LOCUS       NM_198106               3879 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus solute carrier family 9, subfamily C (Na+-transporting
            carboxylic acid decarboxylase), member 1 (Slc9c1), mRNA.
ACCESSION   NM_198106 XM_156183
VERSION     NM_198106.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3879)
  AUTHORS   Hernandez-Garduno,S., Chavez,J.C., Matamoros-Volante,A.,
            Sanchez-Guevara,Y., Torres,P., Trevino,C.L. and Nishigaki,T.
  TITLE     Hyperpolarization induces cytosolic alkalization of mouse sperm
            flagellum probably through sperm Na+/H+ exchanger
  JOURNAL   Reproduction 164 (4), 125-134 (2022)
   PUBMED   35900329
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3879)
  AUTHORS   Balbach,M., Hamzeh,H., Jikeli,J.F., Brenker,C., Schiffer,C.,
            Hansen,J.N., Neugebauer,P., Trotschel,C., Jovine,L., Han,L.,
            Florman,H.M., Kaupp,U.B., Strunker,T. and Wachten,D.
  TITLE     Molecular Mechanism Underlying the Action of Zona-pellucida
            Glycoproteins on Mouse Sperm
  JOURNAL   Front Cell Dev Biol 8, 572735 (2020)
   PUBMED   32984353
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3879)
  AUTHORS   Jansen,V., Alvarez,L., Balbach,M., Strunker,T., Hegemann,P.,
            Kaupp,U.B. and Wachten,D.
  TITLE     Controlling fertilization and cAMP signaling in sperm by
            optogenetics
  JOURNAL   Elife 4, e05161 (2015)
   PUBMED   25601414
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3879)
  AUTHORS   Wang,D., Hu,J., Bobulescu,I.A., Quill,T.A., McLeroy,P., Moe,O.W.
            and Garbers,D.L.
  TITLE     A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression
            and in vivo bicarbonate regulation of the soluble adenylyl cyclase
            (sAC)
  JOURNAL   Proc Natl Acad Sci U S A 104 (22), 9325-9330 (2007)
   PUBMED   17517652
  REMARK    GeneRIF: sperm-specific Na+/H+ exchanger is required for the
            expression of full-length soluble adenylyl cyclase
REFERENCE   5  (bases 1 to 3879)
  AUTHORS   Wang,D., King,S.M., Quill,T.A., Doolittle,L.K. and Garbers,D.L.
  TITLE     A new sperm-specific Na+/H+ exchanger required for sperm motility
            and fertility
  JOURNAL   Nat Cell Biol 5 (12), 1117-1122 (2003)
   PUBMED   14634667
REFERENCE   6  (bases 1 to 3879)
  AUTHORS   Oduru,S., Campbell,J.L., Karri,S., Hendry,W.J., Khan,S.A. and
            Williams,S.C.
  TITLE     Gene discovery in the hamster: a comparative genomics approach for
            gene annotation by sequencing of hamster testis cDNAs
  JOURNAL   BMC Genomics 4 (1), 22 (2003)
   PUBMED   12783626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124636.23.
