LOCUS       NM_033314               4451 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 2a1 (Slco2a1), transcript variant 1, mRNA.
ACCESSION   NM_033314
VERSION     NM_033314.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Nakamura,Y., Ito,M.A., Hoshino,Y., Matsuoka,I., Okada,T., Okada,Y.
            and Nakanishi,T.
  TITLE     Modulation of prostaglandin transport activity of SLCO2A1 by
            annexin A2 and S100A10
  JOURNAL   Am J Physiol Cell Physiol 326 (4), C1042-C1053 (2024)
   PUBMED   38372137
  REMARK    GeneRIF: Modulation of prostaglandin transport activity of SLCO2A1
            by annexin A2 and S100A10.
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Nakamura,Y., Kozakai,H., Nishio,T., Yoshida,K. and Nakanishi,T.
  TITLE     Phenolsulfonphthalein as a surrogate substrate to assess altered
            function of the prostaglandin transporter SLCO2A1
  JOURNAL   Drug Metab Pharmacokinet 44, 100452 (2022)
   PUBMED   35299026
  REMARK    GeneRIF: Phenolsulfonphthalein as a surrogate substrate to assess
            altered function of the prostaglandin transporter SLCO2A1.
REFERENCE   3  (bases 1 to 4451)
  CONSRTM   BRAIN Initiative Cell Census Network (BICCN)
  TITLE     A multimodal cell census and atlas of the mammalian primary motor
            cortex
  JOURNAL   Nature 598 (7879), 86-102 (2021)
   PUBMED   34616075
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Marsh,B. and Blelloch,R.
  TITLE     Single nuclei RNA-seq of mouse placental labyrinth development
  JOURNAL   Elife 9, e60266 (2020)
   PUBMED   33141023
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Inagaki,M., Nishimura,T., Nakanishi,T., Shimada,H., Noguchi,S.,
            Akanuma,S.I., Tachikawa,M., Hosoya,K.I., Tamai,I., Nakashima,E. and
            Tomi,M.
  TITLE     Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to
            Placenta-to-Maternal Hormone Signaling and Labor Induction
  JOURNAL   iScience 23 (5), 101098 (2020)
   PUBMED   32408168
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Chang,H.Y., Locker,J., Lu,R. and Schuster,V.L.
  TITLE     Failure of postnatal ductus arteriosus closure in prostaglandin
            transporter-deficient mice
  JOURNAL   Circulation 121 (4), 529-536 (2010)
   PUBMED   20083684
  REMARK    GeneRIF: Prostaglandin transporter plays a critical role in closure
            of the ductus arteriosus after birth by ensuring a reduction in
            local and/or circulating PGE(2) concentrations.
REFERENCE   7  (bases 1 to 4451)
  AUTHORS   Chi,Y., Pucci,M.L. and Schuster,V.L.
  TITLE     Dietary salt induces transcription of the prostaglandin transporter
            gene in renal collecting ducts
  JOURNAL   Am J Physiol Renal Physiol 295 (3), F765-F771 (2008)
   PUBMED   18579702
  REMARK    GeneRIF: Renal collecting duct prostaglandin transporter
            transcription varied with dietary salt intake.
REFERENCE   8  (bases 1 to 4451)
  AUTHORS   Gao,F., Lei,W., Diao,H.L., Hu,S.J., Luan,L.M. and Yang,Z.M.
  TITLE     Differential expression and regulation of prostaglandin transporter
            and metabolic enzymes in mouse uterus during blastocyst
            implantation
  JOURNAL   Fertil Steril 88 (4 Suppl), 1256-1265 (2007)
   PUBMED   17498705
  REMARK    GeneRIF: Prostaglandin (PG) transporter is expressed in active
            blastocysts and in glandular epithelium of the uterus during early
            pregnancy and may participate in PG signaling in mouse uterus
            during implantation and decidualization.
