LOCUS       NM_130861               2572 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 1a5 (Slco1a5), transcript variant 2, mRNA.
ACCESSION   NM_130861
VERSION     NM_130861.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2572)
  AUTHORS   Selmi-Ruby,S., Bouazza,L., Obregon,M.J., Conscience,A., Flamant,F.,
            Samarut,J., Borson-Chazot,F. and Rousset,B.
  TITLE     The targeted inactivation of TRbeta gene in thyroid follicular
            cells suggests a new mechanism of regulation of thyroid hormone
            production
  JOURNAL   Endocrinology 155 (2), 635-646 (2014)
   PUBMED   24265449
REFERENCE   2  (bases 1 to 2572)
  AUTHORS   Di Cosmo,C., Liao,X.H., Dumitrescu,A.M., Philp,N.J., Weiss,R.E. and
            Refetoff,S.
  TITLE     Mice deficient in MCT8 reveal a mechanism regulating thyroid
            hormone secretion
  JOURNAL   J Clin Invest 120 (9), 3377-3388 (2010)
   PUBMED   20679730
REFERENCE   3  (bases 1 to 2572)
  AUTHORS   van de Steeg,E., Wagenaar,E., van der Kruijssen,C.M.,
            Burggraaff,J.E., de Waart,D.R., Elferink,R.P., Kenworthy,K.E. and
            Schinkel,A.H.
  TITLE     Organic anion transporting polypeptide 1a/1b-knockout mice provide
            insights into hepatic handling of bilirubin, bile acids, and drugs
  JOURNAL   J Clin Invest 120 (8), 2942-2952 (2010)
   PUBMED   20644253
REFERENCE   4  (bases 1 to 2572)
  AUTHORS   Sugiura,T., Otake,T., Shimizu,T., Wakayama,T., Silver,D.L.,
            Utsumi,R., Nishimura,T., Iseki,S., Nakamichi,N., Kubo,Y., Tsuji,A.
            and Kato,Y.
  TITLE     PDZK1 regulates organic anion transporting polypeptide Oatp1a in
            mouse small intestine
  JOURNAL   Drug Metab Pharmacokinet 25 (6), 588-598 (2010)
   PUBMED   21084765
  REMARK    GeneRIF: Immunoreactivity to anti-Oatp1a antibody was colocalized
            with PDZK1 in the small intestine of wild-type mice, whereas apical
            localization of Oatp1a protein was reduced in pdzk1(-/-) mice.
            PDZK1 appears to act as an adaptor for Oatp1a[Oatp1a]
REFERENCE   5  (bases 1 to 2572)
  AUTHORS   Sekine,T., Miyazaki,H. and Endou,H.
  TITLE     Molecular physiology of renal organic anion transporters
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F251-F261 (2006)
   PUBMED   16403838
  REMARK    Review article
REFERENCE   6  (bases 1 to 2572)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     The superfamily of organic anion transporting polypeptides
  JOURNAL   Biochim Biophys Acta 1609 (1), 1-18 (2003)
   PUBMED   12507753
  REMARK    Review article
REFERENCE   7  (bases 1 to 2572)
  AUTHORS   Walters,H.C., Craddock,A.L., Fusegawa,H., Willingham,M.C. and
            Dawson,P.A.
  TITLE     Expression, transport properties, and chromosomal location of
            organic anion transporter subtype 3
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 279 (6), G1188-G1200 (2000)
   PUBMED   11093941
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029706.1.
            
            On Jun 13, 2012 this sequence version replaced NM_130861.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029706.1, AF240694.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1164              AK029706.1         2-1165
            1165-2572           AK029706.1         1167-2574
FEATURES             Location/Qualifiers
     source          1..2572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 73.69 cM"
     gene            1..2572
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /note="solute carrier organic anion transporter family,
                     member 1a5"
                     /db_xref="GeneID:108096"
                     /db_xref="MGI:MGI:1351865"
     exon            1..74
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            75..184
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2137
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /note="solute carrier family 21 (organic anion
                     transporter), member 7; solute carrier family 21 member 7;
                     organic anion-transporting polypeptide 3;
                     sodium-independent organic anion transporter 3"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1A5"
                     /protein_id="NP_570931.1"
                     /db_xref="CCDS:CCDS57464.1"
                     /db_xref="GeneID:108096"
                     /db_xref="MGI:MGI:1351865"
                     /translation="MGETEKRIATHGVRCFSKIKMFLLALTCAYVSKSLSGIYMNSML
                     TQIERQFDIPTSIVGLINGSFEIGNLLLIILVSYFGTKLHRPIMIGIGCVIMGLGCFL
                     MSLPHFLMGRYEYETTISPTSNLSSNSFLCMENRTQTLKPTQDPAECVKEMKSLMWIY
                     VLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILESGKMIGPIVGLLLGSFCA
                     RIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKEGLQ
                     DNVDRTENDKEEKHREKAKEENRGITKDFLPFMKSLSCNPIYMLLILTSVLQINAFIN
                     MFTFLPKYLEQQYGKSTSEVVLLIGVCNLPPICIGYLLIGFIMKKFRITVKKAAYMAF
                     CLSLFEYLLSYFHFMISCDNFQVAGLTTSYEGVQHPLYVENKVLADCNTRCSCLTNTW
                     DPVCGDNGLSYMSACLAGCEKSVGMGTHMVFQNCSCIQSSGNSSAVLGLCKKGPECAN
                     KLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKSEEKSLGIGLHAFCTRIFAGIPAPIY
                     FGALIDRTCLHWGTLKCGEPGACRMYNINNFRRIYLVLPAALRGSSYLPAFFILILMR
                     KFQLPGEMYSSETELADMKLTVKKSECTDVHRIPKVENDGELKTKL"
     exon            185..326
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            327..459
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            460..566
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            567..713
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            714..812
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1034
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1199
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1395
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1561
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1734
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1799
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1917
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2572
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /note="hexamer: AATAAA"
     polyA_site      2570
                     /gene="Slco1a5"
                     /gene_synonym="Oatp-3; Oatp3; Slc21a7"
                     /note="major polyA site"
ORIGIN      
        1 acatgactta ggaaagcatc cgtgagctta tacaccagca gcaaccgtca atgggattgc
       61 tgaggagtgc tcagtggtaa gactgtttaa agaatagtca tttggagaca atcagaagaa
      121 caacatggga gaaacagaga aaaggattgc aacccatggg gtcagatgct tttctaagat
      181 caagatgttt ctgttggcat taacatgtgc atatgtatcc aaatcactct caggaattta
      241 tatgaattcc atgcttacac aaatagagag acaattcgat atccccacat ctatagttgg
      301 acttatcaat gggagctttg agattggaaa tcttttgttg attatactcg tgagttactt
      361 tggaacaaaa ttgcacagac ctatcatgat tggtattgga tgtgtgatta tgggcctagg
      421 gtgtttctta atgtccttac ctcatttcct catgggccga tacgaatatg aaacaacgat
      481 ttcacctaca agcaacttgt cctcaaacag cttcttgtgt atggaaaaca gaacacagac
      541 cttaaagcca acgcaagacc ctgcagagtg tgtgaaagaa atgaaatcat taatgtggat
      601 atatgtactg gtaggaaaca tcatacgtgg aattggtgaa actcccatca tgcccttggg
      661 tatttcctac atagaagatt ttgccaaatc tgaaaactct cctttatata ttgggatttt
      721 agaatcagga aagatgattg gcccaattgt tggacttttg ttgggatcct tctgtgcaag
      781 aatttatgta gacacagggt ctgtgaatac agatgacctg accataactc ccactgatac
      841 acgctgggtc ggtgcttggt ggattggctt tttggtctgt gcaggagtga atatcctgac
      901 cagcatcccc tttttcttct ttccaaaaac actcccaaag gaaggattac aggataatgt
      961 ggatagaact gaaaatgaca aagaggagaa gcacagagaa aaagccaagg aggaaaaccg
     1021 aggaatcact aaagatttcc tgccattcat gaagagcctc tcctgcaatc ctatttacat
     1081 gcttctcatc ctgacaagtg tgctccagat aaacgcattt atcaatatgt ttaccttctt
     1141 gcccaaatac ctggagcagc agtatggaaa atccacttca gaggtcgtcc tcctcatagg
     1201 tgtttgtaac ttacctccaa tctgcattgg atatttactt attggcttta ttatgaagaa
     1261 gttcaggatt actgtcaaga aggctgcata catggcattc tgcctatccc tgtttgagta
     1321 ccttctgtct tactttcact ttatgataag ctgtgataat ttccaagttg ctggcttaac
     1381 tacctcttat gaaggagttc agcaccctct atatgtggag aacaaggtcc ttgctgactg
     1441 caacacaagg tgtagctgct taacaaacac atgggatcca gtgtgtggag acaatggcct
     1501 atcatacatg tcagcctgcc tcgcgggctg tgagaagtct gttggaatgg gaacccacat
     1561 ggtgtttcaa aattgcagct gcattcagtc atcaggaaac tcatctgcag tcctggggct
     1621 gtgtaaaaaa ggccctgagt gtgctaacaa gctgcagtac tttttaatca tgtcggtaat
     1681 tggcagtttc atctattcga tcacagccat acctgggtac atggttcttc tgaggtgtat
     1741 caagtctgaa gagaagtccc ttggaattgg attacacgca ttttgcacaa gaatattcgc
     1801 tggcatccct gcacccattt actttggagc tttgatagac agaacctgct tacattgggg
     1861 aactctgaaa tgtggtgagc caggagcctg taggatgtac aatataaata acttcaggcg
     1921 catttatcta gtgttgcctg cagcactaag aggatcaagc tatctccctg cattcttcat
     1981 tctgatactt atgaggaaat tccagctccc tggggaaatg tactcttctg aaactgaact
     2041 tgcagacatg aagctcacag tgaagaaaag cgagtgcaca gatgtgcaca gaattcctaa
     2101 ggtcgagaat gatggagaac tgaaaactaa gctgtaatga atcttctcct ggcctatgca
     2161 aggccctgaa cagaatgcac attgcacttc ctttgaatca tgagaggtac gagaggaact
     2221 cttttcctaa aataaatcag ggctggactc agtgtaagat attctcaaaa gtcactgtct
     2281 catcctcagg aggcctctgg tgctcactca ttctagtcac atatcccaga gcacagtgct
     2341 actttcaaaa tcatcttaga gtaaaacctt tgaagagggg ccacctaaat gtcgcaatgg
     2401 aaaggcgtgc tttctaccaa ggctgacaag ttgtgtttga tcattgggac caacatggca
     2461 gaaggacaga accaaccacg ctttcaggtt gtccttttct ctttactccc acactgtggt
     2521 gtgcatatcc caccccaaac aaacaaacaa ataaaaaaat ttagaaacta tt
//