            
            On Sep 23, 2011 this sequence version replaced NM_198106.3.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            because no single transcript from the reference genome strain was
            available for the full length of the gene. The genomic coordinates
            used for the transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY368685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC124636.23        97781-97897         c
            118-365             AC124636.23        93425-93672         c
            366-466             AC124636.23        91687-91787         c
            467-595             AC124636.23        89907-90035         c
            596-761             AC124636.23        88308-88473         c
            762-887             AC124636.23        85438-85563         c
            888-1049            AC124636.23        82928-83089         c
            1050-1149           AC124636.23        80165-80264         c
            1150-1293           AC124636.23        78808-78951         c
            1294-1468           AC124636.23        77354-77528         c
            1469-1550           AC124636.23        76496-76577         c
            1551-1717           AC124636.23        74855-75021         c
            1718-1843           AC124636.23        72819-72944         c
            1844-1941           AC124636.23        59738-59835         c
            1942-2061           AC124636.23        57726-57845         c
            2062-2257           AC124636.23        55244-55439         c
            2258-2443           AC124636.23        52903-53088         c
            2444-2593           AC124636.23        51530-51679         c
            2594-2645           AC124636.23        50158-50209         c
            2646-2794           AC124636.23        48674-48822         c
            2795-2920           AC124636.23        43536-43661         c
            2921-3019           AC124636.23        42274-42372         c
            3020-3193           AC124636.23        39671-39844         c
            3194-3325           AC124636.23        33581-33712         c
            3326-3511           AC124636.23        33280-33465         c
            3512-3638           AC124636.23        31163-31289         c
            3639-3694           AC124636.23        27969-28024         c
            3695-3879           AC124636.23        26162-26346         c
FEATURES             Location/Qualifiers
     source          1..3879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.53 cM"
     gene            1..3879
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /note="solute carrier family 9, subfamily C
                     (Na+-transporting carboxylic acid decarboxylase), member
                     1"
                     /db_xref="GeneID:208169"
                     /db_xref="MGI:MGI:2685456"
     exon            1..117
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            118..365
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..3739
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /note="sperm-specific sodium proton exchanger;
                     sodium/hydrogen exchanger 10; solute carrier family 10
                     member 10; solute carrier family 9, member 10;
                     sperm-specific Na(+)/H(+) exchanger; Na(+)/H(+) exchanger
                     10"
                     /codon_start=1
                     /product="solute carrier family 9 member C1"
                     /protein_id="NP_932774.3"
                     /db_xref="CCDS:CCDS28198.2"
                     /db_xref="GeneID:208169"
                     /db_xref="MGI:MGI:2685456"
                     /translation="MEMEEISENLTASHSIKLTNMWLELLKSVFLSTPQDLPEIILIL
                     SLICTVGAFLNMHLKDFPIPLPVILFLIGCCFEILSFASTQIQIYADAIQWMDPDIFF
                     GIFTPVIIFNVAFDMDIYMLQKLFWQILVITIPGFLINYTLILWYLQSVNKLSLKTVP
                     WLLFSAVLISSDPMLTSASIRDLGLSRSLTNLINGESLLTSVLSLVIYSGVVHIRFKS