REFERENCE   9  (bases 1 to 4451)
  AUTHORS   Omran,H., Haffner,K., Burth,S., Fernandez,C., Fargier,B.,
            Villaquiran,A., Nothwang,H.G., Schnittger,S., Lehrach,H., Woo,D.,
            Brandis,M., Sudbrak,R. and Hildebrandt,F.
  TITLE     Human adolescent nephronophthisis: gene locus synteny with
            polycystic kidney disease in pcy mice
  JOURNAL   J Am Soc Nephrol 12 (1), 107-113 (2001)
   PUBMED   11134256
REFERENCE   10 (bases 1 to 4451)
  AUTHORS   Pucci,M.L., Bao,Y., Chan,B., Itoh,S., Lu,R., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Schuster,V.L.
  TITLE     Cloning of mouse prostaglandin transporter PGT cDNA:
            species-specific substrate affinities
  JOURNAL   Am J Physiol 277 (3), R734-R741 (1999)
   PUBMED   10484490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087350.1, AK166724.1 and AC156633.2.
            
            On Jun 19, 2018 this sequence version replaced NM_033314.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169706.1, AK087350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK087350.1         2-3
            3-4035              AK166724.1         2-4034
            4036-4451           AC156633.2         23918-24333
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.72 cM"
     gene            1..4451
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /note="solute carrier organic anion transporter family,
                     member 2a1"
                     /db_xref="GeneID:24059"
                     /db_xref="MGI:MGI:1346021"
     exon            1..229
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2065
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /note="solute carrier family 21 (prostaglandin
                     transporter), member 2"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 2A1"
                     /protein_id="NP_201571.2"
                     /db_xref="CCDS:CCDS23448.1"
                     /db_xref="GeneID:24059"
                     /db_xref="MGI:MGI:1346021"
                     /translation="MGLLPKPGARQGSGTSSVPARRCSRSVFNNIKVFVLCHGLLQLC
                     QLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVNRPRMIG
                     IGGLLLAAGAFVLTLPHFLSEPYQYASTTAGNSSHFQTDLCQKHLPGLLPSKCHSTVP
                     DTQKETSSMWSLMVVAQLLAGVGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFG
                     PAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSLPFF
                     FFPRAMSRGAERSVIAEETMKMEEDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQ
                     CTFSSVIAGLSTFLNKFLEKQYDASAAYANLLIGAVNLPAAALGMLFGGILMKRFVFP
                     LQTIPRVAATIMTISIILCAPLFFMGCSTPAVAEVYPPSTPSSIHPQPPACRRDCLCP
                     DSVFHPVCGDNGVEYLSPCHAGCSSLNVSSAASKQPIYLNCSCVTGGSASAKTGSCPT
                     SCAQLLLPSIFLISFVALIACVSHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLP
                     SPSLYGLLIDSSCIRWNYLCSGRRGACAYYDNDALRNRYLGLQVIYKVLGTLLLFFIS
                     WRVKKNREYSLQENASGLI"
     exon            230..367
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..530
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..758
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..857
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..994
