gggaatgtat ccttgatctt atttgtgagc tatttcggca gccgagtgca
      661 cagaccccgg atgatcggct atggggctct cctggtggcc acggcaggcc tgctcatggc
      721 actccctcac ttcatctcag aaccataccg ctatgaccac agcagctccg acaataggtc
      781 actggacttt gaagcatccc tgtgcctgcc cacgactatg gctccagcct ctgccctgtc
      841 caatggcagc tgttccagtc acacagaaac caagcatctg accatggtgg ggatcatgtt
      901 cgcagcacag accctgcttg gcatcggtgg tgtgcccata cagccttttg ggatctccta
      961 cattgacgac tttgcccacc atagcaactc acccctctac attgggatct tgtttggaat
     1021 aaccacgatg gggcctggcc tggcctatgg gctgggtagc ctcatgctac gcctttatgt
     1081 ggacattgac cggatgccag aaggaggcat caacttgact ccaaaagacc ccagatgggt
     1141 gggtgcctgg tggctgggct tcctcatctc ttcaggactg gtggtcctgg cttccagccc
     1201 ctacttcttc ttccccagag agatgcccaa ggagaaacat gagtttcatt tcaggcggaa
     1261 ggtcttggca agtgcggcct ccactgccag caagggtgag gacctctcct cccagcacga
     1321 gcctttaaag aaacaggctg gattggccca gattgcccca gacttgactt tggtccagtt
     1381 tgtcaaagtc ttccctaggg tgctgctgcg gaatctgcgc caccccatct tcttgctggt
     1441 agtcctgtcc caggtgtgca cctcatccat ggtagcgggc atggccacct tcctgcctaa
     1501 gttcctggaa cgccagtttt ccatcacagc ctcctttgcc aacatgctcc ttggctgcct
     1561 cactatccct ctggtcatcg tgggcatcat gatgggaggt gtcttagtca agcgcctcca
     1621 cctgagcccg gtgcagtgca gtgccctctg cctcctcggc tcgctgttgt gtctgctctt
     1681 cagcgtgccg ctcttcttca ttggctgctc tacccatcaa attgcaggca tcacacaaga
     1741 cctgggtgcc cagccagggc caagcctgtt tcctggctgc tcagagccct gctcctgcca
     1801 atcagatgac tttaaccctg tttgtgatac cagtgcctat gtggagtaca ccacaccctg
     1861 ccatgcaggc tgcacaggtc gtgtcgtcca ggaggctctg ggcaaaagcc aggtcttcta
     1921 caccaactgc agctgtgtgg cagggaatgg cactgttcct gcaggttcct gtgagtcagc
     1981 ctgcagccgc ctggtgctgc ccttcattgt cctgttcagc ctgggggcgg gactggccag
     2041 catcacccac acaccttcct tcatgctcat cctgagaggt gtgaagaaag aagataaaac
     2101 cctggcagtg gggatgcagt tcatgctcct gagagtgctg gcctggatgc ccagccctgt
     2161 gatccatggc agtgccatcg ataccacctg tgttcactgg gccctgacct gtgggcggag
     2221 agctgtctgc cgctactacg accatgacct gctccgaaac cgattcatag gcctccagtt
     2281 cttcttcaaa agtggatccc tggtgtgctt taccttagtt ttggccatct tgaggcaaca
     2341 gagcagagag gccagcacca ggaccactgt aaagagctcg gaactacaac agctataagc
     2401 atcaggacca gagaagaagc ctaaggattc caggaggttg acggtcccag ccccaccctg
     2461 accaggagtg gcatcctctg agcgtttgcc aacaatgggc aaatcagcac ccacggtatc
     2521 ggaagcacca ccgtccagtg cctgagggtc ctctactaaa ctgtgaagtg actttgaaca
     2581 cacttctggc cttgcttgct ctttggcacc aaggagtcac tgtgttggcc atttctcaag
     2641 caagagggcc atccccattc ctcccccagc cagatggcca acctggaacc tagcttcagt
     2701 ggtggggagg agctatacgg cacctctctc ccctgattct agaacaggga gttagacaga
     2761 ctagaccatg ctgtgctcca cccagtgcct cagcccggct ctgccacttg tggagaccct
     2821 ctccatgctc tctcttaggc tccagctgtg cacatctgtg cagtcaaggc ctcctcccca
     2881 agccccagcg gccttcaagt agtgtctatt tggcgccccc tggaggcaga gttcagagat
     2941 gagattaagg agatttccaa atgcaggagg gaggacacta tttgattgac gtgtgtgggt
     3001 gggaatttta gctggagcag gcgagggatt ctttgattca gaatgtcgca gcttttgtca
     3061 tcagggagcc acagttggga aatggaggtt tatcctttct ttcagagacc ttttaacttc
     3121 agagaccact ttatatcggg acctgctcct actaaatgta tattgtcaag atctcgcacg
     3181 tttgaccagg gaccatcaaa gtcactgtag cttttgggaa tagaaaccta gtccatatcc
     3241 ccaggacttt gtaactaata cctgatactg tcgtagccaa gtcaggggtg ccgtctggtt
     3301 ctgtgaggtc tctggaccga tgtgaggtct cagggcagag aagagcaaag ccaagctctg
     3361 catcgtgcag catccttgga tcagatccct ggaaccccca attcttttcc aagtcaggcc
     3421 ttgtcctgct ttctggctag gctcatctga cccagttgct tccaggcagt agaagagaaa
     3481 gccctgatct actcccagcc tggcctggta atgctacacg ccccacctgt gtggctagga
     3541 agggaggtaa ggagctacca gcagcctccc tacctgtgtg ccagctctta gccttagctg
     3601 gggtacttgt tcccagtgca aaagaaggga ctatagaagt ctcattcctg tcaggcatgg
     3661 tggcacgcat ctgtgaccta gcatttagag actagatcag aagttcaata caatgtattt
     3721 ttcactcagc tccatagtga gtttgagtct aacctggact acatgtgaat gtctcaacaa
     3781 agaatagaga gaaggaaaga ggagaagagg aggaggacaa agagatgagc ctggttgctg
     3841 aatttcccac agttgagtgt ttaaccagtg cctgagccta cactaatcag tgccaagaat
     3901 tttgaagtca ctttcaccaa gacaagtctg ttagcgggtt tccattctgt ctattttcct
     3961 gtttcccagt ttgtacagga atagcctggc tgtatacata cagctgatta ttaaatttgt
     4021 ctctgcataa tgactcttcc acgacaaaaa tttatccttc taaactgcat tagaggtttg
     4081 cgtcagccac atcgcttcca gttatttaga cttcagcctc accgggttaa tctaccctgg
     4141 catcctgcat tgtctcctgc ctttatattc cagtctaatt ttccctctga ctagcttatt
     4201 tcctctagta atggtttcaa aaatggaatg cagtcacggg gctgtccgag tcctcacctg
     4261 tcttagttgt cactcaggtt ttacagaaga gaaactgcct cagaaaggtt gagtggcttg
     4321 cttgggacta tgataatact atacataact atatatgtat acacacatgc acacataccc
     4381 acacactcaa tggtgggacc agagctggat ctagatctgt ggaaaacgaa gctaacatat
     4441 ctcaccagtt ctctttatga aaaacaagta gagaatattg agtgcaggtt aaatatgtaa
     4501 accactttca tcaaaatgcc tgagaccaga gtattttgga cttgagatat tttcatattt
     4561 tgaggtattt gtatcataat catgatttct ctcggggatg agactctaat ctaaatacaa
     4621 attcacctgg gtttc
//
