LOCUS       NM_021471               3210 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 1c1 (Slco1c1), transcript variant 1, mRNA.
ACCESSION   NM_021471
VERSION     NM_021471.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Siemes,D., Vancamp,P., Markova,B., Spangenberg,P., Shevchuk,O.,
            Siebels,B., Schluter,H., Mayerl,S., Heuer,H. and Engel,D.R.
  TITLE     Proteome Analysis of Thyroid Hormone Transporter
            Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target
            Molecules Involved in Locomotor Function
  JOURNAL   Cells 12 (20), 2487 (2023)
   PUBMED   37887331
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Chen,J., Salveridou,E., Liebmann,L., Sundaram,S.M., Doycheva,D.,
            Markova,B., Hubner,C.A., Boelen,A., Visser,W.E., Heuer,H. and
            Mayerl,S.
  TITLE     Triac Treatment Prevents Neurodevelopmental and Locomotor
            Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient
            Mice
  JOURNAL   Int J Mol Sci 24 (4), 3452 (2023)
   PUBMED   36834863
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Reinwald,J.R., Weber-Fahr,W., Cosa-Linan,A., Becker,R., Sack,M.,
            Falfan-Melgoza,C., Gass,N., Braun,U., Clemm von Hohenberg,C.,
            Chen,J., Mayerl,S., Muente,T.F., Heuer,H. and Sartorius,A.
  TITLE     TRIAC Treatment Improves Impaired Brain Network Function and White
            Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient
            Mice
  JOURNAL   Int J Mol Sci 23 (24), 15547 (2022)
   PUBMED   36555189
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Maity-Kumar,G., Stander,L., DeAngelis,M., Lee,S., Molenaar,A.,
            Becker,L., Garrett,L., Amerie,O.V., Hoelter,S.M., Wurst,W.,
            Fuchs,H., Feuchtinger,A., Gailus-Durner,V., Garcia-Caceres,C.,
            Othman,A.E., Brockmann,C., Schoffling,V.I., Beiser,K., Krude,H.,
            Mroz,P.A., Hofmann,S., Tuckermann,J., DiMarchi,R.D., Hrabe de
            Angelis,M., Tschop,M.H., Pfluger,P.T. and Muller,T.D.
  TITLE     Validation of Mct8/Oatp1c1 dKO mice as a model organism for the
            Allan-Herndon-Dudley Syndrome
  JOURNAL   Mol Metab 66, 101616 (2022)
   PUBMED   36270613
REFERENCE   5  (bases 1 to 3210)
  AUTHORS   Lademann,F., Mayerl,S., Tsourdi,E., Verrey,F., Leitch,V.D.,
            Williams,G.R., Bassett,J.H.D., Hofbauer,L.C., Heuer,H. and
            Rauner,M.
  TITLE     The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of
            Trabecular Bone Mass and Bone Turnover in Male Mice
  JOURNAL   Endocrinology 163 (1) (2022)
   PUBMED   34669927
REFERENCE   6  (bases 1 to 3210)
  AUTHORS   Braun,D., Kinne,A., Brauer,A.U., Sapin,R., Klein,M.O., Kohrle,J.,
            Wirth,E.K. and Schweizer,U.
  TITLE     Developmental and cell type-specific expression of thyroid hormone
            transporters in the mouse brain and in primary brain cells
  JOURNAL   Glia 59 (3), 463-471 (2011)
   PUBMED   21264952
REFERENCE   7  (bases 1 to 3210)
  AUTHORS   Wirth,E.K., Roth,S., Blechschmidt,C., Holter,S.M., Becker,L.,
            Racz,I., Zimmer,A., Klopstock,T., Gailus-Durner,V., Fuchs,H.,
            Wurst,W., Naumann,T., Brauer,A., de Angelis,M.H., Kohrle,J.,
            Gruters,A. and Schweizer,U.
  TITLE     Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral
            phenotype of mice deficient in Mct8, the neuronal T3 transporter
            mutated in Allan-Herndon-Dudley syndrome
  JOURNAL   J Neurosci 29 (30), 9439-9449 (2009)
   PUBMED   19641107
REFERENCE   8  (bases 1 to 3210)
  AUTHORS   Roberts,L.M., Woodford,K., Zhou,M., Black,D.S., Haggerty,J.E.,
            Tate,E.H., Grindstaff,K.K., Mengesha,W., Raman,C. and Zerangue,N.