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1070
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1235
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1425
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1591
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1755
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1820
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1944
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..4451
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4014..4019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /note="hexamer: ATTATA"
     polyA_site      4037
                     /gene="Slco2a1"
                     /gene_synonym="2310021C19Rik; OATP2A1; Pgt; PHOAR2;
                     Slc21a2"
                     /note="major polyA site"
ORIGIN      
        1 gctcagtctc cacgtctcgc tccccatagc ccggctaccg ccgctgaagc ctgaagcacc
       61 caagtcccgc agaacctgac cccggcctgt cgccaccacc ttggcccggt caggggacgt
      121 cgcctcagtc acgatggggc tcctgcccaa gcccggagca cgccagggca gcggcacctc
      181 ctcggtccca gccagacgtt gctcccgctc ggtcttcaac aacattaagg tcttcgtgct
      241 ttgtcatggc ctcctacagc tctgccagtt gctctacagt gcctacttca agagcagcct
      301 caccactatc gagaagcgct ttgggctctc cagttcttcc tccggtctca tctccagttt
      361 gaatgagatc agcaacgcta tcctcatcat cttcgtcagc tacttcggca gccgggtgaa
      421 ccgcccacgg atgatcggca tagggggtct cctcctggct gcaggggcct ttgtcctcac
      481 cctcccacac ttcctgtcag aaccctatca gtacgcgtcg acaactgctg gaaacagcag
      541 ccactttcag accgacctct gtcagaagca tttgccaggc ctgctcccca gtaagtgcca
      601 cagcaccgtg cccgataccc agaaggagac cagcagcatg tggagcctga tggtggtcgc
      661 tcagctgctg gccggcgttg ggacggtgcc cattcagcca tttgggatct cctatgtgga
      721 cgactttgca gagcctacca actcgcctct gtatatctcc atcttatttg ctatcgccgt
      781 gtttgggccg gctttcgggt acctgctggg ctcagtcatg ctgaggatct tcgtggacta
      841 cggcagagtg gacacggcta cagtgaacct gagcccaggt gaccctcggt ggatcggagc
      901 ctggtggctg ggcctgctca tctcctcagg cttcttgatc gtcacctctt tgcccttttt
      961 cttctttccc cgagcgatgt ccagaggagc agagaggtct gttatcgcag aggagaccat
     1021 gaagatggag gaagacaagt caagaggctc cctgatggat ttcattaaac ggttcccccg
     1081 catcttcctg aggctgctga tgaacccact cttcatgctg gtggtcctga gccagtgcac
     1141 cttctcctca gtcattgctg gcctctccac gttcctcaac aagttcctgg agaagcagta
     1201 cgatgcctcg gcagcctatg ccaacttact cattggtgct gtgaaccttc cagctgcggc
     1261 cttggggatg ctgtttggag gaatcctcat gaagcgtttt gttttccctc tgcaaaccat
     1321 cccccgagta gctgccacca tcatgaccat ctccataatc ctatgtgccc ctctcttctt
     1381 tatgggatgt tccacacccg ccgtggctga ggtctaccct cccagcacac caagttctat
     1441 acatccgcag cctcccgcct gccgcaggga ctgcctgtgc ccagattccg tcttccaccc
     1501 tgtctgcgga gacaatggag tcgagtacct ctccccctgc catgctggct gcagcagcct
     1561 caacgtgagc tcagcagctt ctaagcaacc aatctatttg aactgtagct gtgtgactgg
     1621 aggatccgca tcggccaaga caggctcctg ccctacatcc tgtgcacagc tgctgctccc
     1681 gtccatcttc ctcatctcct ttgtggcact cattgcctgc gtctcccaca accccctcta
     1741 catgatggtc ctacgtgtgg tgaaccagga tgaaaagtcg tttgccattg gagtacagtt
     1801 cttgttgatg cgtttgctgg cctggctgcc atctccatcc ctttatggcc tgctcatcga
     1861 ctcctcctgt atccggtgga actacctatg ctcagggaga cgaggggcct gtgcgtatta
