LOCUS       NM_001381930            2668 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 1a6 (Slco1a6), transcript variant 2, mRNA.
ACCESSION   NM_001381930 XM_017321612
VERSION     NM_001381930.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Tian,J., Keller,M.P., Oler,A.T., Rabaglia,M.E., Schueler,K.L.,
            Stapleton,D.S., Broman,A.T., Zhao,W., Kendziorski,C., Yandell,B.S.,
            Hagenbuch,B., Broman,K.W. and Attie,A.D.
  TITLE     Identification of the Bile Acid Transporter Slco1a6 as a Candidate
            Gene That Broadly Affects Gene Expression in Mouse Pancreatic
            Islets
  JOURNAL   Genetics 201 (3), 1253-1262 (2015)
   PUBMED   26385979
  REMARK    GeneRIF: results suggest that genetic variation in Slco1a6 leads to
            altered transport of taurocholic acid and potentially other bile
            acids) by pancreatic islets, resulting in broad gene regulation
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   van de Steeg,E., Wagenaar,E., van der Kruijssen,C.M.,
            Burggraaff,J.E., de Waart,D.R., Elferink,R.P., Kenworthy,K.E. and
            Schinkel,A.H.
  TITLE     Organic anion transporting polypeptide 1a/1b-knockout mice provide
            insights into hepatic handling of bilirubin, bile acids, and drugs
  JOURNAL   J Clin Invest 120 (8), 2942-2952 (2010)
   PUBMED   20644253
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Sekine,T., Miyazaki,H. and Endou,H.
  TITLE     Molecular physiology of renal organic anion transporters
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F251-F261 (2006)
   PUBMED   16403838
  REMARK    Review article
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Choudhuri,S., Ogura,K. and Klaassen,C.D.
  TITLE     Cloning, expression, and ontogeny of mouse organic
            anion-transporting polypeptide-5, a kidney-specific organic anion
            transporter
  JOURNAL   Biochem Biophys Res Commun 280 (1), 92-98 (2001)
   PUBMED   11162483
  REMARK    Erratum:[Biochem Biophys Res Commun 2001 Feb 23;281(2):610]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142587.1 and AC134836.6.
            
            On Apr 20, 2020 this sequence version replaced XM_017321612.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142587.1, BC071214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2661              AK142587.1         2-2662
            2662-2668           AC134836.6         119999-120005
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 73.42 cM"
     gene            1..2668
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /note="solute carrier organic anion transporter family,
                     member 1a6"
                     /db_xref="GeneID:28254"
                     /db_xref="MGI:MGI:1351906"
     exon            1..91
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            92..233
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            234..366
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            367..473
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            474..620
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            621..719
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            720..941
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1106
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1302
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1468
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1641
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1706
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1824
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2668
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2430..2435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /note="hexamer: AATAAA"