  TITLE     Expression of the thyroid hormone transporters monocarboxylate
            transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at
            the blood-brain barrier
  JOURNAL   Endocrinology 149 (12), 6251-6261 (2008)
   PUBMED   18687783
  REMARK    GeneRIF: OATP14 mRNA and protein are strongly enriched in mouse and
            rat cerebral microvessels but not in human microvessels.
REFERENCE   9  (bases 1 to 3210)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   10 (bases 1 to 3210)
  AUTHORS   Tohyama,K., Kusuhara,H. and Sugiyama,Y.
  TITLE     Involvement of multispecific organic anion transporter, Oatp14
            (Slc21a14), in the transport of thyroxine across the blood-brain
            barrier
  JOURNAL   Endocrinology 145 (9), 4384-4391 (2004)
   PUBMED   15166123
  REMARK    GeneRIF: basolateral localization of mOatp14 in the choroid plexus
            in which it may also play a role in T4 uptake.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155835.3 and AC153834.2.
            
            On Sep 22, 2017 this sequence version replaced NM_021471.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). An in-frame AUG is
            located one codon upstream of the annotated translation start site
            but is not being annotated as a start site since it is not
            conserved and is in a weak Kozak sequence context.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY007379.1, SRR6116558.2719.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               AC155835.3         11634-12022         c
            390-542             AC155835.3         4770-4922           c
            543-684             AC155835.3         3593-3734           c
            685-817             AC153834.2         80640-80772         c
            818-951             AC153834.2         79769-79902         c
            952-1098            AC153834.2         77714-77860         c
            1099-1197           AC153834.2         75121-75219         c
            1198-1443           AC153834.2         73030-73275         c
            1444-1608           AC153834.2         72018-72182         c
            1609-1804           AC153834.2         64765-64960         c
            1805-1970           AC153834.2         60046-60211         c
            1971-2155           AC153834.2         56742-56926         c
            2156-2220           AC153834.2         55373-55437         c
            2221-2338           AC153834.2         52381-52498         c
            2339-3210           AC153834.2         49775-50646         c
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 72.38 cM"
     gene            1..3210
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /note="solute carrier organic anion transporter family,
                     member 1c1"
                     /db_xref="GeneID:58807"
                     /db_xref="MGI:MGI:1889679"
     exon            1..389
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            390..542
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            543..684
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            685..817
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            818..951
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1098
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1197
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1443
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1608
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1804
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1970
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2155
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2220
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2338
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..3210
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /note="hexamer: AATACA"
     regulatory      2618..2623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /note="hexamer: AATAAA"
     polyA_site      2624
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /note="major polyA site"
     polyA_site      2639
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /note="major polyA site"
     regulatory      2728..2733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
