LOCUS       NM_013797               3967 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus solute carrier organic anion transporter family,
            member 1a1 (Slco1a1), mRNA.
ACCESSION   NM_013797 XM_990876
VERSION     NM_013797.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3967)
  AUTHORS   Porteiro,B., Roscam Abbing,R.L.P., In Het Panhuis,W., de
            Waart,D.R., Duijst,S., Bolt,I., Vogels,E.W., Levels,J.H.M.,
            Bosmans,L.A., Vos,W.G., Oude Elferink,R.P.J., Lutgens,E. and van de
            Graaf,S.F.J.
  TITLE     Inhibition of hepatic bile salt uptake by Bulevirtide reduces
            atherosclerosis in Oatp1a1-/-Ldlr-/- mice
  JOURNAL   J Lipid Res 65 (8), 100594 (2024)
   PUBMED   39009243
  REMARK    GeneRIF: Inhibition of hepatic bile salt uptake by Bulevirtide
            reduces atherosclerosis in Oatp1a1[-/-]Ldlr[-/-] mice.
REFERENCE   2  (bases 1 to 3967)
  AUTHORS   Karagianni,P., Moulos,P., Schmidt,D., Odom,D.T. and Talianidis,I.
  TITLE     Bookmarking by Non-pioneer Transcription Factors during Liver
            Development Establishes Competence for Future Gene Activation
  JOURNAL   Cell Rep 30 (5), 1319-1328 (2020)
   PUBMED   32023452
REFERENCE   3  (bases 1 to 3967)
  AUTHORS   Lee,H.H., Leake,B.F., Kim,R.B. and Ho,R.H.
  TITLE     Contribution of Organic Anion-Transporting Polypeptides 1A/1B to
            Doxorubicin Uptake and Clearance
  JOURNAL   Mol Pharmacol 91 (1), 14-24 (2017)
   PUBMED   27777271
  REMARK    GeneRIF: important roles for OATP1A/1B in transporter-mediated
            uptake and disposition of doxorubicin, are reported.
REFERENCE   4  (bases 1 to 3967)
  AUTHORS   Durmus,S., van Hoppe,S. and Schinkel,A.H.
  TITLE     The impact of Organic Anion-Transporting Polypeptides (OATPs) on
            disposition and toxicity of antitumor drugs: Insights from knockout
            and humanized mice
  JOURNAL   Drug Resist Updat 27, 72-88 (2016)
   PUBMED   27449599
  REMARK    GeneRIF: Organic anion-transporting polypeptides exert strong
            impact on disposition and toxicity of antitumor drugs. (Review)
            Review article
REFERENCE   5  (bases 1 to 3967)
  AUTHORS   Iusuf,D., Ludwig,M., Elbatsh,A., van Esch,A., van de Steeg,E.,
            Wagenaar,E., van der Valk,M., Lin,F., van Tellingen,O. and
            Schinkel,A.H.
  TITLE     OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics
            and carboxylesterase expression in knockout and humanized
            transgenic mice
  JOURNAL   Mol Cancer Ther 13 (2), 492-503 (2014)
   PUBMED   24194565
  REMARK    GeneRIF: Data indicate that organic anion-transporting polypeptides
            Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces)
            enzymes, which caused higher conversion of irinotecan to SN-38 in
            plasma, potentially complicating pharmacokinetic analyses.
REFERENCE   6  (bases 1 to 3967)
  AUTHORS   Wolters,H., Elzinga,B.M., Baller,J.F., Boverhof,R., Schwarz,M.,
            Stieger,B., Verkade,H.J. and Kuipers,F.
  TITLE     Effects of bile salt flux variations on the expression of hepatic
            bile salt transporters in vivo in mice
  JOURNAL   J Hepatol 37 (5), 556-563 (2002)
   PUBMED   12399219
  REMARK    GeneRIF: organic anion transporting polypeptide-1 (Oatp1) were
            down-regulated by taurocholate and not affected by cholestyramine
            feeding
REFERENCE   7  (bases 1 to 3967)
  AUTHORS   Shih,D.Q., Bussen,M., Sehayek,E., Ananthanarayanan,M.,
            Shneider,B.L., Suchy,F.J., Shefer,S., Bollileni,J.S.,
            Gonzalez,F.J., Breslow,J.L. and Stoffel,M.