     polyA_site      2457
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /note="major polyA site"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /note="hexamer: ATTAAA"
     polyA_site      2668
                     /gene="Slco1a6"
                     /gene_synonym="4930422F19Rik; Oatp-5; Oatp5; Slc21a13"
                     /note="major polyA site"
ORIGIN      
        1 agagacatcc ttaaacaatc agaagaacaa aatgggagaa cctgggaaaa gggttggaat
       61 ccacagggtc aggtgctttg ccaagatcaa ggtgtttctg ttggcattaa tatgggcata
      121 tatatccaaa atactatcag gagtttacat gagtactatg ctcacacaat tagagagaca
      181 attcaatatt tccacatcta tagttggact tatcaatggg agctttgaga tgggtaacct
      241 tttggtgatt gtattcgtga gttattttgg aacaaaactg catagaccta tcatgattgg
      301 tgttggttgt gcagttatgg gcctagggtg tttcataata tcactacctc atttcctcat
      361 gggcagatac gaatatgaaa caacaatttc acctacaagc aacttgtcct caaacagctt
      421 tttgtgtgtg gaaaacagat cccagacctt aaagccaaca caagacccag cagagtgtgt
      481 gaaagaaatt aaatcattaa tgtggatata tgtactggta ggaaacatta tacgtggaat
      541 tggtgaaact cccatcatgc ctttaggtat ttcctatata gaagactttg ccaaatcaga
      601 aaattctcct ttatacattg gaattttaga agttgggaag atgattggcc caatacttgg
      661 atatttgatg ggacctttct gtgcaaacat ttatgtagac acagggtctg tgaatacaga
      721 tgacctgacc ataactccca ctgatacacg ctgggtcggt gcttggtgga ttggcttttt
      781 ggtctgtgca ggagtgaatg tcctgaccag catccccttt ttcttctttc caaaaacact
      841 cccaaaggaa ggattacagg ataatgggga tggaactgaa aatgccaaag aggagaagca
      901 cagagacaag gccaaggagg aaaaccaagg aatcattaaa gaattcttcc ttatgatgaa
      961 gaacctcttc tgtaacccta tttacatgct ttgcgtcctt acaagtgtgc tccaggtaaa
     1021 tggagttgcc aatattgtga tttacaagcc taaatacctg gaacatcatt ttggaatctc
     1081 cacagcaaag gcagtcttcc tcattggtct ttataccaca ccttcagtat ctgctggata
     1141 tttaattagt ggttttatta tgaagaagtt gaagattact ctcaagaaag ctgcaatcat
     1201 agcactttgc ctattcatgt ctgagtgcct tttatccctt tgtaacttta tgctaacctg
     1261 tgataccact ccaattgccg gcttaactac ctcttatgaa ggaattcagc agtcttttga
     1321 tatggagaat aagtttcttt ctgactgcaa cacaaggtgt aactgcttaa caaaaacatg
     1381 ggatccagtg tgtgggaaca atggcctagc atacatgtca ccttgccttg caggctgtga
     1441 aaagtctgtt ggaacaggag ccaacatggt gtttcaaaat tgcagctgca ttcggtcatc
     1501 aggaaactca tctgcagtcc tggggctgtg taagaaaggc cctgactgtg ctaacaagct
     1561 tcagtacttt ttaatcataa cggtattttg ctgcttcttc tactcgttag caaccatacc
     1621 tgggtacatg gtttttctga gatgtatgaa gtctgaagag aagtcacttg gaattggatt
     1681 acaggcattt ttcatgagac tatttgctgg tattcctgca cctatttact ttggcgcttt
     1741 gatagacaga acatgcttac attggggaac tctgaaatgt ggtgagccag gagcatgcag
     1801 gacctatgaa gtcagtagtt tcaggcgcct ctatcttgga ttgcctgcag ctctaagagg
     1861 atcaatcatt cttccttcat tcttcattct aagacttatc aggaaactcc aaatccctgg
     1921 ggacactgac tcttcagaaa ttgaacttgc agagacgaag cccacagaga aggaaagtga
     1981 gtgcacagac atgcacaaaa gttctaaggt cgagaacgat ggagaactga aaactaagct
     2041 gtaatgaggt ttctactggc ctatgcaagg ccacgaacag aatactcatt tcatttcctt
     2101 tgaatcataa gagaaataat aggaaccctc atctttaagg acctcaaaag ctatttttct
     2161 cattataaaa ataattactg atattatttt cagaacttca gggtagcact taagattttc
     2221 ctagtgaaga ctttaatggt gacccccacc ctggacttta aaaagccttc gttttcaaag
     2281 agcattttct ctttaaactc agtcaaagga aatgtgtgtt tcttgcatat cttcaagtag
     2341 atttcatttc acttaatttc attgaattta catttcaata ttggaggtaa ttagagctga
     2401 aagtatgcct tctggttgtg tcatattgaa ataaattgtt cagattcatc ctttccatgt
     2461 gcaaggtgtc tgcatgtgtc tttaactctt tgggagctgt tatctttctt ttctcattct
     2521 agacttttga tgcttcagag attagactct cactaatgtg tcatctcgtg ttttcaattc
     2581 cctctttcat tattcatgtc acatatttga tcattttgtt tagaactctg acaaatttaa
     2641 acaggttatt aaaactcatg tagaaaaa
//
