LOCUS       NM_020495               3307 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 1b2 (Slco1b2), mRNA.
ACCESSION   NM_020495
VERSION     NM_020495.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Wen,J., Zhao,M. and Liu,L.
  TITLE     Expression of Oatp2 in the Brain and Liver of Alzheimer Disease
            Mouse Model
  JOURNAL   ACS Chem Neurosci 11 (3), 226-227 (2020)
   PUBMED   31967785
  REMARK    GeneRIF: Expression of Oatp2 in the Brain and Liver of Alzheimer
            Disease Mouse Model.
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   Fu,Q., Chen,M., Anderson,J.T., Sun,X., Hu,S., Sparreboom,A. and
            Baker,S.D.
  TITLE     Interaction Between Sex and Organic Anion-Transporting Polypeptide
            1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites
            Regorafenib-N-Oxide and Regorafenib-Glucuronide in Mice
  JOURNAL   Clin Transl Sci 12 (4), 400-407 (2019)
   PUBMED   30955241
  REMARK    GeneRIF: This finding is consistent with the metabolism of
            regorafenib occurring via two competing pathways, and the lack of
            Oatp1b2 results in decreased clearance of Regorafenib.
REFERENCE   3  (bases 1 to 3307)
  AUTHORS   Leblanc,A.F., Sprowl,J.A., Alberti,P., Chiorazzi,A., Arnold,W.D.,
            Gibson,A.A., Hong,K.W., Pioso,M.S., Chen,M., Huang,K.M.,
            Chodisetty,V., Costa,O., Florea,T., de Bruijn,P., Mathijssen,R.H.,
            Reinbolt,R.E., Lustberg,M.B., Sucheston-Campbell,L.E.,
            Cavaletti,G., Sparreboom,A. and Hu,S.
  TITLE     OATP1B2 deficiency protects against paclitaxel-induced
            neurotoxicity
  JOURNAL   J Clin Invest 128 (2), 816-825 (2018)
   PUBMED   29337310
REFERENCE   4  (bases 1 to 3307)
  AUTHORS   Sissung,T.M., Ley,A.M., Strope,J.D., McCrea,E.M., Beedie,S.,
            Peer,C.J., Shukla,S., van Velkinburgh,J., Reece,K., Troutman,S.,
            Campbell,T., Fernandez,E., Huang,P., Smith,J., Thakkar,N.,
            Venzon,D.J., Brenner,S., Lee,W., Merino,M., Luo,J., Jager,W.,
            Price,D.K., Chau,C.H. and Figg,W.D.
  TITLE     Differential Expression of OATP1B3 Mediates Unconjugated
            Testosterone Influx
  JOURNAL   Mol Cancer Res 15 (8), 1096-1105 (2017)
   PUBMED   28389619
  REMARK    GeneRIF: Experiments testing the cellular uptake of androgens
            suggest that testosterone is an excellent substrate of OATP1B3 and
            cells expressing a doxycycline-inducible SLCO1B3 construct had
            greater uptake of a clinically relevant concentration of
            3H-testosterone . When compared with Slco1b2 (-/-) mice, Slco1b2
            (-/-)/hSLCO1B3 knockins had greater greater hepatic uptakeand lower
            plasma exposure to 3H-testosterone
REFERENCE   5  (bases 1 to 3307)
  AUTHORS   Lee,H.H., Leake,B.F., Kim,R.B. and Ho,R.H.
  TITLE     Contribution of Organic Anion-Transporting Polypeptides 1A/1B to
            Doxorubicin Uptake and Clearance
  JOURNAL   Mol Pharmacol 91 (1), 14-24 (2017)
   PUBMED   27777271
  REMARK    GeneRIF: important roles for OATP1A/1B in transporter-mediated
            uptake and disposition of doxorubicin, are reported.
REFERENCE   6  (bases 1 to 3307)
  AUTHORS   Evers,R. and Chu,X.Y.
  TITLE     Role of the murine organic anion-transporting polypeptide 1b2
            (Oatp1b2) in drug disposition and hepatotoxicity
  JOURNAL   Mol Pharmacol 74 (2), 309-311 (2008)
   PUBMED   18492796
  REMARK    GeneRIF: Review summarizes the evidence for the important role of
            mouse liver-specific organic anion transporting polypeptide Oatpb2
            in drug deposition and hepatotoxicity.
            Review article
REFERENCE   7  (bases 1 to 3307)
  AUTHORS   Zaher,H., Meyer zu Schwabedissen,H.E., Tirona,R.G., Cox,M.L.,
            Obert,L.A., Agrawal,N., Palandra,J., Stock,J.L., Kim,R.B. and
            Ware,J.A.
  TITLE     Targeted disruption of murine organic anion-transporting
            polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition
            of prototypical drug substrates pravastatin and rifampin
  JOURNAL   Mol Pharmacol 74 (2), 320-329 (2008)
   PUBMED   18413659
REFERENCE   8  (bases 1 to 3307)
  AUTHORS   Lu,H., Choudhuri,S., Ogura,K., Csanaky,I.L., Lei,X., Cheng,X.,
            Song,P.Z. and Klaassen,C.D.
