LOCUS       NM_177909               3492 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),
            member 9 (Slc9a9), mRNA.
ACCESSION   NM_177909
VERSION     NM_177909.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3492)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3492)
  AUTHORS   Shamroukh,H.S., Lone,N., Akhtar,M., Altayib,A., Sutliff,S.,
            Kassem,Z., Tripathy,S.K. and Kondapalli,K.C.
  TITLE     The sodium proton exchanger NHE9 regulates phagosome maturation and
            bactericidal activity in macrophages
  JOURNAL   J Biol Chem 298 (8), 102150 (2022)
   PUBMED   35716776
REFERENCE   3  (bases 1 to 3492)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3492)
  AUTHORS   Ullman,J.C., Yang,J., Sullivan,M., Bendor,J., Levy,J., Pham,E.,
            Silm,K., Seifikar,H., Sohal,V.S., Nicoll,R.A. and Edwards,R.H.
  TITLE     A mouse model of autism implicates endosome pH in the regulation of
            presynaptic calcium entry
  JOURNAL   Nat Commun 9 (1), 330 (2018)
   PUBMED   29362376
  REMARK    GeneRIF: Inactivation of NHE9 in mice reproduces behavioral
            features of autism spectrum disorders including impaired social
            interaction, repetitive behaviors, and altered sensory processing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3492)
  AUTHORS   Yang,L., Faraone,S.V. and Zhang-James,Y.
  TITLE     Autism spectrum disorder traits in Slc9a9 knock-out mice
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 171B (3), 363-376 (2016)
   PUBMED   26755066
  REMARK    GeneRIF: This is the first animal behavior study that links Slc9a9
            to Autism spectrum disorders.
REFERENCE   6  (bases 1 to 3492)
  AUTHORS   Ouyang,Q., Lizarraga,S.B., Schmidt,M., Yang,U., Gong,J.,
            Ellisor,D., Kauer,J.A. and Morrow,E.M.
  TITLE     Christianson syndrome protein NHE6 modulates TrkB endosomal
            signaling required for neuronal circuit development
  JOURNAL   Neuron 80 (1), 97-112 (2013)
   PUBMED   24035762
REFERENCE   7  (bases 1 to 3492)
  AUTHORS   Hill,J.K., Brett,C.L., Chyou,A., Kallay,L.M., Sakaguchi,M., Rao,R.
            and Gillespie,P.G.
  TITLE     Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers
            NHE6 and NHE9
  JOURNAL   J Neurosci 26 (39), 9944-9955 (2006)
   PUBMED   17005858
  REMARK    GeneRIF: NHE9/Slc9a9 is expressed in the inner ear
REFERENCE   8  (bases 1 to 3492)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   9  (bases 1 to 3492)
  AUTHORS   Nakamura,N., Tanaka,S., Teko,Y., Mitsui,K. and Kanazawa,H.
  TITLE     Four Na+/H+ exchanger isoforms are distributed to Golgi and
            post-Golgi compartments and are involved in organelle pH regulation
  JOURNAL   J Biol Chem 280 (2), 1561-1572 (2005)
   PUBMED   15522866
REFERENCE   10 (bases 1 to 3492)
  AUTHORS   de Silva,M.G., Elliott,K., Dahl,H.H., Fitzpatrick,E., Wilcox,S.,
            Delatycki,M., Williamson,R., Efron,D., Lynch,M. and Forrest,S.
  TITLE     Disruption of a novel member of a sodium/hydrogen exchanger family
            and DOCK3 is associated with an attention deficit hyperactivity
            disorder-like phenotype
  JOURNAL   J Med Genet 40 (10), 733-740 (2003)
   PUBMED   14569117
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB838484.1, AK037058.1 and AC157517.2.