                     KSVNHTLAHKVMSTAWSYIVESFITGIVFTKVIQLWMATIFGDDVNHITLIFSVLYLI
                     FYVCELVGMSGIFTLATIGLFLNSTSFKPGVEAFLLEFWNCLSFIGFLMVFTFIGLLI
                     PAHTYLHISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRLGHGFSWRWAFIMVWSEM
                     KGTPNINMALLLAYSDISLGSERERSQILFHGVSVCVITLIVNRFILPMAVTKLGLRD
                     VTSTKYKSVYYTFQHFQELTKSTAMALKFDKDLANADWNMVDNAIILQNPYAMNQEEI
                     TEHQKVKCPDCNKEIDETLNIEAMELTNRRLLSAQIASYQRQYRNEVLSQSAVQVLVG
                     AAGSFGEKKGEYMSPENIKNFSESKKLLSFLRKLLLNWVYNTKKDKGVPSRYMFLHAC
                     HRIVFTNEFEYTGYLVVLMSTYPMIICWISRLKDIYDNEIKCANYYFLAFYILEALLK
                     VAAMRKEFFSHTWLLFELGITLVGVLDIILIETDSISYNFDLTETVVFMNVIRLLRIL
                     RILKLVTPKLLQIIDKRMSQQISFRYSILKGYVQGEMDVLNIIDQIASSKQTKQILLK
                     RVMRNMEHAMKELGYLEYDHPEIAVTMKTKEEINVMLNMAREIVKAFRSKGIIHKVEG
                     TEINKLIMAKKIQVLDLQSVIQPFNVEEAPCNIPWLSEDPEAITFIQEKAKVVTFDCG
                     NNIFEEGDEPEGIYVIISGMVKLKRSKPHLEMERVSAESEIKIHPLPHTEYLLSGEII
                     GELNCLTKERMQYSATCKTVVETYFIPISHLYEGFEKRCPNMKHKMWQKIGLAITAQK
                     IREHLSFEDWNYKLQLKLCNAFIRDIPKSMKTDIYDETVTHVVLIHGSAEDCQLRKIY
                     KAPFLIPVTCHQIQGMEDFTKVMIIQTSIAVRKFRWNVRKYIPPRRISMKPDSERESF
                     ETLDETSEEDNGKKENQENEELIEENINI"
     exon            366..466
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            467..595
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            596..761
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            762..887
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1049
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1149
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1293
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1468
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1550
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1717
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1843
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1941
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2061
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2257
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2443
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2593
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2645
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2794
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2920
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3019
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3193
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3325
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3511
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3638
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3694
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3879
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3856..3861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /note="hexamer: ATTAAA"
     polyA_site      3879
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; NHE-10; Slc9a10; sNHE; spermNHE"
                     /note="major polyA site"
ORIGIN      
        1 gggcttggaa caagtaactg tcagtgaagt tgcagttggt tttggacagt tctggaatga
       61 gaggaggttt ctggcctcca tttctcatat tctccaggac actcccgtgc cccgatgaaa
      121 aagcaatagg agacaccaag aagaaaaggc cctttgatcc tctgtgagtt tttcagagac
      181 acatcaagtt tgaggcagac tgtaattaaa catggaaatg gaagaaattt ctgaaaattt
      241 aactgcatcc cacagtatca aactgactaa tatgtggctg gaacttctca aaagtgtgtt
      301 tctgagcact ccccaggacc tccctgaaat catcctgata ctatctttga tctgtacagt
      361 tggagcattt ttgaacatgc atctgaaaga ttttccaatt cctcttcctg tgatactatt
      421 tttaattgga tgctgttttg aaattctgag ttttgcatca acccagatcc agatatatgc
      481 agatgccata cagtggatgg atccagacat attctttggt atattcacac cagtgattat
      541 ctttaatgtt gccttcgaca tggatatata catgcttcaa aagttatttt ggcagatact
      601 agtaattaca attcctggat ttctgattaa ttacacctta atactttggt atctgcagtc