  TITLE     Characterization of organic anion transporting polypeptide 1b2-null
            mice: essential role in hepatic uptake/toxicity of phalloidin and
            microcystin-LR
  JOURNAL   Toxicol Sci 103 (1), 35-45 (2008)
   PUBMED   18296417
REFERENCE   9  (bases 1 to 3307)
  AUTHORS   Phan,J., Pesaran,T., Davis,R.C. and Reue,K.
  TITLE     The Diet1 locus confers protection against hypercholesterolemia
            through enhanced bile acid metabolism
  JOURNAL   J Biol Chem 277 (1), 469-477 (2002)
   PUBMED   11682476
REFERENCE   10 (bases 1 to 3307)
  AUTHORS   Ogura,K., Choudhuri,S. and Klaassen,C.D.
  TITLE     Full-length cDNA cloning and genomic organization of the mouse
            liver-specific organic anion transporter-1 (lst-1)
  JOURNAL   Biochem Biophys Res Commun 272 (2), 563-570 (2000)
   PUBMED   10833452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155326.8.
            
            On Apr 7, 2018 this sequence version replaced NM_020495.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031959.1, SRR5189682.129698.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC155326.8         121099-121137       c
            40-123              AC155326.8         117491-117574       c
            124-275             AC155326.8         116120-116271       c
            276-417             AC155326.8         102025-102166       c
            418-550             AC155326.8         98080-98212         c
            551-663             AC155326.8         95237-95349         c
            664-810             AC155326.8         93720-93866         c
            811-909             AC155326.8         93049-93147         c
            910-1152            AC155326.8         86835-87077         c
            1153-1317           AC155326.8         81165-81329         c
            1318-1513           AC155326.8         79397-79592         c
            1514-1685           AC155326.8         78342-78513         c
            1686-1867           AC155326.8         74270-74451         c
            1868-1932           AC155326.8         69281-69345         c
            1933-2050           AC155326.8         67334-67451         c
            2051-3307           AC155326.8         64009-65265         c
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 72.57 cM"
     gene            1..3307
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /note="solute carrier organic anion transporter family,
                     member 1b2"
                     /db_xref="GeneID:28253"
                     /db_xref="MGI:MGI:1351899"
     exon            1..39
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            40..123
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            124..275
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2267
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /note="solute carrier family 21 (organic anion
                     transporter), member 10; solute carrier family 21 (organic
                     anion transporter), member 6; liver-specific organic anion
                     transporter 1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1B2"
                     /protein_id="NP_065241.1"
                     /db_xref="CCDS:CCDS20678.1"
                     /db_xref="GeneID:28253"
                     /db_xref="MGI:MGI:1351899"
                     /translation="MDQTQHPSKAAQPLRSEKTRHCDGFRIFLAALSFSYICKALGGV
                     IMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIM
                     GIGSILTALPHFFMGYYRYATENDISSLHNSTLTCLVNQTTSLTGTSPEIMEKGCEKG
                     SNSYTWIYVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILG
                     FIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCIICSIPFFFLPK
                     IPKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEKQAPANLTGFLWSLRSILTNEQYV
                     IFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLI
                     KRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVDSHIDVP
                     LSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNIEFYDCSCVSGSG
                     FQKGNHSARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSL
                     GMGFHSLVVRTLGGILAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGL
                     SIALKTPILLLYVALIYVMKRKMKRNDNKILENGRKFTDEGNPEPVNNNGYSCVPSDE
                     KNSETPL"
     exon            276..417
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            418..550
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            551..663
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            664..810
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            811..909
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1152
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1317