  TITLE     Hepatocyte nuclear factor-1alpha is an essential regulator of bile
            acid and plasma cholesterol metabolism
  JOURNAL   Nat Genet 27 (4), 375-382 (2001)
   PUBMED   11279518
REFERENCE   8  (bases 1 to 3967)
  AUTHORS   Isern,J., Hagenbuch,B., Stieger,B., Meier,P.J. and Meseguer,A.
  TITLE     Functional analysis and androgen-regulated expression of mouse
            organic anion transporting polypeptide 1 (Oatp1) in the kidney
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 73-78 (2001)
   PUBMED   11267661
REFERENCE   9  (bases 1 to 3967)
  AUTHORS   Lammert,F., Carey,M.C. and Paigen,B.
  TITLE     Chromosomal organization of candidate genes involved in cholesterol
            gallstone formation: a murine gallstone map
  JOURNAL   Gastroenterology 120 (1), 221-238 (2001)
   PUBMED   11208732
  REMARK    Review article
REFERENCE   10 (bases 1 to 3967)
  AUTHORS   Hagenbuch,B., Adler,I.D. and Schmid,T.E.
  TITLE     Molecular cloning and functional characterization of the mouse
            organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the
            gene to chromosome X
  JOURNAL   Biochem J 345 Pt 1 (Pt 1), 115-120 (2000)
   PUBMED   10600646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB848260.1, AF223067.1 and AC156277.6.
            
            On Apr 16, 2010 this sequence version replaced NM_013797.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY243579.1, AY195868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849386,
                                           SAMN00849387 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               BB848260.1         1-239
            240-2482            AF223067.1         74-2316
            2483-3967           AC156277.6         105471-106955       c
FEATURES             Location/Qualifiers
     source          1..3967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 73.09 cM"
     gene            1..3967
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /note="solute carrier organic anion transporter family,
                     member 1a1"
                     /db_xref="GeneID:28248"
                     /db_xref="MGI:MGI:1351891"
     exon            1..384
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..2337
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /note="solute carrier family 21 (organic anion
                     transporter), member 1; solute carrier family 21 member 1;
                     sodium-independent organic anion-transporting polypeptide
                     1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1A1"
                     /protein_id="NP_038825.1"
                     /db_xref="CCDS:CCDS39691.1"
                     /db_xref="GeneID:28248"
                     /db_xref="MGI:MGI:1351891"
                     /translation="MEETEKKVATQEGRFFSKMKVFLMSLTCAYLAKSLSGVYMNSML
                     TQIERQFGIPTSVVGFITGSFEIGNLLLIVFVSYFGRKLHRPIIIGVGCVVMGLGCFL
                     MASPHFLMGRYKYETTISPTSNLSSNSFLCIENRTQTLKPTQDPTECVKEIKSLMWIY
                     VLIGNTMRGIGETPIMPLGISYIEDFAKSENSPLYIGILEMGKIVGPIIGLLLGSFFA
                     RVYVDIGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKKELQ
                     DNVDVTKYEKVEKHRERAKKENLGITKDFLPFMKSLCCNPIYMLFSLTSVLQINGFAS
                     TFTFLPKYLEQQYGKSTSEAVFLIGVYSLPPVCLGYLISGFIMKKFKITVKKAAYIAF
                     GLSLSEYFIFLCNYLLTCDNFPVAGLTTSYKGVQHPLYGEKNVLADCNTRCSCLTDTW
                     DPVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIGSSGNSSAVLGLCKKGPECDN
                     KLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAGIPAPVY
                     FGALIDRTCLHWGTLKCGQPGACRMYDINRFRHIYLGLPAAVRGSSFLPAVFILILMR
                     KFHFPGDIHSPDTELAEMKLTEKESECTDVCRSPKVENDGELKTKL"
     exon            385..526
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..659
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..766
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..913
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1012
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1234
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1399
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1595
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1761
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1934
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..1999
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2117
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..3967
                     /gene="Slco1a1"
                     /gene_synonym="A530084B21; OATP-1; Oatp1; Oatp1a1;
                     Slc21a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctggaag cagcattcct ccttggtttt tgcattgact ccagcatcca ggttgctgct
       61 ttgggctcct gtcctgactt tcctcagcaa tgaagttaat aaacaactgt gagctaaaat
      121 aaaccctttc catttcattt ctctttggtc ctggtatttt gtcacaacaa tagaaactct
      181 gactaaggca ctctatcctt aagagagatt ttttgggggg atgactcgtt acagttcaga
      241 aaataattta tttaacagct ttctctgaga aagacagcag taggactttt aaagcaaaga
      301 aactggaaac atttgaagaa caccatggaa gaaacagaga aaaaggttgc aacacaagaa
      361 ggcagattct tctccaagat gaaggtgttt ctgatgtcat taacatgtgc atacctagcc
      421 aaatcactat caggagttta tatgaattcc atgctcacac aaatagagag acaatttggt
      481 atccctacat ctgtagttgg atttatcact gggagctttg agataggaaa ccttttgttg
      541 attgtattcg tgagttattt tggaaggaaa ctgcacagac ctatcattat tggtgttgga
      601 tgtgtggtta tgggcctggg gtgtttctta atggcatcac ctcatttcct catgggcaga
      661 tacaaatatg aaacaacaat atcacctaca agcaacttgt cctcaaacag cttcttgtgt
      721 atagaaaaca gaacacagac cttaaagcca acgcaagatc caacagagtg tgtaaaagaa
      781 ataaaatcat taatgtggat atatgtacta ataggaaata ctatgcgtgg aattggtgaa
      841 actcccataa tgcccttggg tatttcttac atcgaagact ttgccaaatc agaaaactct
      901 cctttatata ttgggatttt agaaatgggg aagattgttg gcccgattat tggacttttg
      961 ttgggatctt tctttgcacg tgtttatgta gacattgggt ctgtgaatac agatgacctg
     1021 accataactc ccactgatac acgctgggtc ggtgcttggt ggattggctt tttggtctgt
     1081 gcaggagtga atatcctgac cagcatcccc tttttcttct ttccaaagac actgccaaag
     1141 aaagaactac aggataatgt ggatgtgact aaatatgaga aagttgaaaa acatagagaa
     1201 agagccaaaa aggaaaacct tggaatcact aaagatttct tgccattcat gaagagcctc
     1261 tgctgcaatc ctatttatat gctgttcagt cttacgagtg tgctccagat aaatggattt
     1321 gccagtacat ttaccttctt gcccaaatac ctggagcagc aatatggaaa atccacttca
     1381 gaggcagtat tcctcatagg tgtttatagc ttgcctccag tatgccttgg atatttaatc