            
            On Apr 21, 2010 this sequence version replaced NM_177909.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099942.1, AK156494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BB838484.1         2-18
            18-2488             AK037058.1         2-2472
            2489-3492           AC157517.2         58945-59948         c
FEATURES             Location/Qualifiers
     source          1..3492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 49.22 cM"
     gene            1..3492
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /note="solute carrier family 9 (sodium/hydrogen
                     exchanger), member 9"
                     /db_xref="GeneID:331004"
                     /db_xref="MGI:MGI:2679732"
     exon            1..345
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2105
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /note="solute carrier family 9 member 9; Na(+)/H(+)
                     exchanger 9"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 9"
                     /protein_id="NP_808577.3"
                     /db_xref="CCDS:CCDS40726.1"
                     /db_xref="GeneID:331004"
                     /db_xref="MGI:MGI:2679732"
                     /translation="MAGQLRFTSGKDEDHFQHQGAVELLAFNFLLILTILTIWLFKNH
                     RFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVYNCGNLFFSPSTLLVNITDQVY
                     EYKYQREINQHNISPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLG
                     SILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDFHFTDCLFFGSLMSATDPVT
                     VLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDTAAFFQSVG
                     NFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAEAAGLTG
                     IVAVLFCGVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIF
                     NALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAI
                     RNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDESLKEEPSSQQE
                     ANKLDKNMTKTESAQLFRMWYGFDHKYLKPILTHSGPPLTTTLPAWCGPVSRLLTSPQ
                     AYGEQLKEDDVECIVNQDELAMNYQEQSPSPSSPTTKLALDQKSSGQTPGKENIYEGD
                     LGLGGYDLKLEQTRGQPQMD"
     exon            346..548
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            549..626
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            627..703
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            704..819
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            820..925
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1064
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1170
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1259
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1373
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1485
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1639
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1691
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1771
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1877
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..3492
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3465..3470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /note="hexamer: AATAAA"
     polyA_site      3485
                     /gene="Slc9a9"
                     /gene_synonym="5730527A11Rik; 9930105B05; Nhe9"
                     /note="major polyA site"
ORIGIN      
        1 gagaagccgg tctgaatgct aagccatctg aattgcttgc gaagtagcaa caaagtagca
       61 gcgtttattc tgaaattctg tgggcgccag tctatcctag gcaaccctca tctaagggct
      121 catcccttgt ccagggattt ctctgagcat cacagtcggt cgagtggaga atggctgggc
      181 agcttcggtt tacgtcaggg aaggatgaag atcattttca acaccaggga gcagtggagc
      241 tactcgcgtt taattttttg ctcatcctta ccattttaac aatctggtta tttaaaaatc
      301 accgattccg cttcttgcat gagactggag gggcgatggt gtatggcctc ataatgggac