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1513
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1685
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1867
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1932
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2050
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..3307
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3282..3287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="Slco1b2"
                     /gene_synonym="7330442B20Rik; lst-1; mlst-1; OATP-C;
                     Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6"
                     /note="major polyA site"
ORIGIN      
        1 gttagacatg ccacacttgt tgtagaagcc tgagttcagg acaccaagac tgctggtgct
       61 ttgtggctga tcgccagcct aggccaaatg ccagaaagct tgggttgtcg gtggaaggca
      121 tagggtaggc ggtcatttga aaggaagtat ttatcaagag tgatcacaga cattcccatc
      181 acaaccactg ttcaatcatg gaccaaactc agcatccaag caaagctgcc caacctttaa
      241 gatcagagaa gacaaggcac tgcgatggat tcaggatatt tttggcagcc ctctcattca
      301 gctacatatg caaggcacta ggtggagtca ttatgaaaag ttccatcact caaatagaaa
      361 gaagatttga cataccatct tccatttccg gtttgattga tggaggcttt gaaattggga
      421 atttgttagt tattgtattt gtgagttact ttggatccaa gctacaccga ccaaagctga
      481 ttggaactgg ttgcttcatc atgggcattg ggagtattct gactgcgttg ccacatttct
      541 tcatgggata ttacaggtat gcaacagaaa atgacatcag ttctctacat aactccacgt
      601 tgacctgttt agtcaatcaa actacatcac tcactggaac ctcacctgag ataatggaga
      661 aaggttgtga aaaggggtcc aactcataca cctggattta tgtcttgatg gggaacatgc
      721 ttcgtgggat aggggaaacc ccaatagtgc ccctaggagt ttcctacatt gatgactttg
      781 caaaagaagg aaattcttcc atgtacttag gtactctgca tactatagca atgatcggac
      841 caatccttgg ctttatcatg tcatctgtgt ttgctaagct atacgtagac gttggatatg
      901 tagacctgag aagtgtccgc ataactcctc aggatgctcg ttgggttggt gcctggtggc
      961 tcggcttcat tgtgaatgga ctactatgca tcatttgttc tatacccttc ttttttctac
     1021 ccaaaattcc aaagagatca cagaaggaaa ggaaaaattc agcatctctt catgtactca
     1081 aaacagatga agacaagaat cccgtgacta atccaacaac acaagagaaa caagctcctg
     1141 ccaacctgac tggttttcta tggtctctga gaagcatcct taccaatgaa caatatgtca
     1201 tattcttgat actgacgttg ctacaaatca gcagcttcat tggatccttc acttacctgt
     1261 tcaagtttat agagcagcag tttggtcaga cagcatcgca ggccaacttt ctgttaggag
     1321 ttataaccat acccactatg gcaagtggaa tgtttttagg aggatatctc attaaaagat
     1381 taaaattaac cctgcttgga atcactaagt ttgtgttttt caccacaaca atggcctatg
     1441 tgttctacct gtcatatttt cttctaatct gtgaaaacaa ggcatttgct ggcctaacct
     1501 tgacctatga tggaatgaac ccagtggact ctcacataga tgtcccactt tcttattgca
     1561 actcggactg catttgtgat aaaaatcaat gggaacctgt ctgtggggaa aatggagtga
     1621 cttacatttc accttgtctg gcaggatgca aatcatttcg tggtgataag aaactgatga
     1681 atatagaatt ctatgactgc agttgtgtca gcggctctgg tttccagaag ggaaaccatt
     1741 cagcacgttt gggtgaatgc ccaagagaca aatgcaaaac caaatattac ttttatataa
     1801 cttttcaagt cattatatct tttttcactg cactgggaag cacttctctt atgttgattc
     1861 tgataaggag tgtccaacct gaattgaaat cacttggaat gggattccat tcactggttg
     1921 tacgaacact aggaggaatt ctagctccag tctattatgg ggcattaatt gacagaacat
     1981 gtatgaagtg gtctgtaacc agctgtggag cacgtggagc atgcaggcta tataactcga
     2041 gattatttgg aatgatctac gtgggtttga gtatagcttt aaagactcca atacttcttt
     2101 tatatgttgc attaatttat gttatgaaga gaaaaatgaa aagaaatgat aacaagatat
     2161 tagaaaatgg aagaaaattc acagatgaag gaaacccaga acctgtaaat aataatggat
     2221 actcttgtgt accttctgat gaaaaaaaca gtgaaacacc tctttaaggg aagagaaaga
     2281 cacatctgtt gctgtgtttt caaacaaccc cggttctttc actgaggaat ttctcatgtt
     2341 acatatgatg gagaatctgt aatcctgtgc atttatagtg aaacaaacta gaaatcaaaa
     2401 gaaataagag cacccttgtc agggcctagc tgtgcatctg aagctgtatg ggttgtaaag
     2461 actgaatgca atgaatgaag ttggttaggt tccaatagaa aaacaggtat tcacttaagc
     2521 atttataact caagtacaat caataaggag gctaggatgg acaaagcggg aaaggaatgt
     2581 gaaaattggt gactttaaat tagtgtcttc aaaaatcaaa atttgcatgg tgctattctc
     2641 tcctgaagtc tctgcaatgg agggcttcat gatgtggcat attttggtac acatgttaag
     2701 tcatatattt tgcataatga ttaatttgaa attgtgttta atgacacatg cattttcttt
     2761 gcacatgttg taccaaacat tgagaataaa aaaaaaagaa atttaagaaa attagtctat
     2821 aattatcaga aaacttacct tagaatgcat ttttaacagc tatgcaaatg aattggaaga
     2881 cccacattga ctgaagaaag ctaagagcaa tgaataagta agccttcact ccggaggcct
     2941 ttcagttctg agataagtgt gtgccagaca ctggctggta gaggacatca gcagtcaact
     3001 ccaccactgt cttgtttttt tcttttgttt tggatgtgag atatatagat ataggagata
     3061 taggtagata tagatttaga tatatggatc tctctctaca tatatatata tatatatgaa
     3121 attaagatag agtgaatgag aacaaatgtc tttggatatt gtattatata gtgatatcag
     3181 atctagtata gtggatggta gaagttgaac ttgctttatt ttcacatgtt aaaatatttt
     3241 ttgcattaaa atagcctatt gaaatagttt tctgttgcta taataaaata acctggcaaa
     3301 aaagtaa
//