     1921 tgacaacgat gctcttcgaa acaggtacct gggcctacag gtaatctaca aggtcttggg
     1981 cacactgctg ctcttcttca tcagctggag ggtgaagaag aacagggaat acagtctgca
     2041 ggagaatgcc tcgggcctca tctgaccttc agctgggact actgccctgc cccagagact
     2101 ggatatccta cccctccaca cctacctata ttaactaatg ttagcatgcc ttcctcctcc
     2161 ttccctctct ctctccctct ctcttgcgca cacacacaca cacacacata cacacataca
     2221 cacacatgcg ccagtgcgcg cacaaaagag agagagagag agagttagtt cactcacccc
     2281 ttgtctcacc ggcctcttcc tcctaaagtc tcccgcatgg ttcttagggc ctgaagggtc
     2341 ctgagctgaa tgagcgctgg actgaagggt ctagtttctc agagtccttg gaagggatcc
     2401 tctcctcagc cctgggtctt ccactgtccg tactaaggca gcctctgttc tcaccagtct
     2461 ctcaggaaca cttcagtggt gggagaaatg ggagccttga cttccgtgcc aggcagccca
     2521 gctcctctgt ctctgcccac acccaacaga gaggcagggg agcagcaggt ggttgtttct
     2581 tagcagctac cactgggcta agggagcttg gctgtggccg ctttgcatct ggcttcagtc
     2641 tagcatggaa cccaggaggg acctatctcc ctttcctttc ccactttctg ccctcaaggc
     2701 tgatttggaa accaccactt tgggaagtat aaccctctct gtatactact ccctggtgtc
     2761 agagcaggaa cgaaggaacc agcaaggcta ggtcatccaa gcactgttcc taggaacctg
     2821 aggcctaccc tcaggtcagc atgtgcttcc ttctgccttt caaaccaaca aagcccatgt
     2881 aaggagccca tgtaaggagg acccagtctc ccaccctcac agtagagaca aggtctttcc
     2941 cccttcagag acgcaaatag ccatctttac catgccccgg aaacaaaaga gtgacctcac
     3001 atgggctttg ctgtctggac ttcagctcat gtgcagagga gtaaaggcgg tgaatggggg
     3061 gtgtgatcct gagatgcagt cagaccaagg aatggagcag agtggatgcc acctgtcact
     3121 gtgccagatg gcaagttgca gcccacaaag agagtagccg ggttgactcg cttgcaaaca
     3181 cattgtcttc gttggcattt tctcagcttt tcctcactac ctctctggat gtggaggtgg
     3241 gctccttctg tgggcctggg ctgggggcca ccactgccat gcagtggaga ggcaaaggca
     3301 gaggcccagg aatgaggcct tttctcaacg attctgttta tcagagaact ggcttggtgt
     3361 ttgtcaggga tgctgtatgg ttctctgaga gctcccctgg aaaaccttac ctccattcgc
     3421 attgggattg ctcccagaga gcgctcggtg ggcagcaaga acatgctcac acacttgcca
     3481 agcatatcca gaaccaaaaa ggctggcgga aaagatcctg gtctgactgc ccatgcacac
     3541 cctgaggctc cagcaggttg actgtgtgcc tgagctggag atctggctca ccgtgtcccc
     3601 gaagcagcta ggcaattgac attgccctat gtgacattta agtgcctttc agaaatgcct
     3661 tatatggtga gaagccaaat ggtttatgtc ggcgtggcaa aggtcctgtg agactgaagc
     3721 cttcagggag cctttgttac tggcagtgtt ctttctgaag ccaccgggct catttccaca
     3781 gatcttatta aggaggaggc tccacacaac ctcacgggcc agtttcagca tgtggaacgg
     3841 ttctgcttgg aacctgattc tctgcaacta accctgggct tactcactgc agtttaacca
     3901 gattctgaag gcatagcctt ccaccaatct cgcaaacaat gaacgtcaac cttccgttcc
     3961 cggaagatca gctgtcccca caagtcttta ttctattata ttgctattaa tatattataa
     4021 ttctgttctg ggtgtaagtt ggttgtaaat ttgtgctgtc ctgggtctat cagagaacag
     4081 acagaatttg tgccttctag acaaagaagt agccatgctt taaactttag aggcctgtag
     4141 ccaagggtgt tagagaccat gttactctca agccacctgc ctggtgctga gcaggtccca
     4201 ggcattgctg gttgctgtgt ggggccttgt gctttctgtg cagaccaatg tcaaagactc
     4261 atgctcttgg gaggcccagt caccgtcctt gagttcatat ccagaagtgg gctcagtcac
     4321 aaacactata gccatgaata tcacagtcat aattgatcat ttactactat tcagcaaatc
     4381 ttgcctctca aatgccagag gggctttaaa gatctcactt ttttttttcc aattaaagag
     4441 caaattgtca c
//
