LOCUS       NM_030687               3855 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 1a4 (Slco1a4), transcript variant 1, mRNA.
ACCESSION   NM_030687
VERSION     NM_030687.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3855)
  AUTHORS   Takano,J., Maeda,K., Kusuhara,H. and Sugiyama,Y.
  TITLE     Organic Anion Transporting Polypeptide 1a4 is Responsible for the
            Hepatic Uptake of Cardiac Glycosides in Mice
  JOURNAL   Drug Metab Dispos 46 (5), 652-657 (2018)
   PUBMED   29348124
  REMARK    GeneRIF: Oatp1a4 plays a major role in the hepatic accumulation of
            cardiac glycosides in mice.
REFERENCE   2  (bases 1 to 3855)
  AUTHORS   Zhang,Y., Li,F., Wang,Y., Pitre,A., Fang,Z.Z., Frank,M.W.,
            Calabrese,C., Krausz,K.W., Neale,G., Frase,S., Vogel,P., Rock,C.O.,
            Gonzalez,F.J. and Schuetz,J.D.
  TITLE     Maternal bile acid transporter deficiency promotes neonatal demise
  JOURNAL   Nat Commun 6, 8186 (2015)
   PUBMED   26416771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3855)
  AUTHORS   Zhang,Y., Csanaky,I.L., Selwyn,F.P., Lehman-McKeeman,L.D. and
            Klaassen,C.D.
  TITLE     Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important
            for secondary bile acid metabolism
  JOURNAL   Biochem Pharmacol 86 (3), 437-445 (2013)
   PUBMED   23747753
  REMARK    GeneRIF: Oatp1a4 does not appear to mediate the hepatic uptake of
            bile acid, but plays an important male-predominant role in
            secondary bile acid metabolism.
REFERENCE   4  (bases 1 to 3855)
  AUTHORS   Son,E.J., Wu,L., Yoon,H., Kim,S., Choi,J.Y. and Bok,J.
  TITLE     Developmental gene expression profiling along the tonotopic axis of
            the mouse cochlea
  JOURNAL   PLoS One 7 (7), e40735 (2012)
   PUBMED   22808246
REFERENCE   5  (bases 1 to 3855)
  AUTHORS   Bochkis,I.M., Schug,J., Ye,D.Z., Kurinna,S., Stratton,S.A.,
            Barton,M.C. and Kaestner,K.H.
  TITLE     Genome-wide location analysis reveals distinct transcriptional
            circuitry by paralogous regulators Foxa1 and Foxa2
  JOURNAL   PLoS Genet 8 (6), e1002770 (2012)
   PUBMED   22737085
REFERENCE   6  (bases 1 to 3855)
  AUTHORS   Cheng,X. and Klaassen,C.D.
  TITLE     Critical role of PPAR-alpha in perfluorooctanoic acid- and
            perfluorodecanoic acid-induced downregulation of Oatp uptake
            transporters in mouse livers
  JOURNAL   Toxicol Sci 106 (1), 37-45 (2008)
   PUBMED   18703564
  REMARK    GeneRIF: Report critical role of PPAR-alpha in perfluorooctanoic
            acid- and perfluorodecanoic acid-induced downregulation of Oatp1a4
            uptake transporter in mouse liver.
REFERENCE   7  (bases 1 to 3855)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   8  (bases 1 to 3855)
  AUTHORS   van Montfoort,J.E., Schmid,T.E., Adler,I.D., Meier,P.J. and
            Hagenbuch,B.
  TITLE     Functional characterization of the mouse organic-anion-transporting
            polypeptide 2
  JOURNAL   Biochim Biophys Acta 1564 (1), 183-188 (2002)
   PUBMED   12101011
REFERENCE   9  (bases 1 to 3855)
  AUTHORS   Shih,D.Q., Bussen,M., Sehayek,E., Ananthanarayanan,M.,
            Shneider,B.L., Suchy,F.J., Shefer,S., Bollileni,J.S.,
            Gonzalez,F.J., Breslow,J.L. and Stoffel,M.
  TITLE     Hepatocyte nuclear factor-1alpha is an essential regulator of bile
            acid and plasma cholesterol metabolism
  JOURNAL   Nat Genet 27 (4), 375-382 (2001)
   PUBMED   11279518
REFERENCE   10 (bases 1 to 3855)
  AUTHORS   Ogura,K., Choudhuri,S. and Klaassen,C.D.
  TITLE     Genomic organization and tissue-specific expression of splice
            variants of mouse organic anion transporting polypeptide 2
  JOURNAL   Biochem Biophys Res Commun 281 (2), 431-439 (2001)
   PUBMED   11181066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156277.6 and AC164572.4.