                     /note="hexamer: ATTAAA"
     polyA_site      2753
                     /gene="Slco1c1"
                     /gene_synonym="OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14"
ORIGIN      
        1 tctataaaca aagctttatc acgtgtggcc ttaaacttgc tgcaaattgc aaagaaatgg
       61 ctcaaaggct ccagctcttt ctgtgccctg ggagctgaga tgcagggcag tgcccttgcc
      121 agggtgccca attccctgca gactgccaga aaaaaagagg ccaactggaa agacgaaaga
      181 gaaagactgc tcaggggtga gatcagaccc ttggtctttt ctttcctcta atctgccctg
      241 tctgtgccca ccagctctct tgacttgcca gaactgttca caacttctgt ggggtgctgc
      301 ctcagtttcc tgtttcagac tgtgctctgt gatccagacc cttgcgaaca ttctgaaagg
      361 aactggacag ctttgacttc tacctccagg ctgggataag aaacattctc atgatggaca
      421 cctcatccaa agaaaatgcc catttgttcc acaaaaattc agcgcaacct gccggagggc
      481 catcctttac agtcggatat ccgtccacag aggaagcgcg gccatgctgt ggaaaactca
      541 aggtgttctt gggtgccctg tcgtttgttt actttgccaa agcattggca gaaggctatc
      601 tgaagagcac cgtgactcag atagagagaa ggtttgagat cccttcctct ctggtgggaa
      661 taattgatgg tagttttgaa atcgggaatc tcctggtcat aacgtttgtt agctactttg
      721 gtgccaaact tcacaggcca aaaataattg gagcaggatg cctggtcatg ggcttcggaa
      781 ctatgctcat tgctgtaccc cagttcttca tggagaagta cagctatgag aaatatgaga
      841 ggtattcccc gtcctccaat gttactccca gcatctctcc gtgctacctg gagtccagca
      901 gtccatcacc aagctcaatc ctggggaaat cacagaacaa aataagtcac gaatgtgtag
      961 gggattccag ctcctccatg tgggtttatg tcttcctggg aaatcttctc cgagggttag
     1021 gggagacgcc tatccaaccc ctgggcatcg cctatctgga tgactttgcc agtgaagaca
     1081 atgctgcttt ctacatcggg tgtgtgcaga cagtggcaat tataggaccc atttttggct
     1141 tccttttggg ctcattatgc gcaaaactgt atgttgatat tggctttgtg aatctagacc
     1201 atataacaat caccccaaag gatcctcagt gggtcggggc ctggtggctt ggttacctaa
     1261 tagctggatt cctaagtctc cttgcagctg ttcctttctg gtgcttaccc aagactctac
     1321 caagatccca aagtagagag aactctggct ccacatctga gaaatccaag ttcatagatg
     1381 accctattca ctaccaaatg gcccctggag acgataaaat gaaaatcatg gaaatggcaa
     1441 aagattttct tccatcattg aagactcttt ttagaaatcc agtatacatc ttatacttgt
     1501 gtgcaagcac cgttcagttc aattctctat ttggcatggt cacatataaa ccaaaataca
     1561 ttgagcagca gtatgggcag tcttcttcca aagccaactt tgtcattggg ctcatcaaca
     1621 ttcctgcagt ggcccttgga atattctctg ggggaatagt tatgaaaaaa ttcaggctgg
     1681 gtatttgtga agctacaaaa ctctacttgg gatcatctgt ctttggctac ctcctcttcc
     1741 tctctctgtt tgcactggga tgtgaaaatt ctagtgtggc cggactgact gtctcctacc
     1801 aaggaaccaa acctgtctct tatcatgaac gagctctctt ttcagattgc aactcaagat
     1861 gtaaatgttc agactcaaaa tgggagccca tgtgtgggga caatgggatt acctatgtgt
     1921 cggcttgtct tgctggctgt caatcctcca gccggagtgg aaagaacatt atattttcta
     1981 actgcacttg tgtgggattt gcagccccca agtcaggaaa ctggtcaggc atgatgggca
     2041 ggtgtcagaa agataatgga tgttcccaaa tgtttcttta tttccttgtg atttcagtca
     2101 tcacatcata tacattatct ctaggtggca tacctggata tatattactc ttgaggtgca
     2161 ttcaaccaca acttaagtct tttgctctgg gtatctacac cttagcagta agagttcttg
     2221 caggaatccc agcccctgtg tactttggtg ttttgattga cacttcatgc ctcaaatggg
     2281 gatttaagaa atgtggaagc agaggctcct gcaggctgta tgactcccac gctttcagac
     2341 acatatacct gggattaacc acgctcctgg gcacggtgtc tgtcttccta agcatggctg
     2401 tactttttgt tttaaagaaa aaatatgtct cgaaacacag cagcttaata accacaagag
     2461 aaaaaatagg gatgtcttca agcatcaaaa aggagacatg cgctgcaagg gatcgtggat
     2521 tgcagcccaa gtactggcca ggcaaggaga cacgacttta aaaaaaaatc atggaaacaa
     2581 acaaatatgg ggtcatttta tccaatacat gtaaatgaat aaaagcataa tcaaaagggc
     2641 ttcaatgtgc aattcctttc tgcttccaaa ggtatgcctg ctttgctttt gactctaagc
     2701 ataacatgac aaacctctaa ggatgtaatt aaatttattt taaaactttt aaacttgtac
     2761 attcctttta attattttct tatttctgct tcatgctata ttgtctccat tgatatgtga
     2821 tatgtgttcc tggggatggc tgtctattat gtttgattat gacatgtcat ctgtacattg
     2881 tgtcacttga ccagaatcta ctttgagtat ttcctaagga gatctttcag atttagctcc
     2941 tccttgaact gatacagaaa aaaaacattc atgatggggt tgtcttctga gacaatttct
     3001 gttcattagt ttacatataa taagatgtaa ttttataatt tacataaatt cattgtgatt
     3061 ttggaagtat ccatggttac actgcaattc atgtcaccat gtcaccatac tttattgctt
     3121 acgaattcag tgaatcaaaa tatttttaaa caaacacttc ccaaatttcc atgaattagg
     3181 taactctgta cttagacata aattgtattc
//