      661 tgtgaataaa ttatctttga agactgtccc ctggttacta ttttcagctg ttcttataag
      721 ttcagatcct atgcttactt cagcctccat aagagacctt ggtctttcta gaagcctcac
      781 aaatttaatt aatggagaga gtctactgac ctcagtgtta tccttagtta tatatagtgg
      841 tgttgtgcat atcagattca agtcaaagag tgtgaaccac accctagccc acaaggtcat
      901 gtctacagct tggtcgtata ttgttgaaag cttcattact ggaatcgtat ttacaaaagt
      961 gattcagtta tggatggcca ccatctttgg tgatgatgtc aaccacatca ctctcatctt
     1021 ctcagtttta tacctcatct tctatgtttg tgaactagtt ggaatgtctg gaatatttac
     1081 tctggccacc ataggacttt ttctaaattc tacaagcttt aaaccaggag ttgaagcatt
     1141 tctgctcgaa ttctggaact gcctgtcttt tattggtttt cttatggtgt tcactttcat
     1201 tggacttcta atccctgcac acacatactt acatatatca ttttctgatg tatattattc
     1261 attaaatatc tacttcacac tgattgtttt aagacttttg gtctttctgc taatgagccc
     1321 catcttgtct cgacttggtc acgggttcag ctggcgctgg gcgttcatca tggtctggag
     1381 tgaaatgaaa ggaacaccga acataaatat ggcgctcctg cttgcctact cggacatttc
     1441 tctcggttct gagagggaaa gatctcaaat actatttcat ggagtgtcag tatgtgtaat
     1501 taccctgatt gtcaatagat ttattttgcc aatggcagtt actaaactag gtcttcgtga
     1561 tgtcacatca acaaaatata aatcggttta ttatacattc caacactttc aagagctaac
     1621 caaatctaca gccatggcac tcaaatttga caaagatctt gctaatgctg actggaacat
     1681 ggttgacaat gcaattatac ttcaaaatcc atatgcaatg aaccaagaag aaataacaga
     1741 gcatcagaag gtgaaatgtc cagattgcaa caaggaaata gatgagaccc tcaacattga
     1801 agccatggag ctgaccaaca gacgtctcct gtcagcacag atagcgagct accaacgaca
     1861 gtacaggaat gaggttctgt cccagagtgc agtgcaggtg ttggtaggcg cagctggaag
     1921 ctttggtgag aagaagggag aatatatgag tcctgagaat ataaagaatt tttcagaaag
     1981 caaaaaactc ctctcctttc ttagaaaatt actactcaac tgggtgtata atactaaaaa
     2041 agataaaggg gttccatcaa gatacatgtt tcttcatgca tgccatagaa tagtcttcac
     2101 aaatgaattt gaatatactg gataccttgt ggtattaatg agcacatatc ctatgataat
     2161 ctgttggatt tcccgactaa aagacatcta tgacaacgag ataaagtgtg ctaactacta
     2221 ttttcttgcc ttctatattc tagaggctct acttaaggtg gcagcaatga ggaaggaatt
     2281 tttttcacac acctggctcc tgtttgagct ggggattacc ttagtcggcg tcctagatat
     2341 aatacttatc gaaacagact ccattagtta caattttgac ttaactgaga ctgtggtctt
     2401 catgaacgtg attcgactcc ttcgtatact gcgcatcttg aagcttgtaa caccaaaact
     2461 gctgcaaatc atagacaaaa ggatgagcca gcagatatca tttcggtatt ctatactgaa
     2521 aggctatgtc caaggggaaa tggatgtact gaatataatt gatcagattg caagttccaa
     2581 acagactaaa cagatattgt taaagcgggt aatgaggaat atggaacatg ctatgaaaga
     2641 gctaggctac ttagagtatg accatccgga aatcgctgtc actatgaaaa ccaaggagga
     2701 gattaatgtc atgctcaata tggccagaga aattgtcaag gctttcaggt ccaaaggaat
     2761 tatacacaag gtggaaggca ctgagattaa caagttaatc atggccaaaa agatccaggt
     2821 gcttgatctg cagtctgtta tccagccatt taatgttgaa gaagccccgt gcaatatccc
     2881 atggcttagt gaagatcctg aagccataac ctttattcag gaaaaagcaa aagttgtaac
     2941 atttgactgt ggaaataaca tatttgaaga aggtgatgag ccagaaggaa tctatgtaat
     3001 aatttcaggc atggttaagc ttaaaaggtc aaaaccacac ctggagatgg aaagagtatc
     3061 cgcagagtca gagattaaaa ttcatccact gccccacaca gagtacctgc tcagcgggga
     3121 gataatagga gagttaaact gtctgactaa agaacggatg caatattctg ccacctgcaa
     3181 aactgttgtg gagacatatt ttattcccat tagccacttg tatgaaggct ttgaaaaaag
     3241 atgtcctaac atgaaacata aaatgtggca aaaaatcgga cttgccatta ctgcccaaaa
     3301 gatccgagaa cacttatctt ttgaggactg gaactacaag ctgcagttga aactctgcaa
     3361 tgccttcata agagacatcc ccaagtccat gaaaactgac atctatgacg aaacggtaac
     3421 ccacgttgtc ctcatccatg gatctgctga ggactgccag ctgcgaaaaa tttataaggc
     3481 gcctttccta attcctgtga cgtgccatca gatacaaggc atggaagact tcacaaaagt
     3541 gatgattatt caaacttcaa ttgctgtaag aaaattcaga tggaatgtaa gaaagtacat
     3601 cccacctcga agaatttcga tgaaaccaga ttctgaaaga gaatcttttg aaacattgga
     3661 tgaaacctct gaagaggaca atggtaagaa agagaatcaa gaaaatgagg aattgataga
     3721 agagaatatt aacatctaaa gagtcgcctg gaaagttcag ttcgctgcct aagcttttca
     3781 aaatgaccat gaaaatattt atttctggag atagagacaa gccaaagttt atgtgccttt
     3841 tatgtgataa tgtgaattaa agcatctcac actaaccaa
//