            
            On Aug 13, 2022 this sequence version replaced NM_030687.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031814.2, SRR17784649.76780.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC156277.6         54314-54391         c
            79-155              AC156277.6         53403-53479         c
            156-269             AC156277.6         50395-50508         c
            270-379             AC156277.6         43599-43708         c
            380-521             AC164572.4         219998-220139       c
            522-654             AC164572.4         218268-218400       c
            655-761             AC164572.4         213361-213467       c
            762-908             AC164572.4         209444-209590       c
            909-1007            AC164572.4         204982-205080       c
            1008-1229           AC164572.4         203719-203940       c
            1230-1394           AC164572.4         198180-198344       c
            1395-1590           AC164572.4         196458-196653       c
            1591-1756           AC164572.4         194189-194354       c
            1757-1929           AC164572.4         191414-191586       c
            1930-1994           AC164572.4         189190-189254       c
            1995-2112           AC164572.4         188022-188139       c
            2113-3855           AC164572.4         184178-185920       c
FEATURES             Location/Qualifiers
     source          1..3855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 72.9 cM"
     gene            1..3855
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /note="solute carrier organic anion transporter family,
                     member 1a4"
                     /db_xref="GeneID:28250"
                     /db_xref="MGI:MGI:1351896"
     exon            1..78
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            79..155
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            156..269
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            270..379
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            380..521
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            522..654
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            655..761
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            762..908
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1007
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1229
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1394
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1590
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1756
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1929
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..1994
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2112
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..3855
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2551..2556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /note="hexamer: ATTAAA"
     polyA_site      2576
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /note="major polyA site"
     regulatory      3831..3836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /note="hexamer: AATAAA"
     polyA_site      3855
                     /gene="Slco1a4"
                     /gene_synonym="Oatp1a4; Oatp2; Slc21a5"
                     /note="major polyA site"
ORIGIN      
        1 ctgactttcc tttagtctca gcatggagag gaccgtcttc taaggctcct tcatgtgtgg
       61 acttctcact tggctgtgat tcttgtttgt aaaacttctg agacaacaag actgttttga
      121 aaggaatctt caaggtggcg atagaaacta accagttcat cttcactgac atagaaacag
      181 tattcctcca ccatcccaat gcaagtccct cctatttctg cagtcattaa gcccagagct
      241 ctccagtttt ggagaacaac tcccattaga agtaagactg ttcaaagaat agacatttgg
      301 agacaatcag aagaacaaca tgggaaaatc tgagaaagag gttgcaaccc atggggtcag
      361 atgcttttcc aagatcaagg catttctgtt ggcattaaca tgtgcatatg tatccaaatc
      421 actatcagga acttacatga attccatgct cactcaaata gagagacaat tcggtatccc
      481 cacgtctgta gttgggctta tcaatgggag ctttgagata ggaaatcttc tgttgattat
      541 attcgtgagt tacttcggaa caaaactgca caggcctatc atgattggtg taggatgtgc