      361 taattttgcg atatgccaca gcgccgactg atattgatag tggaactgtc tacaactgtg
      421 ggaacttgtt cttcagccca tcaactctac tagtcaacat caccgaccaa gtttatgagt
      481 ataagtacca gagagagatc aaccagcaca atatcagccc ccaccaaggc aacgccatac
      541 tggagaagat gacgtttgac ccagaaatct tcttcaacgt tttgctgcct cccatcatat
      601 ttcatgcagg atacagtctg aagaagagac acttttttca aaacttggga tccattttaa
      661 catatgcctt cttgggaaca gccatctcct gtgtggtcat agggttaatt atgtacggct
      721 ttgtgaaagc catggtgcat gctggccagc tgaagagcgg agacttccac ttcactgact
      781 gtttattttt tggttcactg atgtctgcta cagatccagt gacagtgctg gccattttcc
      841 atgaactcca cgtggaccca gacctgtaca cactgctgtt tggagagagt gtactgaatg
      901 atgcggtggc catagtcctc acatactcta tatccatcta tagtcccaag gagaatccca
      961 acgcgtttga cacggcagcg ttcttccaat ccgtgggcaa tttcctaggg atctttgccg
     1021 gctcctttgc aatgggctcc gcatatgcag ttgttaccgc actgttgacc aaatttacca
     1081 agctccgtga gttcccgatg ctggagacag gcctgttttt cctcctttct tggagtgcct
     1141 tcctgtctgc agaggccgcc ggcttaacag gcatagttgc tgttctcttc tgtggagtca
     1201 cacaggcaca ttacacctac aacaatctgt catcggattc caaactgagg accaaacagc
     1261 tgtttgaatt tatgaacttc ctggctgaaa acgtcatctt ctgctacatg ggcctggctc
     1321 tgttcacctt ccagaatcac attttcaatg ctctttttat actcggagcc tttctagcaa
     1381 tttttgttgc cagagcctgc aacatttacc ccctctcctt cctcctgaat ctgggcagaa
     1441 agcagaagat tccctggaac ttccagcaca tgatgatgtt ttcaggtttg cgaggtgcca
     1501 ttgccttcgc cctggccatc cgcaacacgg aatctcagcc caaacagatg atgttcacca
     1561 ccacactgct ccttgtgttc ttcactgtct gggtgtttgg aggaggaacg acccccatgc
     1621 tgacgtggct tcagatcaga gttggtgtgg acctggatga aagtctgaag gaagagccct
     1681 cctcacagca ggaagcaaat aagttggaca aaaacatgac gaagacagag agtgcacagc
     1741 tcttcagaat gtggtatgga tttgaccaca aatacctgaa acccatccta acacactcag
     1801 gccctccact gaccaccacc ttgccagcgt ggtgtggccc agtctccagg ctgctcacca
     1861 gtccgcaggc ctatggggaa caactgaaag aggatgacgt ggaatgtatc gtcaaccaag
     1921 atgaactggc catgaattac caggagcaga gcccttcacc cagcagtccc accaccaagc
     1981 tagctctgga ccagaagtct tcaggccaga ctccaggcaa ggagaatatc tacgagggag
     2041 atctcggcct gggaggctat gatctcaaac tggagcagac tcggggtcaa ccccagatgg
     2101 actaattggt atgatgagtg cagacttaat cacatgtaac acaagaccac tgaggaatgc
     2161 caacagccaa ggaggtggtg cagagagaga cagaaagagt attaagaaca tgaattggac
     2221 agaatcaaac cttatcacat gtatcctccc gtgccttcag aaatgagaat tcattatctt
     2281 ccctctgtat tatgcaacct catttaatta tctgacagcc atttttactg ctgaattagg
     2341 ggccaggaga gtcaggtcct agctgccatt gggatgaacc atatgtgctg tgtctgcagg
     2401 gggccccttc tgttcctcag acagctctcc aggcccttca tgtggatttt ggattcaatt
     2461 ccattaatta tggaacatta ataacatgaa gaagaagaag aaaaaaaact cctgagcata
     2521 aatgataagc cttatctctc aacttgactc cacttgttcg gaccataggg ctaaatgcag
     2581 aaaccagtgt gtgttcagta cccactcttg atggctttgg agaattcaca tgaattgggg
     2641 gccttgttgt ccttgctggc gctctctcca tgcagttctt cccactcctc caaggagctg
     2701 cttgcccacg ggtgtgtgca tgttaagtgt aggctcttgc cagcttaagg ggactctctc
     2761 cagggaaagc tggtctcttt cccacattct gtgttttatt caaatggtga gcctctcttc
     2821 cttgtgtgca ctgggacaac ttcctgacag gttccctctg catgctggga agtcatgttt
     2881 tgcagcatga cccttccaca tggggttgga ggattgtgca ggagccctca ccttttccac
     2941 caatatctgt aactgattgg caatagaggg gcaaaaagaa cagagctaat gacatttagg
     3001 ccacactgag gcaccaagga caagcaccag tcaggatctc ccccattccc agagtggcca
     3061 gtggctgcat tgaagagacc aacatcatag cttttaattc agctgcatga ctcgtgcctt
     3121 tgaagccata agatacctca agcctagctt ctcttgatgt gcagatgttc tattaggctc
     3181 caaagagcag gcttcagact tgggagccca agatgtaatg ggtttacttt tgagggagat
     3241 gaagaacgat ttctttctca ggcccaaagg ctaaaactaa tgcatgcttc actgagtgct
     3301 tcttaggcct taggcctgtg agatcaggta ccttgcctgc gtgtctgttt ttcttgcttc
     3361 caaatagtag aaactgggag aaacttttat attcaactga gtaaaatctt gtcatgtcag
     3421 gtaaatatgg caaggagaga ggttttctaa tgtgacatca tcctaataaa ctttcttatg
     3481 gagtatgatt gc
//