     1441 agtggcttta ttatgaagaa gtttaagatc actgtcaaga aagctgcata catagcattt
     1501 ggcctgtcct tatctgaata ttttattttt ctctgtaact atttgttgac ctgtgataat
     1561 ttcccagttg ctggattaac cacctcttat aaaggagttc agcaccctct atatggggag
     1621 aaaaatgtcc ttgctgactg caacacaagg tgcagctgct taacggacac atgggatcca
     1681 gtgtgtgggg acaatggcct agcttacatg tcagcctgcc tcgcaggctg tgagaagtct
     1741 gttggaactg gaaccaacat ggtgtttcaa aattgcagct gcattgggtc atcaggaaac
     1801 tcatctgcag tcctggggct gtgtaagaaa ggccctgagt gtgacaacaa gctgcagtac
     1861 tttttaatca agtcagtatt ttccagtttc atcttctcac tcgcagccat ccctggatac
     1921 atggttcttc tgaggtgtgt caaatctgaa gagaagtcaa ttggagttgg attacatgca
     1981 tttttcataa gactattagc tggcattccg gcacctgttt actttggcgc tttgatagac
     2041 agaacctgtt tacattgggg aactctgaaa tgtggtcaac caggggcatg caggatgtat
     2101 gatataaaca gattcaggca catttacctg gggttgcctg cagcagtgag aggatcaagc
     2161 tttctccccg cagtcttcat tctaatcctt atgaggaaat tccatttccc tggcgacatc
     2221 cactctccag acactgaact tgcagagatg aagctcacag agaaggaaag cgagtgcaca
     2281 gatgtgtgca gaagtcctaa ggtcgagaac gatggagaac tgaaaactaa gctgtaatga
     2341 gttttcaact ggcctgtgca aggccatgaa tggaatgtac acttcacttt ctttgaatca
     2401 tgagagatat agtaggaatc ctcatcttta aggacctcaa caattatttt ttactcataa
     2461 taaaaaacaa ttactgatag cagtttcaga acattaaggt actacttcag attttctcag
     2521 attagacatc tacggtgacg cacacactga actttaaagc ttccttcatt ttcacatggc
     2581 attttctctt ttaactcaat caaggggagt tgtgtttcct acatatcttc aaatgggttt
     2641 aaagttttcc tattcctgaa acagcattca attctactga atttatcctt caatgttgga
     2701 ggtatttaga actgaaaata tgcattctgg ttgggacaca ttgaaaaagt tatcttttct
     2761 atgttcaaga tgtctgcata ggtctatatc taggagtttt caatttttta ttattttaga
     2821 catgagtttc taggattaga catctttctc atgtgtcatc ttctgttttc agtctctcct
     2881 ttgtttagcc ctgtcacaca tttgataatt ttgtttagag cactgacaaa cttagtcggg
     2941 ttattaaaaa tcacattgca aagcttgttg gacccatttt ccctagcaac tcaaagtcgt
     3001 tcatgaaaat ctttcttcaa agcaactatt tgagaaagcc agttatttca aaggttcttt
     3061 gtaaagatgt agttgttcct cagctgtaca atgattgcct agcatgtgtg caaccctgca
     3121 ttgaaccaaa aggtagagta gactactgac aataatagac aaaataaagt aaaataagaa
     3181 ataaatgaaa ataaatcaga gctggatgca gtagaagata ttctcaaaga ctactttctt
     3241 atactcagga tgcctctgac tcagtggtca tttttttcat gtgtcctcag aacacatgaa
     3301 taaaatgata acatatttaa aagtataact ataattttat aataaattat aataaagtta
     3361 taaatttaca attaaaatta aactataaca tgaataaaat aacatgactg ttaactttca
     3421 gaatcagagt aaaactttta aagtgagagc aggcagatag ttcaatcgaa aggggtattt
     3481 gccaccaagc ctccacctca aactatatat ggaggcaggg ggtggggggg aggagacaga
     3541 gacagagaca gagacagaga cagagagaga gtttaagcca agactcttgc tgaaaaaaaa
     3601 tttggcttaa taaaattcaa agtatttgta aaaaacaaaa tcaatttgta gtggtttgaa
     3661 tatgaagtgt ccattctcag atagaacaat aaggcaataa gacatttggt ttcctgttga
     3721 taatgctgct tagggaagat tgggcaggaa tatccttgga ggaggaaata catcactgga
     3781 atgacctttg agatttaaaa acctcaccct tcttccagtt catactcttc attgttcttt
     3841 aaagatatga aatcttagct tcctgctcta gtcactgtac ctgctgcttg ctatcatacc
     3901 tccatgacat gagaggctac aatccctctg aaatcataag ccaaaataaa ctctttgttt
     3961 taaaggt
//