      601 agttatgggc ctggggtgtt tcttaatatc gatacctcat ttcctcatgg gcagatatga
      661 atatgaaaca acaattttac ctacaagcaa cttgtcctca aatagctttg tgtgtacgga
      721 aaacagaaca cagaccttaa agccaacgca agacccaaca gagtgtgtga aagaaatgaa
      781 atcattaatg tggatatatg tactggtagg aaacattata cgtggaatgg gtgaaactcc
      841 catcatgccc ttgggtattt cctacataga agattttgca aaatctgaaa actctccttt
      901 atatattggg attttagaaa caggaatgac cattggccct ttgattggac ttctgttggg
      961 atcttcctgt gcaaacattt atgtagacac tgggtctgtg aatacagatg acctgaccat
     1021 aactcccact gatacacgct gggtcggtgc ttggtggatt ggctttttgg tctgtgcagg
     1081 agtgaatatc ctgaccagca tccccttttt cttctttcca aaaacactcc taaaggaagg
     1141 attacaggat aatggagatg gaactgaaaa tgccaaagag gagaagcaca gagaaaaaat
     1201 caaggaggaa aaccgaggaa tcactaaaga tttctttctg ttcatgaaga gcctctcctg
     1261 caatccgatt tacatgattt tcatccttat aagtgtgatc caggtcaatg cctttatcaa
     1321 ttcatttacc ttcatgccta agtatctgga acagcaatat ggaaaatcca ctgctgagat
     1381 agtcttcctc atgggtcttt acatgttacc tccaatatgc ctcggatatt taattggtgg
     1441 tttgattatg aagaagttca agattactgt caagaaagct gcatacatag gattctggct
     1501 atccctgact gagtaccttc tgtcttttgt tagctatata atgacctgtg acaatttccc
     1561 agttgctgga ttaaccacct cttatgaagg agttcagcac cctctatatg tggagaataa
     1621 tgtccttgct gactgcaaca caaagtgtag ctgcttaacg aacacatggg acccagtgtg
     1681 tggagacaat ggtctatcat acatgtcagc ttgcctcgcg ggctgtgaga agtctgttgg
     1741 aactggaacc aacatggtgt ttcaaaattg tagctgcatt cagtcatcag gaaatgcatc
     1801 tgcagtcctg ggcctgtgtg acaagggtcc tgagtgtgct aacaagctgc agtacttttt
     1861 aatcatatca ataattggct gtttcatctt ctcgctggga gccatacctg ggtacatggt
     1921 tcttctgagg tgtatgaagt ctgaagagaa gtcacttgga gttggattac atacattttg
     1981 catgagaata ttaggtggta ttccagcacc tatttacttt ggtgctttga tagacagaac
     2041 ctgtttacac tggggaactc taaaatgtgg tgagccaggg gcatgcagga tgtatgatat
     2101 aaatagcttc aggcgcattt acctggggtt gcctgctgct ctaagaggag caagctttct
     2161 ccctgcactc ttcatcctaa tccttatgag gaaattccaa ttccctgggg acatcgactc
     2221 ttcagacaca gatcctgcag aaatgaagct cactgcgaag gaaagcaagt gcacaaatgt
     2281 gcacagaagt cctacgatgc agaatgatgg agaacggaaa actaagctgt gatgaggttt
     2341 ctactggcca gtgcaaggcc agaaccagaa cgcacatgtc actagttttg aatcatgaga
     2401 agtacaatcg gaactcttat cttattctta aggccttcaa aattacttta ctcatgataa
     2461 aaaatattta ctgatagcat ttccagaagg ttggtgtagc acttaagatt ttcccaggga
     2521 aaacttctgt agcaaacccc cacccttaac attaaagctg ccttcatttt caaaaagtat
     2581 gttctctttt aactcaaggg aaatggatgt ttcccacata tcttcaaata agcttgaaac
     2641 ttttctattg cagaaagact atttaaatgt ttttcattta tattttgatg ctggaggtat
     2701 ttagagctca aaataggcaa ctttgttaag ccacactgaa ataatttgtt ttatcctctg
     2761 tgtgtgaaag atctctacat ctgttgttat gtacttagga gtgctaactc tctctgcttt
     2821 actctagtca agacttccaa ggttagactc tccacagtgg ccatctcctg ttttcagtcc
     2881 cttctttcat tactcctgtc acacagttgg tcatttcttt tgcatcattg aaaactttaa
     2941 tcaggttgtt aaaaatcatg tagcaaaaat gattggaact tttttcccta gcaattcaca
     3001 gctggtcatg aaactcttcc ttaaaatcaa gaatgggaga aaactagtcc ttttaaaggc
     3061 tccttgtcga gatgggctgt atctcggtgg atatgtgatt gcctaataca tgtgaggccc
     3121 tgagttcaac cacaaggtag agtaaactga taaagtaata aaaatcactt gtctagatgt
     3181 agtatcagat attctgagaa gactaattct catattcata gaactttgac ggctcagtgt
     3241 tcattctatt aacgagccat agagcacatg actattaaca ttaataataa ccgtagagta
     3301 aaagctttca agagggacca gctagaaggt tcaatggaaa gaactgtttg cccctcagcc
     3361 tgacaaggtt gttgtgatcc ctgggatcaa catggcagga gaaaagaaca aactcttgca
     3421 agttgcccta tgccttttta ttttaattgt gcatgcccca ccaaaaatca attaataaat
     3481 gaaaaaattt gaaagttgta atactgactt ttgctataaa actggaattc ataaacttga
     3541 aagtacacat tagaaaacta gttgtggttg tttgaatgag aaatatccct cttacgcaca
     3601 gacatttgga catgtggttt ctagtaataa ctctgcttag ggaagattgg acacgcatct
     3661 ttaatatgta ggagggttca aagcttcacc ctacttccag tatagtttct gctttgtgtt
     3721 ttgggtaatg atgtgaaatc tcagctttct gcttcagtca caatgcctgg tgctttctgt
     3781 catacctcct tgccatgagg gacttcagtc cctctggatt cataagtcaa aataaatgcc
     3841 tattcatatg tgtta
//
